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The map label for this gene is pepP [H]

Identifier: 42522891

GI number: 42522891

Start: 1297429

End: 1298703

Strand: Direct

Name: pepP [H]

Synonym: Bd1372

Alternate gene names: 42522891

Gene position: 1297429-1298703 (Clockwise)

Preceding gene: 42522890

Following gene: 42522894

Centisome position: 34.3

GC content: 51.92

Gene sequence:

>1275_bases
ATGTTGTTTGCTGAAAGTGTTTATAAGACCCGTCAGGGGAAAGTGGCCGACGCCTGGAAAGGCCTGTTAGGTCCCCAGGA
TCTGGTCCTGATTCACAGTGGTGAGGCCGTGCAAAAGCCGGGTGGCCTGGATCAGACGTATGATTTTCTGCCTCATCCCT
CCTATTTCTGGCTGACCGGACACCGCCGTGATGAAGGTGTCATGGCTTATTCTGTGAGCGAAGGCTGGATTGAACATCAA
CGTCCACTCAGTCCCGTGGACATCGTCTGGGAGGGCGCTGAAGGAAATTTTGAATGCGAACACACTCTGGTGGATCTGCA
AAAGAAGTTGCAGGGCGGGGCGTACAAGCGCGTGTTCCACCTGGGACAGACATCAGAAAAGTCATTTGAAGCCGAAACCC
GCGAACTGTCGATCAAGCTGGATCAGGTTCGTCGTTGCAAAGATTCACACGAAGTTCAGTTGATTCGTCAGATCGCTGCG
ATGGCCAACAAAGGTTATCAGGCGTTGCAAAATGCATTAAGACCGGGAATCACCGAGCGTGAACTGCAATTGCATTATGA
AAACGCCGTGTTGATGGCGGGCGCTGACAAGATGCCTTACGGTTCGATTGTGGGCAGTGGCGAAAACGCGGCAATCTTGC
ACGCGGTTCCGACCAAAAAGAAAGTTGTTTCTGGCGAATTGGTGCTGGTTGATGCCGGTGCTGATATTGAAGACTATTGT
GTCGATATCACCCGCGTATTCGCTGTGGATGGTAAGTTCACCGGGCAGCAAAAGGATGTTTATGACCTGGTTCATGACGC
TTATAAAGCCTCTGTGGCCCTGTGCCGCCCGGGGACTCAGTGGCGTGATGTTCATATGAAATCCGCCCGCGTGATTGCTG
AAGGTTTGCAGCAGTGGGGCATTTGGAAAAGCTCCGTGGATGCGGCTTTGGAATCCGGCGCGATTTCCGTATTCTATCCG
CATGGCGTGGGTCACCTGGTGGGCTTGAAAGTGCGTGACACCGGCAATCCGGAAAACGTGAATCCACAACGCTATTACGG
AGCTCGTCTGCGTGTGGATCTGGAGTTAAAAGAAAATTACCTGATCACGGTTGAGCCGGGCTGCTATTTCGCCCGTGCGT
TTATTGAAGACAATGACCTCCGCGAAAAATACAAGGACCACATTCAGTGGTCCGAGGCTGAAAAGTGGAAGTCCTTTGGC
GGGGTTCGTCTGGAAGATGACATCCTGATCACAAAAGGTGAGGCAGAGAGTCTTACCAACGTTGTTCTCAAGTAA

Upstream 100 bases:

>100_bases
TGTTCAACCGGGTTGTCGAGCTGCCATCAAGTCACTAAGAAATTGAAAATTCAAACGACGAAGGCAGCCCCGAGCTGCCT
TTGTTTTATAGGTGGTCGCT

Downstream 100 bases:

>100_bases
AATTACAACGAGGTCTCCTGGCCGGCTTTAAGCCAGGAGGACCACTTCTGTGAATCATAGTCTAAATCTGGGACACTTTC
ATGGGCCTCCATTGACGTGT

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLFAESVYKTRQGKVADAWKGLLGPQDLVLIHSGEAVQKPGGLDQTYDFLPHPSYFWLTGHRRDEGVMAYSVSEGWIEHQ
RPLSPVDIVWEGAEGNFECEHTLVDLQKKLQGGAYKRVFHLGQTSEKSFEAETRELSIKLDQVRRCKDSHEVQLIRQIAA
MANKGYQALQNALRPGITERELQLHYENAVLMAGADKMPYGSIVGSGENAAILHAVPTKKKVVSGELVLVDAGADIEDYC
VDITRVFAVDGKFTGQQKDVYDLVHDAYKASVALCRPGTQWRDVHMKSARVIAEGLQQWGIWKSSVDAALESGAISVFYP
HGVGHLVGLKVRDTGNPENVNPQRYYGARLRVDLELKENYLITVEPGCYFARAFIEDNDLREKYKDHIQWSEAEKWKSFG
GVRLEDDILITKGEAESLTNVVLK

Sequences:

>Translated_424_residues
MLFAESVYKTRQGKVADAWKGLLGPQDLVLIHSGEAVQKPGGLDQTYDFLPHPSYFWLTGHRRDEGVMAYSVSEGWIEHQ
RPLSPVDIVWEGAEGNFECEHTLVDLQKKLQGGAYKRVFHLGQTSEKSFEAETRELSIKLDQVRRCKDSHEVQLIRQIAA
MANKGYQALQNALRPGITERELQLHYENAVLMAGADKMPYGSIVGSGENAAILHAVPTKKKVVSGELVLVDAGADIEDYC
VDITRVFAVDGKFTGQQKDVYDLVHDAYKASVALCRPGTQWRDVHMKSARVIAEGLQQWGIWKSSVDAALESGAISVFYP
HGVGHLVGLKVRDTGNPENVNPQRYYGARLRVDLELKENYLITVEPGCYFARAFIEDNDLREKYKDHIQWSEAEKWKSFG
GVRLEDDILITKGEAESLTNVVLK
>Mature_424_residues
MLFAESVYKTRQGKVADAWKGLLGPQDLVLIHSGEAVQKPGGLDQTYDFLPHPSYFWLTGHRRDEGVMAYSVSEGWIEHQ
RPLSPVDIVWEGAEGNFECEHTLVDLQKKLQGGAYKRVFHLGQTSEKSFEAETRELSIKLDQVRRCKDSHEVQLIRQIAA
MANKGYQALQNALRPGITERELQLHYENAVLMAGADKMPYGSIVGSGENAAILHAVPTKKKVVSGELVLVDAGADIEDYC
VDITRVFAVDGKFTGQQKDVYDLVHDAYKASVALCRPGTQWRDVHMKSARVIAEGLQQWGIWKSSVDAALESGAISVFYP
HGVGHLVGLKVRDTGNPENVNPQRYYGARLRVDLELKENYLITVEPGCYFARAFIEDNDLREKYKDHIQWSEAEKWKSFG
GVRLEDDILITKGEAESLTNVVLK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=300, Percent_Identity=31.6666666666667, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI260593665, Length=300, Percent_Identity=31.6666666666667, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI260593663, Length=262, Percent_Identity=33.587786259542, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI11559925, Length=273, Percent_Identity=26.7399267399267, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1789275, Length=284, Percent_Identity=34.1549295774648, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1790282, Length=292, Percent_Identity=29.7945205479452, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788728, Length=293, Percent_Identity=27.3037542662116, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17508215, Length=454, Percent_Identity=28.4140969162996, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI71989583, Length=306, Percent_Identity=23.202614379085, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321118, Length=412, Percent_Identity=29.126213592233, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6320922, Length=291, Percent_Identity=27.8350515463918, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357079, Length=292, Percent_Identity=35.958904109589, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI19920384, Length=411, Percent_Identity=25.0608272506083, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 47517; Mature: 47517

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFAESVYKTRQGKVADAWKGLLGPQDLVLIHSGEAVQKPGGLDQTYDFLPHPSYFWLTG
CCCHHHHHHHCCCCHHHHHHHCCCCCCEEEEECCCHHCCCCCCCCHHHCCCCCCEEEEEC
HRRDEGVMAYSVSEGWIEHQRPLSPVDIVWEGAEGNFECEHTLVDLQKKLQGGAYKRVFH
CCCCCCEEEEEECCCHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEHEE
LGQTSEKSFEAETRELSIKLDQVRRCKDSHEVQLIRQIAAMANKGYQALQNALRPGITER
CCCCCCCCCCCCHHHEEEEHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCH
ELQLHYENAVLMAGADKMPYGSIVGSGENAAILHAVPTKKKVVSGELVLVDAGADIEDYC
HEEEEECCEEEEECCCCCCCCCEEECCCCEEEEEECCCCCEEECCCEEEEECCCCHHHHH
VDITRVFAVDGKFTGQQKDVYDLVHDAYKASVALCRPGTQWRDVHMKSARVIAEGLQQWG
HHEEEEEEECCCCCCCCHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
IWKSSVDAALESGAISVFYPHGVGHLVGLKVRDTGNPENVNPQRYYGARLRVDLELKENY
CCHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCCCCCCCCCHHEECEEEEEEEEECCCE
LITVEPGCYFARAFIEDNDLREKYKDHIQWSEAEKWKSFGGVRLEDDILITKGEAESLTN
EEEECCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHCCCCEEECCEEEECCCHHHHHH
VVLK
HHCC
>Mature Secondary Structure
MLFAESVYKTRQGKVADAWKGLLGPQDLVLIHSGEAVQKPGGLDQTYDFLPHPSYFWLTG
CCCHHHHHHHCCCCHHHHHHHCCCCCCEEEEECCCHHCCCCCCCCHHHCCCCCCEEEEEC
HRRDEGVMAYSVSEGWIEHQRPLSPVDIVWEGAEGNFECEHTLVDLQKKLQGGAYKRVFH
CCCCCCEEEEEECCCHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEHEE
LGQTSEKSFEAETRELSIKLDQVRRCKDSHEVQLIRQIAAMANKGYQALQNALRPGITER
CCCCCCCCCCCCHHHEEEEHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCH
ELQLHYENAVLMAGADKMPYGSIVGSGENAAILHAVPTKKKVVSGELVLVDAGADIEDYC
HEEEEECCEEEEECCCCCCCCCEEECCCCEEEEEECCCCCEEECCCEEEEECCCCHHHHH
VDITRVFAVDGKFTGQQKDVYDLVHDAYKASVALCRPGTQWRDVHMKSARVIAEGLQQWG
HHEEEEEEECCCCCCCCHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
IWKSSVDAALESGAISVFYPHGVGHLVGLKVRDTGNPENVNPQRYYGARLRVDLELKENY
CCHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCCCCCCCCCHHEECEEEEEEEEECCCE
LITVEPGCYFARAFIEDNDLREKYKDHIQWSEAEKWKSFGGVRLEDDILITKGEAESLTN
EEEECCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHCCCCEEECCEEEECCCHHHHHH
VVLK
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]