Click here to switch to the map view.

The map label for this gene is sucD [H]

Identifier: 45358518

GI number: 45358518

Start: 942852

End: 943718

Strand: Direct

Name: sucD [H]

Synonym: MMP0955

Alternate gene names: 45358518

Gene position: 942852-943718 (Clockwise)

Preceding gene: 45358514

Following gene: 45358519

Centisome position: 56.76

GC content: 38.75

Gene sequence:

>867_bases
ATGTTGATTCTTTTAGATGAAAATACACGGGCAATTGTTCAAGGGATCACGGGAAATCAGGGTAGATTCCACACGAAAAA
CATGCTTGAATGCAAAACAAATCTATTGGCAGGAGTAACGCCAGGAAAAGGCGGTCAGGATGTCTACGGAGTTCCAGTTT
ATGATACGGTTTTAGAAACTGTTGAAAAATACGACGCGAATGCATCTTTGATATTTATACCTGCGCCATTTGTAAAAGAT
GCTGCATACGAAGCTATTGATGCGGGAGTTGAGCTCGTTACAATTATTACTGAGCACATTCCAATTCAAGATTCGATGGA
TATCGTAGCATATGGGAAAAAACACGGTGTAAATATAATCGGACCAAATACTCCGGGTTTAGCGTCTCCAAAGGTGGGAA
AACTTGGAATTATCCCGATGAGCATATTAAAAGAAGGAAACATTGGAATGGTATCAAGAAGTGGCACATTAACTTACGAA
ATTGCAAGCCAGCTTACTTTATCAAATTACGGCCAATCATCCTGTGTTGGAATTGGTGGGGATCCGGTAACTGGTTTGAG
ATATATTGAAGTTTTAGAAATGTTTGAAAACGACCCTGAAACTGATGCAGTTGTAATGGTTGGAGAAATCGGTGGAAACG
CCGAAGAAGATGCAGCTAAAAAAATGATTTCAAAAATGAAAAAACCTGTTATTTCATACATTGCAGGACAGTCTGCACCC
GAAGGAAAAAGAATGGGTCACGCTGGTGCAATTATCGAAAAAGGAGTTGGAACTGCAAAAAGCAAAATGCAAGCTCTTGA
AAATGCAGGCGCACATGTTGCAAAAAGAATTTCAGATATTCCATTATTATTGAAAGAAATTATTTAA

Upstream 100 bases:

>100_bases
TATTCCATAAGATGAATCTTTATATATTATAGGATAATATCTGGATATTACGGATTTTTGATATTCATTGATTATTCACT
CTTTTTAGTAGTGAGGTGAA

Downstream 100 bases:

>100_bases
ACTGCTTTTTTCAATTATTTTATTATTAATTTAAAACGTGAAAAAAATGACTGGACTAATCATCTGTGAGAAACCAAACG
TTGCTAAAAAAATTGCAGAA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MLILLDENTRAIVQGITGNQGRFHTKNMLECKTNLLAGVTPGKGGQDVYGVPVYDTVLETVEKYDANASLIFIPAPFVKD
AAYEAIDAGVELVTIITEHIPIQDSMDIVAYGKKHGVNIIGPNTPGLASPKVGKLGIIPMSILKEGNIGMVSRSGTLTYE
IASQLTLSNYGQSSCVGIGGDPVTGLRYIEVLEMFENDPETDAVVMVGEIGGNAEEDAAKKMISKMKKPVISYIAGQSAP
EGKRMGHAGAIIEKGVGTAKSKMQALENAGAHVAKRISDIPLLLKEII

Sequences:

>Translated_288_residues
MLILLDENTRAIVQGITGNQGRFHTKNMLECKTNLLAGVTPGKGGQDVYGVPVYDTVLETVEKYDANASLIFIPAPFVKD
AAYEAIDAGVELVTIITEHIPIQDSMDIVAYGKKHGVNIIGPNTPGLASPKVGKLGIIPMSILKEGNIGMVSRSGTLTYE
IASQLTLSNYGQSSCVGIGGDPVTGLRYIEVLEMFENDPETDAVVMVGEIGGNAEEDAAKKMISKMKKPVISYIAGQSAP
EGKRMGHAGAIIEKGVGTAKSKMQALENAGAHVAKRISDIPLLLKEII
>Mature_288_residues
MLILLDENTRAIVQGITGNQGRFHTKNMLECKTNLLAGVTPGKGGQDVYGVPVYDTVLETVEKYDANASLIFIPAPFVKD
AAYEAIDAGVELVTIITEHIPIQDSMDIVAYGKKHGVNIIGPNTPGLASPKVGKLGIIPMSILKEGNIGMVSRSGTLTYE
IASQLTLSNYGQSSCVGIGGDPVTGLRYIEVLEMFENDPETDAVVMVGEIGGNAEEDAAKKMISKMKKPVISYIAGQSAP
EGKRMGHAGAIIEKGVGTAKSKMQALENAGAHVAKRISDIPLLLKEII

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=277, Percent_Identity=50.1805054151625, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI38569421, Length=313, Percent_Identity=26.517571884984, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI38569423, Length=313, Percent_Identity=26.517571884984, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1786949, Length=288, Percent_Identity=52.4305555555556, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI1786729, Length=200, Percent_Identity=24, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17553126, Length=272, Percent_Identity=47.4264705882353, Blast_Score=233, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17550194, Length=271, Percent_Identity=47.6014760147601, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17557344, Length=306, Percent_Identity=25.8169934640523, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17551266, Length=308, Percent_Identity=25.6493506493506, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324716, Length=280, Percent_Identity=41.4285714285714, Blast_Score=198, Evalue=8e-52,
Organism=Drosophila melanogaster, GI21356559, Length=290, Percent_Identity=44.4827586206897, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI28574296, Length=281, Percent_Identity=46.2633451957295, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI281363477, Length=313, Percent_Identity=26.1980830670927, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI281363475, Length=313, Percent_Identity=26.1980830670927, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281363473, Length=313, Percent_Identity=26.1980830670927, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30507; Mature: 30507

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLILLDENTRAIVQGITGNQGRFHTKNMLECKTNLLAGVTPGKGGQDVYGVPVYDTVLET
CEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHH
VEKYDANASLIFIPAPFVKDAAYEAIDAGVELVTIITEHIPIQDSMDIVAYGKKHGVNII
HHHHCCCCEEEEECCCHHHHHHHHHHHCCHHEEEEHHHCCCCCCCCCEEEECCCCCCEEE
GPNTPGLASPKVGKLGIIPMSILKEGNIGMVSRSGTLTYEIASQLTLSNYGQSSCVGIGG
CCCCCCCCCCCCCCEEEEHHHHHCCCCCEEEECCCEEEEEHHHHHHHHCCCCCCEEECCC
DPVTGLRYIEVLEMFENDPETDAVVMVGEIGGNAEEDAAKKMISKMKKPVISYIAGQSAP
CCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
EGKRMGHAGAIIEKGVGTAKSKMQALENAGAHVAKRISDIPLLLKEII
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MLILLDENTRAIVQGITGNQGRFHTKNMLECKTNLLAGVTPGKGGQDVYGVPVYDTVLET
CEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHH
VEKYDANASLIFIPAPFVKDAAYEAIDAGVELVTIITEHIPIQDSMDIVAYGKKHGVNII
HHHHCCCCEEEEECCCHHHHHHHHHHHCCHHEEEEHHHCCCCCCCCCEEEECCCCCCEEE
GPNTPGLASPKVGKLGIIPMSILKEGNIGMVSRSGTLTYEIASQLTLSNYGQSSCVGIGG
CCCCCCCCCCCCCCEEEEHHHHHCCCCCEEEECCCEEEEEHHHHHHHHCCCCCCEEECCC
DPVTGLRYIEVLEMFENDPETDAVVMVGEIGGNAEEDAAKKMISKMKKPVISYIAGQSAP
CCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
EGKRMGHAGAIIEKGVGTAKSKMQALENAGAHVAKRISDIPLLLKEII
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]