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The map label for this gene is fur [H]

Identifier: 45656893

GI number: 45656893

Start: 1224172

End: 1224654

Strand: Reverse

Name: fur [H]

Synonym: LIC11006

Alternate gene names: 45656893

Gene position: 1224654-1224172 (Counterclockwise)

Preceding gene: 45656894

Following gene: 45656892

Centisome position: 28.63

GC content: 34.58

Gene sequence:

>483_bases
ATGAATCGAGAAAAACAAGAAGCCATTCTAAATAAAACGCAACCAGCGGTCCGTATGGAAATGCAGACATTTTCTGAGTA
TTTACAAAAAGAAGGCTTAAAGATTACCAATCAGAGAATGTTAGTTGCGGAAAGAATTTTTTCCCTTCACAATCATTTTA
CCGCAGAAGGACTTTTAGAAGAATTTAAGGATCAAAGAGATCAAATTTCCAAAGCCACAATTTATAGAATACTTTCCATA
ATGGTTTCAGCAGGTCTATTACAAGAACATAATTTTGGAAAGGATTACAAATATTACGAACATATAATAGGCCACAAACA
TCACGATCATATCATCTGCACAGTCTGCGGAAAAATCGTGGAATTTTTAGACGAAAGAATAGAACAACTTCAAGAACAAG
CAGCAAGAGAAAACGGTTTCAAAATCACAGGTCATAGCTTGAACATTTACGGAACTTGCAACGAACATTCTTCTAGTAAA
TGA

Upstream 100 bases:

>100_bases
GGCAGTTCGAATTGCAGAAGAGACGGAAAGGGGTTGGTATTTTTCTATTGCCGGAAAGATCGATCCCTGATAATCTTGAC
TCGTCCTTTGGTGATCTAAT

Downstream 100 bases:

>100_bases
TTTTTCAAACAACTTCGGAAGACACTCTTACTAAAGCCAGAACCGGAATTTTAAATTTAAACGGAATAGAATTAAAAACC
CCTGTATTTATGCCGGTGGG

Product: FUR family transcriptional regulator

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MNREKQEAILNKTQPAVRMEMQTFSEYLQKEGLKITNQRMLVAERIFSLHNHFTAEGLLEEFKDQRDQISKATIYRILSI
MVSAGLLQEHNFGKDYKYYEHIIGHKHHDHIICTVCGKIVEFLDERIEQLQEQAARENGFKITGHSLNIYGTCNEHSSSK

Sequences:

>Translated_160_residues
MNREKQEAILNKTQPAVRMEMQTFSEYLQKEGLKITNQRMLVAERIFSLHNHFTAEGLLEEFKDQRDQISKATIYRILSI
MVSAGLLQEHNFGKDYKYYEHIIGHKHHDHIICTVCGKIVEFLDERIEQLQEQAARENGFKITGHSLNIYGTCNEHSSSK
>Mature_160_residues
MNREKQEAILNKTQPAVRMEMQTFSEYLQKEGLKITNQRMLVAERIFSLHNHFTAEGLLEEFKDQRDQISKATIYRILSI
MVSAGLLQEHNFGKDYKYYEHIIGHKHHDHIICTVCGKIVEFLDERIEQLQEQAARENGFKITGHSLNIYGTCNEHSSSK

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=136, Percent_Identity=38.2352941176471, Blast_Score=96, Evalue=1e-21,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 18681; Mature: 18681

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNREKQEAILNKTQPAVRMEMQTFSEYLQKEGLKITNQRMLVAERIFSLHNHFTAEGLLE
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EFKDQRDQISKATIYRILSIMVSAGLLQEHNFGKDYKYYEHIIGHKHHDHIICTVCGKIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
EFLDERIEQLQEQAARENGFKITGHSLNIYGTCNEHSSSK
HHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCCCCC
>Mature Secondary Structure
MNREKQEAILNKTQPAVRMEMQTFSEYLQKEGLKITNQRMLVAERIFSLHNHFTAEGLLE
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EFKDQRDQISKATIYRILSIMVSAGLLQEHNFGKDYKYYEHIIGHKHHDHIICTVCGKIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
EFLDERIEQLQEQAARENGFKITGHSLNIYGTCNEHSSSK
HHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083178 [H]