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The map label for this gene is hesA1 [H]

Identifier: 45358797

GI number: 45358797

Start: 1221654

End: 1222373

Strand: Direct

Name: hesA1 [H]

Synonym: MMP1234

Alternate gene names: 45358797

Gene position: 1221654-1222373 (Clockwise)

Preceding gene: 45358794

Following gene: 45358798

Centisome position: 73.54

GC content: 32.36

Gene sequence:

>720_bases
ATGAGCTTGGAAAGATACAAAAGACAGATTTTAATGGATGATTTCGGAGAACTTGGCCAAAAAAAACTACTAGATGCAAC
TGTAACCGTTGTCGGTGTTGGGGGCCTTGGAACCGTTGTTTCACAATATCTAGCTGCCGCAGGAGTTGGAAACTTAAAAT
TAGTTGATTATCAAGAAGTTGAACTTTCAAATTTAAATAGACAGATACTGCACTTTGAAAAAGATATTGGAATAAAAAAG
GTTATTTCTGCAAAAGAAAAGTTAGAAAGCATTAATTCAGAGATAAACATTGAAATTTATCCTGAAAAAGTAAACGAAAA
TCACATCAAAAATTCAGACGTTATCATCGACTGCCTTGATAATTTTGAAGCAAGATATCTATTAAATAACTTTTCAAATA
AATACAAAATCCCGCTAGTTCACGGGGCAATTGAAGACTTACGAGGACAAGTTACGACAATAATTCCTGATGAAACACCA
TGCATTGAATGTATTTTCAAATTAAAAGATGAAGAAAAAAATAAGTCTTTTCCAGTGCTCGGAGTAACTCCTGGGGTAAT
TGGTTCAATTCAGGCAGGTGAAGCGATAAAATTAATAATTGGAATTGGAACTCCTTTAAAAAATAAGTTGCTTTCAATAA
ACATGCGTACAAATGATTATTTCACATTTAATATAAAGAAAAATCCGAAATGCAAAATTTGTGGTGGTTTGAATGATTAG

Upstream 100 bases:

>100_bases
TTTTGTAACCATTTTAGACATTTTTGAACCACACTCCAAAATCATACCATCAATATTATTATAACTTAAAGCATATAATT
GTTTAAATAACTGTGATACT

Downstream 100 bases:

>100_bases
AGTGTCTAATGAAGATTTTAACGTTGACGTTGAAACTAAAGCCCTTTTAAAAAATCATCCTGAAATAGGTGGACTTGTAA
ATTTTGTAGGGGTTGTTAGA

Product: UBA/THIF-type NAD/FAD binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MSLERYKRQILMDDFGELGQKKLLDATVTVVGVGGLGTVVSQYLAAAGVGNLKLVDYQEVELSNLNRQILHFEKDIGIKK
VISAKEKLESINSEINIEIYPEKVNENHIKNSDVIIDCLDNFEARYLLNNFSNKYKIPLVHGAIEDLRGQVTTIIPDETP
CIECIFKLKDEEKNKSFPVLGVTPGVIGSIQAGEAIKLIIGIGTPLKNKLLSINMRTNDYFTFNIKKNPKCKICGGLND

Sequences:

>Translated_239_residues
MSLERYKRQILMDDFGELGQKKLLDATVTVVGVGGLGTVVSQYLAAAGVGNLKLVDYQEVELSNLNRQILHFEKDIGIKK
VISAKEKLESINSEINIEIYPEKVNENHIKNSDVIIDCLDNFEARYLLNNFSNKYKIPLVHGAIEDLRGQVTTIIPDETP
CIECIFKLKDEEKNKSFPVLGVTPGVIGSIQAGEAIKLIIGIGTPLKNKLLSINMRTNDYFTFNIKKNPKCKICGGLND
>Mature_238_residues
SLERYKRQILMDDFGELGQKKLLDATVTVVGVGGLGTVVSQYLAAAGVGNLKLVDYQEVELSNLNRQILHFEKDIGIKKV
ISAKEKLESINSEINIEIYPEKVNENHIKNSDVIIDCLDNFEARYLLNNFSNKYKIPLVHGAIEDLRGQVTTIIPDETPC
IECIFKLKDEEKNKSFPVLGVTPGVIGSIQAGEAIKLIIGIGTPLKNKLLSINMRTNDYFTFNIKKNPKCKICGGLND

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=240, Percent_Identity=37.0833333333333, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI38327032, Length=220, Percent_Identity=28.6363636363636, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI13376212, Length=220, Percent_Identity=28.6363636363636, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI38045944, Length=177, Percent_Identity=31.0734463276836, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI38045942, Length=177, Percent_Identity=31.0734463276836, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4885649, Length=156, Percent_Identity=31.4102564102564, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1787048, Length=238, Percent_Identity=39.9159663865546, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI87082356, Length=241, Percent_Identity=36.5145228215768, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1789177, Length=148, Percent_Identity=29.7297297297297, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540406, Length=241, Percent_Identity=35.6846473029046, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI193203301, Length=153, Percent_Identity=26.797385620915, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI86565433, Length=165, Percent_Identity=30.3030303030303, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI86565431, Length=165, Percent_Identity=30.3030303030303, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71984476, Length=182, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508819, Length=216, Percent_Identity=26.3888888888889, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=248, Percent_Identity=32.6612903225806, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320598, Length=181, Percent_Identity=31.4917127071823, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325323, Length=153, Percent_Identity=32.0261437908497, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322639, Length=167, Percent_Identity=30.5389221556886, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24582879, Length=245, Percent_Identity=40.4081632653061, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24660640, Length=158, Percent_Identity=32.9113924050633, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI20129973, Length=173, Percent_Identity=28.3236994219653, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641311, Length=222, Percent_Identity=27.4774774774775, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573937, Length=187, Percent_Identity=27.807486631016, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 26596; Mature: 26465

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLERYKRQILMDDFGELGQKKLLDATVTVVGVGGLGTVVSQYLAAAGVGNLKLVDYQEV
CCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECHH
ELSNLNRQILHFEKDIGIKKVISAKEKLESINSEINIEIYPEKVNENHIKNSDVIIDCLD
HHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCEEEEECC
NFEARYLLNNFSNKYKIPLVHGAIEDLRGQVTTIIPDETPCIECIFKLKDEEKNKSFPVL
CCCHHHHHHCCCCEEEEEEEHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCEE
GVTPGVIGSIQAGEAIKLIIGIGTPLKNKLLSINMRTNDYFTFNIKKNPKCKICGGLND
EECCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCEEEEEECCCCCEEECCCCCC
>Mature Secondary Structure 
SLERYKRQILMDDFGELGQKKLLDATVTVVGVGGLGTVVSQYLAAAGVGNLKLVDYQEV
CHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECHH
ELSNLNRQILHFEKDIGIKKVISAKEKLESINSEINIEIYPEKVNENHIKNSDVIIDCLD
HHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCEEEEECC
NFEARYLLNNFSNKYKIPLVHGAIEDLRGQVTTIIPDETPCIECIFKLKDEEKNKSFPVL
CCCHHHHHHCCCCEEEEEEEHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCEE
GVTPGVIGSIQAGEAIKLIIGIGTPLKNKLLSINMRTNDYFTFNIKKNPKCKICGGLND
EECCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCEEEEEECCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8709854 [H]