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The map label for this gene is tmk

Identifier: 42522597

GI number: 42522597

Start: 984989

End: 985633

Strand: Direct

Name: tmk

Synonym: Bd1040

Alternate gene names: 42522597

Gene position: 984989-985633 (Clockwise)

Preceding gene: 42522596

Following gene: 42522598

Centisome position: 26.04

GC content: 54.26

Gene sequence:

>645_bases
TTGCGGTGCAAAATGAAATTTATCGTATTTGAGGGGCTGGACGGCTCCGGCAAAAGTTCTTTGATGGCGGCGTTGGAGCG
TGAGCTGCAAAACAGAGCCATCAACTTTTTGCGCACCCGTGAGCCCGGCGGAACTCCGCTGGGTGATGAAATCCGCAACA
TGATCCTGAGAAAAGAAGGCCCGGCACCAACCCCACGCACAGAATTGCTGCTTTATGAAGCCAGCCGTTCCCAGCACGTG
GATCAGGTGATCCGTCCGGCTTTGGCGGCAGGCACGTGGGTTCTGTGTGATCGTTTTGCTGCAAGCTCTGTCGCGTTTCA
AAGTGGCGGGCGTGCGATCTCTGAGGCCGACGTGGTGATGCTGAATACCTTTGCCACCGGCGGTTTGAAAGCCGACATCA
CTGTTCTTTTGGATTTGTCTGTGGAAGAAAGTCGCCGTCGCCGTCAGGGGCGTGGTGCTGTCACCGGAGAAACCGAAGAC
CGCATTGAATCTGAAGCCGACACTTTCCATGAAAACGTTCGTCAGTCCTTCCTGAAGCAGTCCCGTGAAGACGCCGCTGC
GTGGATCGTTCTGGATGCGCGTGAAACCCCGGAAGTACTATTCAAACAGCTGTTGCAGTCTTTGACTGAACGAAAAGTTT
TGTAA

Upstream 100 bases:

>100_bases
CCTTGTTGCAATGCGATTTGTTGACGTCTACACCGCAATATCTGACAAAGTCCACTTGGGTGGGCGTCGTGCTTGCGGCC
CTGTATTCAACTAATCTTTC

Downstream 100 bases:

>100_bases
GGACGTAGCAATGGCCCGGATGCTGGATTTCGTCTTAGGACATCAGGAAACAATCAAAAAAATGGTCGAGTCTTTCGAAA
ACGGAAAGCCCGGTCAGACC

Product: hypothetical protein

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRCKMKFIVFEGLDGSGKSSLMAALERELQNRAINFLRTREPGGTPLGDEIRNMILRKEGPAPTPRTELLLYEASRSQHV
DQVIRPALAAGTWVLCDRFAASSVAFQSGGRAISEADVVMLNTFATGGLKADITVLLDLSVEESRRRRQGRGAVTGETED
RIESEADTFHENVRQSFLKQSREDAAAWIVLDARETPEVLFKQLLQSLTERKVL

Sequences:

>Translated_214_residues
MRCKMKFIVFEGLDGSGKSSLMAALERELQNRAINFLRTREPGGTPLGDEIRNMILRKEGPAPTPRTELLLYEASRSQHV
DQVIRPALAAGTWVLCDRFAASSVAFQSGGRAISEADVVMLNTFATGGLKADITVLLDLSVEESRRRRQGRGAVTGETED
RIESEADTFHENVRQSFLKQSREDAAAWIVLDARETPEVLFKQLLQSLTERKVL
>Mature_214_residues
MRCKMKFIVFEGLDGSGKSSLMAALERELQNRAINFLRTREPGGTPLGDEIRNMILRKEGPAPTPRTELLLYEASRSQHV
DQVIRPALAAGTWVLCDRFAASSVAFQSGGRAISEADVVMLNTFATGGLKADITVLLDLSVEESRRRRQGRGAVTGETED
RIESEADTFHENVRQSFLKQSREDAAAWIVLDARETPEVLFKQLLQSLTERKVL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=212, Percent_Identity=33.0188679245283, Blast_Score=115, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_BDEBA (Q6MP28)

Other databases:

- EMBL:   BX842648
- RefSeq:   NP_967977.1
- ProteinModelPortal:   Q6MP28
- SMR:   Q6MP28
- GeneID:   2734404
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd1040
- NMPDR:   fig|264462.1.peg.947
- HOGENOM:   HBG626009
- OMA:   KGHIVIS
- PhylomeDB:   Q6MP28
- BioCyc:   BBAC264462:BD1040-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23819; Mature: 23819

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCKMKFIVFEGLDGSGKSSLMAALERELQNRAINFLRTREPGGTPLGDEIRNMILRKEG
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
PAPTPRTELLLYEASRSQHVDQVIRPALAAGTWVLCDRFAASSVAFQSGGRAISEADVVM
CCCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LNTFATGGLKADITVLLDLSVEESRRRRQGRGAVTGETEDRIESEADTFHENVRQSFLKQ
EEEECCCCCCEEEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SREDAAAWIVLDARETPEVLFKQLLQSLTERKVL
HHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRCKMKFIVFEGLDGSGKSSLMAALERELQNRAINFLRTREPGGTPLGDEIRNMILRKEG
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
PAPTPRTELLLYEASRSQHVDQVIRPALAAGTWVLCDRFAASSVAFQSGGRAISEADVVM
CCCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LNTFATGGLKADITVLLDLSVEESRRRRQGRGAVTGETEDRIESEADTFHENVRQSFLKQ
EEEECCCCCCEEEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SREDAAAWIVLDARETPEVLFKQLLQSLTERKVL
HHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA