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The map label for this gene is lhr [C]

Identifier: 45358704

GI number: 45358704

Start: 1130105

End: 1132729

Strand: Direct

Name: lhr [C]

Synonym: MMP1141

Alternate gene names: 45358704

Gene position: 1130105-1132729 (Clockwise)

Preceding gene: 45358703

Following gene: 45358705

Centisome position: 68.03

GC content: 35.62

Gene sequence:

>2625_bases
TTGAAAAATGATGGCGAAATATTAGATTTATTTGAACCCGCGGTTAAAAAGTGGTGGTTGAATAAATTTGAGCCCTACAA
ATCAATTAATAATGGATATTTCACACCACCCCAAAGACTTGCAATTCCTAAAATACATTTTGGAAGAAATACTTTAATTT
GCAGTCCAACAGGAAGTGGAAAAACCCTCAGCAGTTTTATTGCAATTATAAACGAACTTTTTAGAATTGAAAAAGAAGAA
GGCCTACAAAACAGCATTTATTGCCTATATATCAGCCCGTTAAAAAGTCTTGCAAACGACATTCATGTAAATTTAGATGA
ACCATTAACTGAAATTAAAGAAATTTTAAAAGAAGAAGGAAATGAAATTACTGGAATTCGGCATGCAATAAGGCATGGAG
ATACTTCAAACTATGAAAAATCAAAAATGCTTAAAAAAACACCCCATATTTTAAATACAACTCCTGAAACTCTTGCAATC
ATATTAAACTCCCCAAAATTTAAAGAAAAATTAAAAACAGTTCAGTGGGTAATTATTGACGAAATCCACGCACTTGCGGA
TAATAAAAGGGGAGTGCACTTAAGTATAAGCCTTGAAAGACTTCGAGAACTTACCAATCAGGAATTCTTAAGAATTGGGT
GCAGTGCAACAGTTGAACCTTTGGAAATGGTTGCAGATTATCTTGGAGGATATTATGATGACGGATACAAGAGGCCCGTT
GAAATAGTTGATACAAGGTTTGTCAGAGGATACGATTTAAAATTACTGTGTCCTGTTGATGATTTAATAAATAAAACTCC
AAAAGAAATTTCTGAAAAACTCTACGAAAAACTTGATAGATTAATTCAAACCCATGAAAATACACTCATATTTACAAATA
CGCGAGGTGGCGCTGAAAGAGTATTATACAACCTTAGAAAACGCTATCCTGAAAAATACGATGAAACAAATAGCGGATGC
CATCATGGGAGTTTATCAAAAGAAAAACGGCTCGAACTCGAAGAAAAATTAAAAAGCGGAAACCTAAAATTTGCAACAAC
CAGCAGCAGCCTCGAACTTGGAATTGATATGCCATATATCGACCTTGTTGTACAGATCGGAAGCCCCAAAAGTGTTAAAA
CAATGCTTCAAAGAATTGGGCGGGCAGGTCACGGAATCGGAAAGGTTGCAAAGGGAAGAATAATCGCACTCGATCGAGAC
GAACTTTTAGAGTGTGCGGTAATGCTGAAAAAAGCAATGGATGGATTTATCGATAAAGTACATATTCCAAAAGGCCCACT
TGATGTTTTGATACAGCATATTTACGGGATTGCGATTAACGGATATATCGAGCTTGAAAGAGTAAAAAATATCGTTAGAA
GAAGCTACAATTACCACGATATTACAGATGAAGACTTTAAAATTCTTATAAATTACATGACTGCATCATACGCAGGAATG
GATGAAAAAAGGATATATTCTAAAATATGGTACGACCCTGACACCCAGATGATTGGAAAAACTGGAAAAACTGCACGAGC
AATATACTATATGAATATCGGCACAATTCCTGATGATTTCAGCTGTGACGTTTATCTTAGGGGAACCACAATCTGGATTG
GAAAACTCGATGAACAGTATTTAGATAGGCTAGAAAAGGGTGATGTATTTACACTTGGTGGAGAACATCTTAAATTCCAA
TACCGGCGTGGAAGTAAGGTTTACGTTGACAAAACTAGTGAAAGGCCAAATATTCCTAGCTGGTACTCTGAAAGACTGCC
TTTAAGCTATGATCTTGGAAGAAATATACTTCTTTTTAAAAAGGAAGCTGTTTCAAAATATAATGCAGGTAGACTTCTTG
ACCTTTTGAGCGAATACCCGCTTGATTCGAATGCTACAAAAAGTCTCTACGGGCTTTTTAATGAACAGATTTTATACAAA
GGAAACGATAGTGTCAGCACATTAAATAAAATGGTTGTAGAAGGCCATATTTTCGACAAAAAAATGCACTACTATTTCCA
CAGCAATTACGGAAGGAAATTTAACGACGGATTCAGTAGGGCTGTCGCTTATGCATTAAGTAAACAGTACAAACTCGGAG
TTTTGGTAAGTATTTCAGATACCGGATTTTCACTAGAATTTGCGAAAAATCAAAAAGTCGATATCGAAAGTGCAATTCGA
TCATTAACTCCAGAAAATATAAAAGATGTATTGAAACAGGCTCTTGAGGGAACAAACCTGCTAAAAAGGATGTTCAGGAT
AAATGCAACGAGAAGCCTCATGATTTTGAGAAATTATATAGGGCATAAAAAATCTGCGAAAAAACAGCAGGTAAGTGCGG
ATATATTAATAAGCTATGCAAAAAGCCTTGATAGATTTGCACCACTTGAAGAAACGCTTCGTGAAATAATTGAAGATTCA
CTTGAACTTGACAATATTCGTGAAGTTCTGGGCGAAATTAGAAGCGGAAAATTAAAAATTAATGTAATAGATGTTCCAAT
TCCCACCCCGATGAGCTTTGGAATCGCGACACTTACTGCAAGCGACTCAGTTCTTGCGGAAAACAAAAACCAGCTTTTAA
AAGAGTTCCACCAGATGGTAATTAAAATGATTGAATACGAAAAGGGAATTTCGCTTGAGGAATAA

Upstream 100 bases:

>100_bases
ATTAGACTTAAAAATTTACAGATTTACACCACATTTTTACGGTGATATTATCCAATCAACTATTTCAGAAAACTTAAAAA
ATCCAGAATATCCATTCGGG

Downstream 100 bases:

>100_bases
TTATGGAAATAAATGGGCATGAAATCCAGTTTAAAGATAATGCAGTATTTTTAGAAGAAAATAAAATTTTAATACTTGCA
GATGTCCACGTTGGAATGGA

Product: ATP-dependent helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 874; Mature: 874

Protein sequence:

>874_residues
MKNDGEILDLFEPAVKKWWLNKFEPYKSINNGYFTPPQRLAIPKIHFGRNTLICSPTGSGKTLSSFIAIINELFRIEKEE
GLQNSIYCLYISPLKSLANDIHVNLDEPLTEIKEILKEEGNEITGIRHAIRHGDTSNYEKSKMLKKTPHILNTTPETLAI
ILNSPKFKEKLKTVQWVIIDEIHALADNKRGVHLSISLERLRELTNQEFLRIGCSATVEPLEMVADYLGGYYDDGYKRPV
EIVDTRFVRGYDLKLLCPVDDLINKTPKEISEKLYEKLDRLIQTHENTLIFTNTRGGAERVLYNLRKRYPEKYDETNSGC
HHGSLSKEKRLELEEKLKSGNLKFATTSSSLELGIDMPYIDLVVQIGSPKSVKTMLQRIGRAGHGIGKVAKGRIIALDRD
ELLECAVMLKKAMDGFIDKVHIPKGPLDVLIQHIYGIAINGYIELERVKNIVRRSYNYHDITDEDFKILINYMTASYAGM
DEKRIYSKIWYDPDTQMIGKTGKTARAIYYMNIGTIPDDFSCDVYLRGTTIWIGKLDEQYLDRLEKGDVFTLGGEHLKFQ
YRRGSKVYVDKTSERPNIPSWYSERLPLSYDLGRNILLFKKEAVSKYNAGRLLDLLSEYPLDSNATKSLYGLFNEQILYK
GNDSVSTLNKMVVEGHIFDKKMHYYFHSNYGRKFNDGFSRAVAYALSKQYKLGVLVSISDTGFSLEFAKNQKVDIESAIR
SLTPENIKDVLKQALEGTNLLKRMFRINATRSLMILRNYIGHKKSAKKQQVSADILISYAKSLDRFAPLEETLREIIEDS
LELDNIREVLGEIRSGKLKINVIDVPIPTPMSFGIATLTASDSVLAENKNQLLKEFHQMVIKMIEYEKGISLEE

Sequences:

>Translated_874_residues
MKNDGEILDLFEPAVKKWWLNKFEPYKSINNGYFTPPQRLAIPKIHFGRNTLICSPTGSGKTLSSFIAIINELFRIEKEE
GLQNSIYCLYISPLKSLANDIHVNLDEPLTEIKEILKEEGNEITGIRHAIRHGDTSNYEKSKMLKKTPHILNTTPETLAI
ILNSPKFKEKLKTVQWVIIDEIHALADNKRGVHLSISLERLRELTNQEFLRIGCSATVEPLEMVADYLGGYYDDGYKRPV
EIVDTRFVRGYDLKLLCPVDDLINKTPKEISEKLYEKLDRLIQTHENTLIFTNTRGGAERVLYNLRKRYPEKYDETNSGC
HHGSLSKEKRLELEEKLKSGNLKFATTSSSLELGIDMPYIDLVVQIGSPKSVKTMLQRIGRAGHGIGKVAKGRIIALDRD
ELLECAVMLKKAMDGFIDKVHIPKGPLDVLIQHIYGIAINGYIELERVKNIVRRSYNYHDITDEDFKILINYMTASYAGM
DEKRIYSKIWYDPDTQMIGKTGKTARAIYYMNIGTIPDDFSCDVYLRGTTIWIGKLDEQYLDRLEKGDVFTLGGEHLKFQ
YRRGSKVYVDKTSERPNIPSWYSERLPLSYDLGRNILLFKKEAVSKYNAGRLLDLLSEYPLDSNATKSLYGLFNEQILYK
GNDSVSTLNKMVVEGHIFDKKMHYYFHSNYGRKFNDGFSRAVAYALSKQYKLGVLVSISDTGFSLEFAKNQKVDIESAIR
SLTPENIKDVLKQALEGTNLLKRMFRINATRSLMILRNYIGHKKSAKKQQVSADILISYAKSLDRFAPLEETLREIIEDS
LELDNIREVLGEIRSGKLKINVIDVPIPTPMSFGIATLTASDSVLAENKNQLLKEFHQMVIKMIEYEKGISLEE
>Mature_874_residues
MKNDGEILDLFEPAVKKWWLNKFEPYKSINNGYFTPPQRLAIPKIHFGRNTLICSPTGSGKTLSSFIAIINELFRIEKEE
GLQNSIYCLYISPLKSLANDIHVNLDEPLTEIKEILKEEGNEITGIRHAIRHGDTSNYEKSKMLKKTPHILNTTPETLAI
ILNSPKFKEKLKTVQWVIIDEIHALADNKRGVHLSISLERLRELTNQEFLRIGCSATVEPLEMVADYLGGYYDDGYKRPV
EIVDTRFVRGYDLKLLCPVDDLINKTPKEISEKLYEKLDRLIQTHENTLIFTNTRGGAERVLYNLRKRYPEKYDETNSGC
HHGSLSKEKRLELEEKLKSGNLKFATTSSSLELGIDMPYIDLVVQIGSPKSVKTMLQRIGRAGHGIGKVAKGRIIALDRD
ELLECAVMLKKAMDGFIDKVHIPKGPLDVLIQHIYGIAINGYIELERVKNIVRRSYNYHDITDEDFKILINYMTASYAGM
DEKRIYSKIWYDPDTQMIGKTGKTARAIYYMNIGTIPDDFSCDVYLRGTTIWIGKLDEQYLDRLEKGDVFTLGGEHLKFQ
YRRGSKVYVDKTSERPNIPSWYSERLPLSYDLGRNILLFKKEAVSKYNAGRLLDLLSEYPLDSNATKSLYGLFNEQILYK
GNDSVSTLNKMVVEGHIFDKKMHYYFHSNYGRKFNDGFSRAVAYALSKQYKLGVLVSISDTGFSLEFAKNQKVDIESAIR
SLTPENIKDVLKQALEGTNLLKRMFRINATRSLMILRNYIGHKKSAKKQQVSADILISYAKSLDRFAPLEETLREIIEDS
LELDNIREVLGEIRSGKLKINVIDVPIPTPMSFGIATLTASDSVLAENKNQLLKEFHQMVIKMIEYEKGISLEE

Specific function: Unknown

COG id: COG1201

COG function: function code R; Lhr-like helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI76880486, Length=405, Percent_Identity=23.4567901234568, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI40217847, Length=417, Percent_Identity=23.021582733813, Blast_Score=71, Evalue=5e-12,
Organism=Homo sapiens, GI169218225, Length=417, Percent_Identity=22.7817745803357, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787942, Length=909, Percent_Identity=29.5929592959296, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI115532546, Length=356, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115532548, Length=356, Percent_Identity=25, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17537519, Length=421, Percent_Identity=23.5154394299287, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17537127, Length=422, Percent_Identity=22.7488151658768, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI9755332, Length=469, Percent_Identity=24.5202558635394, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321360, Length=363, Percent_Identity=26.1707988980716, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321710, Length=392, Percent_Identity=23.469387755102, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24647182, Length=402, Percent_Identity=23.3830845771144, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28574898, Length=412, Percent_Identity=22.5728155339806, Blast_Score=74, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014001
- InterPro:   IPR013701
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR017170 [H]

Pfam domain/function: PF00270 DEAD; PF08494 DEAD_assoc; PF00271 Helicase_C [H]

EC number: 3.6.1.-

Molecular weight: Translated: 99971; Mature: 99971

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNDGEILDLFEPAVKKWWLNKFEPYKSINNGYFTPPQRLAIPKIHFGRNTLICSPTGSG
CCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHCCCCEEEECCCEEEECCCCCC
KTLSSFIAIINELFRIEKEEGLQNSIYCLYISPLKSLANDIHVNLDEPLTEIKEILKEEG
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHEEECCCCHHHHHHHHHHHCC
NEITGIRHAIRHGDTSNYEKSKMLKKTPHILNTTPETLAIILNSPKFKEKLKTVQWVIID
CCCHHHHHHHHCCCCCCHHHHHHHHHCCCHHCCCCHHEEEEECCCHHHHHHHHHHHHHHH
EIHALADNKRGVHLSISLERLRELTNQEFLRIGCSATVEPLEMVADYLGGYYDDGYKRPV
HHHHHHCCCCCEEEEEEHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCH
EIVDTRFVRGYDLKLLCPVDDLINKTPKEISEKLYEKLDRLIQTHENTLIFTNTRGGAER
HHHHHHEECCCCEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHH
VLYNLRKRYPEKYDETNSGCHHGSLSKEKRLELEEKLKSGNLKFATTSSSLELGIDMPYI
HHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCHH
DLVVQIGSPKSVKTMLQRIGRAGHGIGKVAKGRIIALDRDELLECAVMLKKAMDGFIDKV
HEEEECCCCHHHHHHHHHHCCCCCCCCHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHEE
HIPKGPLDVLIQHIYGIAINGYIELERVKNIVRRSYNYHDITDEDFKILINYMTASYAGM
CCCCCHHHHHHHHHHHEEEECEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCC
DEKRIYSKIWYDPDTQMIGKTGKTARAIYYMNIGTIPDDFSCDVYLRGTTIWIGKLDEQY
CHHHHHHHHCCCCCHHHHCCCCCCEEEEEEEEECCCCCCCCCEEEEECEEEEEECCCHHH
LDRLEKGDVFTLGGEHLKFQYRRGSKVYVDKTSERPNIPSWYSERLPLSYDLGRNILLFK
HHHHCCCCEEEECCCEEEEEEECCCEEEEECCCCCCCCCCHHHHCCCEECCCCCCEEEEE
KEAVSKYNAGRLLDLLSEYPLDSNATKSLYGLFNEQILYKGNDSVSTLNKMVVEGHIFDK
HHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHCEEEHH
KMHYYFHSNYGRKFNDGFSRAVAYALSKQYKLGVLVSISDTGFSLEFAKNQKVDIESAIR
HEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCCCHHHHHH
SLTPENIKDVLKQALEGTNLLKRMFRINATRSLMILRNYIGHKKSAKKQQVSADILISYA
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KSLDRFAPLEETLREIIEDSLELDNIREVLGEIRSGKLKINVIDVPIPTPMSFGIATLTA
HHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEEEC
SDSVLAENKNQLLKEFHQMVIKMIEYEKGISLEE
CCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNDGEILDLFEPAVKKWWLNKFEPYKSINNGYFTPPQRLAIPKIHFGRNTLICSPTGSG
CCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHCCCCEEEECCCEEEECCCCCC
KTLSSFIAIINELFRIEKEEGLQNSIYCLYISPLKSLANDIHVNLDEPLTEIKEILKEEG
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHEEECCCCHHHHHHHHHHHCC
NEITGIRHAIRHGDTSNYEKSKMLKKTPHILNTTPETLAIILNSPKFKEKLKTVQWVIID
CCCHHHHHHHHCCCCCCHHHHHHHHHCCCHHCCCCHHEEEEECCCHHHHHHHHHHHHHHH
EIHALADNKRGVHLSISLERLRELTNQEFLRIGCSATVEPLEMVADYLGGYYDDGYKRPV
HHHHHHCCCCCEEEEEEHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCH
EIVDTRFVRGYDLKLLCPVDDLINKTPKEISEKLYEKLDRLIQTHENTLIFTNTRGGAER
HHHHHHEECCCCEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHH
VLYNLRKRYPEKYDETNSGCHHGSLSKEKRLELEEKLKSGNLKFATTSSSLELGIDMPYI
HHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCHH
DLVVQIGSPKSVKTMLQRIGRAGHGIGKVAKGRIIALDRDELLECAVMLKKAMDGFIDKV
HEEEECCCCHHHHHHHHHHCCCCCCCCHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHEE
HIPKGPLDVLIQHIYGIAINGYIELERVKNIVRRSYNYHDITDEDFKILINYMTASYAGM
CCCCCHHHHHHHHHHHEEEECEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCC
DEKRIYSKIWYDPDTQMIGKTGKTARAIYYMNIGTIPDDFSCDVYLRGTTIWIGKLDEQY
CHHHHHHHHCCCCCHHHHCCCCCCEEEEEEEEECCCCCCCCCEEEEECEEEEEECCCHHH
LDRLEKGDVFTLGGEHLKFQYRRGSKVYVDKTSERPNIPSWYSERLPLSYDLGRNILLFK
HHHHCCCCEEEECCCEEEEEEECCCEEEEECCCCCCCCCCHHHHCCCEECCCCCCEEEEE
KEAVSKYNAGRLLDLLSEYPLDSNATKSLYGLFNEQILYKGNDSVSTLNKMVVEGHIFDK
HHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHCEEEHH
KMHYYFHSNYGRKFNDGFSRAVAYALSKQYKLGVLVSISDTGFSLEFAKNQKVDIESAIR
HEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCCCHHHHHH
SLTPENIKDVLKQALEGTNLLKRMFRINATRSLMILRNYIGHKKSAKKQQVSADILISYA
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KSLDRFAPLEETLREIIEDSLELDNIREVLGEIRSGKLKINVIDVPIPTPMSFGIATLTA
HHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEEEC
SDSVLAENKNQLLKEFHQMVIKMIEYEKGISLEE
CCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]