Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 42523121

GI number: 42523121

Start: 1547566

End: 1549536

Strand: Direct

Name: thrS

Synonym: Bd1617

Alternate gene names: 42523121

Gene position: 1547566-1549536 (Clockwise)

Preceding gene: 42523120

Following gene: 42523122

Centisome position: 40.91

GC content: 48.35

Gene sequence:

>1971_bases
ATGCTAATGTCACAAATTACAATTATTTTGCCGGATAACTCTACGAAGGTTTTTGACCATGAACCGACAGCGCTGGAAGT
GGCGATGTCCATTGGCCCTCGCTTGGCCAAAGAAACTCTGGGTGCAAAACTGAACGGATCAACTGAAATCTCTGATCTTC
GCACCGTTTTGAAAGATCAAACGAAGGTGGCCCTGGTCACCACAAAATCTCCTGAATCAGTTGAGGTTGTTCGTCACTCC
TGCGCGCATATCATGGCCCAGGCGATTCAGGACATCTGGCCTGAAGTGAAAGTGACTATCGGTCCGGTGATCGACAATGG
TTTCTATTACGATTTTGATTCTCCGTTTGCCTTCACGGAAGAGCACTTCGAGAAAATCGAAAAGAAGATGTCTGAGATCG
TATCCAAGGATCTGCCAATTCATCGTGAAGACTGGCCGATTCAAAAAGCGATCGAGACCTTCAAGGGCATGAACGAACGC
TTTAAAGTTGAGTTGATCGAGGACCTGGCTAAAAAAGGCGAGACCACTGTTGGCATCTACTTTAACGGCACCAGCTGGTT
TGATCTGTGCCGCGGTCCTCATATCCAATCCACAGGCCAGATCAAAGCGTTCAAACTTTTGAGCGTGGCGGGGGCTTACT
GGAGAGGCGACGAGAAAAACGCCCAGCTTCAGCGCGTGTATGCGACAGCGTTCAACGACAAGAAAGATCTGGAAACATAT
CTTCACAATATCGAAGAAGCCAAAAAACGCGACCACCGTAAACTGGGTAAAGAACTGGGCATGTTCTATTTCAACGAACT
GGCTCCGGGTTCTCCATTCTTCACGGGCAAGGGTGCGACGGTTTACAACTCTTTGCAGACTTATCTGCGTGAGCTGTACT
TCGAAACAGGTTACCAGGAAGTGATCACGCCGCAGATCTTTGACGTGAACCTGTTCCATACGTCCGGTCACTATCAGAAC
TACAAAGAAAACATGTTCTTCACCAAAGTGGATGAGCGTGATTTTGCTTCCAAACCAATGAACTGTCCTTCTCACTGCTT
GCTTTATAACTCTGAGAAGTATTCTTACCGTGATCTGCCTATCAAAATGGCGGACTTTGGTCGTTTGCACCGTTATGAAA
AATCGGGTGCCATGCACGGTTTGACTCGTGTGCGTACGTTCTGTCAGGACGACGCGCACATCTTCTGCCGCATGGATCAG
TTGCAGGAAGAAATCGCCAAGTTCATGAACCTGCTGAATCGTGTTTACGACAAGCTGGGCATGGGCAATTACAAGATCTT
CCTTTCCACTCGTCCGGACAACCGTATGGGCAGTGAGGAATACTGGGATATGGCAGAGGGCGCCTTGGCGGAAGCCTTGA
AATCCCTGAATTTGCCATTTGAGCTGAATCCAGGGGACGGGGCCTTCTATGGACCTAAGTTGGATATCATGTTCGTCGAT
GCATTGAATCGTCCTTGGCAGTTGGGTACACTTCAAGTGGATCCAAATCTTCCGCAGGCGTTTGATTTGAAATACACGGG
CGAGGACAACAAGGAGCACCGTCCAGTGATGCTTCATCGTGCGATCCTGGGCTCTTTGGAGCGCTTTATCGGCGTTTACC
TGGAGCACACGGCAGGTCACCTGCCACCGTGGATGATGCCAGTGCAAGTGGCGATCCTGAATGTGACGGACCGTGTGAAC
TCGTTCTGCGAAGAGTTGCAAAACTCTTTGAAAGGACACAGTGTTCGCGTTGAGTTTGACCGCCGTAACGAGAAGTTGAA
TTATAAAATCCGTGAGGCGCAGCTTCAGAAGATTCCATACATGATTATTGTGGGGGATAAAGAGGCTGAATCCAGAACGG
TTTCATTGCGTTTGAGAGACGGTTCAGAACACAAAGGTCTGACTGTGGATCAGGTGATGAATTTGATTACGACAGATATT
AAAACAAGAAGTTTGCAGAGCTCTCTTGCGAAGTCTGCAACGACAAACTAG

Upstream 100 bases:

>100_bases
CTAATGTGATGCAAATGCATAATTATTCATCACATTTTCAAACCAGTACGGCGCATTCTGCGACGACCCTTTCTGACTCC
GGCCAAGCCGGAGTGCAAGC

Downstream 100 bases:

>100_bases
ACGGCGCACTTAAGCGACGCTAGAATTTAACTTAAATTACTCCGGCGAAGCCGGAGTGTAAGCCAGTGGAGGTTTACCAT
TAGCAAGTTTGAAGGTAATT

Product: hypothetical protein

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MLMSQITIILPDNSTKVFDHEPTALEVAMSIGPRLAKETLGAKLNGSTEISDLRTVLKDQTKVALVTTKSPESVEVVRHS
CAHIMAQAIQDIWPEVKVTIGPVIDNGFYYDFDSPFAFTEEHFEKIEKKMSEIVSKDLPIHREDWPIQKAIETFKGMNER
FKVELIEDLAKKGETTVGIYFNGTSWFDLCRGPHIQSTGQIKAFKLLSVAGAYWRGDEKNAQLQRVYATAFNDKKDLETY
LHNIEEAKKRDHRKLGKELGMFYFNELAPGSPFFTGKGATVYNSLQTYLRELYFETGYQEVITPQIFDVNLFHTSGHYQN
YKENMFFTKVDERDFASKPMNCPSHCLLYNSEKYSYRDLPIKMADFGRLHRYEKSGAMHGLTRVRTFCQDDAHIFCRMDQ
LQEEIAKFMNLLNRVYDKLGMGNYKIFLSTRPDNRMGSEEYWDMAEGALAEALKSLNLPFELNPGDGAFYGPKLDIMFVD
ALNRPWQLGTLQVDPNLPQAFDLKYTGEDNKEHRPVMLHRAILGSLERFIGVYLEHTAGHLPPWMMPVQVAILNVTDRVN
SFCEELQNSLKGHSVRVEFDRRNEKLNYKIREAQLQKIPYMIIVGDKEAESRTVSLRLRDGSEHKGLTVDQVMNLITTDI
KTRSLQSSLAKSATTN

Sequences:

>Translated_656_residues
MLMSQITIILPDNSTKVFDHEPTALEVAMSIGPRLAKETLGAKLNGSTEISDLRTVLKDQTKVALVTTKSPESVEVVRHS
CAHIMAQAIQDIWPEVKVTIGPVIDNGFYYDFDSPFAFTEEHFEKIEKKMSEIVSKDLPIHREDWPIQKAIETFKGMNER
FKVELIEDLAKKGETTVGIYFNGTSWFDLCRGPHIQSTGQIKAFKLLSVAGAYWRGDEKNAQLQRVYATAFNDKKDLETY
LHNIEEAKKRDHRKLGKELGMFYFNELAPGSPFFTGKGATVYNSLQTYLRELYFETGYQEVITPQIFDVNLFHTSGHYQN
YKENMFFTKVDERDFASKPMNCPSHCLLYNSEKYSYRDLPIKMADFGRLHRYEKSGAMHGLTRVRTFCQDDAHIFCRMDQ
LQEEIAKFMNLLNRVYDKLGMGNYKIFLSTRPDNRMGSEEYWDMAEGALAEALKSLNLPFELNPGDGAFYGPKLDIMFVD
ALNRPWQLGTLQVDPNLPQAFDLKYTGEDNKEHRPVMLHRAILGSLERFIGVYLEHTAGHLPPWMMPVQVAILNVTDRVN
SFCEELQNSLKGHSVRVEFDRRNEKLNYKIREAQLQKIPYMIIVGDKEAESRTVSLRLRDGSEHKGLTVDQVMNLITTDI
KTRSLQSSLAKSATTN
>Mature_656_residues
MLMSQITIILPDNSTKVFDHEPTALEVAMSIGPRLAKETLGAKLNGSTEISDLRTVLKDQTKVALVTTKSPESVEVVRHS
CAHIMAQAIQDIWPEVKVTIGPVIDNGFYYDFDSPFAFTEEHFEKIEKKMSEIVSKDLPIHREDWPIQKAIETFKGMNER
FKVELIEDLAKKGETTVGIYFNGTSWFDLCRGPHIQSTGQIKAFKLLSVAGAYWRGDEKNAQLQRVYATAFNDKKDLETY
LHNIEEAKKRDHRKLGKELGMFYFNELAPGSPFFTGKGATVYNSLQTYLRELYFETGYQEVITPQIFDVNLFHTSGHYQN
YKENMFFTKVDERDFASKPMNCPSHCLLYNSEKYSYRDLPIKMADFGRLHRYEKSGAMHGLTRVRTFCQDDAHIFCRMDQ
LQEEIAKFMNLLNRVYDKLGMGNYKIFLSTRPDNRMGSEEYWDMAEGALAEALKSLNLPFELNPGDGAFYGPKLDIMFVD
ALNRPWQLGTLQVDPNLPQAFDLKYTGEDNKEHRPVMLHRAILGSLERFIGVYLEHTAGHLPPWMMPVQVAILNVTDRVN
SFCEELQNSLKGHSVRVEFDRRNEKLNYKIREAQLQKIPYMIIVGDKEAESRTVSLRLRDGSEHKGLTVDQVMNLITTDI
KTRSLQSSLAKSATTN

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=648, Percent_Identity=39.1975308641975, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI38570111, Length=632, Percent_Identity=38.7658227848101, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI20070344, Length=618, Percent_Identity=39.1585760517799, Blast_Score=421, Evalue=1e-118,
Organism=Escherichia coli, GI1788013, Length=641, Percent_Identity=44.4617784711388, Blast_Score=604, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI71984192, Length=636, Percent_Identity=39.1509433962264, Blast_Score=465, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71984184, Length=636, Percent_Identity=39.1509433962264, Blast_Score=465, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322112, Length=651, Percent_Identity=38.863287250384, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322654, Length=403, Percent_Identity=39.9503722084367, Blast_Score=310, Evalue=6e-85,
Organism=Drosophila melanogaster, GI24583842, Length=631, Percent_Identity=41.838351822504, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI28574141, Length=631, Percent_Identity=41.838351822504, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24583839, Length=631, Percent_Identity=41.838351822504, Blast_Score=495, Evalue=1e-140,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_BDEBA (Q6MML0)

Other databases:

- EMBL:   BX842650
- RefSeq:   NP_968501.1
- ProteinModelPortal:   Q6MML0
- SMR:   Q6MML0
- GeneID:   2735370
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd1617
- NMPDR:   fig|264462.1.peg.1471
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- PhylomeDB:   Q6MML0
- BioCyc:   BBAC264462:BD1617-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 75229; Mature: 75229

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMSQITIILPDNSTKVFDHEPTALEVAMSIGPRLAKETLGAKLNGSTEISDLRTVLKDQ
CCCCCEEEEECCCCCEEECCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHCC
TKVALVTTKSPESVEVVRHSCAHIMAQAIQDIWPEVKVTIGPVIDNGFYYDFDSPFAFTE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEECCCCCCCHHH
EHFEKIEKKMSEIVSKDLPIHREDWPIQKAIETFKGMNERFKVELIEDLAKKGETTVGIY
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEE
FNGTSWFDLCRGPHIQSTGQIKAFKLLSVAGAYWRGDEKNAQLQRVYATAFNDKKDLETY
ECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHH
LHNIEEAKKRDHRKLGKELGMFYFNELAPGSPFFTGKGATVYNSLQTYLRELYFETGYQE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCHH
VITPQIFDVNLFHTSGHYQNYKENMFFTKVDERDFASKPMNCPSHCLLYNSEKYSYRDLP
HCCCEEEEEEEEECCCCCCCHHCCEEEEECCCCHHCCCCCCCCCEEEEECCCCCCCCCCC
IKMADFGRLHRYEKSGAMHGLTRVRTFCQDDAHIFCRMDQLQEEIAKFMNLLNRVYDKLG
EEHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHC
MGNYKIFLSTRPDNRMGSEEYWDMAEGALAEALKSLNLPFELNPGDGAFYGPKLDIMFVD
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCEEEEEEEE
ALNRPWQLGTLQVDPNLPQAFDLKYTGEDNKEHRPVMLHRAILGSLERFIGVYLEHTAGH
CCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LPPWMMPVQVAILNVTDRVNSFCEELQNSLKGHSVRVEFDRRNEKLNYKIREAQLQKIPY
CCCCHHHHHHEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEHHHHHHHHCCE
MIIVGDKEAESRTVSLRLRDGSEHKGLTVDQVMNLITTDIKTRSLQSSLAKSATTN
EEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLMSQITIILPDNSTKVFDHEPTALEVAMSIGPRLAKETLGAKLNGSTEISDLRTVLKDQ
CCCCCEEEEECCCCCEEECCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHCC
TKVALVTTKSPESVEVVRHSCAHIMAQAIQDIWPEVKVTIGPVIDNGFYYDFDSPFAFTE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEECCCCCCCHHH
EHFEKIEKKMSEIVSKDLPIHREDWPIQKAIETFKGMNERFKVELIEDLAKKGETTVGIY
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEE
FNGTSWFDLCRGPHIQSTGQIKAFKLLSVAGAYWRGDEKNAQLQRVYATAFNDKKDLETY
ECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHH
LHNIEEAKKRDHRKLGKELGMFYFNELAPGSPFFTGKGATVYNSLQTYLRELYFETGYQE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCHH
VITPQIFDVNLFHTSGHYQNYKENMFFTKVDERDFASKPMNCPSHCLLYNSEKYSYRDLP
HCCCEEEEEEEEECCCCCCCHHCCEEEEECCCCHHCCCCCCCCCEEEEECCCCCCCCCCC
IKMADFGRLHRYEKSGAMHGLTRVRTFCQDDAHIFCRMDQLQEEIAKFMNLLNRVYDKLG
EEHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHC
MGNYKIFLSTRPDNRMGSEEYWDMAEGALAEALKSLNLPFELNPGDGAFYGPKLDIMFVD
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCEEEEEEEE
ALNRPWQLGTLQVDPNLPQAFDLKYTGEDNKEHRPVMLHRAILGSLERFIGVYLEHTAGH
CCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LPPWMMPVQVAILNVTDRVNSFCEELQNSLKGHSVRVEFDRRNEKLNYKIREAQLQKIPY
CCCCHHHHHHEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEHHHHHHHHCCE
MIIVGDKEAESRTVSLRLRDGSEHKGLTVDQVMNLITTDIKTRSLQSSLAKSATTN
EEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA