Click here to switch to the map view.

The map label for this gene is glmS [H]

Identifier: 45359243

GI number: 45359243

Start: 1621139

End: 1622947

Strand: Direct

Name: glmS [H]

Synonym: MMP1680

Alternate gene names: 45359243

Gene position: 1621139-1622947 (Clockwise)

Preceding gene: 45359241

Following gene: 45359246

Centisome position: 97.59

GC content: 31.67

Gene sequence:

>1809_bases
GTGTTTTATATGTGTGGAATTATTGGATATATTGGAAATGAAAAAGCTTCAAAGATATTACTAAAGGGTTTAAAAAGGCT
AGAATATAGGGGATACGATAGCTGCGGAATTGCAACTATTGACGATACAATTAAACTTAAGAAAAATACTGGAAAAGTTT
TAGAAGTCTCGAAAAAAGAAAACTTTGAAGACATGACAGGCTTTATTGGAATAGGACACAGCAGGTGGGCTACACACGGC
GGAATTACAAAAAACAATGCACACCCCCACTACGACTGCAGCGAAAAAATTTGCATCGCACACAATGGAATAATATCAAA
TTACAAGGAATTAAAAGAACTATTGATTTCAAAAGGCCATATTTTCAAATCTGAAACAGATACTGAAGTTATTCCACACT
TAATTGAAGAAGAAATAAAAGATTTTAAAGAAATAACTGAAAAAACATACATTAACGCCATTCAAAATACAATTAAAAAA
CTTAATGGAACGTACGCTCTCTTAATTTTAAATCAAGATTTTCCAGAAATGCTTGTTGGAGTTAGAAATGAAAGTCCACT
CATTTTAGGAATAAAAAAAGATGAATGCTTTATTGGAAGCGATATTTCTGCATTTTTAGAATACACTAAACTTGCAATGC
CATTAAACGATCGCGATATTGTAATTTTGAGAAAAGAAAACGATGAAATAGATATCGAAGTTTTAAACTATGGAAAACAA
GTTCAAAGAGATACAATTGAACTCCAGTGGGATATGGAAAGTGCTGAAAAGGAAGGATATGAGCACTTCATGTTAAAAGA
AATTATGGAAGAACCTGTAATTTTAAAAAATTCAATGAAAATTTCAAAATTGGAAATTGAAAATCTTGGAAAAGAAATTG
AAAAATGTGATAAAATATACATCACCGCAATGGGGACTTCACTTCATGCTGCAATGGTTGCAGAATACTGGTTCTCAGGA
TTAAATAAATTAGTTATTCCAATCGATTCGTCTGAATTTTTAACAAAAGGAATTGTTGATGAAAAAACACTGGTTATTGC
AATAACGCAAAGCGGTGAAACATACGACACGATGAAAGCAGTTAAATACGCTAAAGAAAAAGGTGCGAAAACTGCAACTA
TCGTAAACGTTCTTGGAAGTACTGCAACAAGAGAAGCAGACATTACAATAATGATGGGTTCAGGCCTAGAAATTGCAGTT
TGTGCAACAAAAACATTCATGTCACAGCTTGTTATTTTATACAGGTTATTCATTGAGTACGGTAAAATTATCGGAAAAAA
CATGGATATTTTTGAAAAAGAGTTATTAAATATTCCAAATTACATTTCAAAAGTTTTAGATGAAAAAGAAAACATTTCAA
AAATTGCAGAAGAATTAACTGCTAAAAACTACCTCTTTATTTCAAAAGGAATTAATCTTGCAAATGCCCTTGAAGGGGCC
TTGAAATTTAAAGAAATAACCTATTTGCATGCTGAAGGAATGAGCAGTGGATTTTTAAAACATGGAACAATTTCATTAAT
TGATGAAAATATGGACACTGTTGCACTAATTCCCCCTTCAAAATCTGAACTTTTAAATTCTGTTCTTTCAAATGTTGAAG
AAATAAAAGCAAGAAACGGCAAAATTATCGGAATTTCACCGGTTGAAGATAATTTAAAATATTCGATAAAAGTTCCAGAT
GTAATTGAAGAAGTAAGCCCTTTTGTTTATGCTACTGCTTGTCAGCTTTTAGCATATTACAAAGCTGTTGATTTAAAAAG
AGATGTAGATAAGCCGCGAGGGCTTGCAAAAAGTGTTACAGTTGAGTAA

Upstream 100 bases:

>100_bases
ATAAATCACCGATAATAAGACTGAATAAATAGTACTAACTATAATAATCGAAATTATATTATATAAACAATGTCAAATAG
CTTTCAGTCGAAAATTACAG

Downstream 100 bases:

>100_bases
TTCTTTTTAATCTTTTCTTTTTGTCAATATCTACACCCATATTTTCTTCGAGTTCTACCATTTTTGGAGGAAGTTCATCC
CATCTCCAAAAACCCCTTAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MFYMCGIIGYIGNEKASKILLKGLKRLEYRGYDSCGIATIDDTIKLKKNTGKVLEVSKKENFEDMTGFIGIGHSRWATHG
GITKNNAHPHYDCSEKICIAHNGIISNYKELKELLISKGHIFKSETDTEVIPHLIEEEIKDFKEITEKTYINAIQNTIKK
LNGTYALLILNQDFPEMLVGVRNESPLILGIKKDECFIGSDISAFLEYTKLAMPLNDRDIVILRKENDEIDIEVLNYGKQ
VQRDTIELQWDMESAEKEGYEHFMLKEIMEEPVILKNSMKISKLEIENLGKEIEKCDKIYITAMGTSLHAAMVAEYWFSG
LNKLVIPIDSSEFLTKGIVDEKTLVIAITQSGETYDTMKAVKYAKEKGAKTATIVNVLGSTATREADITIMMGSGLEIAV
CATKTFMSQLVILYRLFIEYGKIIGKNMDIFEKELLNIPNYISKVLDEKENISKIAEELTAKNYLFISKGINLANALEGA
LKFKEITYLHAEGMSSGFLKHGTISLIDENMDTVALIPPSKSELLNSVLSNVEEIKARNGKIIGISPVEDNLKYSIKVPD
VIEEVSPFVYATACQLLAYYKAVDLKRDVDKPRGLAKSVTVE

Sequences:

>Translated_602_residues
MFYMCGIIGYIGNEKASKILLKGLKRLEYRGYDSCGIATIDDTIKLKKNTGKVLEVSKKENFEDMTGFIGIGHSRWATHG
GITKNNAHPHYDCSEKICIAHNGIISNYKELKELLISKGHIFKSETDTEVIPHLIEEEIKDFKEITEKTYINAIQNTIKK
LNGTYALLILNQDFPEMLVGVRNESPLILGIKKDECFIGSDISAFLEYTKLAMPLNDRDIVILRKENDEIDIEVLNYGKQ
VQRDTIELQWDMESAEKEGYEHFMLKEIMEEPVILKNSMKISKLEIENLGKEIEKCDKIYITAMGTSLHAAMVAEYWFSG
LNKLVIPIDSSEFLTKGIVDEKTLVIAITQSGETYDTMKAVKYAKEKGAKTATIVNVLGSTATREADITIMMGSGLEIAV
CATKTFMSQLVILYRLFIEYGKIIGKNMDIFEKELLNIPNYISKVLDEKENISKIAEELTAKNYLFISKGINLANALEGA
LKFKEITYLHAEGMSSGFLKHGTISLIDENMDTVALIPPSKSELLNSVLSNVEEIKARNGKIIGISPVEDNLKYSIKVPD
VIEEVSPFVYATACQLLAYYKAVDLKRDVDKPRGLAKSVTVE
>Mature_602_residues
MFYMCGIIGYIGNEKASKILLKGLKRLEYRGYDSCGIATIDDTIKLKKNTGKVLEVSKKENFEDMTGFIGIGHSRWATHG
GITKNNAHPHYDCSEKICIAHNGIISNYKELKELLISKGHIFKSETDTEVIPHLIEEEIKDFKEITEKTYINAIQNTIKK
LNGTYALLILNQDFPEMLVGVRNESPLILGIKKDECFIGSDISAFLEYTKLAMPLNDRDIVILRKENDEIDIEVLNYGKQ
VQRDTIELQWDMESAEKEGYEHFMLKEIMEEPVILKNSMKISKLEIENLGKEIEKCDKIYITAMGTSLHAAMVAEYWFSG
LNKLVIPIDSSEFLTKGIVDEKTLVIAITQSGETYDTMKAVKYAKEKGAKTATIVNVLGSTATREADITIMMGSGLEIAV
CATKTFMSQLVILYRLFIEYGKIIGKNMDIFEKELLNIPNYISKVLDEKENISKIAEELTAKNYLFISKGINLANALEGA
LKFKEITYLHAEGMSSGFLKHGTISLIDENMDTVALIPPSKSELLNSVLSNVEEIKARNGKIIGISPVEDNLKYSIKVPD
VIEEVSPFVYATACQLLAYYKAVDLKRDVDKPRGLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=688, Percent_Identity=32.9941860465116, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI4826742, Length=688, Percent_Identity=32.703488372093, Blast_Score=316, Evalue=4e-86,
Organism=Homo sapiens, GI29570798, Length=199, Percent_Identity=28.643216080402, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790167, Length=627, Percent_Identity=38.755980861244, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788651, Length=200, Percent_Identity=30.5, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539970, Length=720, Percent_Identity=32.3611111111111, Blast_Score=304, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=31.0185185185185, Blast_Score=195, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=31.0185185185185, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17554892, Length=250, Percent_Identity=29.2, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322745, Length=435, Percent_Identity=32.4137931034483, Blast_Score=201, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=37.378640776699, Blast_Score=133, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6323731, Length=433, Percent_Identity=24.4803695150115, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323958, Length=203, Percent_Identity=25.615763546798, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357745, Length=692, Percent_Identity=31.3583815028902, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI28573187, Length=202, Percent_Identity=23.2673267326733, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67580; Mature: 67580

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYMCGIIGYIGNEKASKILLKGLKRLEYRGYDSCGIATIDDTIKLKKNTGKVLEVSKKE
CEEEEEHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEECCCCCEEEECCCC
NFEDMTGFIGIGHSRWATHGGITKNNAHPHYDCSEKICIAHNGIISNYKELKELLISKGH
CHHHHHHHEECCCCHHCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCC
IFKSETDTEVIPHLIEEEIKDFKEITEKTYINAIQNTIKKLNGTYALLILNQDFPEMLVG
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHC
VRNESPLILGIKKDECFIGSDISAFLEYTKLAMPLNDRDIVILRKENDEIDIEVLNYGKQ
CCCCCCEEEEEECCCCEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCH
VQRDTIELQWDMESAEKEGYEHFMLKEIMEEPVILKNSMKISKLEIENLGKEIEKCDKIY
HCCCEEEEEECCCHHHHCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCEEE
ITAMGTSLHAAMVAEYWFSGLNKLVIPIDSSEFLTKGIVDEKTLVIAITQSGETYDTMKA
EEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCCCCCEEEEEEECCCCCHHHHHH
VKYAKEKGAKTATIVNVLGSTATREADITIMMGSGLEIAVCATKTFMSQLVILYRLFIEY
HHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHH
GKIIGKNMDIFEKELLNIPNYISKVLDEKENISKIAEELTAKNYLFISKGINLANALEGA
HHHHCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHH
LKFKEITYLHAEGMSSGFLKHGTISLIDENMDTVALIPPSKSELLNSVLSNVEEIKARNG
HHHHHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
KIIGISPVEDNLKYSIKVPDVIEEVSPFVYATACQLLAYYKAVDLKRDVDKPRGLAKSVT
EEEEECCCCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VE
CC
>Mature Secondary Structure
MFYMCGIIGYIGNEKASKILLKGLKRLEYRGYDSCGIATIDDTIKLKKNTGKVLEVSKKE
CEEEEEHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEECCCCCEEEECCCC
NFEDMTGFIGIGHSRWATHGGITKNNAHPHYDCSEKICIAHNGIISNYKELKELLISKGH
CHHHHHHHEECCCCHHCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCC
IFKSETDTEVIPHLIEEEIKDFKEITEKTYINAIQNTIKKLNGTYALLILNQDFPEMLVG
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHC
VRNESPLILGIKKDECFIGSDISAFLEYTKLAMPLNDRDIVILRKENDEIDIEVLNYGKQ
CCCCCCEEEEEECCCCEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCH
VQRDTIELQWDMESAEKEGYEHFMLKEIMEEPVILKNSMKISKLEIENLGKEIEKCDKIY
HCCCEEEEEECCCHHHHCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCEEE
ITAMGTSLHAAMVAEYWFSGLNKLVIPIDSSEFLTKGIVDEKTLVIAITQSGETYDTMKA
EEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCCCCCEEEEEEECCCCCHHHHHH
VKYAKEKGAKTATIVNVLGSTATREADITIMMGSGLEIAVCATKTFMSQLVILYRLFIEY
HHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHH
GKIIGKNMDIFEKELLNIPNYISKVLDEKENISKIAEELTAKNYLFISKGINLANALEGA
HHHHCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHH
LKFKEITYLHAEGMSSGFLKHGTISLIDENMDTVALIPPSKSELLNSVLSNVEEIKARNG
HHHHHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
KIIGISPVEDNLKYSIKVPDVIEEVSPFVYATACQLLAYYKAVDLKRDVDKPRGLAKSVT
EEEEECCCCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA