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The map label for this gene is plsC [C]

Identifier: 42523329

GI number: 42523329

Start: 1773773

End: 1774510

Strand: Direct

Name: plsC [C]

Synonym: Bd1844

Alternate gene names: 42523329

Gene position: 1773773-1774510 (Clockwise)

Preceding gene: 42523328

Following gene: 42523330

Centisome position: 46.89

GC content: 53.52

Gene sequence:

>738_bases
ATGTTTTTAAAACTTCTTTCTTATCCTCGTTCTTTGCTGGGTGCGCTTCTGCTGCCGATTCACACGGTGCTGTGTTCTGC
GGCGATGGTCATCTGCAATATTCTGTTTAACAACCGCAAGCTGGAAGACCACATCGTCGAGTTCTGGACCCGCAACTGCT
GTCGCATGTTCAATGTGAAAGTGGAAGTCAAAGGCCTGGAAAACCGTCCCGAAGGCGGCTTCCTGTACGTCTTTAATCAC
ACCAGTTTCTTCGACATCTTTGCCATGAACGGCTGGTTGGGGTCTTTCCGTTTCGGGGCAAAAATTGAACTTTTCAGCAT
TCCGGTGTTTGGCGCCGGGATGAGACGCGCCGGCATTCTGCCCATCGCCAGAAATCGTCGTGACGAGGTCTTTAAAGTCT
ATCAGGCCGCCGAAGCGCGCATCAAAGCCGGAGAGCGTTTTGCATTGGCGCCGGAAGGTACGCGCCAGAAAACCGAAACT
CTGGGGCCCTTCAAGTCCGGTCCGTTCATCTTCGCCATCAGCGCCAAAGCACCAATCGTGCCGGTCGTTGTGAAGGGGGC
CGCCGCGATCATGTCCAAAGGGCAGCTTGTTCCGAATTGGGGCGTGTGGAGTCGCACAATCACGCTGGAGGTTCTTCCTC
CGGTCAGCACCGAAGGATACACTATTGAAGATCGTCCCGTGCTGCAGGAAAAGGTTCGCAAAATGATGGAGCCTTACTTC
GCAGTGGACAACTTCTAA

Upstream 100 bases:

>100_bases
CTCACGACCGTATTTTGTCCGGTCCCAGCGAACATCAGGCTTACAAGGAACGTCAACGAACGGCCGCCAGAAAGCGTCTG
TTTCCGGATCCAGGTTAATT

Downstream 100 bases:

>100_bases
CGTCCAATTTCGAATTTCCAAACGGGGGTTTGGGTGAAAAGCTTTCAGGAGTTCTGGCCTCTGTTCTGACGAAGCAATGG
AACCTGCGGGGGGATTTTAA

Product: putative lysophosphatidic acid acyltransferase

Products: CoA; 1,2-diacyl-sn-glycerol 3-phosphate

Alternate protein names: Phospholipid/Glycerol Acyltransferase; Acyltransferase; 1-Acylglycerol-3-Phosphate O-Acyltransferase; 1-Acyl-Sn-Glycerol-3-Phosphate Acetyltransferase; Acyltransferase Family Protein; Acetyltransferase; 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferases; HAD Family Hydrolase; 1-Acyl-SN-Glycerol-3-Phosphate Acyltransferase; HAD-Superfamily Hydrolase; Lyso-Ornithine Lipid Acyltransferase; Lysophosphatidic Acid Acyltransferase; Bifunctional Phospholipid Biosynthesis PlsC; 1-Acyl-Sn-Glycerol-3-Phosphateacyltransferase; Phospholipids Biosynthesis-Related Protein; [Acyl-]Glycerolphosphate Acyltransferase; Phosphoserine Phosphatase; 2-Acylglycerophosphoethanolamine Acyltransferase; HAD-Superfamily Subfamily IB Hydrolase; Acyltransferase Domain Protein; AMP-Dependent Synthetase And Ligase; 1-Acyl-Glycerol-3-Phosphate Acyltransferase; 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase PlsC; Bifunctional Transmembrane Phospholipid Biosynthesis PlsC; Long-Chain-Fatty-Acid-CoA Ligase; Acyltransferase Family

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MFLKLLSYPRSLLGALLLPIHTVLCSAAMVICNILFNNRKLEDHIVEFWTRNCCRMFNVKVEVKGLENRPEGGFLYVFNH
TSFFDIFAMNGWLGSFRFGAKIELFSIPVFGAGMRRAGILPIARNRRDEVFKVYQAAEARIKAGERFALAPEGTRQKTET
LGPFKSGPFIFAISAKAPIVPVVVKGAAAIMSKGQLVPNWGVWSRTITLEVLPPVSTEGYTIEDRPVLQEKVRKMMEPYF
AVDNF

Sequences:

>Translated_245_residues
MFLKLLSYPRSLLGALLLPIHTVLCSAAMVICNILFNNRKLEDHIVEFWTRNCCRMFNVKVEVKGLENRPEGGFLYVFNH
TSFFDIFAMNGWLGSFRFGAKIELFSIPVFGAGMRRAGILPIARNRRDEVFKVYQAAEARIKAGERFALAPEGTRQKTET
LGPFKSGPFIFAISAKAPIVPVVVKGAAAIMSKGQLVPNWGVWSRTITLEVLPPVSTEGYTIEDRPVLQEKVRKMMEPYF
AVDNF
>Mature_245_residues
MFLKLLSYPRSLLGALLLPIHTVLCSAAMVICNILFNNRKLEDHIVEFWTRNCCRMFNVKVEVKGLENRPEGGFLYVFNH
TSFFDIFAMNGWLGSFRFGAKIELFSIPVFGAGMRRAGILPIARNRRDEVFKVYQAAEARIKAGERFALAPEGTRQKTET
LGPFKSGPFIFAISAKAPIVPVVVKGAAAIMSKGQLVPNWGVWSRTITLEVLPPVSTEGYTIEDRPVLQEKVRKMMEPYF
AVDNF

Specific function: Converts Lysophosphatidic Acid (Lpa) Into Phosphatidic Acid By Incorporating An Acyl Moiety At The 2 Position. This Enzyme Can Utilize Either Acyl-CoA Or Acyl-Acyl Carrier Protein As The Fatty Acyl Donor. [C]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI5453718, Length=188, Percent_Identity=32.4468085106383, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI15100175, Length=188, Percent_Identity=32.4468085106383, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI6041665, Length=233, Percent_Identity=27.0386266094421, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17564032, Length=187, Percent_Identity=28.8770053475936, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320151, Length=243, Percent_Identity=30.0411522633745, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281364648, Length=197, Percent_Identity=31.9796954314721, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24582856, Length=197, Percent_Identity=31.9796954314721, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24582854, Length=197, Percent_Identity=31.9796954314721, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24641614, Length=201, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24641612, Length=201, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.3.1.51

Molecular weight: Translated: 27582; Mature: 27582

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLKLLSYPRSLLGALLLPIHTVLCSAAMVICNILFNNRKLEDHIVEFWTRNCCRMFNVK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEE
VEVKGLENRPEGGFLYVFNHTSFFDIFAMNGWLGSFRFGAKIELFSIPVFGAGMRRAGIL
EEEEECCCCCCCCEEEEECCCCEEEEEEECCCCCCEECCCEEEEEEECEECCCCCCCCCC
PIARNRRDEVFKVYQAAEARIKAGERFALAPEGTRQKTETLGPFKSGPFIFAISAKAPIV
CCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCCCCCCEEEEEECCCCEE
PVVVKGAAAIMSKGQLVPNWGVWSRTITLEVLPPVSTEGYTIEDRPVLQEKVRKMMEPYF
EEEEHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCEEECCCHHHHHHHHHHHCHHH
AVDNF
HCCCC
>Mature Secondary Structure
MFLKLLSYPRSLLGALLLPIHTVLCSAAMVICNILFNNRKLEDHIVEFWTRNCCRMFNVK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEE
VEVKGLENRPEGGFLYVFNHTSFFDIFAMNGWLGSFRFGAKIELFSIPVFGAGMRRAGIL
EEEEECCCCCCCCEEEEECCCCEEEEEEECCCCCCEECCCEEEEEEECEECCCCCCCCCC
PIARNRRDEVFKVYQAAEARIKAGERFALAPEGTRQKTETLGPFKSGPFIFAISAKAPIV
CCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCCCCCCEEEEEECCCCEE
PVVVKGAAAIMSKGQLVPNWGVWSRTITLEVLPPVSTEGYTIEDRPVLQEKVRKMMEPYF
EEEEHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCEEECCCHHHHHHHHHHHCHHH
AVDNF
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; 1-acyl-sn-glycerol 3-phosphate

Specific reaction: acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

General reaction: Acyl group transfer [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA