| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is rsbU [H]
Identifier: 45656838
GI number: 45656838
Start: 1145949
End: 1147658
Strand: Reverse
Name: rsbU [H]
Synonym: LIC10950
Alternate gene names: 45656838
Gene position: 1147658-1145949 (Counterclockwise)
Preceding gene: 45656839
Following gene: 45656837
Centisome position: 26.83
GC content: 35.56
Gene sequence:
>1710_bases TTGATTATGCTTTATTCTAAAGATCTTCTAGAAGCAGAGGCTAGTTCCTTATTTCTTATAAATGAAACCAGAGAATTTTT ATACTGCGAAGTAGCTCTCGGTGAAAAAGGAGAAATCATTCAAAAATATGGACGCCTAAATTTAGGAGAAGGAATCGCGG GTTGGGTCGCCAAAGAGAAAAAAACGATCATCTTAGAAGACGCCTATTCGGATTCTAGATTCAATCCTTCTTGGGATCAA AAAACTGGTTATAGAACCCGCTCCTTAATATGTGTTCCTTTGTTTGTGGAAAATAAAGTGATCGGAACTCTTGAAATTCT AAATAAAACGCAAAACCGTTCTTTTGATTCCTCCGATTTAAATTATCTTACTTCTCTTTCCGAAGTGGCTGCAATAGCGA TCCAGAACGCAAAGATTCACGAGAATCTCAAAAAAAGAATTTTAGAACTTTCTCTTCTTTATGAATTTGAAAAACTAATC GTCTCCGAAAAAAGTATTCATGAATTAGGAAATTGGGTATTACAAAGAATATTAGAATTTTTAGAAGCAAGAACTGGAAC TATCTATCTTGCGGACCATACAAACCAAACCTTAAGAATTTTAGCAGCCAAAGGAATTCCCAAAGAAGCGGTTCAAACAA TTACAGTTCCTTTTGGAGAGGGTGTTGCCGGTTGGGTCGCCAAAGAAAAGAAAAGTCTTCTTATACATAACTTAGAAGAA GACAATCGTTACGATAAGAACGCAAAATATAAGTTCGAAACAAACTCTCTCATCTCTTCTCCTTTAATTTACAGAAATGA ACTTTTAGGAGTTATTAGTGTTAATAGTAAAAAATCAGGCTTTGCGTTTCATCAAAACGATTTGGAAATGTTGGACACGG TTGCCAATAGGCTTGCTCTGACGATTAAAAACGCGGATCTATTTCACAGAGTAATAGATTCGGATCGTGAGTTGCAAAGA GCCAGAGAAGTCATGTCTAAGTTTATTCCAACTACAATCCCTTATATAAAAAATTTGGAAGTTAGCGCAGAGTATATTCC CTATTCGAATGTAGGAGGAGATTTTTATAATATATTTAGATTAGATCCAGAACGAACCGGTTTTTTAATCGCGGATGTTT CCGGTCACGGCCTTTCGGCTTCTGTAATCGCCGCGATGATGAATACGATCATTTCCACTTACGACAAAGAAATTCTTTCT AGTCCTTCTCAATTTTTTACCGAACTCAATCACGCTCTTTATAATAAGATGGTTGGAAATTTTGTAACCGCGTTTTACTG TGTAATCAACACCAATCAAAATACAATTCTTTATTCCAACGCAGGACACAATCATCCCTTACTTTTACAAAACGCTACCA ACAACTTGATTTCTTTAGAAACAAAGGGCAAATTGATAGGGGTAATTCCAGATCTTTTTTTTGAGGAGAACTTGATTGAT TTCGACTTCGGCGACAGACTTGTTTTATATACGGATGGCATTTCGGAACATTATTCTGAAGACAGAACCAAACGTTATAA CGAAGAGTTAATTTCTCTTTCAATTCATAAGTCGATTTCTAAAACCTCAAAGGAAGTAGCGTCTCAAATCATTTCGGATT GTATCGAATTTTGTAACCGTCCTAAGTTTGACGATGACGTTACTCTTCTTGTAATCGATCGTTTAAAACAAAAACGCGAT AGTTTCTACAATTTCTTAATTTTACTGTAA
Upstream 100 bases:
>100_bases ATCTATGCCCCAGACCGTTTTAGAATTTCAAAAACTAAAAAGTATTTTAAATGTCAGTACGATCTTTACCGCAAACTTAG ATCTCTACCAACTTTTACCT
Downstream 100 bases:
>100_bases TCTCCCGAAAATGTGGGAGTTCCCACATCAACTGATAAACGGAATATTCTAATCTTATAAAATGAATTGTCTCAATATCT AAAAGGAAATTATAATTTCT
Product: sigma factor regulatory protein
Products: NA
Alternate protein names: Sigma factor sigB regulation protein rsbU [H]
Number of amino acids: Translated: 569; Mature: 569
Protein sequence:
>569_residues MIMLYSKDLLEAEASSLFLINETREFLYCEVALGEKGEIIQKYGRLNLGEGIAGWVAKEKKTIILEDAYSDSRFNPSWDQ KTGYRTRSLICVPLFVENKVIGTLEILNKTQNRSFDSSDLNYLTSLSEVAAIAIQNAKIHENLKKRILELSLLYEFEKLI VSEKSIHELGNWVLQRILEFLEARTGTIYLADHTNQTLRILAAKGIPKEAVQTITVPFGEGVAGWVAKEKKSLLIHNLEE DNRYDKNAKYKFETNSLISSPLIYRNELLGVISVNSKKSGFAFHQNDLEMLDTVANRLALTIKNADLFHRVIDSDRELQR AREVMSKFIPTTIPYIKNLEVSAEYIPYSNVGGDFYNIFRLDPERTGFLIADVSGHGLSASVIAAMMNTIISTYDKEILS SPSQFFTELNHALYNKMVGNFVTAFYCVINTNQNTILYSNAGHNHPLLLQNATNNLISLETKGKLIGVIPDLFFEENLID FDFGDRLVLYTDGISEHYSEDRTKRYNEELISLSIHKSISKTSKEVASQIISDCIEFCNRPKFDDDVTLLVIDRLKQKRD SFYNFLILL
Sequences:
>Translated_569_residues MIMLYSKDLLEAEASSLFLINETREFLYCEVALGEKGEIIQKYGRLNLGEGIAGWVAKEKKTIILEDAYSDSRFNPSWDQ KTGYRTRSLICVPLFVENKVIGTLEILNKTQNRSFDSSDLNYLTSLSEVAAIAIQNAKIHENLKKRILELSLLYEFEKLI VSEKSIHELGNWVLQRILEFLEARTGTIYLADHTNQTLRILAAKGIPKEAVQTITVPFGEGVAGWVAKEKKSLLIHNLEE DNRYDKNAKYKFETNSLISSPLIYRNELLGVISVNSKKSGFAFHQNDLEMLDTVANRLALTIKNADLFHRVIDSDRELQR AREVMSKFIPTTIPYIKNLEVSAEYIPYSNVGGDFYNIFRLDPERTGFLIADVSGHGLSASVIAAMMNTIISTYDKEILS SPSQFFTELNHALYNKMVGNFVTAFYCVINTNQNTILYSNAGHNHPLLLQNATNNLISLETKGKLIGVIPDLFFEENLID FDFGDRLVLYTDGISEHYSEDRTKRYNEELISLSIHKSISKTSKEVASQIISDCIEFCNRPKFDDDVTLLVIDRLKQKRD SFYNFLILL >Mature_569_residues MIMLYSKDLLEAEASSLFLINETREFLYCEVALGEKGEIIQKYGRLNLGEGIAGWVAKEKKTIILEDAYSDSRFNPSWDQ KTGYRTRSLICVPLFVENKVIGTLEILNKTQNRSFDSSDLNYLTSLSEVAAIAIQNAKIHENLKKRILELSLLYEFEKLI VSEKSIHELGNWVLQRILEFLEARTGTIYLADHTNQTLRILAAKGIPKEAVQTITVPFGEGVAGWVAKEKKSLLIHNLEE DNRYDKNAKYKFETNSLISSPLIYRNELLGVISVNSKKSGFAFHQNDLEMLDTVANRLALTIKNADLFHRVIDSDRELQR AREVMSKFIPTTIPYIKNLEVSAEYIPYSNVGGDFYNIFRLDPERTGFLIADVSGHGLSASVIAAMMNTIISTYDKEILS SPSQFFTELNHALYNKMVGNFVTAFYCVINTNQNTILYSNAGHNHPLLLQNATNNLISLETKGKLIGVIPDLFFEENLID FDFGDRLVLYTDGISEHYSEDRTKRYNEELISLSIHKSISKTSKEVASQIISDCIEFCNRPKFDDDVTLLVIDRLKQKRD SFYNFLILL
Specific function: Positive regulator of sigma-B activity. Dephosphorylates rsbV in response to environmental stress conveyed from the rsbXST module [H]
COG id: COG2208
COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PP2C-like domain [H]
Homologues:
Organism=Homo sapiens, GI194595488, Length=185, Percent_Identity=30.8108108108108, Blast_Score=89, Evalue=8e-18, Organism=Homo sapiens, GI5729972, Length=185, Percent_Identity=30.8108108108108, Blast_Score=89, Evalue=8e-18, Organism=Homo sapiens, GI116536085, Length=326, Percent_Identity=22.6993865030675, Blast_Score=73, Evalue=6e-13, Organism=Homo sapiens, GI61744432, Length=342, Percent_Identity=23.6842105263158, Blast_Score=71, Evalue=2e-12, Organism=Homo sapiens, GI61744430, Length=342, Percent_Identity=23.6842105263158, Blast_Score=71, Evalue=3e-12, Organism=Homo sapiens, GI61744435, Length=342, Percent_Identity=23.6842105263158, Blast_Score=71, Evalue=3e-12, Organism=Caenorhabditis elegans, GI193202333, Length=152, Percent_Identity=28.9473684210526, Blast_Score=87, Evalue=3e-17, Organism=Drosophila melanogaster, GI161076953, Length=334, Percent_Identity=25.748502994012, Blast_Score=99, Evalue=9e-21, Organism=Drosophila melanogaster, GI161076955, Length=334, Percent_Identity=25.748502994012, Blast_Score=98, Evalue=1e-20, Organism=Drosophila melanogaster, GI281361762, Length=150, Percent_Identity=31.3333333333333, Blast_Score=76, Evalue=5e-14,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR017944 - InterPro: IPR001932 - InterPro: IPR014787 - InterPro: IPR010822 - ProDom: PD685490 [H]
Pfam domain/function: PF08673 RsbU_N; PF07228 SpoIIE [H]
EC number: =3.1.3.3 [H]
Molecular weight: Translated: 64768; Mature: 64768
Theoretical pI: Translated: 5.69; Mature: 5.69
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIMLYSKDLLEAEASSLFLINETREFLYCEVALGEKGEIIQKYGRLNLGEGIAGWVAKEK CEEEECHHHHHHCCCCEEEEECCCEEEEEEEEECCCCHHHHHHCCCCCCCCHHHHHCCCC KTIILEDAYSDSRFNPSWDQKTGYRTRSLICVPLFVENKVIGTLEILNKTQNRSFDSSDL CEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHH NYLTSLSEVAAIAIQNAKIHENLKKRILELSLLYEFEKLIVSEKSIHELGNWVLQRILEF HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH LEARTGTIYLADHTNQTLRILAAKGIPKEAVQTITVPFGEGVAGWVAKEKKSLLIHNLEE HHCCCCEEEEEECCCCEEEEEEECCCCHHHHHEEEEECCCCCHHHHHHHCCHHEEECCCC DNRYDKNAKYKFETNSLISSPLIYRNELLGVISVNSKKSGFAFHQNDLEMLDTVANRLAL CCCCCCCCCEEEECCHHHCCCCHHHHHEEEEEEECCCCCCCEEECCCHHHHHHHHHHEEE TIKNADLFHRVIDSDRELQRAREVMSKFIPTTIPYIKNLEVSAEYIPYSNVGGDFYNIFR EEECHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHCCEECEEECCCCCCCCCEEEEEE LDPERTGFLIADVSGHGLSASVIAAMMNTIISTYDKEILSSPSQFFTELNHALYNKMVGN ECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH FVTAFYCVINTNQNTILYSNAGHNHPLLLQNATNNLISLETKGKLIGVIPDLFFEENLID HHEEEEEEEECCCCEEEEECCCCCCCEEEECCCCCEEEEECCCCEEEECCHHHHCCCCEE FDFGDRLVLYTDGISEHYSEDRTKRYNEELISLSIHKSISKTSKEVASQIISDCIEFCNR ECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC PKFDDDVTLLVIDRLKQKRDSFYNFLILL CCCCCCEEEHHHHHHHHHHHHHHEEEEEC >Mature Secondary Structure MIMLYSKDLLEAEASSLFLINETREFLYCEVALGEKGEIIQKYGRLNLGEGIAGWVAKEK CEEEECHHHHHHCCCCEEEEECCCEEEEEEEEECCCCHHHHHHCCCCCCCCHHHHHCCCC KTIILEDAYSDSRFNPSWDQKTGYRTRSLICVPLFVENKVIGTLEILNKTQNRSFDSSDL CEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHH NYLTSLSEVAAIAIQNAKIHENLKKRILELSLLYEFEKLIVSEKSIHELGNWVLQRILEF HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH LEARTGTIYLADHTNQTLRILAAKGIPKEAVQTITVPFGEGVAGWVAKEKKSLLIHNLEE HHCCCCEEEEEECCCCEEEEEEECCCCHHHHHEEEEECCCCCHHHHHHHCCHHEEECCCC DNRYDKNAKYKFETNSLISSPLIYRNELLGVISVNSKKSGFAFHQNDLEMLDTVANRLAL CCCCCCCCCEEEECCHHHCCCCHHHHHEEEEEEECCCCCCCEEECCCHHHHHHHHHHEEE TIKNADLFHRVIDSDRELQRAREVMSKFIPTTIPYIKNLEVSAEYIPYSNVGGDFYNIFR EEECHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHCCEECEEECCCCCCCCCEEEEEE LDPERTGFLIADVSGHGLSASVIAAMMNTIISTYDKEILSSPSQFFTELNHALYNKMVGN ECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH FVTAFYCVINTNQNTILYSNAGHNHPLLLQNATNNLISLETKGKLIGVIPDLFFEENLID HHEEEEEEEECCCCEEEEECCCCCCCEEEECCCCCEEEEECCCCEEEECCHHHHCCCCEE FDFGDRLVLYTDGISEHYSEDRTKRYNEELISLSIHKSISKTSKEVASQIISDCIEFCNR ECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC PKFDDDVTLLVIDRLKQKRDSFYNFLILL CCCCCCEEEHHHHHHHHHHHHHHEEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8002610; 8002609; 9384377; 8824586; 9786195; 12499568 [H]