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The map label for this gene is moaE [H]

Identifier: 45358798

GI number: 45358798

Start: 1222366

End: 1222791

Strand: Direct

Name: moaE [H]

Synonym: MMP1235

Alternate gene names: 45358798

Gene position: 1222366-1222791 (Clockwise)

Preceding gene: 45358797

Following gene: 45358799

Centisome position: 73.59

GC content: 34.04

Gene sequence:

>426_bases
ATGATTAGAGTGTCTAATGAAGATTTTAACGTTGACGTTGAAACTAAAGCCCTTTTAAAAAATCATCCTGAAATAGGTGG
ACTTGTAAATTTTGTAGGGGTTGTTAGAAACGTAGGATACGATAAAGGCGTTGAAAAAGAAGCTGAATTTATTGAATTTG
AATGCTATGAACAGATGGCTTCTAAAAAACTCGAAGAATTAAAAAATAGGGCAATTGAAAAGTTCAACATAATCGATGCT
ACGTTAATCCACAGGATCGGAACCTTGAAAGTAGGGGACAATATTGTATTGATAGTTGTTGGGGCAAAACACAGAAAAGA
AGCATTTTTAGCCTGCGAATATTTAATTGACAGCCTAAAAGAAGAAGTTCCGATATGGAAAAAGGAATTTTCAAAAGATG
GTTCTTACTGGGTAGAACAACACTAA

Upstream 100 bases:

>100_bases
CCTTTAAAAAATAAGTTGCTTTCAATAAACATGCGTACAAATGATTATTTCACATTTAATATAAAGAAAAATCCGAAATG
CAAAATTTGTGGTGGTTTGA

Downstream 100 bases:

>100_bases
ATCATTCTAATTTATTTTAATTTTTAAAAAGGAATACTATGAAATTTTTTCAAGAAAAAATATCCATTAAAGAAACAAAC
ATTCTTTTAAAAGTAGATAA

Product: molybdopterin biosynthesis MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MIRVSNEDFNVDVETKALLKNHPEIGGLVNFVGVVRNVGYDKGVEKEAEFIEFECYEQMASKKLEELKNRAIEKFNIIDA
TLIHRIGTLKVGDNIVLIVVGAKHRKEAFLACEYLIDSLKEEVPIWKKEFSKDGSYWVEQH

Sequences:

>Translated_141_residues
MIRVSNEDFNVDVETKALLKNHPEIGGLVNFVGVVRNVGYDKGVEKEAEFIEFECYEQMASKKLEELKNRAIEKFNIIDA
TLIHRIGTLKVGDNIVLIVVGAKHRKEAFLACEYLIDSLKEEVPIWKKEFSKDGSYWVEQH
>Mature_141_residues
MIRVSNEDFNVDVETKALLKNHPEIGGLVNFVGVVRNVGYDKGVEKEAEFIEFECYEQMASKKLEELKNRAIEKFNIIDA
TLIHRIGTLKVGDNIVLIVVGAKHRKEAFLACEYLIDSLKEEVPIWKKEFSKDGSYWVEQH

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=137, Percent_Identity=30.6569343065693, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1787003, Length=138, Percent_Identity=36.231884057971, Blast_Score=84, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17509279, Length=126, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 16198; Mature: 16198

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVSNEDFNVDVETKALLKNHPEIGGLVNFVGVVRNVGYDKGVEKEAEFIEFECYEQMA
CEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
SKKLEELKNRAIEKFNIIDATLIHRIGTLKVGDNIVLIVVGAKHRKEAFLACEYLIDSLK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEECCCCHHHHHHHHHHHHHHHH
EEVPIWKKEFSKDGSYWVEQH
HHCCHHHHHHCCCCCEEECCC
>Mature Secondary Structure
MIRVSNEDFNVDVETKALLKNHPEIGGLVNFVGVVRNVGYDKGVEKEAEFIEFECYEQMA
CEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
SKKLEELKNRAIEKFNIIDATLIHRIGTLKVGDNIVLIVVGAKHRKEAFLACEYLIDSLK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEECCCCHHHHHHHHHHHHHHHH
EEVPIWKKEFSKDGSYWVEQH
HHCCHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]