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The map label for this gene is moeA [C]

Identifier: 45358108

GI number: 45358108

Start: 548751

End: 550601

Strand: Direct

Name: moeA [C]

Synonym: MMP0545

Alternate gene names: 45358108

Gene position: 548751-550601 (Clockwise)

Preceding gene: 45358107

Following gene: 45358109

Centisome position: 33.03

GC content: 35.01

Gene sequence:

>1851_bases
TTGAGATACCTAGAACTTTGTACAATTGATCATGCTAAAGAAGTTGTAAGGACTCTTTTAAATGAATTAAGCACTGAAGA
AGTAAGTCTTTTCGAACTTCCTGGGAAAATGCTTGCAGAAGATATAGTTTCAAGTGTAGATGTACCTCCATTTGACCGTT
CAAGAATGGATGGTTATGCCGTGAGAGCAAAGGATACTTATGAAGCTGAAGAAGATAAGCCGGTTACTCTTGAAATAATT
GATAAAATACGTGCTGGAGGAAATTCCGATTTAGAAATACTTCCAGGACAGTGTATGGAGATTGCAACAGGGGCACCTCT
TCCAAAAGGTGCTGATGCAGTAGTTATGGTGGAATTTGCAGAAATTGAAGGCAATTCTGTAAAACTCTACAAAGCAGTTT
CTCCGCATGAAAATATCCAACCCTGTGGAAACGATATAATGGTCGGGGAACTTATAATGCGAAAAAATACAGTTATCTCC
CCAAGGGATATCGGCGCAATATCTGCAGTTGGAAAAAATAAGTTAAAAGTATTTAAAAATCCAAGCATCGGGTTATTATC
AACTGGAAACGAACTTATAAGTCCAGATGATAAATTAGAACCTTATAAAATTTATGACGTAAATACCTACACGATAGCAT
CATCTATTTTAGAAAAAGGATGGAATTTTAATTTTTATGGTATTGTACAGGATAATAAAGAAGATTTAATGGAAAAATTG
AAAAAAGCAATGAATGAAGATGTAATCCTGTTAAGTGGTGGGACTTCTGCAGGAGTTGGCGATTTAACAAGCACTGCGAT
CGAAGAACTCGGCGGGGAAATTTTAGTACATGGAATAAAAATAAAACCTGGAAAACCAACGATTATAGGAAGAATTGGAA
AAAAACTGGTTGTGGGACTTCCAGGATATCCAACATCGTGTTTAACCATTTTTGATGTATTATTCAATGAAAAAGGAAAA
ACAATGCGGGCACAAGTCTACAATAGATATATGTCTGCTAAGGGAAGGGAAGAATACCTTCCGGTCTCAATAATTCGTGG
AAACGATGGTTACGGTGCATATCCTGTTTTAAAGGGAAGTGAAGCAATAACTTCGCTTACTTATGCTGACGGATACATTA
TAATTCCTGAAAACAAGGAAATTGTCGAAGATGAGATATTTGATGTCCACATGTTTGGCGACATTAGAATTGGACTTAAT
ATTATTGGAAGCCACTGTGTTGGAATTGATAGAATTTTAAGAAAAGGCCATATTCTTGCAAGAACGGTAAATACAGGCTC
ACTTGGGGGAATAATGGCTGTAAAGAGAAAAGAAGCGGATATTGCAGGAATTCACCTTTTAGACAATAATGGTGAATATA
ATGTATCGTACCTTAAAAAGTACAATGTATCCGATGCTGTTTTAGTCAGGGGTTATATTCGTGAACAGGGCTTCATGTTT
AAAAAAGAGCTTGGAATAAAATCAATAGATGATTTAATCGAAAAAATTCGAGATTACCGGATAATTAATAGAAATAAAGG
TTCTGGAACGAGAATTCTCTTTGATAAATTTTTAAAAGAGAACAATGTTGATAAAAATTCAATTGATGGGTATGATATCG
AGGCAAAAACCCATTCTGCAGTTGGAACAGCGGTTTCGATGGGTAAAGCACAGATCGGTCTTGGAATAAGTACGATTTCT
GACCACTACGGTCTTGAATTTATCCCTATTGCAGATGAATATTACGATCTTTTAATACCTAAAGAGAAATTGTACGACGA
AGACATAATTAAATTTATAGAAACACTCAAAAAAGAAGAACTTCCATTTAAAAAGTCAAAAGATACTGGAAAAATAATTT
ATGAATGTTAA

Upstream 100 bases:

>100_bases
AATTACATCTTGATACGTCCTCAAAAACTCCAAAATGTCCAAAATGTGGTAGAAAAATTGATATGATACTTTAATTTATT
TTTAAGTATTTGGTGATATC

Downstream 100 bases:

>100_bases
ATATTCTTTTTTTAATTTTTAACAGCGTTTTTCGTATTTTTTAGTTATTTAATTAACATAAAAATCTAATCCGAGAATAT
TTATAATTGATGACACAAAA

Product: putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MRYLELCTIDHAKEVVRTLLNELSTEEVSLFELPGKMLAEDIVSSVDVPPFDRSRMDGYAVRAKDTYEAEEDKPVTLEII
DKIRAGGNSDLEILPGQCMEIATGAPLPKGADAVVMVEFAEIEGNSVKLYKAVSPHENIQPCGNDIMVGELIMRKNTVIS
PRDIGAISAVGKNKLKVFKNPSIGLLSTGNELISPDDKLEPYKIYDVNTYTIASSILEKGWNFNFYGIVQDNKEDLMEKL
KKAMNEDVILLSGGTSAGVGDLTSTAIEELGGEILVHGIKIKPGKPTIIGRIGKKLVVGLPGYPTSCLTIFDVLFNEKGK
TMRAQVYNRYMSAKGREEYLPVSIIRGNDGYGAYPVLKGSEAITSLTYADGYIIIPENKEIVEDEIFDVHMFGDIRIGLN
IIGSHCVGIDRILRKGHILARTVNTGSLGGIMAVKRKEADIAGIHLLDNNGEYNVSYLKKYNVSDAVLVRGYIREQGFMF
KKELGIKSIDDLIEKIRDYRIINRNKGSGTRILFDKFLKENNVDKNSIDGYDIEAKTHSAVGTAVSMGKAQIGLGISTIS
DHYGLEFIPIADEYYDLLIPKEKLYDEDIIKFIETLKKEELPFKKSKDTGKIIYEC

Sequences:

>Translated_616_residues
MRYLELCTIDHAKEVVRTLLNELSTEEVSLFELPGKMLAEDIVSSVDVPPFDRSRMDGYAVRAKDTYEAEEDKPVTLEII
DKIRAGGNSDLEILPGQCMEIATGAPLPKGADAVVMVEFAEIEGNSVKLYKAVSPHENIQPCGNDIMVGELIMRKNTVIS
PRDIGAISAVGKNKLKVFKNPSIGLLSTGNELISPDDKLEPYKIYDVNTYTIASSILEKGWNFNFYGIVQDNKEDLMEKL
KKAMNEDVILLSGGTSAGVGDLTSTAIEELGGEILVHGIKIKPGKPTIIGRIGKKLVVGLPGYPTSCLTIFDVLFNEKGK
TMRAQVYNRYMSAKGREEYLPVSIIRGNDGYGAYPVLKGSEAITSLTYADGYIIIPENKEIVEDEIFDVHMFGDIRIGLN
IIGSHCVGIDRILRKGHILARTVNTGSLGGIMAVKRKEADIAGIHLLDNNGEYNVSYLKKYNVSDAVLVRGYIREQGFMF
KKELGIKSIDDLIEKIRDYRIINRNKGSGTRILFDKFLKENNVDKNSIDGYDIEAKTHSAVGTAVSMGKAQIGLGISTIS
DHYGLEFIPIADEYYDLLIPKEKLYDEDIIKFIETLKKEELPFKKSKDTGKIIYEC
>Mature_616_residues
MRYLELCTIDHAKEVVRTLLNELSTEEVSLFELPGKMLAEDIVSSVDVPPFDRSRMDGYAVRAKDTYEAEEDKPVTLEII
DKIRAGGNSDLEILPGQCMEIATGAPLPKGADAVVMVEFAEIEGNSVKLYKAVSPHENIQPCGNDIMVGELIMRKNTVIS
PRDIGAISAVGKNKLKVFKNPSIGLLSTGNELISPDDKLEPYKIYDVNTYTIASSILEKGWNFNFYGIVQDNKEDLMEKL
KKAMNEDVILLSGGTSAGVGDLTSTAIEELGGEILVHGIKIKPGKPTIIGRIGKKLVVGLPGYPTSCLTIFDVLFNEKGK
TMRAQVYNRYMSAKGREEYLPVSIIRGNDGYGAYPVLKGSEAITSLTYADGYIIIPENKEIVEDEIFDVHMFGDIRIGLN
IIGSHCVGIDRILRKGHILARTVNTGSLGGIMAVKRKEADIAGIHLLDNNGEYNVSYLKKYNVSDAVLVRGYIREQGFMF
KKELGIKSIDDLIEKIRDYRIINRNKGSGTRILFDKFLKENNVDKNSIDGYDIEAKTHSAVGTAVSMGKAQIGLGISTIS
DHYGLEFIPIADEYYDLLIPKEKLYDEDIIKFIETLKKEELPFKKSKDTGKIIYEC

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=433, Percent_Identity=30.715935334873, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI66932975, Length=433, Percent_Identity=30.715935334873, Blast_Score=184, Evalue=3e-46,
Organism=Escherichia coli, GI1787049, Length=390, Percent_Identity=31.025641025641, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25147659, Length=297, Percent_Identity=34.3434343434343, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17562606, Length=268, Percent_Identity=22.7611940298507, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136978, Length=283, Percent_Identity=30.3886925795053, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24638841, Length=283, Percent_Identity=30.3886925795053, Blast_Score=112, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 68237; Mature: 68237

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLELCTIDHAKEVVRTLLNELSTEEVSLFELPGKMLAEDIVSSVDVPPFDRSRMDGYA
CCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEE
VRAKDTYEAEEDKPVTLEIIDKIRAGGNSDLEILPGQCMEIATGAPLPKGADAVVMVEFA
EEECCCCCCCCCCCEEHHHHHHHHCCCCCCEEECCCCHHHHHCCCCCCCCCCEEEEEEEE
EIEGNSVKLYKAVSPHENIQPCGNDIMVGELIMRKNTVISPRDIGAISAVGKNKLKVFKN
ECCCCEEEEEEECCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCCCHHHHCCCCCEEEECC
PSIGLLSTGNELISPDDKLEPYKIYDVNTYTIASSILEKGWNFNFYGIVQDNKEDLMEKL
CCEEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHH
KKAMNEDVILLSGGTSAGVGDLTSTAIEELGGEILVHGIKIKPGKPTIIGRIGKKLVVGL
HHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCHHHCCCCCEEEEEC
PGYPTSCLTIFDVLFNEKGKTMRAQVYNRYMSAKGREEYLPVSIIRGNDGYGAYPVLKGS
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEECCC
EAITSLTYADGYIIIPENKEIVEDEIFDVHMFGDIRIGLNIIGSHCVGIDRILRKGHILA
HHHEEEEECCCEEEECCCCHHHCCCEEEEEEEEEEEEEHEECCCHHHHHHHHHHCCCEEE
RTVNTGSLGGIMAVKRKEADIAGIHLLDNNGEYNVSYLKKYNVSDAVLVRGYIREQGFMF
EEECCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHCCCEE
KKELGIKSIDDLIEKIRDYRIINRNKGSGTRILFDKFLKENNVDKNSIDGYDIEAKTHSA
HHHCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCHH
VGTAVSMGKAQIGLGISTISDHYGLEFIPIADEYYDLLIPKEKLYDEDIIKFIETLKKEE
HHHHHHCCCHHCCCCCEEHHHCCCEEEEEECHHHHHHCCCHHHHCHHHHHHHHHHHHHHC
LPFKKSKDTGKIIYEC
CCCCCCCCCCCEEEEC
>Mature Secondary Structure
MRYLELCTIDHAKEVVRTLLNELSTEEVSLFELPGKMLAEDIVSSVDVPPFDRSRMDGYA
CCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEE
VRAKDTYEAEEDKPVTLEIIDKIRAGGNSDLEILPGQCMEIATGAPLPKGADAVVMVEFA
EEECCCCCCCCCCCEEHHHHHHHHCCCCCCEEECCCCHHHHHCCCCCCCCCCEEEEEEEE
EIEGNSVKLYKAVSPHENIQPCGNDIMVGELIMRKNTVISPRDIGAISAVGKNKLKVFKN
ECCCCEEEEEEECCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCCCHHHHCCCCCEEEECC
PSIGLLSTGNELISPDDKLEPYKIYDVNTYTIASSILEKGWNFNFYGIVQDNKEDLMEKL
CCEEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHH
KKAMNEDVILLSGGTSAGVGDLTSTAIEELGGEILVHGIKIKPGKPTIIGRIGKKLVVGL
HHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCHHHCCCCCEEEEEC
PGYPTSCLTIFDVLFNEKGKTMRAQVYNRYMSAKGREEYLPVSIIRGNDGYGAYPVLKGS
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEECCC
EAITSLTYADGYIIIPENKEIVEDEIFDVHMFGDIRIGLNIIGSHCVGIDRILRKGHILA
HHHEEEEECCCEEEECCCCHHHCCCEEEEEEEEEEEEEHEECCCHHHHHHHHHHCCCEEE
RTVNTGSLGGIMAVKRKEADIAGIHLLDNNGEYNVSYLKKYNVSDAVLVRGYIREQGFMF
EEECCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHCCCEE
KKELGIKSIDDLIEKIRDYRIINRNKGSGTRILFDKFLKENNVDKNSIDGYDIEAKTHSA
HHHCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCHH
VGTAVSMGKAQIGLGISTISDHYGLEFIPIADEYYDLLIPKEKLYDEDIIKFIETLKKEE
HHHHHHCCCHHCCCCCEEHHHCCCEEEEEECHHHHHHCCCHHHHCHHHHHHHHHHHHHHC
LPFKKSKDTGKIIYEC
CCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]