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The map label for this gene is ttcA

Identifier: 42523537

GI number: 42523537

Start: 1971934

End: 1972713

Strand: Direct

Name: ttcA

Synonym: Bd2064

Alternate gene names: 42523537

Gene position: 1971934-1972713 (Clockwise)

Preceding gene: 42523536

Following gene: 42523540

Centisome position: 52.13

GC content: 50.64

Gene sequence:

>780_bases
ATGAAATCAGCCGTTAATTTTGAACTTCCCCTGGCGGTAAAAATCCGCAAACAGATCGTGCAGGCCTTGAACGACTTCAA
CATGATTGAAGACGGCGACAAGGTCATGGTCTGCGTTTCCGGCGGCAAAGATTCCAGTGTATTGCTGGCCCTGCTGACCG
AAATCCAAAGACGCTCTGAGCGCAAATTCCAAATCGAAGCTGCCATCCTGGATCAAAAACAACCCGGCTTTGATGTGTCC
AAATTCAAAGTTTGGGTGGAAAGCCTGGGCGTGCCTTTTCATATCGTTGAAAAAGACACTTATTCCATCGTGAAAGAAAA
AGTTCAGGGCGGAACGTTCTGCTCCCTTTGCTCGCGTCTGCGCCGTGCGATTCTTTATGATTTTGCGCACGCCAACGGCT
TTACCAAACTGGCGCTGGGTCATCACCGCGATGACGTCGTTCACACGGCCTTGCTGAACATGTTCTATGTCGGCACCACG
GCGGCCATGCCACCAAAACTGAAATCTGACGACGAACGCAACATTCTGGTCCGCCCGCTGTGCTATGTTTCTGAAAGAGA
TATCGAAGAGCTGGCCGCCGAATGGGCCTTCCCGGTGATCCCGTGCAATCTGTGCGGATCCCAGGACGGACTGAAACGTC
AGCGTATCAAGAAGCTTGTTCGAGACCTCGAAAAAGAGATCCCGAACATCTATGCCTCCATCCAGACTTCCATGACGAAT
ATCAAACCAAGTCAGCTGATGGATCAGGATTTGTGGGACTTTAAGAACCTCAAGACCTAG

Upstream 100 bases:

>100_bases
ATTGGCGACAAGGTTTATGTGCGTGGGATTGAGGCGCTGAAGGCTCAGGGCATCAAATTAGCTCGACAAGTGGTTGAGCT
TTCGGATACAAACCAAGGCC

Downstream 100 bases:

>100_bases
TGGCCCGAGGCTCCTGCAGTGACTTTCAAGCTTGCCGCCGGAGCAGCCAGTTCGTGTTCGTCCTGGCCTGGCGCCGGGAT
ATCAAACCAGTCAATCTGAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MKSAVNFELPLAVKIRKQIVQALNDFNMIEDGDKVMVCVSGGKDSSVLLALLTEIQRRSERKFQIEAAILDQKQPGFDVS
KFKVWVESLGVPFHIVEKDTYSIVKEKVQGGTFCSLCSRLRRAILYDFAHANGFTKLALGHHRDDVVHTALLNMFYVGTT
AAMPPKLKSDDERNILVRPLCYVSERDIEELAAEWAFPVIPCNLCGSQDGLKRQRIKKLVRDLEKEIPNIYASIQTSMTN
IKPSQLMDQDLWDFKNLKT

Sequences:

>Translated_259_residues
MKSAVNFELPLAVKIRKQIVQALNDFNMIEDGDKVMVCVSGGKDSSVLLALLTEIQRRSERKFQIEAAILDQKQPGFDVS
KFKVWVESLGVPFHIVEKDTYSIVKEKVQGGTFCSLCSRLRRAILYDFAHANGFTKLALGHHRDDVVHTALLNMFYVGTT
AAMPPKLKSDDERNILVRPLCYVSERDIEELAAEWAFPVIPCNLCGSQDGLKRQRIKKLVRDLEKEIPNIYASIQTSMTN
IKPSQLMDQDLWDFKNLKT
>Mature_259_residues
MKSAVNFELPLAVKIRKQIVQALNDFNMIEDGDKVMVCVSGGKDSSVLLALLTEIQRRSERKFQIEAAILDQKQPGFDVS
KFKVWVESLGVPFHIVEKDTYSIVKEKVQGGTFCSLCSRLRRAILYDFAHANGFTKLALGHHRDDVVHTALLNMFYVGTT
AAMPPKLKSDDERNILVRPLCYVSERDIEELAAEWAFPVIPCNLCGSQDGLKRQRIKKLVRDLEKEIPNIYASIQTSMTN
IKPSQLMDQDLWDFKNLKT

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=248, Percent_Identity=51.2096774193548, Blast_Score=267, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI193211090, Length=243, Percent_Identity=27.5720164609054, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_BDEBA (Q6MLE7)

Other databases:

- EMBL:   BX842651
- RefSeq:   NP_968917.1
- ProteinModelPortal:   Q6MLE7
- GeneID:   2734745
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd2064
- NMPDR:   fig|264462.1.peg.1888
- HOGENOM:   HBG347038
- OMA:   EHILPEY
- PhylomeDB:   Q6MLE7
- BioCyc:   BBAC264462:BD2064-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 29405; Mature: 29405

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAVNFELPLAVKIRKQIVQALNDFNMIEDGDKVMVCVSGGKDSSVLLALLTEIQRRSE
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHC
RKFQIEAAILDQKQPGFDVSKFKVWVESLGVPFHIVEKDTYSIVKEKVQGGTFCSLCSRL
HHEEEHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHH
RRAILYDFAHANGFTKLALGHHRDDVVHTALLNMFYVGTTAAMPPKLKSDDERNILVRPL
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHH
CYVSERDIEELAAEWAFPVIPCNLCGSQDGLKRQRIKKLVRDLEKEIPNIYASIQTSMTN
HHHCCCCHHHHHHHHCCCCEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IKPSQLMDQDLWDFKNLKT
CCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKSAVNFELPLAVKIRKQIVQALNDFNMIEDGDKVMVCVSGGKDSSVLLALLTEIQRRSE
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHC
RKFQIEAAILDQKQPGFDVSKFKVWVESLGVPFHIVEKDTYSIVKEKVQGGTFCSLCSRL
HHEEEHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHH
RRAILYDFAHANGFTKLALGHHRDDVVHTALLNMFYVGTTAAMPPKLKSDDERNILVRPL
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHH
CYVSERDIEELAAEWAFPVIPCNLCGSQDGLKRQRIKKLVRDLEKEIPNIYASIQTSMTN
HHHCCCCHHHHHHHHCCCCEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IKPSQLMDQDLWDFKNLKT
CCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA