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The map label for this gene is mdmC [H]

Identifier: 45656267

GI number: 45656267

Start: 411359

End: 412054

Strand: Direct

Name: mdmC [H]

Synonym: LIC10364

Alternate gene names: 45656267

Gene position: 411359-412054 (Clockwise)

Preceding gene: 45656266

Following gene: 45656277

Centisome position: 9.62

GC content: 38.07

Gene sequence:

>696_bases
TTGAGTCGAAAGAACATTTCCCTTACCGAAAGTCTGGAAGAATATATCTTTCGGAATTCCGTAAGAGAACCGGATTCTTT
TTTAAAATTGAGAAAAGAAACTGGCACCTTGGCTCAGGCGAATATGCAAATCAGTCCTGAAGAAGGACAATTTTTAAATA
TTCTTACTAAAATCAGCGGAGCAAAAAGAATTATAGAAATCGGAACTTTTACCGGTTATTCTTCTCTTTGTTTCGCTTCT
GCTCTGCCAGAAGATGGTAAAATTCTTTGTTGTGATGTTAGTGAAGAATGGACAAACGTTGCACGTAAATACTGGAAAGA
AAACGGTTTAGAAAATAAGATTTTTCTAAAACTTGGATCTGCATTAGAAACCTTGCAAGTGTTGATTGATTCAAAATCTG
CACCGACTTGGGCTTCCGATTTTGCCTTTGGACCTTCTTCGATCGATTTGTTTTTTTTGGACGCCGATAAAGAAAATTAT
CAGAATTATTATCCGTTGATTTTAAAACTTCTTAAACCTGGCGGTCTTTTGATTGCGGATAACGTTCTTTGGGGTGGAAG
TGTGGCTGATCTTTCTCATCAAGAGCCTTCTACCGTCGGGATTCGAAAGTTTAACGAACTCGTATATAACGATTCTTTGG
TGGATGTAAGCTTAGTTCCGATTGCAGACGGGGTTTCGTTGGTGAGGAAGAGATAA

Upstream 100 bases:

>100_bases
TACATAGGGATTCCATTCTTCTTTCGATTGGTGGGGGAACCAACGAGGCGATGCAAAAAAACATCGTCGCCGATTTGAAA
AAAATCTACGAAGGTACTCC

Downstream 100 bases:

>100_bases
CCGTAATTGATTTCGAAGATCCTTCCCTCGTTTGATATCGAAAAGAAGGAAGGATCGTTTTTTATTTACAAGCGTTTGGA
GCCAATCCCCCATCCTCGTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSRKNISLTESLEEYIFRNSVREPDSFLKLRKETGTLAQANMQISPEEGQFLNILTKISGAKRIIEIGTFTGYSSLCFAS
ALPEDGKILCCDVSEEWTNVARKYWKENGLENKIFLKLGSALETLQVLIDSKSAPTWASDFAFGPSSIDLFFLDADKENY
QNYYPLILKLLKPGGLLIADNVLWGGSVADLSHQEPSTVGIRKFNELVYNDSLVDVSLVPIADGVSLVRKR

Sequences:

>Translated_231_residues
MSRKNISLTESLEEYIFRNSVREPDSFLKLRKETGTLAQANMQISPEEGQFLNILTKISGAKRIIEIGTFTGYSSLCFAS
ALPEDGKILCCDVSEEWTNVARKYWKENGLENKIFLKLGSALETLQVLIDSKSAPTWASDFAFGPSSIDLFFLDADKENY
QNYYPLILKLLKPGGLLIADNVLWGGSVADLSHQEPSTVGIRKFNELVYNDSLVDVSLVPIADGVSLVRKR
>Mature_230_residues
SRKNISLTESLEEYIFRNSVREPDSFLKLRKETGTLAQANMQISPEEGQFLNILTKISGAKRIIEIGTFTGYSSLCFASA
LPEDGKILCCDVSEEWTNVARKYWKENGLENKIFLKLGSALETLQVLIDSKSAPTWASDFAFGPSSIDLFFLDADKENYQ
NYYPLILKLLKPGGLLIADNVLWGGSVADLSHQEPSTVGIRKFNELVYNDSLVDVSLVPIADGVSLVRKR

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=219, Percent_Identity=36.0730593607306, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI72001127, Length=214, Percent_Identity=35.5140186915888, Blast_Score=109, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17565612, Length=214, Percent_Identity=33.6448598130841, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25148771, Length=223, Percent_Identity=32.2869955156951, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI72001028, Length=230, Percent_Identity=31.304347826087, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71991493, Length=240, Percent_Identity=25.8333333333333, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 25752; Mature: 25620

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKNISLTESLEEYIFRNSVREPDSFLKLRKETGTLAQANMQISPEEGQFLNILTKISG
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEECCEEECCCCCHHHHHHHHHCC
AKRIIEIGTFTGYSSLCFASALPEDGKILCCDVSEEWTNVARKYWKENGLENKIFLKLGS
CCEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEHHH
ALETLQVLIDSKSAPTWASDFAFGPSSIDLFFLDADKENYQNYYPLILKLLKPGGLLIAD
HHHHHHHHHCCCCCCCCCHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEC
NVLWGGSVADLSHQEPSTVGIRKFNELVYNDSLVDVSLVPIADGVSLVRKR
CEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHCC
>Mature Secondary Structure 
SRKNISLTESLEEYIFRNSVREPDSFLKLRKETGTLAQANMQISPEEGQFLNILTKISG
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEECCEEECCCCCHHHHHHHHHCC
AKRIIEIGTFTGYSSLCFASALPEDGKILCCDVSEEWTNVARKYWKENGLENKIFLKLGS
CCEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEHHH
ALETLQVLIDSKSAPTWASDFAFGPSSIDLFFLDADKENYQNYYPLILKLLKPGGLLIAD
HHHHHHHHHCCCCCCCCCHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEC
NVLWGGSVADLSHQEPSTVGIRKFNELVYNDSLVDVSLVPIADGVSLVRKR
CEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]