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The map label for this gene is aprT

Identifier: 42522417

GI number: 42522417

Start: 793048

End: 793545

Strand: Direct

Name: aprT

Synonym: Bd0845

Alternate gene names: 42522417

Gene position: 793048-793545 (Clockwise)

Preceding gene: 42522416

Following gene: 42522418

Centisome position: 20.96

GC content: 52.21

Gene sequence:

>498_bases
GTGGATTTAAAGAGCCTGATTCGTGATGTTCCTGATTTCCCCAAGCCAGGGATTATTTTCCGTGATATGTCCCCGCTGCT
GCAAAACGCTGAAGCCCTCAGTTTTGTTTCCCACAATCTTTTAAAGCACGTCGATCTGACTCATGTGGATTATTTCGCCG
GCATTGAATCCCGTGGATTTATCCTGGCAGCCCACATGGCGGCGACTCACAAAAAAGGCTTCCTGCCAATTCGTAAAGCG
GGGAAGCTGCCGCCTCCGACGCGCAAGGTTTCCTATGCTCTGGAGTACGGTACAGCTGAAATTGAGCTTCCTCCGGGCCG
CGGGAATGTGGTGATCGTGGATGATGTTCTGGCGACCGGTGGCACGCTGCAGGCGGCGATTGACCTCTGTCTGCTGGCCG
GGTACTCCGTGGAGTCAGTGGCAGTTCTGGTCAATCTGACGTTCCTTAACAAGATGACCTACAACGATCAAAAGGTGGCT
TCGCTTGTTCAATATTAA

Upstream 100 bases:

>100_bases
CGCGCCTCTTTATTTTCCGGGCTTGATGGTGGAATAGATTTCCTTTACTCACAGCAGGGTTTCCCTTAAGAATAAGGGTG
CAACTGCCAAGGAGTGGCCC

Downstream 100 bases:

>100_bases
TGACGTGGCTTTGGTGATGGCGCTTCCGGGCGAGTCTCAGGGCTTCTTTGAAAAAGAAAATATCCCTGTGGTCTATACCG
GCATTGGCAAAGTGAATGCC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MDLKSLIRDVPDFPKPGIIFRDMSPLLQNAEALSFVSHNLLKHVDLTHVDYFAGIESRGFILAAHMAATHKKGFLPIRKA
GKLPPPTRKVSYALEYGTAEIELPPGRGNVVIVDDVLATGGTLQAAIDLCLLAGYSVESVAVLVNLTFLNKMTYNDQKVA
SLVQY

Sequences:

>Translated_165_residues
MDLKSLIRDVPDFPKPGIIFRDMSPLLQNAEALSFVSHNLLKHVDLTHVDYFAGIESRGFILAAHMAATHKKGFLPIRKA
GKLPPPTRKVSYALEYGTAEIELPPGRGNVVIVDDVLATGGTLQAAIDLCLLAGYSVESVAVLVNLTFLNKMTYNDQKVA
SLVQY
>Mature_165_residues
MDLKSLIRDVPDFPKPGIIFRDMSPLLQNAEALSFVSHNLLKHVDLTHVDYFAGIESRGFILAAHMAATHKKGFLPIRKA
GKLPPPTRKVSYALEYGTAEIELPPGRGNVVIVDDVLATGGTLQAAIDLCLLAGYSVESVAVLVNLTFLNKMTYNDQKVA
SLVQY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=172, Percent_Identity=43.6046511627907, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI71773201, Length=122, Percent_Identity=47.5409836065574, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1786675, Length=149, Percent_Identity=39.5973154362416, Blast_Score=107, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17509087, Length=166, Percent_Identity=42.7710843373494, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6323619, Length=124, Percent_Identity=35.4838709677419, Blast_Score=82, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320649, Length=141, Percent_Identity=35.4609929078014, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136334, Length=171, Percent_Identity=39.1812865497076, Blast_Score=97, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_BDEBA (Q6MPK7)

Other databases:

- EMBL:   BX842648
- RefSeq:   NP_967797.1
- ProteinModelPortal:   Q6MPK7
- SMR:   Q6MPK7
- GeneID:   2733916
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd0845
- NMPDR:   fig|264462.1.peg.767
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   BBAC264462:BD0845-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18006; Mature: 18006

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKSLIRDVPDFPKPGIIFRDMSPLLQNAEALSFVSHNLLKHVDLTHVDYFAGIESRGF
CCHHHHHHHCCCCCCCCEEECCHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCE
ILAAHMAATHKKGFLPIRKAGKLPPPTRKVSYALEYGTAEIELPPGRGNVVIVDDVLATG
EEEEEHHHHCCCCCCCHHHCCCCCCCCCCEEEEEECCCEEEEECCCCCCEEEEECCCCCC
GTLQAAIDLCLLAGYSVESVAVLVNLTFLNKMTYNDQKVASLVQY
CHHHHHHHHHHHCCCCHHHHHHEEEHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MDLKSLIRDVPDFPKPGIIFRDMSPLLQNAEALSFVSHNLLKHVDLTHVDYFAGIESRGF
CCHHHHHHHCCCCCCCCEEECCHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCE
ILAAHMAATHKKGFLPIRKAGKLPPPTRKVSYALEYGTAEIELPPGRGNVVIVDDVLATG
EEEEEHHHHCCCCCCCHHHCCCCCCCCCCEEEEEECCCEEEEECCCCCCEEEEECCCCCC
GTLQAAIDLCLLAGYSVESVAVLVNLTFLNKMTYNDQKVASLVQY
CHHHHHHHHHHHCCCCHHHHHHEEEHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA