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The map label for this gene is tyrS

Identifier: 45357826

GI number: 45357826

Start: 263868

End: 264827

Strand: Direct

Name: tyrS

Synonym: MMP0263

Alternate gene names: 45357826

Gene position: 263868-264827 (Clockwise)

Preceding gene: 45357818

Following gene: 45357827

Centisome position: 15.88

GC content: 35.42

Gene sequence:

>960_bases
TTGTTAATATTTGTAAAATCAGGCGAAAACATGTTAGAATCTATATTAAAAAACACTTCAGAAATAGTATCCATCGAAGA
ATTAACTGAACTCTTAAAAAAAGAAGAAAAAATTGCATATATTGGATTTGAACCCAGTGGAAGAATTCACATGGGCCATT
ACTTGCAGATAAGAAAGATGATCGATCTTCAAAAGGCAGGATTTAAAATAGTAATTTTACTGGCGGATTTACACGCTTAC
TTAAACCAAAAAGGAACAATGGATGAAGTAAGGGCTCTCGGTGAAGAAAACAGAAAAGTATTTGAAGCAATGGGACTTGT
TGCAGATTACGTTTACGGAAGCGAGTTTCAGTTAAAAGACGAGTATACAATAGATGTTTACAAACTCGCACTTTCAACCA
CGTTAAACCGGGCAAGAAGAAGTATGGAAGTAATTGCCAGAGAAGACGAAAACCCGAAAGTTGCAAGTGTCGTATATCCA
CTAATGCAGGTGAACGACATAAAACACTTAAATGCAGATGTTGCAGTTGGCGGAATGGAGCAGAGGAAAATTCACATGCT
TTCAAGAGAGATTTTACCAAGCATGGGATACAAAGCGCCAGTATGTATACACAATCCTGTTTTAACTGGGCTTGATGGTG
AAGGTAAGATGTCTTCATCAAAAGGAAATTTCATTGCAGTAGATGACGATGAAGCTACAATAAAGAAAAAGATGAAAAAT
GCATTCTGTCCGATGAAAGAAGTTTCAGGAAACCCCGTTTTAGAAATTGCTAAATACTATTTAAAATACCCTGCAACTGT
AAAAAGGCCAGAAAAATTCGGTGGAGATTTAGTTTTAGAATCTTACGAAGCTTTAGAAAATGCGTTTGTTGAAGGACTTC
ACCCAATGGATGTTAAAAACCTCGTTTCAGAACAATTAATTGAAATTTTAAGACCTATCCGCGAAAAAATGAATAAATAA

Upstream 100 bases:

>100_bases
TTAGAAAAGTATAAATCGGTAAGTTTAGACATTAGTATAAACACAATTACTTTTGTAAAAGAATTATTATAATAATGCAA
ATTACGAATAAACGTTTTTA

Downstream 100 bases:

>100_bases
GGATAAATAGTGAAATTATGGCGTTAGATCAATTATATTTTGGAAATACCCTGTATTCATACATGATATTTTTAATATTC
ATATTTTTCGGGGTATTCTT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MLIFVKSGENMLESILKNTSEIVSIEELTELLKKEEKIAYIGFEPSGRIHMGHYLQIRKMIDLQKAGFKIVILLADLHAY
LNQKGTMDEVRALGEENRKVFEAMGLVADYVYGSEFQLKDEYTIDVYKLALSTTLNRARRSMEVIAREDENPKVASVVYP
LMQVNDIKHLNADVAVGGMEQRKIHMLSREILPSMGYKAPVCIHNPVLTGLDGEGKMSSSKGNFIAVDDDEATIKKKMKN
AFCPMKEVSGNPVLEIAKYYLKYPATVKRPEKFGGDLVLESYEALENAFVEGLHPMDVKNLVSEQLIEILRPIREKMNK

Sequences:

>Translated_319_residues
MLIFVKSGENMLESILKNTSEIVSIEELTELLKKEEKIAYIGFEPSGRIHMGHYLQIRKMIDLQKAGFKIVILLADLHAY
LNQKGTMDEVRALGEENRKVFEAMGLVADYVYGSEFQLKDEYTIDVYKLALSTTLNRARRSMEVIAREDENPKVASVVYP
LMQVNDIKHLNADVAVGGMEQRKIHMLSREILPSMGYKAPVCIHNPVLTGLDGEGKMSSSKGNFIAVDDDEATIKKKMKN
AFCPMKEVSGNPVLEIAKYYLKYPATVKRPEKFGGDLVLESYEALENAFVEGLHPMDVKNLVSEQLIEILRPIREKMNK
>Mature_319_residues
MLIFVKSGENMLESILKNTSEIVSIEELTELLKKEEKIAYIGFEPSGRIHMGHYLQIRKMIDLQKAGFKIVILLADLHAY
LNQKGTMDEVRALGEENRKVFEAMGLVADYVYGSEFQLKDEYTIDVYKLALSTTLNRARRSMEVIAREDENPKVASVVYP
LMQVNDIKHLNADVAVGGMEQRKIHMLSREILPSMGYKAPVCIHNPVLTGLDGEGKMSSSKGNFIAVDDDEATIKKKMKN
AFCPMKEVSGNPVLEIAKYYLKYPATVKRPEKFGGDLVLESYEALENAFVEGLHPMDVKNLVSEQLIEILRPIREKMNK

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily

Homologues:

Organism=Homo sapiens, GI4507947, Length=324, Percent_Identity=35.4938271604938, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71992775, Length=317, Percent_Identity=28.7066246056782, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321624, Length=327, Percent_Identity=34.5565749235474, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21357223, Length=317, Percent_Identity=33.7539432176656, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYY_METMP (Q6M0K7)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_987383.1
- ProteinModelPortal:   Q6M0K7
- SMR:   Q6M0K7
- GeneID:   2761432
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP0263
- NMPDR:   fig|267377.1.peg.263
- HOGENOM:   HBG330667
- OMA:   DVAVGGM
- ProtClustDB:   PRK08560
- BioCyc:   MMAR267377:MMP0263-MONOMER
- BRENDA:   6.1.1.1
- GO:   GO:0005737
- HAMAP:   MF_02008
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307
- InterPro:   IPR015624
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11946:SF8
- PIRSF:   PIRSF006588
- PRINTS:   PR01040
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 36077; Mature: 36077

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 40-40 BINDING 159-159 BINDING 163-163 BINDING 166-166 BINDING 181-181 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIFVKSGENMLESILKNTSEIVSIEELTELLKKEEKIAYIGFEPSGRIHMGHYLQIRKM
CEEEEECCHHHHHHHHHHHHHHEEHHHHHHHHHCCCCEEEEEECCCCCEECHHHHHHHHH
IDLQKAGFKIVILLADLHAYLNQKGTMDEVRALGEENRKVFEAMGLVADYVYGSEFQLKD
HHHHHCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
EYTIDVYKLALSTTLNRARRSMEVIAREDENPKVASVVYPLMQVNDIKHLNADVAVGGME
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCH
QRKIHMLSREILPSMGYKAPVCIHNPVLTGLDGEGKMSSSKGNFIAVDDDEATIKKKMKN
HHHHHHHHHHHHHHCCCCCCEEECCCEEECCCCCCCCCCCCCCEEEECCCHHHHHHHHHH
AFCPMKEVSGNPVLEIAKYYLKYPATVKRPEKFGGDLVLESYEALENAFVEGLHPMDVKN
HCCCHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHH
LVSEQLIEILRPIREKMNK
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLIFVKSGENMLESILKNTSEIVSIEELTELLKKEEKIAYIGFEPSGRIHMGHYLQIRKM
CEEEEECCHHHHHHHHHHHHHHEEHHHHHHHHHCCCCEEEEEECCCCCEECHHHHHHHHH
IDLQKAGFKIVILLADLHAYLNQKGTMDEVRALGEENRKVFEAMGLVADYVYGSEFQLKD
HHHHHCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
EYTIDVYKLALSTTLNRARRSMEVIAREDENPKVASVVYPLMQVNDIKHLNADVAVGGME
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCH
QRKIHMLSREILPSMGYKAPVCIHNPVLTGLDGEGKMSSSKGNFIAVDDDEATIKKKMKN
HHHHHHHHHHHHHHCCCCCCEEECCCEEECCCCCCCCCCCCCCEEEECCCHHHHHHHHHH
AFCPMKEVSGNPVLEIAKYYLKYPATVKRPEKFGGDLVLESYEALENAFVEGLHPMDVKN
HCCCHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHH
LVSEQLIEILRPIREKMNK
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA