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The map label for this gene is sphH

Identifier: 45656555

GI number: 45656555

Start: 802139

End: 803803

Strand: Direct

Name: sphH

Synonym: LIC10657

Alternate gene names: 45656555

Gene position: 802139-803803 (Clockwise)

Preceding gene: 45656554

Following gene: 45656565

Centisome position: 18.75

GC content: 32.13

Gene sequence:

>1665_bases
ATGCGAAACATTTTCCGAAAAAAAAATAATGAAATACGAAATACATACAAGAAATCGAAATCTTTAATAGGTTTTTATTG
TCTCTTTATATTCTTTTTGAATTGTCTACCGGATAAACAAAAAGTACATGCAGATTTACTAATGTCTCTTTTACTTTTTT
CAAAAGATCAAAATATTCAATTTGCAAATATAAGTGCAGAAAGAATAGGAATTGATGCTCAAGTATCTTCGGAAGTGGAT
ATAAAAATTCTAAGTTACAATCTTTTTATGTATCATAAAGGACTTTTTAATTCTGGAAATTGGGGTCAAGAAAAAAGAGC
ACGGTTGCTTGTAGATTCAAAATATGTTAAAGATCAAGATGTACTTGTACTGGAAGGAGTTTTTGATACAAAATCGAAAA
ATATACTTATGAATGGACTCCGCTCTCAATACCCAAATCAAATCGATGTTATTGGAAGAGCTACATATGGTTGGAATCAA
ACTCTAGGTGATTTTAGAGCTTTTCCGCTGGATAACGATTATAATGGAGGAGTGATTGTCTTAAGCAAATGGCCTATTGA
AGAAAAAATACAATATATCTTTGAAAATCACGGATGTGGAAACGACTACTATTATAACAAAGGATTTGTTTATGTAAAAA
TTAATAAACATGGTCGCAAATATCATATCATTGGAACTGACGTTCAAAATACTTCTTGTTCGGATTTGGGACAAAATGCA
AGAAAACATCAGTTTGTAGAGATTAAAAATTTTATCAATTTAAAACAAGTGCCAAAAAACGAAACAATATTTCTGGCTGG
AAGTTTTAACGTAAATAAAGGTAGTGCAGAATATCAAGATATTCTAATGATTTTAGGTGTAGATGAACCTCATTACGCAG
GAATTTCTTTTACTTGGGATCCTAAAAAAAATGCAATTGCTTCTTACACCAGTGGTACAAATCAAGTATCCAGTTATTTG
GAGTATATATTTGTTGTAGGAACTCATTTTAAACCTCAAGTTTGGCAAAATTTGGCATATGATCCCATAACCCCGACTAC
CTGGAATGTTGTCGGATACACAGGTTATGAGTTTTCCGATCGATATCCTGTTTACGGTTTTACTTATGCTGATTCTAATA
CTCCAACTCAATCCGCACACAGAAGAAAATACGACCAAGTATCTTTTGAATCAATGTCAACTGGAAAAAAAATTCAAGCT
GATCCTAAACAAGCAAATGGTTGGTTACAAGTAAACGCATCAGATGAAACTGAATTTACAAAGTTCAATCTGCTGCAGGA
AGCCGATCCTAAATCCGATACCAATTGTCTCAAAAGTGGGTATACTCGGATTGAACCTTCTTATTATCTAAATTATTATT
GGAATTGGTGGCTCGGAGGAGGTAAGGGCAATTATGCTTACTATCCTAAATTTAACGATGCTTCTAATAATTTACAAATT
CATGTTCTTGACGAAGAAGAATGTATAAAAGACGGAAGTAGAATTGTATTCAAAGATTATGATGGAGCTACTCTGGATTA
TTATTATCTTACGATTTGGGATGGTGGTAATTGGGATGGATATTTATATCTTTGGAATAAAACTTACAATTTAAGGGAAA
CTTTCAAAGTTAGATTGAACACAAAACCTGAAAGAGATTGGAAAGACGATTTAATTTATCGTTAG

Upstream 100 bases:

>100_bases
ATATCTGTTTTTTTATTTTGAATTTTTTTTGTAAAAAAGTATATCTTTTTTGATACTGCGTCTCAGAATCCAGAAAATCA
ATTATTAACGAGGCTTAAAA

Downstream 100 bases:

>100_bases
TCCTTGACTTTGGTTGAGTTTTTTAAAACGAACTTTTCTATAAAATCTAAAAATAACGATCCTAAAGTCGAATTTTTTCA
CAAAACCACTGTTTGGCGAC

Product: hemolysin

Products: NA

Alternate protein names: Sphingomyelin phosphodiesterase; SMase [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MRNIFRKKNNEIRNTYKKSKSLIGFYCLFIFFLNCLPDKQKVHADLLMSLLLFSKDQNIQFANISAERIGIDAQVSSEVD
IKILSYNLFMYHKGLFNSGNWGQEKRARLLVDSKYVKDQDVLVLEGVFDTKSKNILMNGLRSQYPNQIDVIGRATYGWNQ
TLGDFRAFPLDNDYNGGVIVLSKWPIEEKIQYIFENHGCGNDYYYNKGFVYVKINKHGRKYHIIGTDVQNTSCSDLGQNA
RKHQFVEIKNFINLKQVPKNETIFLAGSFNVNKGSAEYQDILMILGVDEPHYAGISFTWDPKKNAIASYTSGTNQVSSYL
EYIFVVGTHFKPQVWQNLAYDPITPTTWNVVGYTGYEFSDRYPVYGFTYADSNTPTQSAHRRKYDQVSFESMSTGKKIQA
DPKQANGWLQVNASDETEFTKFNLLQEADPKSDTNCLKSGYTRIEPSYYLNYYWNWWLGGGKGNYAYYPKFNDASNNLQI
HVLDEEECIKDGSRIVFKDYDGATLDYYYLTIWDGGNWDGYLYLWNKTYNLRETFKVRLNTKPERDWKDDLIYR

Sequences:

>Translated_554_residues
MRNIFRKKNNEIRNTYKKSKSLIGFYCLFIFFLNCLPDKQKVHADLLMSLLLFSKDQNIQFANISAERIGIDAQVSSEVD
IKILSYNLFMYHKGLFNSGNWGQEKRARLLVDSKYVKDQDVLVLEGVFDTKSKNILMNGLRSQYPNQIDVIGRATYGWNQ
TLGDFRAFPLDNDYNGGVIVLSKWPIEEKIQYIFENHGCGNDYYYNKGFVYVKINKHGRKYHIIGTDVQNTSCSDLGQNA
RKHQFVEIKNFINLKQVPKNETIFLAGSFNVNKGSAEYQDILMILGVDEPHYAGISFTWDPKKNAIASYTSGTNQVSSYL
EYIFVVGTHFKPQVWQNLAYDPITPTTWNVVGYTGYEFSDRYPVYGFTYADSNTPTQSAHRRKYDQVSFESMSTGKKIQA
DPKQANGWLQVNASDETEFTKFNLLQEADPKSDTNCLKSGYTRIEPSYYLNYYWNWWLGGGKGNYAYYPKFNDASNNLQI
HVLDEEECIKDGSRIVFKDYDGATLDYYYLTIWDGGNWDGYLYLWNKTYNLRETFKVRLNTKPERDWKDDLIYR
>Mature_554_residues
MRNIFRKKNNEIRNTYKKSKSLIGFYCLFIFFLNCLPDKQKVHADLLMSLLLFSKDQNIQFANISAERIGIDAQVSSEVD
IKILSYNLFMYHKGLFNSGNWGQEKRARLLVDSKYVKDQDVLVLEGVFDTKSKNILMNGLRSQYPNQIDVIGRATYGWNQ
TLGDFRAFPLDNDYNGGVIVLSKWPIEEKIQYIFENHGCGNDYYYNKGFVYVKINKHGRKYHIIGTDVQNTSCSDLGQNA
RKHQFVEIKNFINLKQVPKNETIFLAGSFNVNKGSAEYQDILMILGVDEPHYAGISFTWDPKKNAIASYTSGTNQVSSYL
EYIFVVGTHFKPQVWQNLAYDPITPTTWNVVGYTGYEFSDRYPVYGFTYADSNTPTQSAHRRKYDQVSFESMSTGKKIQA
DPKQANGWLQVNASDETEFTKFNLLQEADPKSDTNCLKSGYTRIEPSYYLNYYWNWWLGGGKGNYAYYPKFNDASNNLQI
HVLDEEECIKDGSRIVFKDYDGATLDYYYLTIWDGGNWDGYLYLWNKTYNLRETFKVRLNTKPERDWKDDLIYR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.12 [H]

Molecular weight: Translated: 64428; Mature: 64428

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNIFRKKNNEIRNTYKKSKSLIGFYCLFIFFLNCLPDKQKVHADLLMSLLLFSKDQNIQ
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEE
FANISAERIGIDAQVSSEVDIKILSYNLFMYHKGLFNSGNWGQEKRARLLVDSKYVKDQD
EEECCHHHCCCCEEECCCEEEEEEEEEEEEEECCCCCCCCCCCHHHHEEEEECCCCCCCC
VLVLEGVFDTKSKNILMNGLRSQYPNQIDVIGRATYGWNQTLGDFRAFPLDNDYNGGVIV
EEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCEEECCCCCCCCCCEEE
LSKWPIEEKIQYIFENHGCGNDYYYNKGFVYVKINKHGRKYHIIGTDVQNTSCSDLGQNA
EECCCHHHHHHHHHHCCCCCCCCEECCCEEEEEECCCCCEEEEEECCCCCCCHHHHHCCH
RKHQFVEIKNFINLKQVPKNETIFLAGSFNVNKGSAEYQDILMILGVDEPHYAGISFTWD
HHHHEEEHHHHCCHHCCCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCEEEEEC
PKKNAIASYTSGTNQVSSYLEYIFVVGTHFKPQVWQNLAYDPITPTTWNVVGYTGYEFSD
CCCCCEEEECCCHHHHHHHHHEEEEECCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCC
RYPVYGFTYADSNTPTQSAHRRKYDQVSFESMSTGKKIQADPKQANGWLQVNASDETEFT
CCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHCCCCEEECCCCCCCCEEEEECCCCCCCC
KFNLLQEADPKSDTNCLKSGYTRIEPSYYLNYYWNWWLGGGKGNYAYYPKFNDASNNLQI
EEEHHHCCCCCCCHHHHHCCCCEECCCEEEEEEEEEEEECCCCCEEECCCCCCCCCCEEE
HVLDEEECIKDGSRIVFKDYDGATLDYYYLTIWDGGNWDGYLYLWNKTYNLRETFKVRLN
EEECHHHHHCCCCEEEEECCCCCEEEEEEEEEEECCCCCEEEEEEECCCCCCEEEEEEEC
TKPERDWKDDLIYR
CCCCCCCCHHCCCC
>Mature Secondary Structure
MRNIFRKKNNEIRNTYKKSKSLIGFYCLFIFFLNCLPDKQKVHADLLMSLLLFSKDQNIQ
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEE
FANISAERIGIDAQVSSEVDIKILSYNLFMYHKGLFNSGNWGQEKRARLLVDSKYVKDQD
EEECCHHHCCCCEEECCCEEEEEEEEEEEEEECCCCCCCCCCCHHHHEEEEECCCCCCCC
VLVLEGVFDTKSKNILMNGLRSQYPNQIDVIGRATYGWNQTLGDFRAFPLDNDYNGGVIV
EEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCEEECCCCCCCCCCEEE
LSKWPIEEKIQYIFENHGCGNDYYYNKGFVYVKINKHGRKYHIIGTDVQNTSCSDLGQNA
EECCCHHHHHHHHHHCCCCCCCCEECCCEEEEEECCCCCEEEEEECCCCCCCHHHHHCCH
RKHQFVEIKNFINLKQVPKNETIFLAGSFNVNKGSAEYQDILMILGVDEPHYAGISFTWD
HHHHEEEHHHHCCHHCCCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCEEEEEC
PKKNAIASYTSGTNQVSSYLEYIFVVGTHFKPQVWQNLAYDPITPTTWNVVGYTGYEFSD
CCCCCEEEECCCHHHHHHHHHEEEEECCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCC
RYPVYGFTYADSNTPTQSAHRRKYDQVSFESMSTGKKIQADPKQANGWLQVNASDETEFT
CCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHCCCCEEECCCCCCCCEEEEECCCCCCCC
KFNLLQEADPKSDTNCLKSGYTRIEPSYYLNYYWNWWLGGGKGNYAYYPKFNDASNNLQI
EEEHHHCCCCCCCHHHHHCCCCEECCCEEEEEEEEEEEECCCCCEEECCCCCCCCCCEEE
HVLDEEECIKDGSRIVFKDYDGATLDYYYLTIWDGGNWDGYLYLWNKTYNLRETFKVRLN
EEECHHHHHCCCCEEEEECCCCCEEEEEEEEEEECCCCCEEEEEEECCCCCCEEEEEEEC
TKPERDWKDDLIYR
CCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2163985 [H]