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The map label for this gene is sdh [H]

Identifier: 45656099

GI number: 45656099

Start: 223315

End: 224067

Strand: Reverse

Name: sdh [H]

Synonym: LIC10194

Alternate gene names: 45656099

Gene position: 224067-223315 (Counterclockwise)

Preceding gene: 45656100

Following gene: 45656098

Centisome position: 5.24

GC content: 32.67

Gene sequence:

>753_bases
ATGAAAGCACCAAACGGCGATTTAGCGATAGTTACTGGTTCTTCCAAAGGAATCGGAAAAGCCATTTCAGAATTTTTGGT
TTCCGAAGGTTATAGAGTAATCGGAATTTCTAGAACAGAGCCGAATTCATATCTTTTAAAAGATTCTTCTTTATACCGAC
ACATTTACATGGATCTTTCCAACACAAAAGAAATTGAATTCAAATTATCTAATATTCTTAAAGAAGAACGTACTCTCAAA
ATATTGGTGAATAACGCCGGCATGGGTAATTTTTCACCTCACGAAGAAATTTCATTTGACACATTGGAAAAAATGCTTCT
TGTAAATTTTGTATCTCCGATTCTTATCACTAAATTATTTTTAAGAGATTTGAAAAAAAATGAAGGATGGATCTTTCAAA
TCCACTCCATCGCAGCTTTAAAAGAATCTATCCGAGGTGCCGCATACGCCGGATCCAAAGCAGGTCTTAGACATTTCGGT
TTAAATTTATTTGAAGAAATTAGAAAATCGGGAGTCAAATTAGTAAACATCAATCCGGACATTACGAAAACCGAATTTTA
TGACCATTTAGATTTTGAAATGGATTCCGATCCTACATCGTATTTAAACGTTTCCGAAATTTTAAACGTTTTTAAATTTT
CTCTTTCTAATCCGGAAAATGTAGGTTTTACCGAAATTACGATTCGTCCAAAACTTCATCGAATTTCTAAAAAACCTTTT
GTTCGAAAAAATGAAAACGATTTGAAAGATTAA

Upstream 100 bases:

>100_bases
ATTTGGAAAAAGAAATGTTTGCAGTCGTTGAAAAAGAATTAGAACTTTTCGTTTCAAAAGAAAAAATTCACAGACTCTTT
GCCAACGAAATAGGATTCAA

Downstream 100 bases:

>100_bases
TTAGAAATCATTTAAATTATTTGTAATTAATTTTGAGACAGGTTTTAAAAATAAGATTCCAAAGTCATTTAAGGAGGATC
AATTGAATCCAAATGAATTA

Product: short-chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MKAPNGDLAIVTGSSKGIGKAISEFLVSEGYRVIGISRTEPNSYLLKDSSLYRHIYMDLSNTKEIEFKLSNILKEERTLK
ILVNNAGMGNFSPHEEISFDTLEKMLLVNFVSPILITKLFLRDLKKNEGWIFQIHSIAALKESIRGAAYAGSKAGLRHFG
LNLFEEIRKSGVKLVNINPDITKTEFYDHLDFEMDSDPTSYLNVSEILNVFKFSLSNPENVGFTEITIRPKLHRISKKPF
VRKNENDLKD

Sequences:

>Translated_250_residues
MKAPNGDLAIVTGSSKGIGKAISEFLVSEGYRVIGISRTEPNSYLLKDSSLYRHIYMDLSNTKEIEFKLSNILKEERTLK
ILVNNAGMGNFSPHEEISFDTLEKMLLVNFVSPILITKLFLRDLKKNEGWIFQIHSIAALKESIRGAAYAGSKAGLRHFG
LNLFEEIRKSGVKLVNINPDITKTEFYDHLDFEMDSDPTSYLNVSEILNVFKFSLSNPENVGFTEITIRPKLHRISKKPF
VRKNENDLKD
>Mature_250_residues
MKAPNGDLAIVTGSSKGIGKAISEFLVSEGYRVIGISRTEPNSYLLKDSSLYRHIYMDLSNTKEIEFKLSNILKEERTLK
ILVNNAGMGNFSPHEEISFDTLEKMLLVNFVSPILITKLFLRDLKKNEGWIFQIHSIAALKESIRGAAYAGSKAGLRHFG
LNLFEEIRKSGVKLVNINPDITKTEFYDHLDFEMDSDPTSYLNVSEILNVFKFSLSNPENVGFTEITIRPKLHRISKKPF
VRKNENDLKD

Specific function: Catalyzes the oxidation of the hydroxyl group of serine to form 2-aminomalonate semialdehyde which is spontaneously converted into 2-aminoacetaldehyde and CO(2). Also acts on D- serine, L-glycerate, D-glycerate and 2-methyl-DL-serine. Does not act on O-me

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI226371731, Length=190, Percent_Identity=32.1052631578947, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4504503, Length=209, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787820, Length=193, Percent_Identity=28.4974093264249, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787335, Length=221, Percent_Identity=28.5067873303167, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786701, Length=214, Percent_Identity=26.6355140186916, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=223, Percent_Identity=29.5964125560538, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=199, Percent_Identity=28.1407035175879, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322226, Length=188, Percent_Identity=30.3191489361702, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322227, Length=197, Percent_Identity=28.9340101522843, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI116007236, Length=240, Percent_Identity=25, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24641388, Length=247, Percent_Identity=28.3400809716599, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI23397609, Length=219, Percent_Identity=26.027397260274, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI116007234, Length=246, Percent_Identity=25.609756097561, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: 1300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.276 [H]

Molecular weight: Translated: 28361; Mature: 28361

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAPNGDLAIVTGSSKGIGKAISEFLVSEGYRVIGISRTEPNSYLLKDSSLYRHIYMDLS
CCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCEEEEEEEECC
NTKEIEFKLSNILKEERTLKILVNNAGMGNFSPHEEISFDTLEKMLLVNFVSPILITKLF
CCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRDLKKNEGWIFQIHSIAALKESIRGAAYAGSKAGLRHFGLNLFEEIRKSGVKLVNINPD
HHHHHCCCCEEEEEHHHHHHHHHHCCHHCCCCHHHHHHHCHHHHHHHHHCCCEEEECCCC
ITKTEFYDHLDFEMDSDPTSYLNVSEILNVFKFSLSNPENVGFTEITIRPKLHRISKKPF
CCHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHCCCCC
VRKNENDLKD
CCCCCCCCCC
>Mature Secondary Structure
MKAPNGDLAIVTGSSKGIGKAISEFLVSEGYRVIGISRTEPNSYLLKDSSLYRHIYMDLS
CCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCEEEEEEEECC
NTKEIEFKLSNILKEERTLKILVNNAGMGNFSPHEEISFDTLEKMLLVNFVSPILITKLF
CCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRDLKKNEGWIFQIHSIAALKESIRGAAYAGSKAGLRHFGLNLFEEIRKSGVKLVNINPD
HHHHHCCCCEEEEEHHHHHHHHHHCCHHCCCCHHHHHHHCHHHHHHHHHCCCEEEECCCC
ITKTEFYDHLDFEMDSDPTSYLNVSEILNVFKFSLSNPENVGFTEITIRPKLHRISKKPF
CCHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHCCCCC
VRKNENDLKD
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]