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The map label for this gene is argH [H]

Identifier: 45357576

GI number: 45357576

Start: 22602

End: 24047

Strand: Direct

Name: argH [H]

Synonym: MMP0013

Alternate gene names: 45357576

Gene position: 22602-24047 (Clockwise)

Preceding gene: 45357575

Following gene: 45357581

Centisome position: 1.36

GC content: 35.13

Gene sequence:

>1446_bases
ATGAACATTTTAAGAAGGGGAAGACTTGGAAGCAACGTCAAGGAAGACGTGATGAAATTCACTACAAGCCTTGAATTTGA
TAAAGAAATCTTTGAAAGCGATATTTTGTGCGACATTGCGCACACGACGATGCTCGTTGAACAGAACGTGATTTCAGAAG
AAAACGGTAAAAAAATAATTGCAGAACTTAAAAAAATAGCGAAAAGGGGCATGGAAAATCTTGATCTTGATCCATCTCTT
GACGACATTCACATGGTAATTGAAAGTGAATTAATAAAAGAACTTGGTGAAGATGTTGCTGGAAGAATGCATACTGGAAG
GAGCCGAAATGACGAAGTTGCAACTGATTTGAGGCTTTCTTTGAGGAAAAAAGTTCTTGAAATAATTGGTCATTTGATTA
CAATGGAAAAAAATATGCTCACGGTTTCAGATGCACATAAAGAAACATTAACCGTTGGATACACACATTTACAGCAAGCA
CAGCCTGTAACTTTTGGACATCAAATTTTAAGCCATGTTTCAGCGATTGAACGAGATATTTCAAGGTTTTTTGATACATA
CAACAGGATTAATATCTCCCCGTTAGGATGCGGTGCAATGGCTACAACGGGATTTAATTTGAATAGAAAAAGAACAAAAG
ACCTTCTTGGATTTTACGGAATAATTGAAAATTCAATGGATGGTGTGTCTTCAAGAGATTTCATTGTTGAAACAATGGCA
AACATCTCAATGCTTGGAACAAACCTCTCAAAAATATGTGAAGAGCTCGTCGTATTCTCAAGTGCAGAATTCAACACCAT
TGAAATTGCAAATGAATACACGTCCACCTCTTCGATCATGCCTCAGAAAAAAAACCCTGATGTTGCTGAAATTACAAGGG
CAAAACTTTCAACGCTAAATGGAGAGCTTGTAACAGTTTTAACGATTATGAAAGCGCTTCCAAACACATATAATAGAGAT
TTACAGGAAATCAGCCCGCATCTTTGGAAAAGTGTCTATACATTAATAGACAGTATTCAAATGGTTGACGGAATGATATC
AACCGTTAAAGTAAATAAGGAAAGAATGAAAGAAAATGCAGAGAAAAACTATTCTACTGCTACAGAACTTGCAGATACGC
TTGTAAGAGAATGCGGAATTGCATTTAGAATGGCTCACGGGATTGTTGGAGAATTAGTAAAACGATCTATTGAAGAAAAA
GTTGAAATTAAGGAAATAATTTCAGAGGTTCTTGAAAAGAATAACCTTTCATTAAGCCAGGAAAAAATTGATACTGCACT
CGATCCTTTTGAAAACGTGAAATTAAGAAATGTAATCGGCGGACCTGCACCAGAAGAAGTAGAAAGGGCAATATCTTCAT
TTAATGAAAAAATTTCAGCACATAAAGACAAATTAGATGAAAAAATTTCTGAAATTAAAACTGCTGAAAAAAATCTCTTA
GAATAA

Upstream 100 bases:

>100_bases
ACGGTTTTGATGTCGTTTTGGAAAAGTGCATCATGACTACAAATCAAAAATTTTTATAGTTTAAGGAAATAGTTAGTTTA
ATTTAAAAAAGGTGACTTTG

Downstream 100 bases:

>100_bases
AAAATTAAAAAAATTATAAAATATTAAAAACCCTTTTTAAAATTATAGTTGCGTAGCTTCCTTTCTTTAAACTAAATTCC
AAATCTATTTTGTACTTTTT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNILRRGRLGSNVKEDVMKFTTSLEFDKEIFESDILCDIAHTTMLVEQNVISEENGKKIIAELKKIAKRGMENLDLDPSL
DDIHMVIESELIKELGEDVAGRMHTGRSRNDEVATDLRLSLRKKVLEIIGHLITMEKNMLTVSDAHKETLTVGYTHLQQA
QPVTFGHQILSHVSAIERDISRFFDTYNRINISPLGCGAMATTGFNLNRKRTKDLLGFYGIIENSMDGVSSRDFIVETMA
NISMLGTNLSKICEELVVFSSAEFNTIEIANEYTSTSSIMPQKKNPDVAEITRAKLSTLNGELVTVLTIMKALPNTYNRD
LQEISPHLWKSVYTLIDSIQMVDGMISTVKVNKERMKENAEKNYSTATELADTLVRECGIAFRMAHGIVGELVKRSIEEK
VEIKEIISEVLEKNNLSLSQEKIDTALDPFENVKLRNVIGGPAPEEVERAISSFNEKISAHKDKLDEKISEIKTAEKNLL
E

Sequences:

>Translated_481_residues
MNILRRGRLGSNVKEDVMKFTTSLEFDKEIFESDILCDIAHTTMLVEQNVISEENGKKIIAELKKIAKRGMENLDLDPSL
DDIHMVIESELIKELGEDVAGRMHTGRSRNDEVATDLRLSLRKKVLEIIGHLITMEKNMLTVSDAHKETLTVGYTHLQQA
QPVTFGHQILSHVSAIERDISRFFDTYNRINISPLGCGAMATTGFNLNRKRTKDLLGFYGIIENSMDGVSSRDFIVETMA
NISMLGTNLSKICEELVVFSSAEFNTIEIANEYTSTSSIMPQKKNPDVAEITRAKLSTLNGELVTVLTIMKALPNTYNRD
LQEISPHLWKSVYTLIDSIQMVDGMISTVKVNKERMKENAEKNYSTATELADTLVRECGIAFRMAHGIVGELVKRSIEEK
VEIKEIISEVLEKNNLSLSQEKIDTALDPFENVKLRNVIGGPAPEEVERAISSFNEKISAHKDKLDEKISEIKTAEKNLL
E
>Mature_481_residues
MNILRRGRLGSNVKEDVMKFTTSLEFDKEIFESDILCDIAHTTMLVEQNVISEENGKKIIAELKKIAKRGMENLDLDPSL
DDIHMVIESELIKELGEDVAGRMHTGRSRNDEVATDLRLSLRKKVLEIIGHLITMEKNMLTVSDAHKETLTVGYTHLQQA
QPVTFGHQILSHVSAIERDISRFFDTYNRINISPLGCGAMATTGFNLNRKRTKDLLGFYGIIENSMDGVSSRDFIVETMA
NISMLGTNLSKICEELVVFSSAEFNTIEIANEYTSTSSIMPQKKNPDVAEITRAKLSTLNGELVTVLTIMKALPNTYNRD
LQEISPHLWKSVYTLIDSIQMVDGMISTVKVNKERMKENAEKNYSTATELADTLVRECGIAFRMAHGIVGELVKRSIEEK
VEIKEIISEVLEKNNLSLSQEKIDTALDPFENVKLRNVIGGPAPEEVERAISSFNEKISAHKDKLDEKISEIKTAEKNLL
E

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=460, Percent_Identity=33.695652173913, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI68303542, Length=460, Percent_Identity=33.695652173913, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI68303547, Length=464, Percent_Identity=31.4655172413793, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI68303549, Length=460, Percent_Identity=31.304347826087, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=34.2857142857143, Blast_Score=290, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6321806, Length=469, Percent_Identity=33.6886993603412, Blast_Score=246, Evalue=6e-66,
Organism=Drosophila melanogaster, GI221473854, Length=442, Percent_Identity=33.4841628959276, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI78706858, Length=442, Percent_Identity=33.4841628959276, Blast_Score=258, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 54053; Mature: 54053

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILRRGRLGSNVKEDVMKFTTSLEFDKEIFESDILCDIAHTTMLVEQNVISEENGKKII
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AELKKIAKRGMENLDLDPSLDDIHMVIESELIKELGEDVAGRMHTGRSRNDEVATDLRLS
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LRKKVLEIIGHLITMEKNMLTVSDAHKETLTVGYTHLQQAQPVTFGHQILSHVSAIERDI
HHHHHHHHHHHHHHHHCCCEEECHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRFFDTYNRINISPLGCGAMATTGFNLNRKRTKDLLGFYGIIENSMDGVSSRDFIVETMA
HHHHHHHCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
NISMLGTNLSKICEELVVFSSAEFNTIEIANEYTSTSSIMPQKKNPDVAEITRAKLSTLN
HHHHHCCCHHHHHHHHHHHCCCCCCEEEEHHHHCCHHHCCCCCCCCCHHHHHHHHHHHCC
GELVTVLTIMKALPNTYNRDLQEISPHLWKSVYTLIDSIQMVDGMISTVKVNKERMKENA
CHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EKNYSTATELADTLVRECGIAFRMAHGIVGELVKRSIEEKVEIKEIISEVLEKNNLSLSQ
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
EKIDTALDPFENVKLRNVIGGPAPEEVERAISSFNEKISAHKDKLDEKISEIKTAEKNLL
HHHHHHHCCHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
E
C
>Mature Secondary Structure
MNILRRGRLGSNVKEDVMKFTTSLEFDKEIFESDILCDIAHTTMLVEQNVISEENGKKII
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AELKKIAKRGMENLDLDPSLDDIHMVIESELIKELGEDVAGRMHTGRSRNDEVATDLRLS
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LRKKVLEIIGHLITMEKNMLTVSDAHKETLTVGYTHLQQAQPVTFGHQILSHVSAIERDI
HHHHHHHHHHHHHHHHCCCEEECHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRFFDTYNRINISPLGCGAMATTGFNLNRKRTKDLLGFYGIIENSMDGVSSRDFIVETMA
HHHHHHHCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
NISMLGTNLSKICEELVVFSSAEFNTIEIANEYTSTSSIMPQKKNPDVAEITRAKLSTLN
HHHHHCCCHHHHHHHHHHHCCCCCCEEEEHHHHCCHHHCCCCCCCCCHHHHHHHHHHHCC
GELVTVLTIMKALPNTYNRDLQEISPHLWKSVYTLIDSIQMVDGMISTVKVNKERMKENA
CHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EKNYSTATELADTLVRECGIAFRMAHGIVGELVKRSIEEKVEIKEIISEVLEKNNLSLSQ
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
EKIDTALDPFENVKLRNVIGGPAPEEVERAISSFNEKISAHKDKLDEKISEIKTAEKNLL
HHHHHHHCCHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA