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The map label for this gene is hisB

Identifier: 45656022

GI number: 45656022

Start: 129999

End: 130619

Strand: Direct

Name: hisB

Synonym: LIC10112

Alternate gene names: 45656022

Gene position: 129999-130619 (Clockwise)

Preceding gene: 45656021

Following gene: 45656023

Centisome position: 3.04

GC content: 36.88

Gene sequence:

>621_bases
TTGACAGACAAGTTGATCGGATTCTATGATCCAGTTAGAATGAAAGCAGAAAGAAAAACTTCCGAAACCGAGATCAAATT
GGAAATGAATCTTCGAGGAACCGGTCAATATCAGTTTGATACAGAGATTCCTTTTTTCGAACATATGCTTTCACATATTT
CTAAACATGGATTGATCGATTTAAATCTTTGGTTAAGAGGGGATATTGAAATCGATTGTCATCATTCCGTGGAAGATACT
GCAATTTTAATGGGAACTACAATTCATAAACAATTAGGTGATAAGGCCGGAATTTTTAGATATGGACATTTTACTCTTAC
TATGGATGAAGTTCTTACTACCGTTGCCGTGGATTTAGGTGGTAGATACTTTTTTAAATACACTGGGCCTGAGCTAACGG
GCAAGTTTGGAATTTATGATGCAGAACTTTCTTTGGAATTTTTACAAAAGCTTGCTCTCAATGCAAAGATGAATCTACAC
GTAGTTGTTCATTACGGAGATAACAAACATCATGTTCACGAATCTATTTTTAAAGCTTTAGGTAAAGCACTCAGAATGGC
GATTGCACAGGACTCTGCAGCCGCAGGTGCAATTCCTTCCACTAAAGGAGTCTTAGAATGA

Upstream 100 bases:

>100_bases
TGCGTCTACCAATTCCGCCACTTCGGCGATTTATAGTGAGAAATTGCTCCTACAATTTCGATAGGTTTAGCTTTTCCGTC
ATCCATTATTTTGGAATTCA

Downstream 100 bases:

>100_bases
TCGCCATTCTTGATTATGGAATGGGAAATATTCATTCTTGTTTAAAAGCCGTATCTCTTTATACTAAGGATTTTGTTTTT
ACAAAAGATCATTCAACGAT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTDKLIGFYDPVRMKAERKTSETEIKLEMNLRGTGQYQFDTEIPFFEHMLSHISKHGLIDLNLWLRGDIEIDCHHSVEDT
AILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLGGRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLH
VVVHYGDNKHHVHESIFKALGKALRMAIAQDSAAAGAIPSTKGVLE

Sequences:

>Translated_206_residues
MTDKLIGFYDPVRMKAERKTSETEIKLEMNLRGTGQYQFDTEIPFFEHMLSHISKHGLIDLNLWLRGDIEIDCHHSVEDT
AILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLGGRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLH
VVVHYGDNKHHVHESIFKALGKALRMAIAQDSAAAGAIPSTKGVLE
>Mature_205_residues
TDKLIGFYDPVRMKAERKTSETEIKLEMNLRGTGQYQFDTEIPFFEHMLSHISKHGLIDLNLWLRGDIEIDCHHSVEDTA
ILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLGGRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLHV
VVHYGDNKHHVHESIFKALGKALRMAIAQDSAAAGAIPSTKGVLE

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=188, Percent_Identity=38.2978723404255, Blast_Score=125, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324776, Length=213, Percent_Identity=31.924882629108, Blast_Score=95, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 23168; Mature: 23037

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKLIGFYDPVRMKAERKTSETEIKLEMNLRGTGQYQFDTEIPFFEHMLSHISKHGLID
CCCCCCCCCCCHHHHHHCCCCCEEEEEEEEECCCCCEEECCCCCHHHHHHHHHHHCCEEE
LNLWLRGDIEIDCHHSVEDTAILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLG
EEEEEEECEEEEECCCCCCCEEEEECHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHCC
GRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLHVVVHYGDNKHHVHESIFKAL
CEEEEEEECCCCCCEECEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHH
GKALRMAIAQDSAAAGAIPSTKGVLE
HHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDKLIGFYDPVRMKAERKTSETEIKLEMNLRGTGQYQFDTEIPFFEHMLSHISKHGLID
CCCCCCCCCCHHHHHHCCCCCEEEEEEEEECCCCCEEECCCCCHHHHHHHHHHHCCEEE
LNLWLRGDIEIDCHHSVEDTAILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLG
EEEEEEECEEEEECCCCCCCEEEEECHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHCC
GRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLHVVVHYGDNKHHVHESIFKAL
CEEEEEEECCCCCCEECEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHH
GKALRMAIAQDSAAAGAIPSTKGVLE
HHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA