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The map label for this gene is hisB [H]

Identifier: 45358111

GI number: 45358111

Start: 552862

End: 553434

Strand: Direct

Name: hisB [H]

Synonym: MMP0548

Alternate gene names: 45358111

Gene position: 552862-553434 (Clockwise)

Preceding gene: 45358110

Following gene: 45358112

Centisome position: 33.28

GC content: 34.21

Gene sequence:

>573_bases
ATGAGAGCCTTCAAAGTAAAAAGAGATACAAATGAAACGAAAATACAGCTTGAATTAAACATTGACGGGACAGGAAAATA
TTCAATAACTACAGGAATTCCTTTTTTTGACCATGTTTTATCGTCATTTGCTAAACACGGTTCATTTGATTTAAAATTAG
ATGTTTTAGGGGATTTGGAGATCGATGATCACCACACTGTAGAAGATGTTGGTATAGTTTTAGGTAAAGCATTTGAAAAT
ATGGAAAAGAAGAATATCAAAAGATTTGGGTGGGCAATAATTCCAATGGATGAGGCAAAAGCAACAGTATCTATTGATAT
TGGCGGAAGGCCATTTGTTGTTGGAAATTATGTTCCAAACACCGAAAGAATAGGCAGTTTTTCAACTGAAAATGTGGTAC
ACTTCTTTGAATCATTCTCAAACAATGCAAAAATAAATTTACATTTCGAAGTAACTGGTGAAAACGAACACCACAAAGTA
GAAGCTCTCTTTAAGGCATTCGGTGTTGCAATGGATATGGCAACGCAAATAGACGAAAGGAAAGGAATTGTAAGTACAAA
AGGCGTAATTTAA

Upstream 100 bases:

>100_bases
TGTGGGCGAACAGTTGAAAAAATAAACTGTTAAACGATACCTGATTAAAAGTATAAATAACGGGATATAATATATTATTA
GCCAAAAATTGGGGGATATC

Downstream 100 bases:

>100_bases
GAGGATAAAATGAAAAGGAATAAAAAAATAGCACTTGTATCACACTGTATTTTAAACGCCAATTCAAAAGTTGAAGGGTT
ATCCGAATACGGCGGTATGT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MRAFKVKRDTNETKIQLELNIDGTGKYSITTGIPFFDHVLSSFAKHGSFDLKLDVLGDLEIDDHHTVEDVGIVLGKAFEN
MEKKNIKRFGWAIIPMDEAKATVSIDIGGRPFVVGNYVPNTERIGSFSTENVVHFFESFSNNAKINLHFEVTGENEHHKV
EALFKAFGVAMDMATQIDERKGIVSTKGVI

Sequences:

>Translated_190_residues
MRAFKVKRDTNETKIQLELNIDGTGKYSITTGIPFFDHVLSSFAKHGSFDLKLDVLGDLEIDDHHTVEDVGIVLGKAFEN
MEKKNIKRFGWAIIPMDEAKATVSIDIGGRPFVVGNYVPNTERIGSFSTENVVHFFESFSNNAKINLHFEVTGENEHHKV
EALFKAFGVAMDMATQIDERKGIVSTKGVI
>Mature_190_residues
MRAFKVKRDTNETKIQLELNIDGTGKYSITTGIPFFDHVLSSFAKHGSFDLKLDVLGDLEIDDHHTVEDVGIVLGKAFEN
MEKKNIKRFGWAIIPMDEAKATVSIDIGGRPFVVGNYVPNTERIGSFSTENVVHFFESFSNNAKINLHFEVTGENEHHKV
EALFKAFGVAMDMATQIDERKGIVSTKGVI

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=191, Percent_Identity=43.455497382199, Blast_Score=160, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324776, Length=212, Percent_Identity=37.2641509433962, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21218; Mature: 21218

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAFKVKRDTNETKIQLELNIDGTGKYSITTGIPFFDHVLSSFAKHGSFDLKLDVLGDLE
CCCEEECCCCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCE
IDDHHTVEDVGIVLGKAFENMEKKNIKRFGWAIIPMDEAKATVSIDIGGRPFVVGNYVPN
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEEECCCCEEEECCCCC
TERIGSFSTENVVHFFESFSNNAKINLHFEVTGENEHHKVEALFKAFGVAMDMATQIDER
HHHCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KGIVSTKGVI
CCCCCCCCCC
>Mature Secondary Structure
MRAFKVKRDTNETKIQLELNIDGTGKYSITTGIPFFDHVLSSFAKHGSFDLKLDVLGDLE
CCCEEECCCCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCE
IDDHHTVEDVGIVLGKAFENMEKKNIKRFGWAIIPMDEAKATVSIDIGGRPFVVGNYVPN
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEEECCCCEEEECCCCC
TERIGSFSTENVVHFFESFSNNAKINLHFEVTGENEHHKVEALFKAFGVAMDMATQIDER
HHHCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KGIVSTKGVI
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA