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The map label for this gene is ivd

Identifier: 45656266

GI number: 45656266

Start: 410178

End: 411362

Strand: Direct

Name: ivd

Synonym: LIC10363

Alternate gene names: 45656266

Gene position: 410178-411362 (Clockwise)

Preceding gene: 45656256

Following gene: 45656267

Centisome position: 9.59

GC content: 41.18

Gene sequence:

>1185_bases
ATGAGAGCTTTACTTGAAAAATCAAATGATTTATTTAATCCGACCGAGAACCATCTTGCACTTCGAGAAAATGTTGCAAA
GTTCGCGAAAGAGAATATGGACACTCAGGCAAAAGAACACGACGACTATGAAACCTTTAACTTATCTCTGTTTCGCAGAA
TCGGTTCTGAGCTTGGACTTTTTGGGGTTACCGTTCCAGAAGAAGACGGTGGAATGGGAATGGATGCGGTCGCAGCTGTA
ATCATCCACGAAGAATTATCCGCATACGATCCTGGTTTTACACTTTCTTATTTGGCCCACGAAGTTTTGTTTGTAAATAA
TTTTTATCATAGTTCCAACGCTGCTCAAAGAGCTAAGTATCTTTTAAAAGTAATTTCTGGAGAATGGATCGGCGGAATGG
GAATGACCGAGCCAGGAGCGGGTACGGACGTTTTAGGAATGAGAACGATCGCCGTAAAGAAAGGCGACAAATACGTGTTA
AACGGTTCTAAACAATATATCACCAACGGGAACGTTGGAAGTGTGTTTTTAGTATATGCTAAAATGGATAAGGATTCTAA
AAGAACCACTTCCTTTATCGTAGAAAGTTCTTTTCCAGGATTTAGCGTTGGTAAAAAAGAAGAAAAGATGGGAATGCGTT
CCTCTCCCACAACTCAACTTATATTCGAAGATTGTGAAGTTCCCGCAGAAAACTTAGTCGGTCAGGAAGACGGCGCACTC
GTTCATATGATGAGAAATTTAGAAATTGAGCGGATAACTCTTGCAGCTCAATCTTTAGGTATCGCAAAACGTTGTGTAGA
CGTTATGGCGGATTACACAATTCGTCATAGGGAAGCGTTTGGTAAAAAACTTTCCGAGTTTGGACAAATTCAAAGACTTT
TAGCAGAATCTTATGCAGATTATCAAGCAGCTCGAGCACTCGTATATCAAGTAGCAAGTGGGATTCATCCAGAAAGTAGG
AATTCTCTTGGTGCCGCCTCTGCAAAGTTAGTTGCTACTCAAATGGCGGAAAGAGTTTCTCGAAACGCCATTCAAGCGTT
AGGTGGTTATGGATATTGTCGCGAATATCCAGTAGAAAGATTACATAGGGATTCCATTCTTCTTTCGATTGGTGGGGGAA
CCAACGAGGCGATGCAAAAAAACATCGTCGCCGATTTGAAAAAAATCTACGAAGGTACTCCTTGA

Upstream 100 bases:

>100_bases
TCAAAATCAGAGCGTAGATCATAAGATAGTTTTTGGAGAGCAAAGATTCTCTGTCGAGCTGTTTTAGCCTTGGGAAAGAG
AATATTAGAGAAGAGGAAAC

Downstream 100 bases:

>100_bases
GTCGAAAGAACATTTCCCTTACCGAAAGTCTGGAAGAATATATCTTTCGGAATTCCGTAAGAGAACCGGATTCTTTTTTA
AAATTGAGAAAAGAAACTGG

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MRALLEKSNDLFNPTENHLALRENVAKFAKENMDTQAKEHDDYETFNLSLFRRIGSELGLFGVTVPEEDGGMGMDAVAAV
IIHEELSAYDPGFTLSYLAHEVLFVNNFYHSSNAAQRAKYLLKVISGEWIGGMGMTEPGAGTDVLGMRTIAVKKGDKYVL
NGSKQYITNGNVGSVFLVYAKMDKDSKRTTSFIVESSFPGFSVGKKEEKMGMRSSPTTQLIFEDCEVPAENLVGQEDGAL
VHMMRNLEIERITLAAQSLGIAKRCVDVMADYTIRHREAFGKKLSEFGQIQRLLAESYADYQAARALVYQVASGIHPESR
NSLGAASAKLVATQMAERVSRNAIQALGGYGYCREYPVERLHRDSILLSIGGGTNEAMQKNIVADLKKIYEGTP

Sequences:

>Translated_394_residues
MRALLEKSNDLFNPTENHLALRENVAKFAKENMDTQAKEHDDYETFNLSLFRRIGSELGLFGVTVPEEDGGMGMDAVAAV
IIHEELSAYDPGFTLSYLAHEVLFVNNFYHSSNAAQRAKYLLKVISGEWIGGMGMTEPGAGTDVLGMRTIAVKKGDKYVL
NGSKQYITNGNVGSVFLVYAKMDKDSKRTTSFIVESSFPGFSVGKKEEKMGMRSSPTTQLIFEDCEVPAENLVGQEDGAL
VHMMRNLEIERITLAAQSLGIAKRCVDVMADYTIRHREAFGKKLSEFGQIQRLLAESYADYQAARALVYQVASGIHPESR
NSLGAASAKLVATQMAERVSRNAIQALGGYGYCREYPVERLHRDSILLSIGGGTNEAMQKNIVADLKKIYEGTP
>Mature_394_residues
MRALLEKSNDLFNPTENHLALRENVAKFAKENMDTQAKEHDDYETFNLSLFRRIGSELGLFGVTVPEEDGGMGMDAVAAV
IIHEELSAYDPGFTLSYLAHEVLFVNNFYHSSNAAQRAKYLLKVISGEWIGGMGMTEPGAGTDVLGMRTIAVKKGDKYVL
NGSKQYITNGNVGSVFLVYAKMDKDSKRTTSFIVESSFPGFSVGKKEEKMGMRSSPTTQLIFEDCEVPAENLVGQEDGAL
VHMMRNLEIERITLAAQSLGIAKRCVDVMADYTIRHREAFGKKLSEFGQIQRLLAESYADYQAARALVYQVASGIHPESR
NSLGAASAKLVATQMAERVSRNAIQALGGYGYCREYPVERLHRDSILLSIGGGTNEAMQKNIVADLKKIYEGTP

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=379, Percent_Identity=39.5778364116095, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI226958414, Length=331, Percent_Identity=40.785498489426, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI4557233, Length=379, Percent_Identity=34.3007915567282, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=35.4497354497354, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=35.4497354497354, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI21361497, Length=337, Percent_Identity=36.2017804154303, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI4501857, Length=385, Percent_Identity=31.1688311688312, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI4501859, Length=390, Percent_Identity=32.8205128205128, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI7656849, Length=356, Percent_Identity=32.8651685393258, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI76496475, Length=369, Percent_Identity=31.1653116531165, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI4557235, Length=369, Percent_Identity=31.1653116531165, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI7669494, Length=360, Percent_Identity=26.9444444444444, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4503943, Length=358, Percent_Identity=27.0949720670391, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI48976061, Length=284, Percent_Identity=28.169014084507, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI211971008, Length=284, Percent_Identity=28.169014084507, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38505218, Length=278, Percent_Identity=24.4604316546763, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87081958, Length=332, Percent_Identity=31.6265060240964, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1786223, Length=351, Percent_Identity=26.2108262108262, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI87082384, Length=269, Percent_Identity=24.907063197026, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538396, Length=386, Percent_Identity=37.8238341968912, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=33.8624338624339, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=34.7368421052632, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=34.9206349206349, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17508101, Length=382, Percent_Identity=34.0314136125654, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=32.0954907161804, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71985184, Length=333, Percent_Identity=35.4354354354354, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17533517, Length=368, Percent_Identity=32.0652173913043, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71990804, Length=308, Percent_Identity=35.0649350649351, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=29.6791443850267, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17505929, Length=371, Percent_Identity=30.188679245283, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71985192, Length=268, Percent_Identity=35.8208955223881, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=35.0877192982456, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=30.1818181818182, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17534353, Length=358, Percent_Identity=28.2122905027933, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562446, Length=273, Percent_Identity=27.4725274725275, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21355753, Length=390, Percent_Identity=38.4615384615385, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21356377, Length=380, Percent_Identity=35.5263157894737, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24666513, Length=378, Percent_Identity=33.5978835978836, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24660351, Length=385, Percent_Identity=34.2857142857143, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24646207, Length=382, Percent_Identity=34.5549738219895, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI281363737, Length=384, Percent_Identity=31.25, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI19920834, Length=290, Percent_Identity=30, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 43426; Mature: 43426

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALLEKSNDLFNPTENHLALRENVAKFAKENMDTQAKEHDDYETFNLSLFRRIGSELGL
CCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHCCE
FGVTVPEEDGGMGMDAVAAVIIHEELSAYDPGFTLSYLAHEVLFVNNFYHSSNAAQRAKY
EEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
LLKVISGEWIGGMGMTEPGAGTDVLGMRTIAVKKGDKYVLNGSKQYITNGNVGSVFLVYA
HHHHHCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCEEEECCCEEEEECCCCCEEEEEEE
KMDKDSKRTTSFIVESSFPGFSVGKKEEKMGMRSSPTTQLIFEDCEVPAENLVGQEDGAL
ECCCCCCHHHHEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCHHHCCCCCCCHH
VHMMRNLEIERITLAAQSLGIAKRCVDVMADYTIRHREAFGKKLSEFGQIQRLLAESYAD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQAARALVYQVASGIHPESRNSLGAASAKLVATQMAERVSRNAIQALGGYGYCREYPVER
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHH
LHRDSILLSIGGGTNEAMQKNIVADLKKIYEGTP
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRALLEKSNDLFNPTENHLALRENVAKFAKENMDTQAKEHDDYETFNLSLFRRIGSELGL
CCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHCCE
FGVTVPEEDGGMGMDAVAAVIIHEELSAYDPGFTLSYLAHEVLFVNNFYHSSNAAQRAKY
EEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
LLKVISGEWIGGMGMTEPGAGTDVLGMRTIAVKKGDKYVLNGSKQYITNGNVGSVFLVYA
HHHHHCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCEEEECCCEEEEECCCCCEEEEEEE
KMDKDSKRTTSFIVESSFPGFSVGKKEEKMGMRSSPTTQLIFEDCEVPAENLVGQEDGAL
ECCCCCCHHHHEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCHHHCCCCCCCHH
VHMMRNLEIERITLAAQSLGIAKRCVDVMADYTIRHREAFGKKLSEFGQIQRLLAESYAD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQAARALVYQVASGIHPESRNSLGAASAKLVATQMAERVSRNAIQALGGYGYCREYPVER
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHH
LHRDSILLSIGGGTNEAMQKNIVADLKKIYEGTP
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]