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The map label for this gene is panE2

Identifier: 45656492

GI number: 45656492

Start: 726776

End: 727822

Strand: Direct

Name: panE2

Synonym: LIC10594

Alternate gene names: NA

Gene position: 726776-727822 (Clockwise)

Preceding gene: 45656491

Following gene: 45656493

Centisome position: 16.99

GC content: 35.72

Gene sequence:

>1047_bases
ATGAAGCTTTCAATAGCAATTTTAGGTTCTGGAAGTATCGGAACATACATCGGTTGTAAACTTTTGGCGGCTGGAAATCC
GGTCACGTTCTATGGCAGAGCAAGGATTCAGAATGAGTTGAAAACTTTCGGTGCAAAAATCACCGATTATACAAATCAAG
AAATTCTTCTTCCTCCTAACACGATTTCTTTTACTACTTCTTTTTCTGATATTTCGAACGCGGATGTTTTTTTAGTTACG
GTAAAATCCAAGGACACAAAAGATCTTGCTAAAGAACTTAACGGAATTCTTGAAAAAAGACAAAACAGATCTCAAACCAT
TCCGATCGTAGTCAGTTTTCAAAACGGAGTTCGAAACGCGGAAATTTTAAAAGAAGAATTGAGAGATCTTCCCGTTGAAG
TGTTTGCCGGAATGGTTCCTTTTAACGTAGTATCTAAAGGTAACGGTCATTTTCATAGGGGTACAAGTGGGAATTTAGTG
ATCGAAGATTCTAAATCTTCTCAGACGTTAGTTAAGGTTTTTAAACGGGCTGGGCTTTCTATCAACACACATAAAAACAT
CCTTGGAATTCTTTGGGGAAAATTGATTTTTAATTTGAACAATTCTTTAAACGCTCTTTCTGGACTTACTTTAAAAGCGG
AAATATCAAAACGAGGTTATCGAAAAATTCTTTCTAAACTTATGAAAGAATCACTTGAAATCTTAAGATTTGCAGAGATC
AGACCGATTCGTTCGGGAAAGATGATTCCTAGTTTAGCTCCTATTATTTTGAATCTTCCGGATTTTTTATTTTTCAGAAT
TGCGTCTGGAATGGTTAAGATTGATCCTCAAGCCAGATCTTCAATGTGGGAGGATTTGGTCAAAAAAAGACCGACTGAAA
TTGATTCTCTCAATGGAGAAATTGTCAAACTAGCGGACGTAATGGGTCATCCAGCTCCTTTTAACAGAGAAATTGTACGA
TTGATTAAAGAAGCTGAGTCAAATCCTCAAATTTTAAATCTAAGTCCGGAAGAACTTGCCAAAAAATTAAAAATCAAATT
AACGTGA

Upstream 100 bases:

>100_bases
AATTGGAATCTATCTTAAATGTAGAGTTTTTTTGTTTTTTTCCCAACTAACAAACAATAGTTGTAGATTAAATCTTAAAT
TCTAATTAGATGCGTAACAA

Downstream 100 bases:

>100_bases
GTTTTACGTAAGGACCAACCCCACAAGTTGAATAGGATTTTAGAATCAAAATGAACTCAACAGAACGGGCTTTCTATGAA
TCGCCGTTCTGGGCTCAAAA

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MKLSIAILGSGSIGTYIGCKLLAAGNPVTFYGRARIQNELKTFGAKITDYTNQEILLPPNTISFTTSFSDISNADVFLVT
VKSKDTKDLAKELNGILEKRQNRSQTIPIVVSFQNGVRNAEILKEELRDLPVEVFAGMVPFNVVSKGNGHFHRGTSGNLV
IEDSKSSQTLVKVFKRAGLSINTHKNILGILWGKLIFNLNNSLNALSGLTLKAEISKRGYRKILSKLMKESLEILRFAEI
RPIRSGKMIPSLAPIILNLPDFLFFRIASGMVKIDPQARSSMWEDLVKKRPTEIDSLNGEIVKLADVMGHPAPFNREIVR
LIKEAESNPQILNLSPEELAKKLKIKLT

Sequences:

>Translated_348_residues
MKLSIAILGSGSIGTYIGCKLLAAGNPVTFYGRARIQNELKTFGAKITDYTNQEILLPPNTISFTTSFSDISNADVFLVT
VKSKDTKDLAKELNGILEKRQNRSQTIPIVVSFQNGVRNAEILKEELRDLPVEVFAGMVPFNVVSKGNGHFHRGTSGNLV
IEDSKSSQTLVKVFKRAGLSINTHKNILGILWGKLIFNLNNSLNALSGLTLKAEISKRGYRKILSKLMKESLEILRFAEI
RPIRSGKMIPSLAPIILNLPDFLFFRIASGMVKIDPQARSSMWEDLVKKRPTEIDSLNGEIVKLADVMGHPAPFNREIVR
LIKEAESNPQILNLSPEELAKKLKIKLT
>Mature_348_residues
MKLSIAILGSGSIGTYIGCKLLAAGNPVTFYGRARIQNELKTFGAKITDYTNQEILLPPNTISFTTSFSDISNADVFLVT
VKSKDTKDLAKELNGILEKRQNRSQTIPIVVSFQNGVRNAEILKEELRDLPVEVFAGMVPFNVVSKGNGHFHRGTSGNLV
IEDSKSSQTLVKVFKRAGLSINTHKNILGILWGKLIFNLNNSLNALSGLTLKAEISKRGYRKILSKLMKESLEILRFAEI
RPIRSGKMIPSLAPIILNLPDFLFFRIASGMVKIDPQARSSMWEDLVKKRPTEIDSLNGEIVKLADVMGHPAPFNREIVR
LIKEAESNPQILNLSPEELAKKLKIKLT

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 38610; Mature: 38610

Theoretical pI: Translated: 10.53; Mature: 10.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSIAILGSGSIGTYIGCKLLAAGNPVTFYGRARIQNELKTFGAKITDYTNQEILLPPN
CEEEEEEEECCCCCHHHCEEEEECCCCEEEEEHHHHHHHHHHHCCHHCCCCCCEEEECCC
TISFTTSFSDISNADVFLVTVKSKDTKDLAKELNGILEKRQNRSQTIPIVVSFQNGVRNA
CEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHH
EILKEELRDLPVEVFAGMVPFNVVSKGNGHFHRGTSGNLVIEDSKSSQTLVKVFKRAGLS
HHHHHHHHCCCHHHHHCCCCCEEEECCCCCEECCCCCCEEEECCCCHHHHHHHHHHCCCE
INTHKNILGILWGKLIFNLNNSLNALSGLTLKAEISKRGYRKILSKLMKESLEILRFAEI
ECCCHHHHHHHHHHHHHHCCCCHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPIRSGKMIPSLAPIILNLPDFLFFRIASGMVKIDPQARSSMWEDLVKKRPTEIDSLNGE
CCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHCCCCCHHCCCCC
IVKLADVMGHPAPFNREIVRLIKEAESNPQILNLSPEELAKKLKIKLT
EEEEHHHHCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHHHEEECC
>Mature Secondary Structure
MKLSIAILGSGSIGTYIGCKLLAAGNPVTFYGRARIQNELKTFGAKITDYTNQEILLPPN
CEEEEEEEECCCCCHHHCEEEEECCCCEEEEEHHHHHHHHHHHCCHHCCCCCCEEEECCC
TISFTTSFSDISNADVFLVTVKSKDTKDLAKELNGILEKRQNRSQTIPIVVSFQNGVRNA
CEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHH
EILKEELRDLPVEVFAGMVPFNVVSKGNGHFHRGTSGNLVIEDSKSSQTLVKVFKRAGLS
HHHHHHHHCCCHHHHHCCCCCEEEECCCCCEECCCCCCEEEECCCCHHHHHHHHHHCCCE
INTHKNILGILWGKLIFNLNNSLNALSGLTLKAEISKRGYRKILSKLMKESLEILRFAEI
ECCCHHHHHHHHHHHHHHCCCCHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPIRSGKMIPSLAPIILNLPDFLFFRIASGMVKIDPQARSSMWEDLVKKRPTEIDSLNGE
CCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHCCCCCHHCCCCC
IVKLADVMGHPAPFNREIVRLIKEAESNPQILNLSPEELAKKLKIKLT
EEEEHHHHCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]