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The map label for this gene is flpA [H]

Identifier: 45358160

GI number: 45358160

Start: 593316

End: 594008

Strand: Direct

Name: flpA [H]

Synonym: MMP0597

Alternate gene names: 45358160

Gene position: 593316-594008 (Clockwise)

Preceding gene: 45358159

Following gene: 45358161

Centisome position: 35.72

GC content: 33.48

Gene sequence:

>693_bases
ATGGAAAAAATTAGGGTAAAAGAAATTTTTGATAACGTATATTCAGTAGATTTTGGAGACGGACTTAAAAGAATTGCTAC
AAAATCATTAGTTCCTGGAAAAAGAGTTTACGGGGAAAAATTAGTATATTCTGACAGTATAGAGTATAGAATATGGAATC
CAAACAAGAGTAAACTTGGAGCTGCAATTATAAACGGTTTAAAAAAGATGCCGATAAAAAAAGGAGAGAAAGTTCTCTAC
CTTGGAGCATCTGCTGGAACTACTCCTTCACACGTTGCAGATATTGCAGAAAATTCCCTTGTTTATGCTCTTGAGTTTGC
ACCAAGAATCATGAGGGAATTTATTGATTCATGCAATGAAAGGAAAAATTTAATTCCTGTTTTGGGGGATGCAAACAGGC
CTCAGGACTATTCAAACATCGTTGAAAAAGTTGATGTTATATTTGAAGATGTTGCACAGCCAAATCAGGCAGAAATTCTT
GTAAAAAATGCAAAATGGTTTTTAAAAGAAAATGGATATGCGATGATATCAATAAAAGCAAGAAGTGTCGATGTTACAAA
AAATCCAAGAGAAATATTTGCTGAACAAAAGAAAATATTAATTGAAGGCGGATTTGAAATTGTTGATGAGGTAAACATCG
AACCTTTCGAAAAAGACCACATGATGATGGTTGGAATCTGGAAAGGAAACTAA

Upstream 100 bases:

>100_bases
GATCTGGCGAAAAAAGAAGAGATTCGACAAAAAAAGTTAAAGCTGAGCGAAAAGTAATCGGAAAAACTTCCTCACAGAAT
TAAGCCATATGGTGAGTTAA

Downstream 100 bases:

>100_bases
AATCATATACTATTTATTTACTTTTAAATAACCTTAAAATATTTCTTTTTTATAAAATATATATTGATCGAAATTGTTGT
GTATTTTTAACTTTATATAG

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MEKIRVKEIFDNVYSVDFGDGLKRIATKSLVPGKRVYGEKLVYSDSIEYRIWNPNKSKLGAAIINGLKKMPIKKGEKVLY
LGASAGTTPSHVADIAENSLVYALEFAPRIMREFIDSCNERKNLIPVLGDANRPQDYSNIVEKVDVIFEDVAQPNQAEIL
VKNAKWFLKENGYAMISIKARSVDVTKNPREIFAEQKKILIEGGFEIVDEVNIEPFEKDHMMMVGIWKGN

Sequences:

>Translated_230_residues
MEKIRVKEIFDNVYSVDFGDGLKRIATKSLVPGKRVYGEKLVYSDSIEYRIWNPNKSKLGAAIINGLKKMPIKKGEKVLY
LGASAGTTPSHVADIAENSLVYALEFAPRIMREFIDSCNERKNLIPVLGDANRPQDYSNIVEKVDVIFEDVAQPNQAEIL
VKNAKWFLKENGYAMISIKARSVDVTKNPREIFAEQKKILIEGGFEIVDEVNIEPFEKDHMMMVGIWKGN
>Mature_230_residues
MEKIRVKEIFDNVYSVDFGDGLKRIATKSLVPGKRVYGEKLVYSDSIEYRIWNPNKSKLGAAIINGLKKMPIKKGEKVLY
LGASAGTTPSHVADIAENSLVYALEFAPRIMREFIDSCNERKNLIPVLGDANRPQDYSNIVEKVDVIFEDVAQPNQAEIL
VKNAKWFLKENGYAMISIKARSVDVTKNPREIFAEQKKILIEGGFEIVDEVNIEPFEKDHMMMVGIWKGN

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family [H]

Homologues:

Organism=Homo sapiens, GI12056465, Length=209, Percent_Identity=46.4114832535885, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17563672, Length=209, Percent_Identity=45.933014354067, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6320190, Length=215, Percent_Identity=41.3953488372093, Blast_Score=179, Evalue=4e-46,
Organism=Drosophila melanogaster, GI17647425, Length=209, Percent_Identity=43.0622009569378, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24646406, Length=197, Percent_Identity=32.48730964467, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000692
- InterPro:   IPR020813 [H]

Pfam domain/function: PF01269 Fibrillarin [H]

EC number: NA

Molecular weight: Translated: 26026; Mature: 26026

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIRVKEIFDNVYSVDFGDGLKRIATKSLVPGKRVYGEKLVYSDSIEYRIWNPNKSKLG
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCEEEEECCCCEEEECCCHHHHH
AAIINGLKKMPIKKGEKVLYLGASAGTTPSHVADIAENSLVYALEFAPRIMREFIDSCNE
HHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCC
RKNLIPVLGDANRPQDYSNIVEKVDVIFEDVAQPNQAEILVKNAKWFLKENGYAMISIKA
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEECCCEEEEEEEE
RSVDVTKNPREIFAEQKKILIEGGFEIVDEVNIEPFEKDHMMMVGIWKGN
EEEECCCCHHHHHHHHHEEEEECCCEEEECCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MEKIRVKEIFDNVYSVDFGDGLKRIATKSLVPGKRVYGEKLVYSDSIEYRIWNPNKSKLG
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCEEEEECCCCEEEECCCHHHHH
AAIINGLKKMPIKKGEKVLYLGASAGTTPSHVADIAENSLVYALEFAPRIMREFIDSCNE
HHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCC
RKNLIPVLGDANRPQDYSNIVEKVDVIFEDVAQPNQAEILVKNAKWFLKENGYAMISIKA
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEECCCEEEEEEEE
RSVDVTKNPREIFAEQKKILIEGGFEIVDEVNIEPFEKDHMMMVGIWKGN
EEEECCCCHHHHHHHHHEEEEECCCEEEECCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA