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The map label for this gene is speB [C]

Identifier: 45359148

GI number: 45359148

Start: 1534843

End: 1535691

Strand: Direct

Name: speB [C]

Synonym: MMP1585

Alternate gene names: 45359148

Gene position: 1534843-1535691 (Clockwise)

Preceding gene: 45359147

Following gene: 45359149

Centisome position: 92.4

GC content: 34.98

Gene sequence:

>849_bases
ATGTATTTTGAAGATTATTCCAAGTTTCTCACAGCTTATGATACATTTAACGATGCTGATTTTGTTATTTTTGGAATTCC
TTTTGATGCTACAACTTCATACAAACCAGGCGCGAGATTTGGGCCTGATGAAGTTAGAAACGCTTCATGGGGACTTGAAA
CATTTAGCCCAATTTTAAAAAAAGATTTAATCGATGTAAAAATTTGCGACAAATACAACCTTTTAATGGAAGGAAACCAG
TCTGAAATTATAAATCGGGCATATAGTGCTTCAAAAGATATTTTAGAAGCTAAAAAAATACCGGTAATGATTGGTGGAGA
ACACTCTGTAACATACCCTGTTGTAAAAGCTGTAAAATCGGTTTATGATGACTTTGCAGTAATTCACTTCGATGCACACT
GCGATTTAAGGGAAGAATATATGGGAAACGAACAGTCCCATGCAAGTGTAATTAGAAGAACTTACGATTTAACAAAAGAT
ATCTTCCAGTTTGGAATCAGAAGTGGCGACCAAGATGAATGGGAATTTGGATGGGAAAACACCAATATTTCAATGGAAAT
GCCCACAAAAGACGATATCAAAAAGATAAAAGAACTTGAAAAACCAATTTACGTAACAATTGACATTGATGTACTTGACC
CTGCATTTGTACCTGGAACTGGAACTCCAGAACCCTGCGGATTTACACCAAAAGAACTTATAAACTCACTTTATCTTTTG
GAAGAAATTAAAGAAAAAATTGTTGGTTTTGACGTGGTTGAAGTTTCACCACATTACGACATCGGCAAGATTACATCTGT
TACCGCAGCAAAAATCATTCGTGAATTGATACTTACCATAAGCAAATAA

Upstream 100 bases:

>100_bases
AATACTACGATCAGGACGTTCACAAGGGAGTATTTTTAGCAACACCTAGATACTTAAAAGAATAATTTCTAACTTTTTTA
TTATTTTTTGGTGATAATTC

Downstream 100 bases:

>100_bases
TACGTCAATATTTTCAAAAATAAGCGTGCATACAAAATCAAATGTTAAAATTTAAATATAAAAATAAACATATCTGTAAA
AAGTAAGAATCGTGGTGATA

Product: arginase

Products: putrescine; urea

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MYFEDYSKFLTAYDTFNDADFVIFGIPFDATTSYKPGARFGPDEVRNASWGLETFSPILKKDLIDVKICDKYNLLMEGNQ
SEIINRAYSASKDILEAKKIPVMIGGEHSVTYPVVKAVKSVYDDFAVIHFDAHCDLREEYMGNEQSHASVIRRTYDLTKD
IFQFGIRSGDQDEWEFGWENTNISMEMPTKDDIKKIKELEKPIYVTIDIDVLDPAFVPGTGTPEPCGFTPKELINSLYLL
EEIKEKIVGFDVVEVSPHYDIGKITSVTAAKIIRELILTISK

Sequences:

>Translated_282_residues
MYFEDYSKFLTAYDTFNDADFVIFGIPFDATTSYKPGARFGPDEVRNASWGLETFSPILKKDLIDVKICDKYNLLMEGNQ
SEIINRAYSASKDILEAKKIPVMIGGEHSVTYPVVKAVKSVYDDFAVIHFDAHCDLREEYMGNEQSHASVIRRTYDLTKD
IFQFGIRSGDQDEWEFGWENTNISMEMPTKDDIKKIKELEKPIYVTIDIDVLDPAFVPGTGTPEPCGFTPKELINSLYLL
EEIKEKIVGFDVVEVSPHYDIGKITSVTAAKIIRELILTISK
>Mature_282_residues
MYFEDYSKFLTAYDTFNDADFVIFGIPFDATTSYKPGARFGPDEVRNASWGLETFSPILKKDLIDVKICDKYNLLMEGNQ
SEIINRAYSASKDILEAKKIPVMIGGEHSVTYPVVKAVKSVYDDFAVIHFDAHCDLREEYMGNEQSHASVIRRTYDLTKD
IFQFGIRSGDQDEWEFGWENTNISMEMPTKDDIKKIKELEKPIYVTIDIDVLDPAFVPGTGTPEPCGFTPKELINSLYLL
EEIKEKIVGFDVVEVSPHYDIGKITSVTAAKIIRELILTISK

Specific function: Catalyzes The Formation Of Putrescine From Agmatine. [C]

COG id: COG0010

COG function: function code E; Arginase/agmatinase/formimionoglutamate hydrolase, arginase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arginase family [H]

Homologues:

Organism=Homo sapiens, GI37537722, Length=289, Percent_Identity=32.5259515570934, Blast_Score=154, Evalue=7e-38,
Organism=Escherichia coli, GI1789306, Length=275, Percent_Identity=32.7272727272727, Blast_Score=120, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005925
- InterPro:   IPR006035
- InterPro:   IPR020855 [H]

Pfam domain/function: PF00491 Arginase [H]

EC number: 3.5.3.11

Molecular weight: Translated: 32046; Mature: 32046

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00147 ARGINASE_1 ; PS00148 ARGINASE_2 ; PS01053 ARGINASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFEDYSKFLTAYDTFNDADFVIFGIPFDATTSYKPGARFGPDEVRNASWGLETFSPILK
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHH
KDLIDVKICDKYNLLMEGNQSEIINRAYSASKDILEAKKIPVMIGGEHSVTYPVVKAVKS
HHCCCEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHH
VYDDFAVIHFDAHCDLREEYMGNEQSHASVIRRTYDLTKDIFQFGIRSGDQDEWEFGWEN
HHCCEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
TNISMEMPTKDDIKKIKELEKPIYVTIDIDVLDPAFVPGTGTPEPCGFTPKELINSLYLL
CCEEEECCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
EEIKEKIVGFDVVEVSPHYDIGKITSVTAAKIIRELILTISK
HHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYFEDYSKFLTAYDTFNDADFVIFGIPFDATTSYKPGARFGPDEVRNASWGLETFSPILK
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHH
KDLIDVKICDKYNLLMEGNQSEIINRAYSASKDILEAKKIPVMIGGEHSVTYPVVKAVKS
HHCCCEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHH
VYDDFAVIHFDAHCDLREEYMGNEQSHASVIRRTYDLTKDIFQFGIRSGDQDEWEFGWEN
HHCCEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
TNISMEMPTKDDIKKIKELEKPIYVTIDIDVLDPAFVPGTGTPEPCGFTPKELINSLYLL
CCEEEECCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
EEIKEKIVGFDVVEVSPHYDIGKITSVTAAKIIRELILTISK
HHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: agmatine; H2O

Specific reaction: agmatine + H2O = putrescine + urea

General reaction: Amidine hydrolysis [C]

Inhibitor: EDTA; EGTA [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]