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The map label for this gene is sucC [H]

Identifier: 45358668

GI number: 45358668

Start: 1096371

End: 1097459

Strand: Direct

Name: sucC [H]

Synonym: MMP1105

Alternate gene names: 45358668

Gene position: 1096371-1097459 (Clockwise)

Preceding gene: 45358667

Following gene: 45358669

Centisome position: 66.0

GC content: 34.8

Gene sequence:

>1089_bases
ATGAAATTACACGAATATGAAGCAAAGGAAATTTTTAAAGAAAATAATATCCCGATTCCAAAAAATAAACTTGTAAGCGG
AAAGGTTGAAAGCATCGACTACCCTGTTGTTATAAAAGCGCAAGTTTTAGTTGGCGGAAGAGGTAAAGCTGGCGGAATCT
TATTTGCAGATAATGTCGATGATGCAAACGAAAAAATTGAATCATTAATTGGAAACACGGTTAAAGGCGAACTTGTTGAA
AAAGTACTCCTCGAAGAGCAGATAAAAATTGTAAAAGAATATTATGTTGGTGTTGTTGTTAATAGAAACGAAAAAAACAA
TGTTGTTATATTTTCAACAGAAGGTGGAGTAGATATCGAAGAAGTAGCTTCAAAAACTCCTGAAAAAATAATAAAATTAT
CATTAAACCCTGAAAAAGAATTTTTACCATACCTTGCAAGAGGCATGCTTAAAAAAGCAGGCATCCCAAGTGCAGAAATT
CCAAAAGTAGCAGATGTTTTATGCAAAGTTTACAAAGCATTCAAAAACATGGACGGAATTTTAGCGGAAATAAACCCACT
CGTATTTACTGAAGATGGAAAAATCATTGCTGCTGATGCAGTTTTAAATGTTGACGACGATGCATACTTTAGACATAACT
ATGAGAAATTTGAAGAATTTAATAAACAGGAAAAATCCGAATTTGCATATGTTGAACTTGATGGAGACATTGCAGTTATT
GGAAACGGTGCGGGACTTACCCTTGCAAGCATGGACATTGTAAAAGAATTTGGCGGAAACCCTGCATGTTTCTTAGATGT
TGGTGGCGGTTCAAATAGGGAAACCGTAAAAAAAGCACTTTTAAAAGCAACCTCCCGAAAAAACGTTAAAGGAGCATTTA
TAAACATTCTTGGCGGAATTACACGGTGTGATGAAGTTTCGATGGGAATTGTAGATGTTTTAAAAGAAAATCCAAATCTT
AAGTTTGCTGTCAGGATGATGGGAACGAACGAAGAAGAAGGAAGAAGAATATTATCTGAAAATGGAATAAGCTTCGAAAG
CTCGATGGAAGGGGCTGCAAAAGCACTTACTGAATTAATAAATAGTTAA

Upstream 100 bases:

>100_bases
ATACTGCGAAAAATTCATTAATTCAATTATAATCTCAAAATAAACCCTAGTTTTTTTATATTTTCAGTAACTATTATCAT
GAGAACTGTTGGTGATTTTT

Downstream 100 bases:

>100_bases
ACGTGATTTTCAATGTTTAACATCCGAAAGAAAAAGCAGGAAACCGTTTCAAGAGATAAATATGAAGATATTAAAAAAAT
ATATATTGAATCTAAAAAGT

Product: succinate-CoA ligase (ADP-forming), beta chain

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKLHEYEAKEIFKENNIPIPKNKLVSGKVESIDYPVVIKAQVLVGGRGKAGGILFADNVDDANEKIESLIGNTVKGELVE
KVLLEEQIKIVKEYYVGVVVNRNEKNNVVIFSTEGGVDIEEVASKTPEKIIKLSLNPEKEFLPYLARGMLKKAGIPSAEI
PKVADVLCKVYKAFKNMDGILAEINPLVFTEDGKIIAADAVLNVDDDAYFRHNYEKFEEFNKQEKSEFAYVELDGDIAVI
GNGAGLTLASMDIVKEFGGNPACFLDVGGGSNRETVKKALLKATSRKNVKGAFINILGGITRCDEVSMGIVDVLKENPNL
KFAVRMMGTNEEEGRRILSENGISFESSMEGAAKALTELINS

Sequences:

>Translated_362_residues
MKLHEYEAKEIFKENNIPIPKNKLVSGKVESIDYPVVIKAQVLVGGRGKAGGILFADNVDDANEKIESLIGNTVKGELVE
KVLLEEQIKIVKEYYVGVVVNRNEKNNVVIFSTEGGVDIEEVASKTPEKIIKLSLNPEKEFLPYLARGMLKKAGIPSAEI
PKVADVLCKVYKAFKNMDGILAEINPLVFTEDGKIIAADAVLNVDDDAYFRHNYEKFEEFNKQEKSEFAYVELDGDIAVI
GNGAGLTLASMDIVKEFGGNPACFLDVGGGSNRETVKKALLKATSRKNVKGAFINILGGITRCDEVSMGIVDVLKENPNL
KFAVRMMGTNEEEGRRILSENGISFESSMEGAAKALTELINS
>Mature_362_residues
MKLHEYEAKEIFKENNIPIPKNKLVSGKVESIDYPVVIKAQVLVGGRGKAGGILFADNVDDANEKIESLIGNTVKGELVE
KVLLEEQIKIVKEYYVGVVVNRNEKNNVVIFSTEGGVDIEEVASKTPEKIIKLSLNPEKEFLPYLARGMLKKAGIPSAEI
PKVADVLCKVYKAFKNMDGILAEINPLVFTEDGKIIAADAVLNVDDDAYFRHNYEKFEEFNKQEKSEFAYVELDGDIAVI
GNGAGLTLASMDIVKEFGGNPACFLDVGGGSNRETVKKALLKATSRKNVKGAFINILGGITRCDEVSMGIVDVLKENPNL
KFAVRMMGTNEEEGRRILSENGISFESSMEGAAKALTELINS

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=393, Percent_Identity=33.0788804071247, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI157779135, Length=381, Percent_Identity=30.7086614173228, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI294862256, Length=360, Percent_Identity=30.8333333333333, Blast_Score=162, Evalue=3e-40,
Organism=Escherichia coli, GI1786948, Length=381, Percent_Identity=36.745406824147, Blast_Score=218, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17539378, Length=394, Percent_Identity=34.2639593908629, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17567829, Length=401, Percent_Identity=31.6708229426434, Blast_Score=186, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321683, Length=397, Percent_Identity=31.7380352644836, Blast_Score=197, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21356231, Length=393, Percent_Identity=34.0966921119593, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI281361397, Length=376, Percent_Identity=33.2446808510638, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281361395, Length=376, Percent_Identity=33.2446808510638, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI161078106, Length=376, Percent_Identity=33.5106382978723, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24645208, Length=376, Percent_Identity=33.5106382978723, Blast_Score=177, Evalue=8e-45,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 39612; Mature: 39612

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50975 ATP_GRASP ; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLHEYEAKEIFKENNIPIPKNKLVSGKVESIDYPVVIKAQVLVGGRGKAGGILFADNVD
CCCCHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCEEEEEEEEECCCCCCCCEEEECCCC
DANEKIESLIGNTVKGELVEKVLLEEQIKIVKEYYVGVVVNRNEKNNVVIFSTEGGVDIE
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCHH
EVASKTPEKIIKLSLNPEKEFLPYLARGMLKKAGIPSAEIPKVADVLCKVYKAFKNMDGI
HHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCH
LAEINPLVFTEDGKIIAADAVLNVDDDAYFRHNYEKFEEFNKQEKSEFAYVELDGDIAVI
HHHCCCEEEECCCCEEEEEEEEECCCCHHHHCCHHHHHHHCHHHHCCEEEEEECCCEEEE
GNGAGLTLASMDIVKEFGGNPACFLDVGGGSNRETVKKALLKATSRKNVKGAFINILGGI
ECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCC
TRCDEVSMGIVDVLKENPNLKFAVRMMGTNEEEGRRILSENGISFESSMEGAAKALTELI
CHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
NS
CC
>Mature Secondary Structure
MKLHEYEAKEIFKENNIPIPKNKLVSGKVESIDYPVVIKAQVLVGGRGKAGGILFADNVD
CCCCHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCEEEEEEEEECCCCCCCCEEEECCCC
DANEKIESLIGNTVKGELVEKVLLEEQIKIVKEYYVGVVVNRNEKNNVVIFSTEGGVDIE
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCHH
EVASKTPEKIIKLSLNPEKEFLPYLARGMLKKAGIPSAEIPKVADVLCKVYKAFKNMDGI
HHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCH
LAEINPLVFTEDGKIIAADAVLNVDDDAYFRHNYEKFEEFNKQEKSEFAYVELDGDIAVI
HHHCCCEEEECCCCEEEEEEEEECCCCHHHHCCHHHHHHHCHHHHCCEEEEEECCCEEEE
GNGAGLTLASMDIVKEFGGNPACFLDVGGGSNRETVKKALLKATSRKNVKGAFINILGGI
ECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCC
TRCDEVSMGIVDVLKENPNLKFAVRMMGTNEEEGRRILSENGISFESSMEGAAKALTELI
CHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
NS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]