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The map label for this gene is yngJ [H]

Identifier: 42522736

GI number: 42522736

Start: 1141446

End: 1142732

Strand: Direct

Name: yngJ [H]

Synonym: Bd1201

Alternate gene names: 42522736

Gene position: 1141446-1142732 (Clockwise)

Preceding gene: 42522734

Following gene: 42522737

Centisome position: 30.17

GC content: 50.89

Gene sequence:

>1287_bases
TTGTGGTCAAAACCTTGCCCCGAAGGCAGTCACTACATAGATTCACCAGACTGTACTGCACCTTTAAGGAGTCCTAATAT
GTCTTTCAATTGGAAAGAATTCGATCTGTACAATCCAACCCCTGAACACGCAATGTTGCGTGAAACTTTGAAGTCTTTCA
CTGAGGCTGAAATCGAGCCGCAAGCGCACGAACATGATCGCAGTGAAAAGTTCAATCTGGAGTTGTTCCGTAAAGTGGGT
GAGTTGGGTCTGTTGGGAATCACCGTTCCTGAGCAGTTCGGCGGTGCAGGGATGGATGCCACAGCGGCGACCATCGTTCA
TGAAGAGTTTTCTGCCGCGGATCCGGGTTTCTGCCTGGCGTATCTGGCGCACTCCATGCTTTGCGTGAACAACATTGCTG
TGAACGGCAGTGATGAACAGCGCCACCGTATTTTACCAAAGCTTTGCTCTGGTGAGTGGGTGGGCTCCATGGCGATGTCA
GAGCCTGCTATCGGAACCGACGTTCTGGGCATGCAGACGACCGCAGTAAAAAAAGGTGATGAATACATCATCAACGGCCG
TAAGATGTGGATCACCAACGGTACCATCGATGAAAACAACACTCCTTGTGACCTGGTTCTGGTCTATGCCCGCACTGGTG
AAAAACACGGGCGTGCTTTGATCTCCACTTTCCTGGTTGAAAAAGATCACAAAGGTTTCGCTGTCGGTCAGAAGATCAAA
GACAAGCTGGGCATGCGTGGTTCCAACACCGCAGAACTTGTGTTCCAGGACTGTCACGTTCCGGCAAGTGCACTGATCGG
CCACGAAGGTGACTCCATGTTGCACATGATGCGCAATCTTGAAATCGAGCGCCTGACACTGGCTGCGATGAGTTTGGGTA
TTGCCCGTCGTTCTATTGAAATCATGAACCGTTACGCGACCGAGCGTGAGGCTTTCGGCAAATCCTTGAATCACTTCGGT
CAGATGCAGCGTTATATCGCGGATTCCTATGCTGAATACAAAGCGGCTCGTGCGTATGTTTACGAAACAGCTCGCCGTAT
GGATTTGAACAAAGAAGGCAACCGTCTGGATTCTGACGGTGTGAAACTTGTGGCAACCACGATGGCGAAAAACGTGGCAG
ACCGTGCGATTCAGGTTCTGGGTGGTTACGGCTACGTGGGCGAATACGTGGTGGAAAGACTTTGGAGAGACGCGAAGTTG
CTTGAGATCGGTGGCGGTACTTTGGAGGCCCACCAGAAGAACATCACTCGCGACCTGGCAAAAAATCCGGAAGCTCTTTA
CAAATAG

Upstream 100 bases:

>100_bases
CTGCGGTCTCCCTCGAAGAAATTTAAGGTATTCCACCCCCGGATTTGCGTCCAGAACCAATGCCGGGCCCCTTGTTAAAT
GGCACAGATGCGACGCATTA

Downstream 100 bases:

>100_bases
TCCAGTCTACAGAGGTCAGAATGTTCCCATATGGGCCCGAACTTGAAATCAATGCCAATCTTCGCGTGAACTACCAGCTG
GTGCTGGAGAAGATCGGGCC

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MWSKPCPEGSHYIDSPDCTAPLRSPNMSFNWKEFDLYNPTPEHAMLRETLKSFTEAEIEPQAHEHDRSEKFNLELFRKVG
ELGLLGITVPEQFGGAGMDATAATIVHEEFSAADPGFCLAYLAHSMLCVNNIAVNGSDEQRHRILPKLCSGEWVGSMAMS
EPAIGTDVLGMQTTAVKKGDEYIINGRKMWITNGTIDENNTPCDLVLVYARTGEKHGRALISTFLVEKDHKGFAVGQKIK
DKLGMRGSNTAELVFQDCHVPASALIGHEGDSMLHMMRNLEIERLTLAAMSLGIARRSIEIMNRYATEREAFGKSLNHFG
QMQRYIADSYAEYKAARAYVYETARRMDLNKEGNRLDSDGVKLVATTMAKNVADRAIQVLGGYGYVGEYVVERLWRDAKL
LEIGGGTLEAHQKNITRDLAKNPEALYK

Sequences:

>Translated_428_residues
MWSKPCPEGSHYIDSPDCTAPLRSPNMSFNWKEFDLYNPTPEHAMLRETLKSFTEAEIEPQAHEHDRSEKFNLELFRKVG
ELGLLGITVPEQFGGAGMDATAATIVHEEFSAADPGFCLAYLAHSMLCVNNIAVNGSDEQRHRILPKLCSGEWVGSMAMS
EPAIGTDVLGMQTTAVKKGDEYIINGRKMWITNGTIDENNTPCDLVLVYARTGEKHGRALISTFLVEKDHKGFAVGQKIK
DKLGMRGSNTAELVFQDCHVPASALIGHEGDSMLHMMRNLEIERLTLAAMSLGIARRSIEIMNRYATEREAFGKSLNHFG
QMQRYIADSYAEYKAARAYVYETARRMDLNKEGNRLDSDGVKLVATTMAKNVADRAIQVLGGYGYVGEYVVERLWRDAKL
LEIGGGTLEAHQKNITRDLAKNPEALYK
>Mature_428_residues
MWSKPCPEGSHYIDSPDCTAPLRSPNMSFNWKEFDLYNPTPEHAMLRETLKSFTEAEIEPQAHEHDRSEKFNLELFRKVG
ELGLLGITVPEQFGGAGMDATAATIVHEEFSAADPGFCLAYLAHSMLCVNNIAVNGSDEQRHRILPKLCSGEWVGSMAMS
EPAIGTDVLGMQTTAVKKGDEYIINGRKMWITNGTIDENNTPCDLVLVYARTGEKHGRALISTFLVEKDHKGFAVGQKIK
DKLGMRGSNTAELVFQDCHVPASALIGHEGDSMLHMMRNLEIERLTLAAMSLGIARRSIEIMNRYATEREAFGKSLNHFG
QMQRYIADSYAEYKAARAYVYETARRMDLNKEGNRLDSDGVKLVATTMAKNVADRAIQVLGGYGYVGEYVVERLWRDAKL
LEIGGGTLEAHQKNITRDLAKNPEALYK

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=384, Percent_Identity=43.2291666666667, Blast_Score=295, Evalue=5e-80,
Organism=Homo sapiens, GI226958414, Length=354, Percent_Identity=43.5028248587571, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI4501857, Length=391, Percent_Identity=34.2710997442455, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI4557233, Length=408, Percent_Identity=34.3137254901961, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI187960098, Length=399, Percent_Identity=31.328320802005, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4557231, Length=399, Percent_Identity=31.328320802005, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4501859, Length=427, Percent_Identity=29.9765807962529, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI21361497, Length=371, Percent_Identity=33.1536388140162, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI7656849, Length=367, Percent_Identity=31.3351498637602, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI4557235, Length=420, Percent_Identity=28.5714285714286, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI76496475, Length=383, Percent_Identity=28.9817232375979, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI7669494, Length=377, Percent_Identity=29.1777188328912, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=29.1777188328912, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI48976061, Length=448, Percent_Identity=26.7857142857143, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI211971008, Length=448, Percent_Identity=26.7857142857143, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI38505218, Length=357, Percent_Identity=26.890756302521, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI87081958, Length=376, Percent_Identity=29.5212765957447, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1786223, Length=390, Percent_Identity=25.6410256410256, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI87082384, Length=272, Percent_Identity=25, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=388, Percent_Identity=41.7525773195876, Blast_Score=294, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=31.5245478036176, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17508101, Length=389, Percent_Identity=31.8766066838046, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17569725, Length=388, Percent_Identity=32.4742268041237, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=31.2169312169312, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17534899, Length=405, Percent_Identity=31.1111111111111, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17505929, Length=397, Percent_Identity=32.2418136020151, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17551932, Length=384, Percent_Identity=30.9895833333333, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=29.6, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=37.1428571428571, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71985184, Length=346, Percent_Identity=30.3468208092486, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71982178, Length=286, Percent_Identity=30.4195804195804, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=291, Percent_Identity=29.553264604811, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=235, Percent_Identity=32.7659574468085, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17534353, Length=396, Percent_Identity=27.020202020202, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17562446, Length=291, Percent_Identity=28.5223367697594, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17531909, Length=247, Percent_Identity=27.1255060728745, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=309, Percent_Identity=27.831715210356, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=309, Percent_Identity=27.831715210356, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=44.3864229765013, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI21356377, Length=395, Percent_Identity=32.9113924050633, Blast_Score=218, Evalue=9e-57,
Organism=Drosophila melanogaster, GI24646207, Length=392, Percent_Identity=32.9081632653061, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI24666513, Length=386, Percent_Identity=31.0880829015544, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24660351, Length=383, Percent_Identity=31.5926892950392, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI281363737, Length=387, Percent_Identity=30.2325581395349, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI19920834, Length=378, Percent_Identity=28.042328042328, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 47675; Mature: 47675

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWSKPCPEGSHYIDSPDCTAPLRSPNMSFNWKEFDLYNPTPEHAMLRETLKSFTEAEIEP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCC
QAHEHDRSEKFNLELFRKVGELGLLGITVPEQFGGAGMDATAATIVHEEFSAADPGFCLA
CHHHCCCCCCCCHHHHHHHHCCCEEEEECCHHHCCCCCCHHHHHHHHHHHCCCCCCHHHH
YLAHSMLCVNNIAVNGSDEQRHRILPKLCSGEWVGSMAMSEPAIGTDVLGMQTTAVKKGD
HHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCHHCCHHHCCCCCCCCCCCCCHHHHCCCC
EYIINGRKMWITNGTIDENNTPCDLVLVYARTGEKHGRALISTFLVEKDHKGFAVGQKIK
CEEECCEEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
DKLGMRGSNTAELVFQDCHVPASALIGHEGDSMLHMMRNLEIERLTLAAMSLGIARRSIE
HHHCCCCCCHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IMNRYATEREAFGKSLNHFGQMQRYIADSYAEYKAARAYVYETARRMDLNKEGNRLDSDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
VKLVATTMAKNVADRAIQVLGGYGYVGEYVVERLWRDAKLLEIGGGTLEAHQKNITRDLA
CEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
KNPEALYK
CCCHHHCC
>Mature Secondary Structure
MWSKPCPEGSHYIDSPDCTAPLRSPNMSFNWKEFDLYNPTPEHAMLRETLKSFTEAEIEP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCC
QAHEHDRSEKFNLELFRKVGELGLLGITVPEQFGGAGMDATAATIVHEEFSAADPGFCLA
CHHHCCCCCCCCHHHHHHHHCCCEEEEECCHHHCCCCCCHHHHHHHHHHHCCCCCCHHHH
YLAHSMLCVNNIAVNGSDEQRHRILPKLCSGEWVGSMAMSEPAIGTDVLGMQTTAVKKGD
HHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCHHCCHHHCCCCCCCCCCCCCHHHHCCCC
EYIINGRKMWITNGTIDENNTPCDLVLVYARTGEKHGRALISTFLVEKDHKGFAVGQKIK
CEEECCEEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
DKLGMRGSNTAELVFQDCHVPASALIGHEGDSMLHMMRNLEIERLTLAAMSLGIARRSIE
HHHCCCCCCHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IMNRYATEREAFGKSLNHFGQMQRYIADSYAEYKAARAYVYETARRMDLNKEGNRLDSDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
VKLVATTMAKNVADRAIQVLGGYGYVGEYVVERLWRDAKLLEIGGGTLEAHQKNITRDLA
CEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
KNPEALYK
CCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]