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The map label for this gene is 42523510

Identifier: 42523510

GI number: 42523510

Start: 1945454

End: 1946812

Strand: Direct

Name: 42523510

Synonym: Bd2036

Alternate gene names: NA

Gene position: 1945454-1946812 (Clockwise)

Preceding gene: 42523506

Following gene: 42523511

Centisome position: 51.43

GC content: 47.09

Gene sequence:

>1359_bases
ATGGAGATCGGATTTTTAGGAGCTGCCGGCACTGTGACAGGGTCCAAGTTTCTGGTACATAATAACGACACCCGAATTTT
GGTCGACTGTGGCATGTTCCAGGGCTTTAAGGAACTTCGAGAACTCAATTGGGAGGATTTCCCATTTGATCCACGCGATA
TTCAGGCTGTCGTGCTGACTCACGCCCATCTGGATCACTGCGGAGCTTTGCCTTTGTTGGTTAAAAAAGGTTTTAAAGGT
CCGATTTATTGTACTGAACCGACACTGGAGCTGACGAAAATCATTCTGCTGGATTCAGCCAAGATCCAGGAAGAAGATGC
GGACTACGCCAACAAAAAAGGCTTCTCAAAACACAGTCCGGCTCTGGCGTTGTATACAACGGAAGATGTCGAAAGAACTT
TGCCGCTGCTGCGGCCCGTGAATCTGCATACTCAATTTGAAATCGGCTCCCTGAAGGTTTGTTTTTACAGCAGCGGCCAT
ATCCTGGGGGCGGCTTCAGCAACGATTTCAAACGGCGAAAAAAGCATCCACTTTTCCGGTGATTTAGGCCGATATAATGA
TCCTTTGATGCCAGCTCCTGAACCACCGGCCAAAGCTGATTATCTCGTGATGGAATCAACCTATGGTGACCGCGATCATT
CTCCGAAAACCTCCAAAGAAGTTCTTAAAGAATGCATCTTGGAAATCGTGAAATCACGGGGAGTCCTGCTGATTCCAAGT
TTTGCTGTGGGTCGTGCACAGAATCTGCTGTTTGAAATAACGGAGCTAAAAAGAGACGGGGAGGTCCCCGCCCAAATCCC
CGTTTATTTTAATTCTCCTATGGGCCATGAAGTCGCCCTCCTTTACGAAAAATACCACCCATTCCATCGTCTGGGTTCCG
GTCAGTTCGCTGAGGTTATGTCAGAAGTTCATACGATTAAAACCGCTGAAGAATCCAGGGCCCTGAATGATGATAAATCC
GGGCCCAAGATCATCATCGCAGCCAGCGGTATGTTGACTGGCGGCCGGGTTTTGCATCATTTAAAAGCTTTTGGACCTGA
TTCCAGGAACATTGTTTTACTGGCAGGATTCCAAAGCCCCGGAACCCGTGGATTCAGCTTGTTGAATGGCGCCAGAGAAA
TCAAAATCCATGGTCTATATGTGGAGATAAACTGCAAAGTGATTCCATCTGATTCATTTTCAGCTCATGCAGACAGAAGT
GATTTGATGACCTGGTTAAAACAGGCTCCAGAGATCCCCAAAAGGATGTTTTTAGTGCATGGGGAACCGGTGGCGGCCGA
TGAGCTTCGAAAACGCATCGATAAAGAATTAAAATGGTACGTTACAGTGCCTAGAATGGGTCAGATTATAAGCACTTAG

Upstream 100 bases:

>100_bases
GCGGACCTTCCGCGTGAATACAATTCTGACCGCGCGCATAAAAGGTCAAAATACGGTCAGATTTAGGGCTATTCTAAAGA
AAAGCAACAAAGGGGAGTCT

Downstream 100 bases:

>100_bases
GGGTTTTAGCCCAAAAAGACCCCTCTACTTACCGTTACATAATATAACTTATCAGAAGATTATATATCCCACTTCAACCG
TGGGTATTCCCATCGAATTG

Product: beta-lactamase family exonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MEIGFLGAAGTVTGSKFLVHNNDTRILVDCGMFQGFKELRELNWEDFPFDPRDIQAVVLTHAHLDHCGALPLLVKKGFKG
PIYCTEPTLELTKIILLDSAKIQEEDADYANKKGFSKHSPALALYTTEDVERTLPLLRPVNLHTQFEIGSLKVCFYSSGH
ILGAASATISNGEKSIHFSGDLGRYNDPLMPAPEPPAKADYLVMESTYGDRDHSPKTSKEVLKECILEIVKSRGVLLIPS
FAVGRAQNLLFEITELKRDGEVPAQIPVYFNSPMGHEVALLYEKYHPFHRLGSGQFAEVMSEVHTIKTAEESRALNDDKS
GPKIIIAASGMLTGGRVLHHLKAFGPDSRNIVLLAGFQSPGTRGFSLLNGAREIKIHGLYVEINCKVIPSDSFSAHADRS
DLMTWLKQAPEIPKRMFLVHGEPVAADELRKRIDKELKWYVTVPRMGQIIST

Sequences:

>Translated_452_residues
MEIGFLGAAGTVTGSKFLVHNNDTRILVDCGMFQGFKELRELNWEDFPFDPRDIQAVVLTHAHLDHCGALPLLVKKGFKG
PIYCTEPTLELTKIILLDSAKIQEEDADYANKKGFSKHSPALALYTTEDVERTLPLLRPVNLHTQFEIGSLKVCFYSSGH
ILGAASATISNGEKSIHFSGDLGRYNDPLMPAPEPPAKADYLVMESTYGDRDHSPKTSKEVLKECILEIVKSRGVLLIPS
FAVGRAQNLLFEITELKRDGEVPAQIPVYFNSPMGHEVALLYEKYHPFHRLGSGQFAEVMSEVHTIKTAEESRALNDDKS
GPKIIIAASGMLTGGRVLHHLKAFGPDSRNIVLLAGFQSPGTRGFSLLNGAREIKIHGLYVEINCKVIPSDSFSAHADRS
DLMTWLKQAPEIPKRMFLVHGEPVAADELRKRIDKELKWYVTVPRMGQIIST
>Mature_452_residues
MEIGFLGAAGTVTGSKFLVHNNDTRILVDCGMFQGFKELRELNWEDFPFDPRDIQAVVLTHAHLDHCGALPLLVKKGFKG
PIYCTEPTLELTKIILLDSAKIQEEDADYANKKGFSKHSPALALYTTEDVERTLPLLRPVNLHTQFEIGSLKVCFYSSGH
ILGAASATISNGEKSIHFSGDLGRYNDPLMPAPEPPAKADYLVMESTYGDRDHSPKTSKEVLKECILEIVKSRGVLLIPS
FAVGRAQNLLFEITELKRDGEVPAQIPVYFNSPMGHEVALLYEKYHPFHRLGSGQFAEVMSEVHTIKTAEESRALNDDKS
GPKIIIAASGMLTGGRVLHHLKAFGPDSRNIVLLAGFQSPGTRGFSLLNGAREIKIHGLYVEINCKVIPSDSFSAHADRS
DLMTWLKQAPEIPKRMFLVHGEPVAADELRKRIDKELKWYVTVPRMGQIIST

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=460, Percent_Identity=30, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI7706427, Length=442, Percent_Identity=28.7330316742081, Blast_Score=174, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI32564696, Length=459, Percent_Identity=28.7581699346405, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI32566029, Length=443, Percent_Identity=27.0880361173815, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323307, Length=430, Percent_Identity=26.046511627907, Blast_Score=144, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24648013, Length=448, Percent_Identity=30.1339285714286, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI21358523, Length=468, Percent_Identity=30.7692307692308, Blast_Score=175, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 50113; Mature: 50113

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIGFLGAAGTVTGSKFLVHNNDTRILVDCGMFQGFKELRELNWEDFPFDPRDIQAVVLT
CCEEEEECCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHCCCCCCCCCCHHCEEEEEE
HAHLDHCGALPLLVKKGFKGPIYCTEPTLELTKIILLDSAKIQEEDADYANKKGFSKHSP
EHHHHHCCCCHHHHHCCCCCCEEECCCCHHEEEEEEECCCCCCCCCCCHHHCCCCCCCCC
ALALYTTEDVERTLPLLRPVNLHTQFEIGSLKVCFYSSGHILGAASATISNGEKSIHFSG
EEEEEEHHHHHHHHHHHCCCCCCEEEECCCEEEEEEECCCEEEEEEEEECCCCEEEEECC
DLGRYNDPLMPAPEPPAKADYLVMESTYGDRDHSPKTSKEVLKECILEIVKSRGVLLIPS
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEC
FAVGRAQNLLFEITELKRDGEVPAQIPVYFNSPMGHEVALLYEKYHPFHRLGSGQFAEVM
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEHHCCHHHHCCCCHHHHHH
SEVHTIKTAEESRALNDDKSGPKIIIAASGMLTGGRVLHHLKAFGPDSRNIVLLAGFQSP
HHHHHHHCCHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEECCCC
GTRGFSLLNGAREIKIHGLYVEINCKVIPSDSFSAHADRSDLMTWLKQAPEIPKRMFLVH
CCCCHHHHCCCEEEEEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEE
GEPVAADELRKRIDKELKWYVTVPRMGQIIST
CCCCCHHHHHHHHCCCEEEEEECCCCCHHHCC
>Mature Secondary Structure
MEIGFLGAAGTVTGSKFLVHNNDTRILVDCGMFQGFKELRELNWEDFPFDPRDIQAVVLT
CCEEEEECCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHCCCCCCCCCCHHCEEEEEE
HAHLDHCGALPLLVKKGFKGPIYCTEPTLELTKIILLDSAKIQEEDADYANKKGFSKHSP
EHHHHHCCCCHHHHHCCCCCCEEECCCCHHEEEEEEECCCCCCCCCCCHHHCCCCCCCCC
ALALYTTEDVERTLPLLRPVNLHTQFEIGSLKVCFYSSGHILGAASATISNGEKSIHFSG
EEEEEEHHHHHHHHHHHCCCCCCEEEECCCEEEEEEECCCEEEEEEEEECCCCEEEEECC
DLGRYNDPLMPAPEPPAKADYLVMESTYGDRDHSPKTSKEVLKECILEIVKSRGVLLIPS
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEC
FAVGRAQNLLFEITELKRDGEVPAQIPVYFNSPMGHEVALLYEKYHPFHRLGSGQFAEVM
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEHHCCHHHHCCCCHHHHHH
SEVHTIKTAEESRALNDDKSGPKIIIAASGMLTGGRVLHHLKAFGPDSRNIVLLAGFQSP
HHHHHHHCCHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEECCCC
GTRGFSLLNGAREIKIHGLYVEINCKVIPSDSFSAHADRSDLMTWLKQAPEIPKRMFLVH
CCCCHHHHCCCEEEEEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEE
GEPVAADELRKRIDKELKWYVTVPRMGQIIST
CCCCCHHHHHHHHCCCEEEEEECCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA