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The map label for this gene is hisA

Identifier: 45656024

GI number: 45656024

Start: 131245

End: 131970

Strand: Direct

Name: hisA

Synonym: LIC10114

Alternate gene names: 45656024

Gene position: 131245-131970 (Clockwise)

Preceding gene: 45656023

Following gene: 45656025

Centisome position: 3.07

GC content: 36.78

Gene sequence:

>726_bases
ATGATTGTAATTCCTGCTATAGATCTATTCGATAATTGTGCAGTTCGTTTATTTAAGGGAAACTATGAAGAAAAGAAAAT
CTATTCTTCCGAACCTTGGAAACTTGCGGAAAGTTTTGCTAAGAATGGGGCGACTTTGCTTCATCTAGTAGATTTAAACG
GAGCTAGAAATCAACTCGGTGTCAATGAAGATTCTATTTTAAAAATCCGAGAGACTACTTCCCTCAAAGTGCAGTTAGGT
GGTGGAATTCGTGATAAAGAAAAATTGGCTTATTACGATAAAATTGGAATCAATCGTTTTATTCTTGGAACCGCTGCTGT
TACAAATCCGGATCTTTTGAAATATGCACTCGATAATTACGGAAAAGAAAGAGTCGTGGTAGCGGTCGATGCAAGAGATG
GGATTGTAAAAATTGCAGGTTGGGAAAAAGATTCAGGTATTCATTACAGAGACTTATTAGAGCGGCTTGTAAAAGCGGGA
ATTGAACATATTGTTTTTACAGATATTGCTCAAGATGGAACACTCGCAGGTCCGAATCTGGAAGCATATAGAGAAATATT
AAATTCTTATCCGTTTCAAGTAATTGCTTCCGGTGGAATTGCATCTCTCAAGGATTTGATGGATCTTTCTTCTCTTAAAA
CTAAAATTTCTCTCTACGGAGTGATTACTGGGAAAGCTTTGTACGAAGGAAAGCTGGATCTTGCAAAAGCAATTTCTTCC
ATTTAA

Upstream 100 bases:

>100_bases
CAGCCGTTGTAGAGAAAAATAATATTTTCGGAACACAGTTCCATCCTGAAAAATCACATACCCACGGACTTAAACTTTTG
GAGAATTTTATTCGTTTTAT

Downstream 100 bases:

>100_bases
GGAAACAGAAAATAGAATTAGATTTTTCTTTCCATCTGAAAAGGAACCACACATAAAGGTAAATCTATCTTACAAGATTT
TGGGATATTCATGAATCAAT

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase protein

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MIVIPAIDLFDNCAVRLFKGNYEEKKIYSSEPWKLAESFAKNGATLLHLVDLNGARNQLGVNEDSILKIRETTSLKVQLG
GGIRDKEKLAYYDKIGINRFILGTAAVTNPDLLKYALDNYGKERVVVAVDARDGIVKIAGWEKDSGIHYRDLLERLVKAG
IEHIVFTDIAQDGTLAGPNLEAYREILNSYPFQVIASGGIASLKDLMDLSSLKTKISLYGVITGKALYEGKLDLAKAISS
I

Sequences:

>Translated_241_residues
MIVIPAIDLFDNCAVRLFKGNYEEKKIYSSEPWKLAESFAKNGATLLHLVDLNGARNQLGVNEDSILKIRETTSLKVQLG
GGIRDKEKLAYYDKIGINRFILGTAAVTNPDLLKYALDNYGKERVVVAVDARDGIVKIAGWEKDSGIHYRDLLERLVKAG
IEHIVFTDIAQDGTLAGPNLEAYREILNSYPFQVIASGGIASLKDLMDLSSLKTKISLYGVITGKALYEGKLDLAKAISS
I
>Mature_241_residues
MIVIPAIDLFDNCAVRLFKGNYEEKKIYSSEPWKLAESFAKNGATLLHLVDLNGARNQLGVNEDSILKIRETTSLKVQLG
GGIRDKEKLAYYDKIGINRFILGTAAVTNPDLLKYALDNYGKERVVVAVDARDGIVKIAGWEKDSGIHYRDLLERLVKAG
IEHIVFTDIAQDGTLAGPNLEAYREILNSYPFQVIASGGIASLKDLMDLSSLKTKISLYGVITGKALYEGKLDLAKAISS
I

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=247, Percent_Identity=35.2226720647773, Blast_Score=162, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26492; Mature: 26492

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVIPAIDLFDNCAVRLFKGNYEEKKIYSSEPWKLAESFAKNGATLLHLVDLNGARNQLG
CEEECCHHHHHHHEEEEECCCCCHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCC
VNEDSILKIRETTSLKVQLGGGIRDKEKLAYYDKIGINRFILGTAAVTNPDLLKYALDNY
CCCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCC
GKERVVVAVDARDGIVKIAGWEKDSGIHYRDLLERLVKAGIEHIVFTDIAQDGTLAGPNL
CCCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCHHHEEEEECCCCCCCCCCCH
EAYREILNSYPFQVIASGGIASLKDLMDLSSLKTKISLYGVITGKALYEGKLDLAKAISS
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHEEEEEEEEECCEEECCCHHHHHHHHC
I
C
>Mature Secondary Structure
MIVIPAIDLFDNCAVRLFKGNYEEKKIYSSEPWKLAESFAKNGATLLHLVDLNGARNQLG
CEEECCHHHHHHHEEEEECCCCCHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCC
VNEDSILKIRETTSLKVQLGGGIRDKEKLAYYDKIGINRFILGTAAVTNPDLLKYALDNY
CCCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCC
GKERVVVAVDARDGIVKIAGWEKDSGIHYRDLLERLVKAGIEHIVFTDIAQDGTLAGPNL
CCCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCHHHEEEEECCCCCCCCCCCH
EAYREILNSYPFQVIASGGIASLKDLMDLSSLKTKISLYGVITGKALYEGKLDLAKAISS
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHEEEEEEEEECCEEECCCHHHHHHHHC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA