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The map label for this gene is ntrB [H]

Identifier: 45656030

GI number: 45656030

Start: 140027

End: 141856

Strand: Reverse

Name: ntrB [H]

Synonym: LIC10120

Alternate gene names: 45656030

Gene position: 141856-140027 (Counterclockwise)

Preceding gene: 45656036

Following gene: 45656029

Centisome position: 3.32

GC content: 32.9

Gene sequence:

>1830_bases
ATGACGATCCGAAGACTCATCGCCTTAGGGCCCATTGTATATTTAATTCTTCTGATAGTCTGTTTTCAGCTTATCTTTGC
ATTAATTATACGGTCATTCCATTTCTTTTCCTTGGAATCCTACGGATTTATTTTCACACTTTTAGTTGGAGCAATTTTAG
GGTTTATAACCTATATCGTTTCGGTTAGAGTTTTAAAACTAACTTCCAGTAAATTTTTAAGAAGAATTTTTCCATTCCTT
CAATTTTCTAATAGTGAAATCGTTAAATACCTTTCGATTTTAGATCAATTTAAAAACGATCTGATTGCTACAAATCTAAC
AGGACTCGTTTGTGAAAAAATTCTGAAATTCATCCAAACCATAATTCCAACAAAAAAAGTTATCGTCTTTTTCTGGAAGG
AAGAAATGGGTAAGTTCGCGCCCTTTCCAGATTCAGGAGAAATTCAATTTTTCATTTTTGATCCGTTTCTTCTTTGGATT
ACCGAAAACGATAGGATCTATAATTTTAAAGAATTTGCAACCGATCCCAGTCTAAGTAAAATTCGCAATTCTGCTGAAAA
CTTTTTTACAAAAACCGAAGCCGAGTTGGTAGTACCTTTAATTCTCAATAAAAGTCTTTTAGGAATAATCGTTTTAGGTG
AAAGACAAAATCGGAAAAATTATACTCTTTCCGAAATCAATAAACTGAATGAAATACGTTCTGTTTCGGTGATGGCGCTT
TCAAATGCAATTTTCTACGAACGTCTAATTGAATTAACTGAAACCTTAGAAGAAAAAGTCAAGATTAGAACTCAAGAGTT
AGAAGAAACACAGTCTCAACTGATCATGTCAGAGAAAATGGCTTCTCTCGGTATCATGGTGGCTGGAATCGCCCACGAAA
TCAATACGCCTGCAGGTGTGATCAACGGAGCCGCCGATAATTTAGATCAAAACATGAATTATCTGGTTCAAAACGTTTTT
GACGTCGTTCTTTTTGCGAGATATAGAAAACTCAGAAAAAATTTCGAACTCGCCTTACTTCATTTACTTCGGGATAAAAA
AAAATCAGAACTGGATTCGAAAGAAAAATTTCGTTTAAAAAATCAACTTAAAGAAGAAATGAAAAGTATGAACTTCAGTC
CTACTCTTACTTCCGAACTCTCAAATTTTATTATAGAAAACCAGATCGGCAAAGAACGGAAATATATTTATAACATCATT
TTAAAAGACGATGATCGTGGATATTTTATGCTAAAAAACGCGGCTTATATCAACCGAAATATCAAAAACATAAGATATGC
CATTCGAAACATAGTTCGAATTGTAAAAGCGTTGAAATCTTATTCCCATTTGGATCAATCCAAAACATTTTCTTCTTCGA
ACATTATAGAAGGTATGGAAACTACATTAATTATTCTTAATAATCAAATAAAATACGGAATCGATGTAATTAAAAATTTT
CAGGAAATCCCACTTGTAATTTGTAATCCGGATGAATTGAATCAAGTTTGGACAAATCTAATTCAAAATTCGATTCAGGC
GTTAAAAGGAAAAGGTAAAATCGAAATTTCAGTTTTTCCTTGGAATGGTTATGTAGTTGTTGAAATTGAAGATAACGGTC
CTGGAATTCCCGCCAAAATTCAAGATCGAATTTGGGATCCTTTTTTTACAACCAAGGATCAAGGAGAAGGGACGGGACTT
GGTTTAGGAATCGTTAAGGGAATCGTGGAAAAACATAAAGGTAAAATTACTTTAAACTCGAATCCTGGAAAAACCGTTTT
TAGAGTGGAATTACCAATCAATCCGGAAAATAATATAGTCAAAGTGGAAACGAGAAATAAAAAATTATAA

Upstream 100 bases:

>100_bases
TTTGAAGAATAAATTTCATAGTACGCTCCGTAAACTCGGGAGATGGTAAAAAATTCTTTGACTGAGGAATCTGACTCTAA
CATGATCTCTATGCACTGTA

Downstream 100 bases:

>100_bases
TAACTCAGAGAGGTTATTTTCTAGATCCAAATATTCAGTAAACCAATCATAAAAGAATTTTTTCCAAGTAACTACGAAAA
TTTAACTACATTAGAACTAC

Product: histidine kinase sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MTIRRLIALGPIVYLILLIVCFQLIFALIIRSFHFFSLESYGFIFTLLVGAILGFITYIVSVRVLKLTSSKFLRRIFPFL
QFSNSEIVKYLSILDQFKNDLIATNLTGLVCEKILKFIQTIIPTKKVIVFFWKEEMGKFAPFPDSGEIQFFIFDPFLLWI
TENDRIYNFKEFATDPSLSKIRNSAENFFTKTEAELVVPLILNKSLLGIIVLGERQNRKNYTLSEINKLNEIRSVSVMAL
SNAIFYERLIELTETLEEKVKIRTQELEETQSQLIMSEKMASLGIMVAGIAHEINTPAGVINGAADNLDQNMNYLVQNVF
DVVLFARYRKLRKNFELALLHLLRDKKKSELDSKEKFRLKNQLKEEMKSMNFSPTLTSELSNFIIENQIGKERKYIYNII
LKDDDRGYFMLKNAAYINRNIKNIRYAIRNIVRIVKALKSYSHLDQSKTFSSSNIIEGMETTLIILNNQIKYGIDVIKNF
QEIPLVICNPDELNQVWTNLIQNSIQALKGKGKIEISVFPWNGYVVVEIEDNGPGIPAKIQDRIWDPFFTTKDQGEGTGL
GLGIVKGIVEKHKGKITLNSNPGKTVFRVELPINPENNIVKVETRNKKL

Sequences:

>Translated_609_residues
MTIRRLIALGPIVYLILLIVCFQLIFALIIRSFHFFSLESYGFIFTLLVGAILGFITYIVSVRVLKLTSSKFLRRIFPFL
QFSNSEIVKYLSILDQFKNDLIATNLTGLVCEKILKFIQTIIPTKKVIVFFWKEEMGKFAPFPDSGEIQFFIFDPFLLWI
TENDRIYNFKEFATDPSLSKIRNSAENFFTKTEAELVVPLILNKSLLGIIVLGERQNRKNYTLSEINKLNEIRSVSVMAL
SNAIFYERLIELTETLEEKVKIRTQELEETQSQLIMSEKMASLGIMVAGIAHEINTPAGVINGAADNLDQNMNYLVQNVF
DVVLFARYRKLRKNFELALLHLLRDKKKSELDSKEKFRLKNQLKEEMKSMNFSPTLTSELSNFIIENQIGKERKYIYNII
LKDDDRGYFMLKNAAYINRNIKNIRYAIRNIVRIVKALKSYSHLDQSKTFSSSNIIEGMETTLIILNNQIKYGIDVIKNF
QEIPLVICNPDELNQVWTNLIQNSIQALKGKGKIEISVFPWNGYVVVEIEDNGPGIPAKIQDRIWDPFFTTKDQGEGTGL
GLGIVKGIVEKHKGKITLNSNPGKTVFRVELPINPENNIVKVETRNKKL
>Mature_608_residues
TIRRLIALGPIVYLILLIVCFQLIFALIIRSFHFFSLESYGFIFTLLVGAILGFITYIVSVRVLKLTSSKFLRRIFPFLQ
FSNSEIVKYLSILDQFKNDLIATNLTGLVCEKILKFIQTIIPTKKVIVFFWKEEMGKFAPFPDSGEIQFFIFDPFLLWIT
ENDRIYNFKEFATDPSLSKIRNSAENFFTKTEAELVVPLILNKSLLGIIVLGERQNRKNYTLSEINKLNEIRSVSVMALS
NAIFYERLIELTETLEEKVKIRTQELEETQSQLIMSEKMASLGIMVAGIAHEINTPAGVINGAADNLDQNMNYLVQNVFD
VVLFARYRKLRKNFELALLHLLRDKKKSELDSKEKFRLKNQLKEEMKSMNFSPTLTSELSNFIIENQIGKERKYIYNIIL
KDDDRGYFMLKNAAYINRNIKNIRYAIRNIVRIVKALKSYSHLDQSKTFSSSNIIEGMETTLIILNNQIKYGIDVIKNFQ
EIPLVICNPDELNQVWTNLIQNSIQALKGKGKIEISVFPWNGYVVVEIEDNGPGIPAKIQDRIWDPFFTTKDQGEGTGLG
LGIVKGIVEKHKGKITLNSNPGKTVFRVELPINPENNIVKVETRNKKL

Specific function: NtrB acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC. In nitrogen limitation ntrB activates ntrC by phosphorylating it, while in nitrogen excess ntrC is dephosphorylated and consequently inactiva

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=176, Percent_Identity=33.5227272727273, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1790436, Length=113, Percent_Identity=42.4778761061947, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790300, Length=146, Percent_Identity=30.1369863013699, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI145693157, Length=118, Percent_Identity=33.8983050847458, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 70023; Mature: 69892

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRRLIALGPIVYLILLIVCFQLIFALIIRSFHFFSLESYGFIFTLLVGAILGFITYIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVRVLKLTSSKFLRRIFPFLQFSNSEIVKYLSILDQFKNDLIATNLTGLVCEKILKFIQT
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIPTKKVIVFFWKEEMGKFAPFPDSGEIQFFIFDPFLLWITENDRIYNFKEFATDPSLSK
HCCCCCEEEEEEEHHCCCCCCCCCCCCEEEEEECCEEEEEECCCCEEEHHHHCCCCCHHH
IRNSAENFFTKTEAELVVPLILNKSLLGIIVLGERQNRKNYTLSEINKLNEIRSVSVMAL
HHHHHHHHHHCCHHHEEHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
SNAIFYERLIELTETLEEKVKIRTQELEETQSQLIMSEKMASLGIMVAGIAHEINTPAGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
INGAADNLDQNMNYLVQNVFDVVLFARYRKLRKNFELALLHLLRDKKKSELDSKEKFRLK
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
NQLKEEMKSMNFSPTLTSELSNFIIENQIGKERKYIYNIILKDDDRGYFMLKNAAYINRN
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEEECHHHHHCC
IKNIRYAIRNIVRIVKALKSYSHLDQSKTFSSSNIIEGMETTLIILNNQIKYGIDVIKNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCEEEEEECCCHHHHHHHHCCH
QEIPLVICNPDELNQVWTNLIQNSIQALKGKGKIEISVFPWNGYVVVEIEDNGPGIPAKI
HHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCCCCCCHH
QDRIWDPFFTTKDQGEGTGLGLGIVKGIVEKHKGKITLNSNPGKTVFRVELPINPENNIV
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCCCCCEE
KVETRNKKL
EEECCCCCC
>Mature Secondary Structure 
TIRRLIALGPIVYLILLIVCFQLIFALIIRSFHFFSLESYGFIFTLLVGAILGFITYIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVRVLKLTSSKFLRRIFPFLQFSNSEIVKYLSILDQFKNDLIATNLTGLVCEKILKFIQT
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIPTKKVIVFFWKEEMGKFAPFPDSGEIQFFIFDPFLLWITENDRIYNFKEFATDPSLSK
HCCCCCEEEEEEEHHCCCCCCCCCCCCEEEEEECCEEEEEECCCCEEEHHHHCCCCCHHH
IRNSAENFFTKTEAELVVPLILNKSLLGIIVLGERQNRKNYTLSEINKLNEIRSVSVMAL
HHHHHHHHHHCCHHHEEHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
SNAIFYERLIELTETLEEKVKIRTQELEETQSQLIMSEKMASLGIMVAGIAHEINTPAGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
INGAADNLDQNMNYLVQNVFDVVLFARYRKLRKNFELALLHLLRDKKKSELDSKEKFRLK
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
NQLKEEMKSMNFSPTLTSELSNFIIENQIGKERKYIYNIILKDDDRGYFMLKNAAYINRN
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEEECHHHHHCC
IKNIRYAIRNIVRIVKALKSYSHLDQSKTFSSSNIIEGMETTLIILNNQIKYGIDVIKNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCEEEEEECCCHHHHHHHHCCH
QEIPLVICNPDELNQVWTNLIQNSIQALKGKGKIEISVFPWNGYVVVEIEDNGPGIPAKI
HHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCCCCCCHH
QDRIWDPFFTTKDQGEGTGLGLGIVKGIVEKHKGKITLNSNPGKTVFRVELPINPENNIV
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCCCCCEE
KVETRNKKL
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2710108; 8355615 [H]