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The map label for this gene is cyoA

Identifier: 45656113

GI number: 45656113

Start: 237054

End: 238055

Strand: Direct

Name: cyoA

Synonym: LIC10208

Alternate gene names: 45656113

Gene position: 237054-238055 (Clockwise)

Preceding gene: 45656112

Following gene: 45656114

Centisome position: 5.54

GC content: 40.42

Gene sequence:

>1002_bases
ATGACCTGGTTGAACCTCATTACGGCAACGAGTTTTATGCCGGTTCAGGCTTCCGAAGTAGCAAAGAATGTAGATCATCT
CTATCTCTTTCTGCTCGTATCCAGTCTGATCTCTTTTGTCATTCTCATTGGGGGAATGACTTGGTTTATTTTTAAATACC
GGAGAAAAACGGACTCGGATAAAACTGCTTATATCACACACAATACATTGGCAGAATTTCTTTGGTCCTTTATTCCCTTG
GTGATCATGATCGTGATTTTTTGGTGGGGCTGGAGAATTTTCGCCGATCTTAGAAGCGTTCATGAAAAAGGTGATATTGA
AATTCACGTTACTGCAAGACAGTGGCAATGGACATTCAAATATCCGAATGGTGTAACTATTGTTTCTCCAAACGCGACTG
AAAAATTAAATACTCTTTTTCAACCTAACGGAATTTATGTTCCCGTTGGGAAAACGGTTCGTTTGGTGATGACTTCTCAA
GATGTGCTTCATTCATTTTACGTCCCTGCATTTAGAAACAAGATGGATGCAATTCCAGGACGTTATACAACACTGACGTT
TACTCCGACTGAAAAAGGAGATTTCGTAGTTTATTGTACCGAATTTTGTGGAACTTCTCATTCTAATATGCTTTCGGCGA
TTCGTGTTGTAGATAACGAAACGTTTGATAAATGGTATGCGGAAGCTGGAAATGTGGATCTTTCTAAGATTCCTCCCACA
GAACTCGGTAAAAAACTTTACGCAGAGAAAGCTTGTGCGGGTTGTCATTCAACGGACGGTTCTCGTTTAGTTGGTCCTTC
CTACAAAGGACTTTTTGGAAGCACGAGAGAATTCGAGTCTGGACCTGGTGTAATTGCAGATGAAAACTATATTCGTAAAT
CTATTTTGCAACCGACAGCTCAGGTTGTAAAAGGTTATCCACCTGCTATGCCTTCTTATCAGGGACAGCTTTCCGACGAC
GAAATCAACGCTCTGATCGAGTATATTAAAACCCTTAAATAG

Upstream 100 bases:

>100_bases
GGATTCTTCACTCTTCTCATTATGGCGGCGTTCTTGATCCCATTCTGGATCAGGCATAACAGAAATTCCGAACTCATTAG
GAAGGAGTAACTTCAATAAA

Downstream 100 bases:

>100_bases
GAGAGGAAATATGTCTACAGCAACTGCAAGTCATACTGACAACTACCTCAACCACGAAAAGGGAATCTGGTCCTGGCTCA
CTACGATCGATCATAAACGG

Product: cytochrome c oxidase polypeptide II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II; Oxidase aa(3) subunit 2 [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MTWLNLITATSFMPVQASEVAKNVDHLYLFLLVSSLISFVILIGGMTWFIFKYRRKTDSDKTAYITHNTLAEFLWSFIPL
VIMIVIFWWGWRIFADLRSVHEKGDIEIHVTARQWQWTFKYPNGVTIVSPNATEKLNTLFQPNGIYVPVGKTVRLVMTSQ
DVLHSFYVPAFRNKMDAIPGRYTTLTFTPTEKGDFVVYCTEFCGTSHSNMLSAIRVVDNETFDKWYAEAGNVDLSKIPPT
ELGKKLYAEKACAGCHSTDGSRLVGPSYKGLFGSTREFESGPGVIADENYIRKSILQPTAQVVKGYPPAMPSYQGQLSDD
EINALIEYIKTLK

Sequences:

>Translated_333_residues
MTWLNLITATSFMPVQASEVAKNVDHLYLFLLVSSLISFVILIGGMTWFIFKYRRKTDSDKTAYITHNTLAEFLWSFIPL
VIMIVIFWWGWRIFADLRSVHEKGDIEIHVTARQWQWTFKYPNGVTIVSPNATEKLNTLFQPNGIYVPVGKTVRLVMTSQ
DVLHSFYVPAFRNKMDAIPGRYTTLTFTPTEKGDFVVYCTEFCGTSHSNMLSAIRVVDNETFDKWYAEAGNVDLSKIPPT
ELGKKLYAEKACAGCHSTDGSRLVGPSYKGLFGSTREFESGPGVIADENYIRKSILQPTAQVVKGYPPAMPSYQGQLSDD
EINALIEYIKTLK
>Mature_332_residues
TWLNLITATSFMPVQASEVAKNVDHLYLFLLVSSLISFVILIGGMTWFIFKYRRKTDSDKTAYITHNTLAEFLWSFIPLV
IMIVIFWWGWRIFADLRSVHEKGDIEIHVTARQWQWTFKYPNGVTIVSPNATEKLNTLFQPNGIYVPVGKTVRLVMTSQD
VLHSFYVPAFRNKMDAIPGRYTTLTFTPTEKGDFVVYCTEFCGTSHSNMLSAIRVVDNETFDKWYAEAGNVDLSKIPPTE
LGKKLYAEKACAGCHSTDGSRLVGPSYKGLFGSTREFESGPGVIADENYIRKSILQPTAQVVKGYPPAMPSYQGQLSDDE
INALIEYIKTLK

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cytochrome c domain [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=160, Percent_Identity=32.5, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1786635, Length=206, Percent_Identity=25.7281553398058, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6226540, Length=205, Percent_Identity=27.3170731707317, Blast_Score=86, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR009056
- InterPro:   IPR003088
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM; PF00034 Cytochrom_C [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 37680; Mature: 37549

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA ; PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWLNLITATSFMPVQASEVAKNVDHLYLFLLVSSLISFVILIGGMTWFIFKYRRKTDSD
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KTAYITHNTLAEFLWSFIPLVIMIVIFWWGWRIFADLRSVHEKGDIEIHVTARQWQWTFK
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEE
YPNGVTIVSPNATEKLNTLFQPNGIYVPVGKTVRLVMTSQDVLHSFYVPAFRNKMDAIPG
CCCCEEEECCCCHHHHHHHCCCCCEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHCCCC
RYTTLTFTPTEKGDFVVYCTEFCGTSHSNMLSAIRVVDNETFDKWYAEAGNVDLSKIPPT
CEEEEEECCCCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHH
ELGKKLYAEKACAGCHSTDGSRLVGPSYKGLFGSTREFESGPGVIADENYIRKSILQPTA
HHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHH
QVVKGYPPAMPSYQGQLSDDEINALIEYIKTLK
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TWLNLITATSFMPVQASEVAKNVDHLYLFLLVSSLISFVILIGGMTWFIFKYRRKTDSD
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KTAYITHNTLAEFLWSFIPLVIMIVIFWWGWRIFADLRSVHEKGDIEIHVTARQWQWTFK
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEE
YPNGVTIVSPNATEKLNTLFQPNGIYVPVGKTVRLVMTSQDVLHSFYVPAFRNKMDAIPG
CCCCEEEECCCCHHHHHHHCCCCCEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHCCCC
RYTTLTFTPTEKGDFVVYCTEFCGTSHSNMLSAIRVVDNETFDKWYAEAGNVDLSKIPPT
CEEEEEECCCCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHH
ELGKKLYAEKACAGCHSTDGSRLVGPSYKGLFGSTREFESGPGVIADENYIRKSILQPTA
HHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHH
QVVKGYPPAMPSYQGQLSDDEINALIEYIKTLK
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]