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The map label for this gene is cobD

Identifier: 45358514

GI number: 45358514

Start: 939228

End: 940148

Strand: Direct

Name: cobD

Synonym: MMP0951

Alternate gene names: 45358514

Gene position: 939228-940148 (Clockwise)

Preceding gene: 45358513

Following gene: 45358518

Centisome position: 56.54

GC content: 30.51

Gene sequence:

>921_bases
ATGATAAACCCAATTTATTTAATTTTAGCAGATTTTTTCGATAGATACATTGGAGAACCGCCTGAAAAAGTCCACCCTGT
TGTATTCATCGGAAAATTAATCAGCTTTTTTGAAAATGTCTTCAAATCAACTAATTCAGTAAATAAAAATCGAGATCTAC
TTTTTGGTTTTTTAAATGTAGTTTTAGTTTTAGCAATTGTATTTTTCATGGCTTTTGAAATAGAACAGGCTATAAACTCG
ATTTCAAATTCGTATATTAGAATTTCTCTTTATTCAATAATCCTTTCATTTTCAATCGGACACAAATCATTGATTGAATT
TTCAAAATCCCCGATAAAATTTATCGTAAATAACGACCTTGAAAGCGCGAAAAAGTCTGTTCAGTGTATCGTAAGTAGAA
ATACAAACGAATTAGATAAAAAACATGTTTTATCAGCATCAATTGAAAGTGCGTCAGAAAACATTACAGACAGTATTATT
GCACCACTAATTTATGCGGCAATTTTTGGACTTCCTGGTGCTTTTTTATATCGAGCGGTTAACACGTTTGATGCGATGAT
TGGTTACAAATCGGAAAAATATCTATATTATGGAAAAACTGCCGCATATTTGGATGATATTTTAAATTTTATTCCTTCAA
GAATTGCAGGAATGCTTTTAATTATATCTGCGCCATTTTACGGTGGAAATGTAAAATCTGCACTTTTAGGATATTTTAAT
GAAGGAAGCAAAACCCCTTCACCAAATTCGGGATACACAATGGCAACGCTTGCAAACTCCCTGAGTATGGAACTTGAAAA
AATTGGATATTATAAACTTGGAAAAGGAGAAATTACGGTTGAAAAAGCGCTAAATTCGTTAAAAGCAGTTGATTATTCAG
TTTTACTTTTTTTAATAATTTATATGATATTATTCATGTAA

Upstream 100 bases:

>100_bases
GATAAAATAGATATTAAAAAGTTCGAAAAATACAGTAAAATCAAAAAAGATAAAACTAAAAACTTCTTAAACGCTCTTGG
AAAACTTTAAGGTCAAAACA

Downstream 100 bases:

>100_bases
ATTGAAATTTTAAATAATCTTTTAATTTTTAATTTTAAAAGTAACTGTTTTAAAAAAGCATTAATATTTAAAAAAAGTTA
TAATCAGACAAATTATTTGC

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MINPIYLILADFFDRYIGEPPEKVHPVVFIGKLISFFENVFKSTNSVNKNRDLLFGFLNVVLVLAIVFFMAFEIEQAINS
ISNSYIRISLYSIILSFSIGHKSLIEFSKSPIKFIVNNDLESAKKSVQCIVSRNTNELDKKHVLSASIESASENITDSII
APLIYAAIFGLPGAFLYRAVNTFDAMIGYKSEKYLYYGKTAAYLDDILNFIPSRIAGMLLIISAPFYGGNVKSALLGYFN
EGSKTPSPNSGYTMATLANSLSMELEKIGYYKLGKGEITVEKALNSLKAVDYSVLLFLIIYMILFM

Sequences:

>Translated_306_residues
MINPIYLILADFFDRYIGEPPEKVHPVVFIGKLISFFENVFKSTNSVNKNRDLLFGFLNVVLVLAIVFFMAFEIEQAINS
ISNSYIRISLYSIILSFSIGHKSLIEFSKSPIKFIVNNDLESAKKSVQCIVSRNTNELDKKHVLSASIESASENITDSII
APLIYAAIFGLPGAFLYRAVNTFDAMIGYKSEKYLYYGKTAAYLDDILNFIPSRIAGMLLIISAPFYGGNVKSALLGYFN
EGSKTPSPNSGYTMATLANSLSMELEKIGYYKLGKGEITVEKALNSLKAVDYSVLLFLIIYMILFM
>Mature_306_residues
MINPIYLILADFFDRYIGEPPEKVHPVVFIGKLISFFENVFKSTNSVNKNRDLLFGFLNVVLVLAIVFFMAFEIEQAINS
ISNSYIRISLYSIILSFSIGHKSLIEFSKSPIKFIVNNDLESAKKSVQCIVSRNTNELDKKHVLSASIESASENITDSII
APLIYAAIFGLPGAFLYRAVNTFDAMIGYKSEKYLYYGKTAAYLDDILNFIPSRIAGMLLIISAPFYGGNVKSALLGYFN
EGSKTPSPNSGYTMATLANSLSMELEKIGYYKLGKGEITVEKALNSLKAVDYSVLLFLIIYMILFM

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBD_METMP (Q6LYN9)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_988071.1
- GeneID:   2761508
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP0951
- NMPDR:   fig|267377.1.peg.951
- HOGENOM:   HBG647131
- OMA:   MINPIYL
- ProtClustDB:   PRK01209
- BioCyc:   MMAR267377:MMP0951-MONOMER
- HAMAP:   MF_00024
- InterPro:   IPR004485
- TIGRFAMs:   TIGR00380

Pfam domain/function: PF03186 CobD_Cbib

EC number: 6.3.1.10

Molecular weight: Translated: 34145; Mature: 34145

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xda699b0)-; HASH(0xdd70370)-; HASH(0xd76d0e0)-; HASH(0xcfb20c4)-; HASH(0xacd1228)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINPIYLILADFFDRYIGEPPEKVHPVVFIGKLISFFENVFKSTNSVNKNRDLLFGFLNV
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VLVLAIVFFMAFEIEQAINSISNSYIRISLYSIILSFSIGHKSLIEFSKSPIKFIVNNDL
HHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCH
ESAKKSVQCIVSRNTNELDKKHVLSASIESASENITDSIIAPLIYAAIFGLPGAFLYRAV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
NTFDAMIGYKSEKYLYYGKTAAYLDDILNFIPSRIAGMLLIISAPFYGGNVKSALLGYFN
HHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
EGSKTPSPNSGYTMATLANSLSMELEKIGYYKLGKGEITVEKALNSLKAVDYSVLLFLII
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
YMILFM
HHHHHH
>Mature Secondary Structure
MINPIYLILADFFDRYIGEPPEKVHPVVFIGKLISFFENVFKSTNSVNKNRDLLFGFLNV
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VLVLAIVFFMAFEIEQAINSISNSYIRISLYSIILSFSIGHKSLIEFSKSPIKFIVNNDL
HHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCH
ESAKKSVQCIVSRNTNELDKKHVLSASIESASENITDSIIAPLIYAAIFGLPGAFLYRAV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
NTFDAMIGYKSEKYLYYGKTAAYLDDILNFIPSRIAGMLLIISAPFYGGNVKSALLGYFN
HHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
EGSKTPSPNSGYTMATLANSLSMELEKIGYYKLGKGEITVEKALNSLKAVDYSVLLFLII
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
YMILFM
HHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA