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The map label for this gene is yegE [H]

Identifier: 45657010

GI number: 45657010

Start: 1390199

End: 1391134

Strand: Reverse

Name: yegE [H]

Synonym: LIC11126

Alternate gene names: 45657010

Gene position: 1391134-1390199 (Counterclockwise)

Preceding gene: 45657011

Following gene: 45657009

Centisome position: 32.52

GC content: 39.74

Gene sequence:

>936_bases
TTGGAAAAACGTCACATGAGTTATCAAAACGAATACAACCTCGAAAAATTCTACAACTATTCTTTGGATTTGTTTTCGAT
CCAACGGCTGGATGGCACTGTGATCTCCGTCAATCCCTCATTTGAAAGAATTCTAGGATGGAAAGAAGAAGAACTTTTAG
GACGCGATCCATTTCACTTGTTACATCCGGAGGATTTAGGAAGCGCCAAAGAATTTGAAGAACTAGACGGAGGAGTTCCG
AGATCCTCAATTCAAAACCGAATCCGATGTGCAGATGGAACGTATAAACATTTCGCTTGGACCGGATATCCGGATCTTGA
AGCGGGCCTAGTCTACGTAACCGGACGAGACATTACAGAAACCATCGAAGCAAATCGGCAAATCAGTCAGCTTGCAACTG
AATTGAAGGAAGCTAACGACTTATTGTTCGAACAAGCAACAACCGATCCTTTGACCAAGTTGAAAAATCGCAGAGCATTT
ACGAATGACCTTCATAGTCTTCTCAGATTTATGCAACAAGAGAAAAGTTTTCTTTCACTTCTTATGATAGACGTGGATCA
TTTTAAGACTTACAACGATCAATTTGGTCATCTCGCCGGAGATAAAGTATTGGTCTGTCTTGCTAAAGTTCTTGAGAATA
CCTTGCGATCAAACGACTTATTGGGGCGTTTCGGAGGAGAAGAATTTGTAGCCGCCTTACCAAATACTTGCGAAAAAAAA
TCGATAGAAATTGGGGAAAGATTGGTTAACGCAGTCCGAGAATTCAATTGGGAATATCGTTCCATTACGATCAGTGTAGG
AATCTCTACTTCAGACTTTGAAAAAAAACAGTTAGACGTTGATTCCACTAATTTGATCGAAAAGGCGGATAAAGCGCTTT
ATCAATCTAAAGTTAACGGAAGAAATAAGGCTACTCATAGTTCTCAAATATATTAA

Upstream 100 bases:

>100_bases
AGGATCCTTCCTTGTAAAGAAGCGTAATCCTATAGAAAAAACCTACGCGTCTGTTAATCGGCGAACCTATAATAAGAACG
ACTTTACTTATAAATCTTTT

Downstream 100 bases:

>100_bases
TTTATTTGAATACGATATTATTTTCCGTTTTTTTAAACACCAGTGAACGTAGGATTCCAAAAAGAACAATTCTTTTTACG
TTAATTCAATTCTAGGAAAA

Product: GGDEF family protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MEKRHMSYQNEYNLEKFYNYSLDLFSIQRLDGTVISVNPSFERILGWKEEELLGRDPFHLLHPEDLGSAKEFEELDGGVP
RSSIQNRIRCADGTYKHFAWTGYPDLEAGLVYVTGRDITETIEANRQISQLATELKEANDLLFEQATTDPLTKLKNRRAF
TNDLHSLLRFMQQEKSFLSLLMIDVDHFKTYNDQFGHLAGDKVLVCLAKVLENTLRSNDLLGRFGGEEFVAALPNTCEKK
SIEIGERLVNAVREFNWEYRSITISVGISTSDFEKKQLDVDSTNLIEKADKALYQSKVNGRNKATHSSQIY

Sequences:

>Translated_311_residues
MEKRHMSYQNEYNLEKFYNYSLDLFSIQRLDGTVISVNPSFERILGWKEEELLGRDPFHLLHPEDLGSAKEFEELDGGVP
RSSIQNRIRCADGTYKHFAWTGYPDLEAGLVYVTGRDITETIEANRQISQLATELKEANDLLFEQATTDPLTKLKNRRAF
TNDLHSLLRFMQQEKSFLSLLMIDVDHFKTYNDQFGHLAGDKVLVCLAKVLENTLRSNDLLGRFGGEEFVAALPNTCEKK
SIEIGERLVNAVREFNWEYRSITISVGISTSDFEKKQLDVDSTNLIEKADKALYQSKVNGRNKATHSSQIY
>Mature_311_residues
MEKRHMSYQNEYNLEKFYNYSLDLFSIQRLDGTVISVNPSFERILGWKEEELLGRDPFHLLHPEDLGSAKEFEELDGGVP
RSSIQNRIRCADGTYKHFAWTGYPDLEAGLVYVTGRDITETIEANRQISQLATELKEANDLLFEQATTDPLTKLKNRRAF
TNDLHSLLRFMQQEKSFLSLLMIDVDHFKTYNDQFGHLAGDKVLVCLAKVLENTLRSNDLLGRFGGEEFVAALPNTCEKK
SIEIGERLVNAVREFNWEYRSITISVGISTSDFEKKQLDVDSTNLIEKADKALYQSKVNGRNKATHSSQIY

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=281, Percent_Identity=32.3843416370107, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082007, Length=163, Percent_Identity=36.8098159509202, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786584, Length=177, Percent_Identity=33.8983050847458, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI87081881, Length=286, Percent_Identity=28.3216783216783, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI145693134, Length=191, Percent_Identity=32.4607329842932, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787802, Length=165, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787262, Length=166, Percent_Identity=32.5301204819277, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787816, Length=168, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081977, Length=175, Percent_Identity=33.7142857142857, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788085, Length=165, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787541, Length=174, Percent_Identity=30.4597701149425, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787056, Length=165, Percent_Identity=30.9090909090909, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081974, Length=160, Percent_Identity=28.125, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788956, Length=269, Percent_Identity=25.6505576208178, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 35677; Mature: 35677

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50112 PAS ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRHMSYQNEYNLEKFYNYSLDLFSIQRLDGTVISVNPSFERILGWKEEELLGRDPFHL
CCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCEEEEECCCHHHHHCCCHHHHCCCCCCEE
LHPEDLGSAKEFEELDGGVPRSSIQNRIRCADGTYKHFAWTGYPDLEAGLVYVTGRDITE
ECCHHCCCHHHHHHHCCCCCHHHHHHHEECCCCCCCCEEECCCCCCCCCEEEEECCCHHH
TIEANRQISQLATELKEANDLLFEQATTDPLTKLKNRRAFTNDLHSLLRFMQQEKSFLSL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LMIDVDHFKTYNDQFGHLAGDKVLVCLAKVLENTLRSNDLLGRFGGEEFVAALPNTCEKK
HHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCCHHHH
SIEIGERLVNAVREFNWEYRSITISVGISTSDFEKKQLDVDSTNLIEKADKALYQSKVNG
HHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCC
RNKATHSSQIY
CCCCCCCCCCC
>Mature Secondary Structure
MEKRHMSYQNEYNLEKFYNYSLDLFSIQRLDGTVISVNPSFERILGWKEEELLGRDPFHL
CCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCEEEEECCCHHHHHCCCHHHHCCCCCCEE
LHPEDLGSAKEFEELDGGVPRSSIQNRIRCADGTYKHFAWTGYPDLEAGLVYVTGRDITE
ECCHHCCCHHHHHHHCCCCCHHHHHHHEECCCCCCCCEEECCCCCCCCCEEEEECCCHHH
TIEANRQISQLATELKEANDLLFEQATTDPLTKLKNRRAFTNDLHSLLRFMQQEKSFLSL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LMIDVDHFKTYNDQFGHLAGDKVLVCLAKVLENTLRSNDLLGRFGGEEFVAALPNTCEKK
HHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCCHHHH
SIEIGERLVNAVREFNWEYRSITISVGISTSDFEKKQLDVDSTNLIEKADKALYQSKVNG
HHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCC
RNKATHSSQIY
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]