Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 45358103

GI number: 45358103

Start: 545004

End: 545744

Strand: Direct

Name: purC [H]

Synonym: MMP0540

Alternate gene names: 45358103

Gene position: 545004-545744 (Clockwise)

Preceding gene: 45358102

Following gene: 45358104

Centisome position: 32.81

GC content: 33.6

Gene sequence:

>741_bases
ATGTCAGAATATGATATTTCAAAAATACTCGCAAATGAACCAATTTATGCTGGAAAGGCAAAATCAATTTACAAAATTGA
AGAAAACGAAAAAGAAGTTTTGGTAGAATTTAGGGACGATATAACCGCTGGAAACGGTGCAAAACACGACGTAAAATCCG
GAAAAGGGTACTTAAACACACTTATCTCAACTGAACTTTTCAACGTGCTCGAAAAAAATAATGTTCCAACACATTTGATA
GAATACATCGAACCAAACATAATGATTGCAAAAAACGTTAAAATAATTCCTTTAGAAGTAATTGTAAGAAACATTGCCGC
AGGAAGCCTCTGCAAAAAATACCCATTTGAACAAGGACAGGTATTAAAAACAGCTGTTACACAGTACGATTACAAAAATG
ACGACTATGGCGACCCAATGTTAAATAATGAAATTGCAATTGAACTTGGGCTTGCAACAGAAGAAGAATTGGTCGAAATC
AAAAAACTCGCTTTAAAAGTAAACGACGTTTTAAAAGGATTTTTTGATGAAAAAGGAATAATGCTAGTTGATTTCAAAAT
TGAAGTTGGAAAAACCGCTGATGGACAAATCGTTGTAGCTGATGAAATAAGCCCTGATACAATGAGACTTTGGGACAAAG
AAACAAAAGACGTGCTTGACAAGGATGTATTTAGAAAAGACTTAGGCGATGTTTTAGAAAAATACAAAATCGTTGCTGAA
AGAATCGGATGCTTAAAATAA

Upstream 100 bases:

>100_bases
AACTTAAAAATAACACATTAATTTTCGATTTTTTTATTTTTACTATCTAATTTATAACAATAATTGTTATTATATTATAA
TTTGAAGATCTGGTGAAATC

Downstream 100 bases:

>100_bases
TTATTTTTACTTTTCTTTTTACCGATTGGTGGAATAATGACAGATAATTTAGTAAAAAAACTTATTTTATTTGATTTAGA
TAGTACACTTGCGGACTGCG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSEYDISKILANEPIYAGKAKSIYKIEENEKEVLVEFRDDITAGNGAKHDVKSGKGYLNTLISTELFNVLEKNNVPTHLI
EYIEPNIMIAKNVKIIPLEVIVRNIAAGSLCKKYPFEQGQVLKTAVTQYDYKNDDYGDPMLNNEIAIELGLATEEELVEI
KKLALKVNDVLKGFFDEKGIMLVDFKIEVGKTADGQIVVADEISPDTMRLWDKETKDVLDKDVFRKDLGDVLEKYKIVAE
RIGCLK

Sequences:

>Translated_246_residues
MSEYDISKILANEPIYAGKAKSIYKIEENEKEVLVEFRDDITAGNGAKHDVKSGKGYLNTLISTELFNVLEKNNVPTHLI
EYIEPNIMIAKNVKIIPLEVIVRNIAAGSLCKKYPFEQGQVLKTAVTQYDYKNDDYGDPMLNNEIAIELGLATEEELVEI
KKLALKVNDVLKGFFDEKGIMLVDFKIEVGKTADGQIVVADEISPDTMRLWDKETKDVLDKDVFRKDLGDVLEKYKIVAE
RIGCLK
>Mature_245_residues
SEYDISKILANEPIYAGKAKSIYKIEENEKEVLVEFRDDITAGNGAKHDVKSGKGYLNTLISTELFNVLEKNNVPTHLIE
YIEPNIMIAKNVKIIPLEVIVRNIAAGSLCKKYPFEQGQVLKTAVTQYDYKNDDYGDPMLNNEIAIELGLATEEELVEIK
KLALKVNDVLKGFFDEKGIMLVDFKIEVGKTADGQIVVADEISPDTMRLWDKETKDVLDKDVFRKDLGDVLEKYKIVAER
IGCLK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=245, Percent_Identity=29.7959183673469, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI5453539, Length=245, Percent_Identity=29.7959183673469, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI119220559, Length=252, Percent_Identity=29.3650793650794, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1788820, Length=229, Percent_Identity=40.174672489083, Blast_Score=174, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17531275, Length=230, Percent_Identity=29.1304347826087, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI18860083, Length=245, Percent_Identity=29.3877551020408, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24583917, Length=255, Percent_Identity=27.4509803921569, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27763; Mature: 27632

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEYDISKILANEPIYAGKAKSIYKIEENEKEVLVEFRDDITAGNGAKHDVKSGKGYLNT
CCCHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHCCCHHHHH
LISTELFNVLEKNNVPTHLIEYIEPNIMIAKNVKIIPLEVIVRNIAAGSLCKKYPFEQGQ
HHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCEEEHHHHHHHHHHHHHHHHHCCCCCCH
VLKTAVTQYDYKNDDYGDPMLNNEIAIELGLATEEELVEIKKLALKVNDVLKGFFDEKGI
HHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
MLVDFKIEVGKTADGQIVVADEISPDTMRLWDKETKDVLDKDVFRKDLGDVLEKYKIVAE
EEEEEEEEECCCCCCCEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIGCLK
HHCCCC
>Mature Secondary Structure 
SEYDISKILANEPIYAGKAKSIYKIEENEKEVLVEFRDDITAGNGAKHDVKSGKGYLNT
CCHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHCCCHHHHH
LISTELFNVLEKNNVPTHLIEYIEPNIMIAKNVKIIPLEVIVRNIAAGSLCKKYPFEQGQ
HHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCEEEHHHHHHHHHHHHHHHHHCCCCCCH
VLKTAVTQYDYKNDDYGDPMLNNEIAIELGLATEEELVEIKKLALKVNDVLKGFFDEKGI
HHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
MLVDFKIEVGKTADGQIVVADEISPDTMRLWDKETKDVLDKDVFRKDLGDVLEKYKIVAE
EEEEEEEEECCCCCCCEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIGCLK
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]