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The map label for this gene is mfnA [H]

Identifier: 45357694

GI number: 45357694

Start: 137305

End: 138459

Strand: Direct

Name: mfnA [H]

Synonym: MMP0131

Alternate gene names: 45357694

Gene position: 137305-138459 (Clockwise)

Preceding gene: 45357693

Following gene: 45357695

Centisome position: 8.27

GC content: 34.29

Gene sequence:

>1155_bases
ATGGATGAGCAGGATATTTTAAACGAATTACGAGAATACAGGAATCAGGATTTGAAATACGAAGAAGGCTATATTTTAGG
GTCCATGTGCACAAAACCACACCCAATGGCACGAAAAATTTCGGAAATGTTTTTTGAGACAAATTTGGGAGATCCAGGGC
TATTTAAAGGTACTTCAAAGCTAGAAAAAGAAGTAGTTTCAATGATTGGCGGTATATTACATAATAAAAATGCTTTTGGT
TATCTTATTTCTGGAGGAACTGAAGCAAACCTTACGGCAATGAGGGCATTTAAAAATATCTCAAAATCTAAGGGTAAACC
TCAAAATATCATAATTCCTGAAACTGCGCACTTTTCTTTTGACAAAGCAAAAGATATGATGGATTTAAATGTTGTACGGC
CTCCTTTAACGAAATATTTTACAATGGATGTAAAATTTATTAAAGATTATATTGAAGATTCTAAAAACGAAGTATCTGGA
ATTGTAGGGATTGCAGGATGTACGGAACTTGGATCAATTGATAATATCTGCGAATTATCAAAAATCGCGGTTGAAAATGA
TATTTTGCTTCACGTGGATGCTGCATTTGGTGGTTTTGTAATTCCATTTTTAGACGATAAATACAAATTAGATGGATATA
ATTACGATTTTGATTTTTCACTAAACGGGGTTTCTTCAATTACTATTGATCCGCACAAAATGGGGCTTGCTCCAATTTCT
GCCGGAGGAATTTTGTTTAGAGATAATATGTTTAAAAAATATCTGGATGTAGATGCCCCTTATTTAACTGAAAAACAGCA
GGCAACCATAATTGGAACCCGATCTGGCGTAGGTGTTGCGTCAACTTGGGGAATTATGAAATTACTTGGAATTGACGGAT
ACGAAACCCTTGTAAACGAATCGATGGAAAAAACAATGTATCTGGTAAAAAAAGCTAGAGAATATGGGTTTGAAACTGCA
ATAGATCCGGTAATGAATATTGTTGCATTAAATGATGAAAATAAACACGATACATGTATGAAATTACGTGACGAGAACTG
GTATGTCTCTGTTTGCAGGTGTGTTGACGCTTTGAGGATTGTTGTAATGCCGCATCTTGAAATTGAACATATCGACGGAT
TTTTAGAAAGCCTTTCAAATACAAAAAAATATTAA

Upstream 100 bases:

>100_bases
AATAATCAAACGATCTGATACAAAGGTTTTTTAAAAAGTGCAGCGATTTTATAAACAATTAACTCAAAGAAATTAAAAAA
ATCTTACCGGTAGATTACCA

Downstream 100 bases:

>100_bases
GAATTAAAATCTTATCTGCATTAAAAGTATTTTTGATGGTGGTTTAGTCATGAAAATTTATCTCGATGGAAACTTCGTAG
AGAAAGAAGATGCGAAAGTA

Product: L-tyrosine decarboxylase

Products: NA

Alternate protein names: TDC [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MDEQDILNELREYRNQDLKYEEGYILGSMCTKPHPMARKISEMFFETNLGDPGLFKGTSKLEKEVVSMIGGILHNKNAFG
YLISGGTEANLTAMRAFKNISKSKGKPQNIIIPETAHFSFDKAKDMMDLNVVRPPLTKYFTMDVKFIKDYIEDSKNEVSG
IVGIAGCTELGSIDNICELSKIAVENDILLHVDAAFGGFVIPFLDDKYKLDGYNYDFDFSLNGVSSITIDPHKMGLAPIS
AGGILFRDNMFKKYLDVDAPYLTEKQQATIIGTRSGVGVASTWGIMKLLGIDGYETLVNESMEKTMYLVKKAREYGFETA
IDPVMNIVALNDENKHDTCMKLRDENWYVSVCRCVDALRIVVMPHLEIEHIDGFLESLSNTKKY

Sequences:

>Translated_384_residues
MDEQDILNELREYRNQDLKYEEGYILGSMCTKPHPMARKISEMFFETNLGDPGLFKGTSKLEKEVVSMIGGILHNKNAFG
YLISGGTEANLTAMRAFKNISKSKGKPQNIIIPETAHFSFDKAKDMMDLNVVRPPLTKYFTMDVKFIKDYIEDSKNEVSG
IVGIAGCTELGSIDNICELSKIAVENDILLHVDAAFGGFVIPFLDDKYKLDGYNYDFDFSLNGVSSITIDPHKMGLAPIS
AGGILFRDNMFKKYLDVDAPYLTEKQQATIIGTRSGVGVASTWGIMKLLGIDGYETLVNESMEKTMYLVKKAREYGFETA
IDPVMNIVALNDENKHDTCMKLRDENWYVSVCRCVDALRIVVMPHLEIEHIDGFLESLSNTKKY
>Mature_384_residues
MDEQDILNELREYRNQDLKYEEGYILGSMCTKPHPMARKISEMFFETNLGDPGLFKGTSKLEKEVVSMIGGILHNKNAFG
YLISGGTEANLTAMRAFKNISKSKGKPQNIIIPETAHFSFDKAKDMMDLNVVRPPLTKYFTMDVKFIKDYIEDSKNEVSG
IVGIAGCTELGSIDNICELSKIAVENDILLHVDAAFGGFVIPFLDDKYKLDGYNYDFDFSLNGVSSITIDPHKMGLAPIS
AGGILFRDNMFKKYLDVDAPYLTEKQQATIIGTRSGVGVASTWGIMKLLGIDGYETLVNESMEKTMYLVKKAREYGFETA
IDPVMNIVALNDENKHDTCMKLRDENWYVSVCRCVDALRIVVMPHLEIEHIDGFLESLSNTKKY

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine [H]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31982936, Length=325, Percent_Identity=31.3846153846154, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25148342, Length=392, Percent_Identity=27.0408163265306, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17543922, Length=319, Percent_Identity=29.4670846394984, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17557272, Length=268, Percent_Identity=30.5970149253731, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71993058, Length=276, Percent_Identity=25.7246376811594, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555682, Length=274, Percent_Identity=25.1824817518248, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71993062, Length=274, Percent_Identity=25.5474452554745, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320500, Length=335, Percent_Identity=29.2537313432836, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323905, Length=309, Percent_Identity=24.9190938511327, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21355963, Length=349, Percent_Identity=29.512893982808, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24654344, Length=349, Percent_Identity=29.512893982808, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR021115
- InterPro:   IPR020931 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.25 [H]

Molecular weight: Translated: 43145; Mature: 43145

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQDILNELREYRNQDLKYEEGYILGSMCTKPHPMARKISEMFFETNLGDPGLFKGTSK
CCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHH
LEKEVVSMIGGILHNKNAFGYLISGGTEANLTAMRAFKNISKSKGKPQNIIIPETAHFSF
HHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCH
DKAKDMMDLNVVRPPLTKYFTMDVKFIKDYIEDSKNEVSGIVGIAGCTELGSIDNICELS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHEEEECCCHHCCCCHHHHHHH
KIAVENDILLHVDAAFGGFVIPFLDDKYKLDGYNYDFDFSLNGVSSITIDPHKMGLAPIS
HHHCCCCEEEEEECCCCCEEEEEECCCEEECCCCCEEEEECCCCEEEEECHHHCCCCEEC
AGGILFRDNMFKKYLDVDAPYLTEKQQATIIGTRSGVGVASTWGIMKLLGIDGYETLVNE
CCCEEEEHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHH
SMEKTMYLVKKAREYGFETAIDPVMNIVALNDENKHDTCMKLRDENWYVSVCRCVDALRI
HHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCCCCHHHEECCCCCCHHHHHHHHHHHH
VVMPHLEIEHIDGFLESLSNTKKY
HHCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDEQDILNELREYRNQDLKYEEGYILGSMCTKPHPMARKISEMFFETNLGDPGLFKGTSK
CCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHH
LEKEVVSMIGGILHNKNAFGYLISGGTEANLTAMRAFKNISKSKGKPQNIIIPETAHFSF
HHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCH
DKAKDMMDLNVVRPPLTKYFTMDVKFIKDYIEDSKNEVSGIVGIAGCTELGSIDNICELS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHEEEECCCHHCCCCHHHHHHH
KIAVENDILLHVDAAFGGFVIPFLDDKYKLDGYNYDFDFSLNGVSSITIDPHKMGLAPIS
HHHCCCCEEEEEECCCCCEEEEEECCCEEECCCCCEEEEECCCCEEEEECHHHCCCCEEC
AGGILFRDNMFKKYLDVDAPYLTEKQQATIIGTRSGVGVASTWGIMKLLGIDGYETLVNE
CCCEEEEHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHH
SMEKTMYLVKKAREYGFETAIDPVMNIVALNDENKHDTCMKLRDENWYVSVCRCVDALRI
HHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCCCCHHHEECCCCCCHHHHHHHHHHHH
VVMPHLEIEHIDGFLESLSNTKKY
HHCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA