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The map label for this gene is purM [H]

Identifier: 45358817

GI number: 45358817

Start: 1236961

End: 1238010

Strand: Direct

Name: purM [H]

Synonym: MMP1254

Alternate gene names: 45358817

Gene position: 1236961-1238010 (Clockwise)

Preceding gene: 45358816

Following gene: 45358818

Centisome position: 74.46

GC content: 34.0

Gene sequence:

>1050_bases
TTGGTAACTTACAAAGACGCTGGTGTGGACATATATAAAGAAGACAAGGTAATTAGGGCGCTTGCTTCTCAAATTAAATT
TGAAAGGACTGATGCAATAAAACCTGCTGATTTAAAAGGGCATTATGCAGGAGCTATTGAATTTGGAGACTATTATTTAG
TGCTCTGTACAGATGGTGTTGGAAGTAAAATGGTTGTTGCAGAAATGGCAAACAAATTTGACACCGTTCCAATAGACATG
ATTGCAATGAATGTAAACGATGCAATATGTATCGGAGCTGAACCAGTTGCACTTGTTGACTACATGGCTGTTGAAGATAT
AACTGAAGACATTGCTTCACAAATTGGAAAAGGATTGAATGACGGAATAAAAGAATCAAACATCAATTTAATCGGCGGAG
AAACTGCATCACTTCCAAACATGATTAAAGGAGTAGATTTAGCAGGAACAGTTCTTGCAGTTGTTAAAAAAGATGAAATC
GTATCTGGAAAAGAAGTAAAATCTGGTGATTTAATCGTTGGTTTAAGAAGCAGCGGAATTCACAGTAACGGTTTATCACT
TGCAAGAAAAGTATTTTTCGATATTGCAAACCTTGATGTTAACAGCAAATTATCACACGGAAAAACGGTTGCTGAAGAAC
TTTTAACCCCCACAAAAATTTACGTAAAACCAGTTTTAGAAATGATTAAACAAGTAAACGTAAAAGGACTCGCACACATT
ACTGGCGGCGGTTTTAGAAAATTAAAAAGATTAAACAAAGAAGTATGCTACAAAATCGATGAATTACCTGAAATTCTTCC
AATATTTAAAGAAATGCAGAAATTAGGAAATGTAGCGGATGAAGAAATGTTTAAAACATTTAACATGGGCATTGGATTTT
GCGTAATCGTTGAAAAGGAAGATGCAGAAAAAATAATTGAAATATCAAACCACCACAACATCCCTGCATTTGTAATTGGA
AAAATCGAAGACAGCGTTGAAGTAAATGGCGAAACTAAAAAAGAAACTGTTTTAGTTGAATACAATAACAAAAAAATGAT
AATGGAATAA

Upstream 100 bases:

>100_bases
CGATAACGTTCTTTTAAGGAAAGAGATAAGTAAAGTTTAAAATTAATAAAAGCAAATTACAATAGAGAAAAACATTTATT
CATTTATTTAAGGTGGTATT

Downstream 100 bases:

>100_bases
TTTAGAATATACGTTTAAATTAAAAATATGGGTGAATACTGTGCCTACAATTAACGTGAATAAAGTAGATTTGGAACGAT
TGAGCAATATTTCGCTTTCG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MVTYKDAGVDIYKEDKVIRALASQIKFERTDAIKPADLKGHYAGAIEFGDYYLVLCTDGVGSKMVVAEMANKFDTVPIDM
IAMNVNDAICIGAEPVALVDYMAVEDITEDIASQIGKGLNDGIKESNINLIGGETASLPNMIKGVDLAGTVLAVVKKDEI
VSGKEVKSGDLIVGLRSSGIHSNGLSLARKVFFDIANLDVNSKLSHGKTVAEELLTPTKIYVKPVLEMIKQVNVKGLAHI
TGGGFRKLKRLNKEVCYKIDELPEILPIFKEMQKLGNVADEEMFKTFNMGIGFCVIVEKEDAEKIIEISNHHNIPAFVIG
KIEDSVEVNGETKKETVLVEYNNKKMIME

Sequences:

>Translated_349_residues
MVTYKDAGVDIYKEDKVIRALASQIKFERTDAIKPADLKGHYAGAIEFGDYYLVLCTDGVGSKMVVAEMANKFDTVPIDM
IAMNVNDAICIGAEPVALVDYMAVEDITEDIASQIGKGLNDGIKESNINLIGGETASLPNMIKGVDLAGTVLAVVKKDEI
VSGKEVKSGDLIVGLRSSGIHSNGLSLARKVFFDIANLDVNSKLSHGKTVAEELLTPTKIYVKPVLEMIKQVNVKGLAHI
TGGGFRKLKRLNKEVCYKIDELPEILPIFKEMQKLGNVADEEMFKTFNMGIGFCVIVEKEDAEKIIEISNHHNIPAFVIG
KIEDSVEVNGETKKETVLVEYNNKKMIME
>Mature_349_residues
MVTYKDAGVDIYKEDKVIRALASQIKFERTDAIKPADLKGHYAGAIEFGDYYLVLCTDGVGSKMVVAEMANKFDTVPIDM
IAMNVNDAICIGAEPVALVDYMAVEDITEDIASQIGKGLNDGIKESNINLIGGETASLPNMIKGVDLAGTVLAVVKKDEI
VSGKEVKSGDLIVGLRSSGIHSNGLSLARKVFFDIANLDVNSKLSHGKTVAEELLTPTKIYVKPVLEMIKQVNVKGLAHI
TGGGFRKLKRLNKEVCYKIDELPEILPIFKEMQKLGNVADEEMFKTFNMGIGFCVIVEKEDAEKIIEISNHHNIPAFVIG
KIEDSVEVNGETKKETVLVEYNNKKMIME

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=335, Percent_Identity=34.9253731343284, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI209869995, Length=335, Percent_Identity=34.9253731343284, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI209869993, Length=335, Percent_Identity=34.9253731343284, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI1788845, Length=335, Percent_Identity=37.910447761194, Blast_Score=207, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17567511, Length=302, Percent_Identity=37.7483443708609, Blast_Score=167, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6321203, Length=323, Percent_Identity=35.6037151702786, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24582400, Length=272, Percent_Identity=35.2941176470588, Blast_Score=165, Evalue=5e-41,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38199; Mature: 38199

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTYKDAGVDIYKEDKVIRALASQIKFERTDAIKPADLKGHYAGAIEFGDYYLVLCTDGV
CCEEECCCCEEEHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEEEEEECCEEEEEEECCC
GSKMVVAEMANKFDTVPIDMIAMNVNDAICIGAEPVALVDYMAVEDITEDIASQIGKGLN
CCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC
DGIKESNINLIGGETASLPNMIKGVDLAGTVLAVVKKDEIVSGKEVKSGDLIVGLRSSGI
CCCCCCCCEEECCCCCCCCHHHHCCCHHHHHEEEEECCCCCCCCCCCCCCEEEEEECCCC
HSNGLSLARKVFFDIANLDVNSKLSHGKTVAEELLTPTKIYVKPVLEMIKQVNVKGLAHI
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEE
TGGGFRKLKRLNKEVCYKIDELPEILPIFKEMQKLGNVADEEMFKTFNMGIGFCVIVEKE
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEECC
DAEKIIEISNHHNIPAFVIGKIEDSVEVNGETKKETVLVEYNNKKMIME
CHHHHHHHCCCCCCCEEEEEECCCCEEECCCCCCEEEEEEECCCEEECC
>Mature Secondary Structure
MVTYKDAGVDIYKEDKVIRALASQIKFERTDAIKPADLKGHYAGAIEFGDYYLVLCTDGV
CCEEECCCCEEEHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEEEEEECCEEEEEEECCC
GSKMVVAEMANKFDTVPIDMIAMNVNDAICIGAEPVALVDYMAVEDITEDIASQIGKGLN
CCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC
DGIKESNINLIGGETASLPNMIKGVDLAGTVLAVVKKDEIVSGKEVKSGDLIVGLRSSGI
CCCCCCCCEEECCCCCCCCHHHHCCCHHHHHEEEEECCCCCCCCCCCCCCEEEEEECCCC
HSNGLSLARKVFFDIANLDVNSKLSHGKTVAEELLTPTKIYVKPVLEMIKQVNVKGLAHI
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEE
TGGGFRKLKRLNKEVCYKIDELPEILPIFKEMQKLGNVADEEMFKTFNMGIGFCVIVEKE
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEECC
DAEKIIEISNHHNIPAFVIGKIEDSVEVNGETKKETVLVEYNNKKMIME
CHHHHHHHCCCCCCCEEEEEECCCCEEECCCCCCEEEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA