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The map label for this gene is 42523132

Identifier: 42523132

GI number: 42523132

Start: 1566251

End: 1567231

Strand: Direct

Name: 42523132

Synonym: Bd1629

Alternate gene names: NA

Gene position: 1566251-1567231 (Clockwise)

Preceding gene: 42523131

Following gene: 42523133

Centisome position: 41.4

GC content: 49.75

Gene sequence:

>981_bases
ATGAAACAAGTGACTGTATCTGCTCCATCCAATATCGCCCTTATCAAGTACATGGGTAAAATTGAGGGCTCTGGCAATAA
ACCGACCAACGGTTCGTTGTCCTATACTTTGGAAAACCTGCGCACCTATGTTCGCCTGACTGAAGTCGACGGCGCACAAG
ATCAGTGGAAACCCTTGGTTCGTGAAGACCTGCAAAAAATCGAATTGTCTGAAAAAGGCCAGCAGCGCTTTATCAAGCAC
CTGCAAAATCTAAAGGACAAGTGGGGCATAAAACAAAGTTTCCTGATTGAGTCCGCGAACAATTTCCCATCAGACTGCGG
TCTGGCCAGCTCGGCTTCCAGTTTTGCGGCCCTGACTTTGGCGGCGGCAGAAATGTTCCAGCAGATCAACCCACAGCCGT
GGGGCACGGATAAAAAATATCTTTCCGAGCTTTCCCGCCAGGGTTCGGGTTCTTCCTGCCGTTCCTTGTTCACACCGTGG
GCGTTGTGGCAGCATGAGTACGCCGAGCCGATGGCGTTTGAAGTCAAAAACCTGCACCACATGGTGGTGATTGTCGAAGA
CTCTAAAAAAGAGGTTTCCAGTTCTGAGGCGCACAAACTTGTGACCACAAGCCCGCGTTTCACCGGTCGTCCAGAGCGTG
CGGAATTGCGCCTGAAAGACCTAAGCATGGCCTTGCAGTTCAATGACTGGCATATCGCGCGTCAGATCGTCTGGGATGAG
TTCATCGATATGCACCGTTTGTTTGAAACCAGCACGCCGTCTTTCACTTATATGAACGATGGATCCAAAAAGGTTCTGGA
AGATTGCCAGGCGTTTTGGAACAAATGGCAAGATGGCCCTTTGGTGACCATGGATGCGGGTGCCAACGTGCACTTGTTGT
TCCGTCATGATCAGAAAAAACAGTTCGCGCAGTATCGTGAGCATTTTGAAAAGGACTTCAAGGTCATGGCCTTTGAAGGT
GTGAAAGACAATGTCCATTGA

Upstream 100 bases:

>100_bases
GTGAAACTGCAGGTGTTAAAGCCTACTGTGAAAGCAAGGGCCTGTCCGTGCTTTCTTCCTCTGATAAAATCTCGTCCGGA
CTTCAGGTCCGAGGTAGCCT

Downstream 100 bases:

>100_bases
TTTCACCTGCAAAGCCTTTGGTAAATGTATCATAGCTGGTGAGCACGCGGTTTTGCGTGGTGTACCGGCGGTGGTATTTC
CCATCCAGTCCCGCAATCTG

Product: diphosphomevalonate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; GHMP Kinase

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MKQVTVSAPSNIALIKYMGKIEGSGNKPTNGSLSYTLENLRTYVRLTEVDGAQDQWKPLVREDLQKIELSEKGQQRFIKH
LQNLKDKWGIKQSFLIESANNFPSDCGLASSASSFAALTLAAAEMFQQINPQPWGTDKKYLSELSRQGSGSSCRSLFTPW
ALWQHEYAEPMAFEVKNLHHMVVIVEDSKKEVSSSEAHKLVTTSPRFTGRPERAELRLKDLSMALQFNDWHIARQIVWDE
FIDMHRLFETSTPSFTYMNDGSKKVLEDCQAFWNKWQDGPLVTMDAGANVHLLFRHDQKKQFAQYREHFEKDFKVMAFEG
VKDNVH

Sequences:

>Translated_326_residues
MKQVTVSAPSNIALIKYMGKIEGSGNKPTNGSLSYTLENLRTYVRLTEVDGAQDQWKPLVREDLQKIELSEKGQQRFIKH
LQNLKDKWGIKQSFLIESANNFPSDCGLASSASSFAALTLAAAEMFQQINPQPWGTDKKYLSELSRQGSGSSCRSLFTPW
ALWQHEYAEPMAFEVKNLHHMVVIVEDSKKEVSSSEAHKLVTTSPRFTGRPERAELRLKDLSMALQFNDWHIARQIVWDE
FIDMHRLFETSTPSFTYMNDGSKKVLEDCQAFWNKWQDGPLVTMDAGANVHLLFRHDQKKQFAQYREHFEKDFKVMAFEG
VKDNVH
>Mature_326_residues
MKQVTVSAPSNIALIKYMGKIEGSGNKPTNGSLSYTLENLRTYVRLTEVDGAQDQWKPLVREDLQKIELSEKGQQRFIKH
LQNLKDKWGIKQSFLIESANNFPSDCGLASSASSFAALTLAAAEMFQQINPQPWGTDKKYLSELSRQGSGSSCRSLFTPW
ALWQHEYAEPMAFEVKNLHHMVVIVEDSKKEVSSSEAHKLVTTSPRFTGRPERAELRLKDLSMALQFNDWHIARQIVWDE
FIDMHRLFETSTPSFTYMNDGSKKVLEDCQAFWNKWQDGPLVTMDAGANVHLLFRHDQKKQFAQYREHFEKDFKVMAFEG
VKDNVH

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=327, Percent_Identity=28.1345565749235, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537201, Length=329, Percent_Identity=25.531914893617, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324371, Length=326, Percent_Identity=32.8220858895706, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28571205, Length=320, Percent_Identity=27.1875, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 37428; Mature: 37428

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVTVSAPSNIALIKYMGKIEGSGNKPTNGSLSYTLENLRTYVRLTEVDGAQDQWKPLV
CCEEEECCCCCEEEEEEEHHHCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHH
REDLQKIELSEKGQQRFIKHLQNLKDKWGIKQSFLIESANNFPSDCGLASSASSFAALTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
AAAEMFQQINPQPWGTDKKYLSELSRQGSGSSCRSLFTPWALWQHEYAEPMAFEVKNLHH
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHCCCHHHHHCCCEE
MVVIVEDSKKEVSSSEAHKLVTTSPRFTGRPERAELRLKDLSMALQFNDWHIARQIVWDE
EEEEEECCCHHHCCHHHCEEEECCCCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHHH
FIDMHRLFETSTPSFTYMNDGSKKVLEDCQAFWNKWQDGPLVTMDAGANVHLLFRHDQKK
HHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCHHH
QFAQYREHFEKDFKVMAFEGVKDNVH
HHHHHHHHHHHCCEEEEEECCCCCCC
>Mature Secondary Structure
MKQVTVSAPSNIALIKYMGKIEGSGNKPTNGSLSYTLENLRTYVRLTEVDGAQDQWKPLV
CCEEEECCCCCEEEEEEEHHHCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHH
REDLQKIELSEKGQQRFIKHLQNLKDKWGIKQSFLIESANNFPSDCGLASSASSFAALTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
AAAEMFQQINPQPWGTDKKYLSELSRQGSGSSCRSLFTPWALWQHEYAEPMAFEVKNLHH
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHCCCHHHHHCCCEE
MVVIVEDSKKEVSSSEAHKLVTTSPRFTGRPERAELRLKDLSMALQFNDWHIARQIVWDE
EEEEEECCCHHHCCHHHCEEEECCCCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHHH
FIDMHRLFETSTPSFTYMNDGSKKVLEDCQAFWNKWQDGPLVTMDAGANVHLLFRHDQKK
HHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCHHH
QFAQYREHFEKDFKVMAFEGVKDNVH
HHHHHHHHHHHCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA