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The map label for this gene is fumA [C]

Identifier: 45357693

GI number: 45357693

Start: 136315

End: 137160

Strand: Direct

Name: fumA [C]

Synonym: MMP0130

Alternate gene names: 45357693

Gene position: 136315-137160 (Clockwise)

Preceding gene: 45357692

Following gene: 45357694

Centisome position: 8.21

GC content: 36.05

Gene sequence:

>846_bases
ATGAGCAATATTTCAGAAATTGTTGTTGAATTATTTAAAGAAGCCTCAATTTATCTTCCAGACGACGTTAAGTCTAAATT
AAAACACGCTGAAGAAGTAGAGTGTGGTGCATGTAAGGATACGCTACAGGCAATTGAATTAAACAATAAAATTGCGGAAA
CTAAACAAATCCCCCTCTGTCAGGATACAGGAGTTCCAGTTATTTTTTTAAAAATTGGAACGGGGATTTCAAGTGAAAGA
ATAATTGAAATAATCAAAGAAATTGAAAGTGGCGTAAAACGGGCAACCGCAGAAGTGCCATTGCGGCCAAACGTTGTAAA
CCCAATTACTCGGGAAAATTTAGGCACGAATACTGGAATGGGTGCACCGTTTATAAATTTTGAATTTAGTGAAAATTTGA
ATAATGAAATCGAAATATCTGTGTTTCCAAAAGGAGCAGGAAGCGAAAACATGAGCGCTTTAAAGATGCTGACTCCTTCT
GAAGGGTTAATGGGAATAAAAAAATTTATCCTTGAAACAGTTGCAAATGCAGGCGGTAAACCGTGTCCTCCAATAGTGTT
GGGTATAGGAATAGGTGGAACTGCAGATATTTCATTGAAACTTGCTAAAAAAGCTCTTTTAAGAGATATTGGAAACAGAA
ATCCTGAAAAAACAATTGAAAATCTGGAAAAAGAGCTGTTGGATAGTATAAATCAGCTTGGAATTGGTACAATGGGACTT
GGTGGTAAAATAACTGCTTTAGATGTATTTATCGAGGTAAATGGATGTCATACTGCATCCCTTCCGGTTGGAATATGTAT
CCAGTGCTGGGCGGATAGAAAAGCGAAAAGAAAAATAAAATTATAA

Upstream 100 bases:

>100_bases
AGTGGGACTTGGTGCAGGAATGTCTTTTAGGGAACTTGAAAATTCATTAACAACAAATCCCTTAGAAATTTTAAAAAGAA
TATAATTTACCGGTGTTTTT

Downstream 100 bases:

>100_bases
AAGTTTGTAAAAAATTATATCATTACAAAAAATCTCTTTTTTTAAATAATCAAACGATCTGATACAAAGGTTTTTTAAAA
AGTGCAGCGATTTTATAAAC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MSNISEIVVELFKEASIYLPDDVKSKLKHAEEVECGACKDTLQAIELNNKIAETKQIPLCQDTGVPVIFLKIGTGISSER
IIEIIKEIESGVKRATAEVPLRPNVVNPITRENLGTNTGMGAPFINFEFSENLNNEIEISVFPKGAGSENMSALKMLTPS
EGLMGIKKFILETVANAGGKPCPPIVLGIGIGGTADISLKLAKKALLRDIGNRNPEKTIENLEKELLDSINQLGIGTMGL
GGKITALDVFIEVNGCHTASLPVGICIQCWADRKAKRKIKL

Sequences:

>Translated_281_residues
MSNISEIVVELFKEASIYLPDDVKSKLKHAEEVECGACKDTLQAIELNNKIAETKQIPLCQDTGVPVIFLKIGTGISSER
IIEIIKEIESGVKRATAEVPLRPNVVNPITRENLGTNTGMGAPFINFEFSENLNNEIEISVFPKGAGSENMSALKMLTPS
EGLMGIKKFILETVANAGGKPCPPIVLGIGIGGTADISLKLAKKALLRDIGNRNPEKTIENLEKELLDSINQLGIGTMGL
GGKITALDVFIEVNGCHTASLPVGICIQCWADRKAKRKIKL
>Mature_280_residues
SNISEIVVELFKEASIYLPDDVKSKLKHAEEVECGACKDTLQAIELNNKIAETKQIPLCQDTGVPVIFLKIGTGISSERI
IEIIKEIESGVKRATAEVPLRPNVVNPITRENLGTNTGMGAPFINFEFSENLNNEIEISVFPKGAGSENMSALKMLTPSE
GLMGIKKFILETVANAGGKPCPPIVLGIGIGGTADISLKLAKKALLRDIGNRNPEKTIENLEKELLDSINQLGIGTMGLG
GKITALDVFIEVNGCHTASLPVGICIQCWADRKAKRKIKL

Specific function: Unknown

COG id: COG1951

COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789442, Length=283, Percent_Identity=33.2155477031802, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1790564, Length=247, Percent_Identity=31.5789473684211, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1787897, Length=246, Percent_Identity=31.7073170731707, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646 [H]

Pfam domain/function: PF05681 Fumerase [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 30262; Mature: 30131

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNISEIVVELFKEASIYLPDDVKSKLKHAEEVECGACKDTLQAIELNNKIAETKQIPLC
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCC
QDTGVPVIFLKIGTGISSERIIEIIKEIESGVKRATAEVPLRPNVVNPITRENLGTNTGM
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCC
GAPFINFEFSENLNNEIEISVFPKGAGSENMSALKMLTPSEGLMGIKKFILETVANAGGK
CCCEEEEEECCCCCCEEEEEEECCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHCCCC
PCPPIVLGIGIGGTADISLKLAKKALLRDIGNRNPEKTIENLEKELLDSINQLGIGTMGL
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEECC
GGKITALDVFIEVNGCHTASLPVGICIQCWADRKAKRKIKL
CCEEEEEEEEEEECCCEECCCCHHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure 
SNISEIVVELFKEASIYLPDDVKSKLKHAEEVECGACKDTLQAIELNNKIAETKQIPLC
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCC
QDTGVPVIFLKIGTGISSERIIEIIKEIESGVKRATAEVPLRPNVVNPITRENLGTNTGM
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCC
GAPFINFEFSENLNNEIEISVFPKGAGSENMSALKMLTPSEGLMGIKKFILETVANAGGK
CCCEEEEEECCCCCCEEEEEEECCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHCCCC
PCPPIVLGIGIGGTADISLKLAKKALLRDIGNRNPEKTIENLEKELLDSINQLGIGTMGL
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEECC
GGKITALDVFIEVNGCHTASLPVGICIQCWADRKAKRKIKL
CCEEEEEEEEEEECCCEECCCCHHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]