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The map label for this gene is gltT [H]

Identifier: 45655973

GI number: 45655973

Start: 73514

End: 74797

Strand: Reverse

Name: gltT [H]

Synonym: LIC10059

Alternate gene names: 45655973

Gene position: 74797-73514 (Counterclockwise)

Preceding gene: 45655978

Following gene: 45655972

Centisome position: 1.75

GC content: 36.53

Gene sequence:

>1284_bases
ATGCGAGTTTTCGAGAAACTAACTTCCCTTAATATCAAGATCCTAAGTAGTTTGAAAGAAAAACTTTGGTTAAAAATCTT
CGTTGGAATGTTAGCTGGAATTCTTACTGGGGTTTTACTTGGTTCCGATTTATCTTTGGTAGATAGAAACACCGCACAAC
TTACCACTTCTTGGCTCATTATACCCGGACTTATATTTATCAACCTTTTGCAGATGATTATGATACCCTTAATTTTTTCT
TCTATTATTCTCGGAATTTGTTCCGCCGAAAATTTAGAGAATATTAAGAAACTAGGAATCAGAACCTTAATTTATTTCGT
TTTTACAACCTTCATCGCAGTTACAATTGGGATTACGTTAGCACTTTGGTTAAAACCCGGAAAGTCAGCGGTCCAAATTC
AAACCACTTTCAGTTCCAAAGTTCCAGCTCCGGCTGAAATCCCATCTTTAGATAAATATCCAGAGTTATTGATGTCATTC
TTTCCGAAAAATCCGTTTCTATCGATCACTCAGGGAGAAATGTTAAACGTAATCGTATTTTCAATTTTACTTGGAATTGC
AATCCTTTCTGTTTCAAAAGATTTATCAAAACCAATTTTGACAATATTGAATTCAGTTTTTCAGATTAGTATGAAAATTG
TACATTGGGCGATGGTTCTAACCCCTTTCGCCGTTTTCGGTTTAATGACAAAAGCGATTTCTTCTATTGGCATAGAATTG
CTAGTTACCTTAGGCGTTTATATGAGCGTCGTTTTATTGGGACTTCTTTTAATTATTGGAGTTTATTCGATTATCCTTAT
TTTTTTAGCAAGAAGAAGCCCGATTGACTTTTTCACTAAAATTGCAGGTTTACAATTACTAGCATTTTCAACCTCAAGTT
CAGCAGCTGTAATGCCCGTTTCAATTCAAACCGCAACTGAAAATTTAGGAGTAAGAAAAAACATAGCAGAGTTTATCATC
CCGGTCGGAGCAACGATTAACATGGATGGGACCGCACTTTATCAGTCAGTAGCTACAATATTTTTAGCGCAGTATTTTGG
AATCGAATTGGCCCCAGCTCAATTGGTATTTATTCTTTTTGCGACTGTCGGAGCATCAATTGGAACCCCAAGTACCCCAG
GTATTGGAATTGTAATTTTAGCCACAATTCTTTCAGGACTAGGCATTCCGACAGAAGGGATTGGAATCATTTTAGGAGTA
GATCGTTTTTTAGACATGTGTAGAACGACTATTAACGTTACGGGGGACATTACGGCATCCTGTGTAATGGATAAGATGAC
TTGA

Upstream 100 bases:

>100_bases
AAAAAATAGGGCTTCATTAAAATCTCGAAAACGGCTTTAATAATTCACACCAAAACTAAAAATCAATAGAAAAAATAAGG
AATCAAAAGAGTTTTCCAAT

Downstream 100 bases:

>100_bases
TTGGGATATCAAAAATTTGTCCCGAAAAGAACTTAACACTTTGTTACCTAAAGATCTCTCGATAAGTATTGAAACACGTC
ATAAGTTTTACAAACTTACA

Product: proton glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRVFEKLTSLNIKILSSLKEKLWLKIFVGMLAGILTGVLLGSDLSLVDRNTAQLTTSWLIIPGLIFINLLQMIMIPLIFS
SIILGICSAENLENIKKLGIRTLIYFVFTTFIAVTIGITLALWLKPGKSAVQIQTTFSSKVPAPAEIPSLDKYPELLMSF
FPKNPFLSITQGEMLNVIVFSILLGIAILSVSKDLSKPILTILNSVFQISMKIVHWAMVLTPFAVFGLMTKAISSIGIEL
LVTLGVYMSVVLLGLLLIIGVYSIILIFLARRSPIDFFTKIAGLQLLAFSTSSSAAVMPVSIQTATENLGVRKNIAEFII
PVGATINMDGTALYQSVATIFLAQYFGIELAPAQLVFILFATVGASIGTPSTPGIGIVILATILSGLGIPTEGIGIILGV
DRFLDMCRTTINVTGDITASCVMDKMT

Sequences:

>Translated_427_residues
MRVFEKLTSLNIKILSSLKEKLWLKIFVGMLAGILTGVLLGSDLSLVDRNTAQLTTSWLIIPGLIFINLLQMIMIPLIFS
SIILGICSAENLENIKKLGIRTLIYFVFTTFIAVTIGITLALWLKPGKSAVQIQTTFSSKVPAPAEIPSLDKYPELLMSF
FPKNPFLSITQGEMLNVIVFSILLGIAILSVSKDLSKPILTILNSVFQISMKIVHWAMVLTPFAVFGLMTKAISSIGIEL
LVTLGVYMSVVLLGLLLIIGVYSIILIFLARRSPIDFFTKIAGLQLLAFSTSSSAAVMPVSIQTATENLGVRKNIAEFII
PVGATINMDGTALYQSVATIFLAQYFGIELAPAQLVFILFATVGASIGTPSTPGIGIVILATILSGLGIPTEGIGIILGV
DRFLDMCRTTINVTGDITASCVMDKMT
>Mature_427_residues
MRVFEKLTSLNIKILSSLKEKLWLKIFVGMLAGILTGVLLGSDLSLVDRNTAQLTTSWLIIPGLIFINLLQMIMIPLIFS
SIILGICSAENLENIKKLGIRTLIYFVFTTFIAVTIGITLALWLKPGKSAVQIQTTFSSKVPAPAEIPSLDKYPELLMSF
FPKNPFLSITQGEMLNVIVFSILLGIAILSVSKDLSKPILTILNSVFQISMKIVHWAMVLTPFAVFGLMTKAISSIGIEL
LVTLGVYMSVVLLGLLLIIGVYSIILIFLARRSPIDFFTKIAGLQLLAFSTSSSAAVMPVSIQTATENLGVRKNIAEFII
PVGATINMDGTALYQSVATIFLAQYFGIELAPAQLVFILFATVGASIGTPSTPGIGIVILATILSGLGIPTEGIGIILGV
DRFLDMCRTTINVTGDITASCVMDKMT

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=451, Percent_Identity=30.3769401330377, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI40254478, Length=411, Percent_Identity=32.1167883211679, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI194239697, Length=456, Percent_Identity=30.0438596491228, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI21314632, Length=413, Percent_Identity=28.0871670702179, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4827012, Length=441, Percent_Identity=28.3446712018141, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI5032093, Length=394, Percent_Identity=31.7258883248731, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI169790839, Length=257, Percent_Identity=34.2412451361868, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI223468566, Length=248, Percent_Identity=34.6774193548387, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI223468564, Length=249, Percent_Identity=34.5381526104418, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI301601644, Length=178, Percent_Identity=34.2696629213483, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI262359914, Length=188, Percent_Identity=33.5106382978723, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1790514, Length=396, Percent_Identity=33.5858585858586, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1788024, Length=412, Percent_Identity=29.8543689320388, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789947, Length=415, Percent_Identity=27.2289156626506, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789473, Length=379, Percent_Identity=24.5382585751979, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71996953, Length=441, Percent_Identity=32.4263038548753, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17537407, Length=417, Percent_Identity=29.4964028776978, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71983099, Length=409, Percent_Identity=31.7848410757946, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71983106, Length=409, Percent_Identity=31.5403422982885, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193206505, Length=437, Percent_Identity=30.2059496567506, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI193206654, Length=449, Percent_Identity=28.9532293986637, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17541374, Length=418, Percent_Identity=28.7081339712919, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24583025, Length=428, Percent_Identity=28.7383177570093, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17137668, Length=428, Percent_Identity=28.7383177570093, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24583023, Length=428, Percent_Identity=28.7383177570093, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI281360483, Length=456, Percent_Identity=28.9473684210526, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI17137666, Length=456, Percent_Identity=28.9473684210526, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI281360481, Length=456, Percent_Identity=28.9473684210526, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46029; Mature: 46029

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVFEKLTSLNIKILSSLKEKLWLKIFVGMLAGILTGVLLGSDLSLVDRNTAQLTTSWLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHH
IPGLIFINLLQMIMIPLIFSSIILGICSAENLENIKKLGIRTLIYFVFTTFIAVTIGITL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALWLKPGKSAVQIQTTFSSKVPAPAEIPSLDKYPELLMSFFPKNPFLSITQGEMLNVIVF
HEEECCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHHHH
SILLGIAILSVSKDLSKPILTILNSVFQISMKIVHWAMVLTPFAVFGLMTKAISSIGIEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVTLGVYMSVVLLGLLLIIGVYSIILIFLARRSPIDFFTKIAGLQLLAFSTSSSAAVMPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEECCCCCEEEEE
SIQTATENLGVRKNIAEFIIPVGATINMDGTALYQSVATIFLAQYFGIELAPAQLVFILF
EEEHHHHHCCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCEECHHHHHHHHH
ATVGASIGTPSTPGIGIVILATILSGLGIPTEGIGIILGVDRFLDMCRTTINVTGDITAS
HHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHH
CVMDKMT
HHHHCCC
>Mature Secondary Structure
MRVFEKLTSLNIKILSSLKEKLWLKIFVGMLAGILTGVLLGSDLSLVDRNTAQLTTSWLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHH
IPGLIFINLLQMIMIPLIFSSIILGICSAENLENIKKLGIRTLIYFVFTTFIAVTIGITL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALWLKPGKSAVQIQTTFSSKVPAPAEIPSLDKYPELLMSFFPKNPFLSITQGEMLNVIVF
HEEECCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHHHH
SILLGIAILSVSKDLSKPILTILNSVFQISMKIVHWAMVLTPFAVFGLMTKAISSIGIEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVTLGVYMSVVLLGLLLIIGVYSIILIFLARRSPIDFFTKIAGLQLLAFSTSSSAAVMPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEECCCCCEEEEE
SIQTATENLGVRKNIAEFIIPVGATINMDGTALYQSVATIFLAQYFGIELAPAQLVFILF
EEEHHHHHCCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCEECHHHHHHHHH
ATVGASIGTPSTPGIGIVILATILSGLGIPTEGIGIILGVDRFLDMCRTTINVTGDITAS
HHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHH
CVMDKMT
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]