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The map label for this gene is dinF [H]

Identifier: 45655972

GI number: 45655972

Start: 72115

End: 73497

Strand: Reverse

Name: dinF [H]

Synonym: LIC10058

Alternate gene names: 45655972

Gene position: 73497-72115 (Counterclockwise)

Preceding gene: 45655973

Following gene: 45655969

Centisome position: 1.72

GC content: 31.67

Gene sequence:

>1383_bases
TTGTCCCGAAAAGAACTTAACACTTTGTTACCTAAAGATCTCTCGATAAGTATTGAAACACGTCATAAGTTTTACAAACT
TACATTCTACAACATTCTTGCAAATATCACGGTTCCTCTTACTGGTATAGTAGATACATCTATATTAGGGAATCTTAATA
CCTATGTTTTCATGGCGGGAGCTGCTTTATCCGGAATTCTTTTTGATTTTATGTTTTGGATGTTCGGTTTTTTAAGAATG
GGAACCACAGGTTTAACTGCACAGGCAGTAGGAGAAAAAAATGAAAAAGAATCTATTTTCATTTTGGTTCGATCAATTTC
TTTAGCTTGTTTTTTCGGAGCGATGATTCTAATTTTTTCTCCTTGGATTCGAGAAATTGGATTTCAAATTTTGGAAGGAA
GTTCCGAAGTCAAAATGGCGGGAATTTCATACTTTGACGCTAGAATTCCGGGTTCGATTGCGGTTCTTTGTAATTACGTT
TTTACGGGCTGGTTTTTAGGAAGAGGAAAGAGCTCGGTCGTATTGATTGCAACCGTAGTTGGAAACGGAATCAATGTTAT
TTTAGATGTTTGGTTTATTTTCAAATTAGGTTGGGAAGCTTATGGAGCAGGTTTAGCCACAAGCATCAGTCAATTTGGAA
TGTTGTTAATTTTTATATTTTTATTTTTTATAGAATTAAAAATTCAGAATATTTCAAAATTCTTATTCTTAAATAATAAA
AATTTATTTTCAGTCCAAGGTTTTTCTTCCCTTCTCCATCTCAATAAGGACATCTTTTTGAGAACCTTTTTTCTGATTAT
TACATTTAGTATATTTCGAAATTTTAGTTCGGAAGCGGGTACAGAGATTTTAGCGACAAATTCAATTTTGCTTCAACTGA
TACTTGTCAGCGCTTATTTAGTAGACGGTGCAGCGTTTGCTACGGAAAGTTTAGCCGGAAATATATACGGTAAAAAAAAT
TGGAAACTACTTAAAGAACTTCTTTATTTAGCTTTTTATAATTCTATTTTTTTTACTTCCATTTTTCTTGGTTCTGTTTT
TTTGTTTCCCAATTTTATTTTCGGAATGATTACAAAAAGTGATAAGGTATTATCTCTATTAATAGACTATAGATTCTGGT
TGTTTCCTGTATTAGAAGTCGGAGCAATAGCATTTATTTTAGACGGTTTTTTTATAGGACTTACAAAAGGAAAAATTCTC
CGTAATTCTATGTTGATAAGTACCGCTTTTTTCTTTTTTCCAATTGTTTATCTTGGAAAAATTCAGAAGGACAATCACCT
TCTTTGGCTTTCTCTAGTTTTATTCATGGTTGGAAGAGCTTTAACTTTATCCTTTCAAGCAAAAAAAATTTTTGAAAATT
CTAAACTACAAAACGTAAACTAA

Upstream 100 bases:

>100_bases
GATCGTTTTTTAGACATGTGTAGAACGACTATTAACGTTACGGGGGACATTACGGCATCCTGTGTAATGGATAAGATGAC
TTGATTGGGATATCAAAAAT

Downstream 100 bases:

>100_bases
CATGAGTTTGGCGTAAAATGGAAAAAAGATCTTATAATTAACGTGAATTCGTGAAGAAATCTATGATTCTGAAAAAATTA
GAATCTGAACCTGCAAATTT

Product: drug:Na+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSRKELNTLLPKDLSISIETRHKFYKLTFYNILANITVPLTGIVDTSILGNLNTYVFMAGAALSGILFDFMFWMFGFLRM
GTTGLTAQAVGEKNEKESIFILVRSISLACFFGAMILIFSPWIREIGFQILEGSSEVKMAGISYFDARIPGSIAVLCNYV
FTGWFLGRGKSSVVLIATVVGNGINVILDVWFIFKLGWEAYGAGLATSISQFGMLLIFIFLFFIELKIQNISKFLFLNNK
NLFSVQGFSSLLHLNKDIFLRTFFLIITFSIFRNFSSEAGTEILATNSILLQLILVSAYLVDGAAFATESLAGNIYGKKN
WKLLKELLYLAFYNSIFFTSIFLGSVFLFPNFIFGMITKSDKVLSLLIDYRFWLFPVLEVGAIAFILDGFFIGLTKGKIL
RNSMLISTAFFFFPIVYLGKIQKDNHLLWLSLVLFMVGRALTLSFQAKKIFENSKLQNVN

Sequences:

>Translated_460_residues
MSRKELNTLLPKDLSISIETRHKFYKLTFYNILANITVPLTGIVDTSILGNLNTYVFMAGAALSGILFDFMFWMFGFLRM
GTTGLTAQAVGEKNEKESIFILVRSISLACFFGAMILIFSPWIREIGFQILEGSSEVKMAGISYFDARIPGSIAVLCNYV
FTGWFLGRGKSSVVLIATVVGNGINVILDVWFIFKLGWEAYGAGLATSISQFGMLLIFIFLFFIELKIQNISKFLFLNNK
NLFSVQGFSSLLHLNKDIFLRTFFLIITFSIFRNFSSEAGTEILATNSILLQLILVSAYLVDGAAFATESLAGNIYGKKN
WKLLKELLYLAFYNSIFFTSIFLGSVFLFPNFIFGMITKSDKVLSLLIDYRFWLFPVLEVGAIAFILDGFFIGLTKGKIL
RNSMLISTAFFFFPIVYLGKIQKDNHLLWLSLVLFMVGRALTLSFQAKKIFENSKLQNVN
>Mature_459_residues
SRKELNTLLPKDLSISIETRHKFYKLTFYNILANITVPLTGIVDTSILGNLNTYVFMAGAALSGILFDFMFWMFGFLRMG
TTGLTAQAVGEKNEKESIFILVRSISLACFFGAMILIFSPWIREIGFQILEGSSEVKMAGISYFDARIPGSIAVLCNYVF
TGWFLGRGKSSVVLIATVVGNGINVILDVWFIFKLGWEAYGAGLATSISQFGMLLIFIFLFFIELKIQNISKFLFLNNKN
LFSVQGFSSLLHLNKDIFLRTFFLIITFSIFRNFSSEAGTEILATNSILLQLILVSAYLVDGAAFATESLAGNIYGKKNW
KLLKELLYLAFYNSIFFTSIFLGSVFLFPNFIFGMITKSDKVLSLLIDYRFWLFPVLEVGAIAFILDGFFIGLTKGKILR
NSMLISTAFFFFPIVYLGKIQKDNHLLWLSLVLFMVGRALTLSFQAKKIFENSKLQNVN

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790477, Length=431, Percent_Identity=33.4106728538283, Blast_Score=191, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51838; Mature: 51707

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKELNTLLPKDLSISIETRHKFYKLTFYNILANITVPLTGIVDTSILGNLNTYVFMAG
CCHHHHHHHCCCCCEEEEEECHHEEEHHHHHHHHHHHCCCHHHHHHHHHCCCCHHEEEHH
AALSGILFDFMFWMFGFLRMGTTGLTAQAVGEKNEKESIFILVRSISLACFFGAMILIFS
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
PWIREIGFQILEGSSEVKMAGISYFDARIPGSIAVLCNYVFTGWFLGRGKSSVVLIATVV
HHHHHHHHHHHCCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
GNGINVILDVWFIFKLGWEAYGAGLATSISQFGMLLIFIFLFFIELKIQNISKFLFLNNK
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
NLFSVQGFSSLLHLNKDIFLRTFFLIITFSIFRNFSSEAGTEILATNSILLQLILVSAYL
CEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHCCCEEEEHHHHHHHHHHHHHHH
VDGAAFATESLAGNIYGKKNWKLLKELLYLAFYNSIFFTSIFLGSVFLFPNFIFGMITKS
HCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DKVLSLLIDYRFWLFPVLEVGAIAFILDGFFIGLTKGKILRNSMLISTAFFFFPIVYLGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHC
IQKDNHLLWLSLVLFMVGRALTLSFQAKKIFENSKLQNVN
CCCCCCCHHHHHHHHHHCHHHEEEHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SRKELNTLLPKDLSISIETRHKFYKLTFYNILANITVPLTGIVDTSILGNLNTYVFMAG
CHHHHHHHCCCCCEEEEEECHHEEEHHHHHHHHHHHCCCHHHHHHHHHCCCCHHEEEHH
AALSGILFDFMFWMFGFLRMGTTGLTAQAVGEKNEKESIFILVRSISLACFFGAMILIFS
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
PWIREIGFQILEGSSEVKMAGISYFDARIPGSIAVLCNYVFTGWFLGRGKSSVVLIATVV
HHHHHHHHHHHCCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
GNGINVILDVWFIFKLGWEAYGAGLATSISQFGMLLIFIFLFFIELKIQNISKFLFLNNK
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
NLFSVQGFSSLLHLNKDIFLRTFFLIITFSIFRNFSSEAGTEILATNSILLQLILVSAYL
CEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHCCCEEEEHHHHHHHHHHHHHHH
VDGAAFATESLAGNIYGKKNWKLLKELLYLAFYNSIFFTSIFLGSVFLFPNFIFGMITKS
HCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DKVLSLLIDYRFWLFPVLEVGAIAFILDGFFIGLTKGKILRNSMLISTAFFFFPIVYLGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHC
IQKDNHLLWLSLVLFMVGRALTLSFQAKKIFENSKLQNVN
CCCCCCCHHHHHHHHHHCHHHEEEHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]