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The map label for this gene is ispA

Identifier: 45656187

GI number: 45656187

Start: 322520

End: 323518

Strand: Direct

Name: ispA

Synonym: LIC10283

Alternate gene names: 45656187

Gene position: 322520-323518 (Clockwise)

Preceding gene: 45656186

Following gene: 45656188

Centisome position: 7.54

GC content: 36.54

Gene sequence:

>999_bases
TTGGTTTGTCGGACTTTGCTTTACAATTGGAAGTTTTCTTTCAGTTTTGGAGTTAGAGTGAATTCATCTTCCTTTTCCAA
AATATTCCATTCTTACAAAAGTACGTTTGAAAATTTTTTAAATTCTCAAACTCTTTCGATACTTTCTAAACAATCTGCTC
CTGAACTTTTTGAAGCTATGAAATATAGTCTCGTGGCCGGAGGGAAGCGACTTAGACCCGTTTTGGCTTTGGCTGCTTTT
GGTGGACTTCAAAATGAAACTCAAAACGTTCTTTTACTTGGGGCTTCTTTGGAATGTATTCATACTTATTCTTTGATTCA
CGACGATCTTCCAAGTATGGATAACGACGATTTTAGAAGGGGGTTGCCGACTCTTCATAAAAAATTTTCCGAATCTACGG
CGATTTTGGCCGGAGACGCTTTAAACTCTTTCGCATTTTATTTTATTTCTTGGATCCGGGTTGAAAATGGTGATCATTTT
TTACATAGGAATCTATTAGAAATTTTGCATGCAGGTTGTGGTGCGCCTGGAATGGTTTCCGGACAAGTTTATGATTTACA
GATGGAAAGAGAAAATGTGAAAGAAAATGATTTAACAAACCAATCCGATAAGATAGAGATGCTTCAATTGACTCACCGTT
TAAAAACGGGAGCGTTGATTAAGTCAGCCTTATTGTTAGGGAACCGTCTTCGTAAAGATTGGAAAAAAAGAGAAACGTCT
TTATCTCAATACGGAGAAGATCTAGGTTTACTGTTTCAGATTACAGACGATATTTTAGACGTGGAAGGAACTCAGGAATC
TTTAGGAAAAACCCCAGGTAAGGATCAAAAATCTGGCAAGATCACCTATCCTATGTTATTCGGAATGGATCGTTGTAAAA
AGATGGTAGAAGAACTTCAGAAAAATCTAATTTTTACTTCTTCTGATTTTGTTTCCACAGAAGAAGAACAAACATTCTTT
CAGGAGCTTCCGATTTACATTGGCCAGAGAAAAAATTAG

Upstream 100 bases:

>100_bases
AAATCATTTACGACTCCAAAATAATAAAACCCAAAACCAATAAAGCTGTGCTTGTCATCTACTCAAAGTAATTCGTTGTT
TCAGCAAAACTGTTTTATGA

Downstream 100 bases:

>100_bases
GCTCGATGTTCTTCTTTTTGAAAGGGGATTTGCCGATTCTCTGGAAAAAGCGAAAAGTTTAATTCTTTCGGGCTCTGTAT
TAGTAAACGAACAAAAGATT

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MVCRTLLYNWKFSFSFGVRVNSSSFSKIFHSYKSTFENFLNSQTLSILSKQSAPELFEAMKYSLVAGGKRLRPVLALAAF
GGLQNETQNVLLLGASLECIHTYSLIHDDLPSMDNDDFRRGLPTLHKKFSESTAILAGDALNSFAFYFISWIRVENGDHF
LHRNLLEILHAGCGAPGMVSGQVYDLQMERENVKENDLTNQSDKIEMLQLTHRLKTGALIKSALLLGNRLRKDWKKRETS
LSQYGEDLGLLFQITDDILDVEGTQESLGKTPGKDQKSGKITYPMLFGMDRCKKMVEELQKNLIFTSSDFVSTEEEQTFF
QELPIYIGQRKN

Sequences:

>Translated_332_residues
MVCRTLLYNWKFSFSFGVRVNSSSFSKIFHSYKSTFENFLNSQTLSILSKQSAPELFEAMKYSLVAGGKRLRPVLALAAF
GGLQNETQNVLLLGASLECIHTYSLIHDDLPSMDNDDFRRGLPTLHKKFSESTAILAGDALNSFAFYFISWIRVENGDHF
LHRNLLEILHAGCGAPGMVSGQVYDLQMERENVKENDLTNQSDKIEMLQLTHRLKTGALIKSALLLGNRLRKDWKKRETS
LSQYGEDLGLLFQITDDILDVEGTQESLGKTPGKDQKSGKITYPMLFGMDRCKKMVEELQKNLIFTSSDFVSTEEEQTFF
QELPIYIGQRKN
>Mature_332_residues
MVCRTLLYNWKFSFSFGVRVNSSSFSKIFHSYKSTFENFLNSQTLSILSKQSAPELFEAMKYSLVAGGKRLRPVLALAAF
GGLQNETQNVLLLGASLECIHTYSLIHDDLPSMDNDDFRRGLPTLHKKFSESTAILAGDALNSFAFYFISWIRVENGDHF
LHRNLLEILHAGCGAPGMVSGQVYDLQMERENVKENDLTNQSDKIEMLQLTHRLKTGALIKSALLLGNRLRKDWKKRETS
LSQYGEDLGLLFQITDDILDVEGTQESLGKTPGKDQKSGKITYPMLFGMDRCKKMVEELQKNLIFTSSDFVSTEEEQTFF
QELPIYIGQRKN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=259, Percent_Identity=29.7297297297297, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786623, Length=293, Percent_Identity=39.5904436860068, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1789578, Length=236, Percent_Identity=30.9322033898305, Blast_Score=98, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17505681, Length=266, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319475, Length=232, Percent_Identity=29.3103448275862, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24651612, Length=258, Percent_Identity=30.2325581395349, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 37685; Mature: 37685

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVCRTLLYNWKFSFSFGVRVNSSSFSKIFHSYKSTFENFLNSQTLSILSKQSAPELFEAM
CCHHHEEEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHH
KYSLVAGGKRLRPVLALAAFGGLQNETQNVLLLGASLECIHTYSLIHDDLPSMDNDDFRR
HHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHH
GLPTLHKKFSESTAILAGDALNSFAFYFISWIRVENGDHFLHRNLLEILHAGCGAPGMVS
CCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCC
GQVYDLQMERENVKENDLTNQSDKIEMLQLTHRLKTGALIKSALLLGNRLRKDWKKRETS
CEEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSQYGEDLGLLFQITDDILDVEGTQESLGKTPGKDQKSGKITYPMLFGMDRCKKMVEELQ
HHHHCCHHHHHHEEHHHHHCCCCCHHHHCCCCCCCCCCCCEEHHHHHCHHHHHHHHHHHH
KNLIFTSSDFVSTEEEQTFFQELPIYIGQRKN
HCCEECCCCCCCCHHHHHHHHHCCHHHCCCCC
>Mature Secondary Structure
MVCRTLLYNWKFSFSFGVRVNSSSFSKIFHSYKSTFENFLNSQTLSILSKQSAPELFEAM
CCHHHEEEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHH
KYSLVAGGKRLRPVLALAAFGGLQNETQNVLLLGASLECIHTYSLIHDDLPSMDNDDFRR
HHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHH
GLPTLHKKFSESTAILAGDALNSFAFYFISWIRVENGDHFLHRNLLEILHAGCGAPGMVS
CCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCC
GQVYDLQMERENVKENDLTNQSDKIEMLQLTHRLKTGALIKSALLLGNRLRKDWKKRETS
CEEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSQYGEDLGLLFQITDDILDVEGTQESLGKTPGKDQKSGKITYPMLFGMDRCKKMVEELQ
HHHHCCHHHHHHEEHHHHHCCCCCHHHHCCCCCCCCCCCCEEHHHHHCHHHHHHHHHHHH
KNLIFTSSDFVSTEEEQTFFQELPIYIGQRKN
HCCEECCCCCCCCHHHHHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]