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The map label for this gene is kefC [H]

Identifier: 42522245

GI number: 42522245

Start: 608772

End: 610724

Strand: Direct

Name: kefC [H]

Synonym: Bd0658

Alternate gene names: 42522245

Gene position: 608772-610724 (Clockwise)

Preceding gene: 42522240

Following gene: 42522246

Centisome position: 16.09

GC content: 52.53

Gene sequence:

>1953_bases
ATGTCCAAAGTCACGGTGATAAAAATAAACCAAATGCCTGCAGTTTTCTTTGTCATAGGCCTCAGACTAAAAGATCGTTC
CCGGCTTGTCACAGGATTCTTGCCGGGATCAAAACCGCTTGGTACCTTCGTTAGCATGATTTTACATGAGCAACTGTTGC
AGATTCTCGCGTTCCTGGGTTTTTCCGTCGTTCTGGTTTCATTGTTTCAAAAGCTGGGCTTGGGAACTATTCTGGGTTAC
CTGGCTGCCGGTATTTTGATTGGGCCTCTGGGCTGGGGATTGATTTCAGACTTTCATTTTGTGCAAACCATTGCCGAATT
TGGCGTGGTCTTTCTGCTCTTTATTATTGGTCTTGAGCTGCAACCCAAAAAGCTGTGGGGCTTGCGAAAAACTCTGTTGG
GTTTTGGCGGCTTGCAGATCCTGGTTTGTACCGTGGTTTTCACTTTAGCGGGACATCAGCTGGGAATTTCCTGGGCCAGT
GCTGCGGTGGTGGGGTTTGCTCTTTCACTGTCTTCAACCGCGTTTGCTCTGCAAAGTCTGTCTGAAAGAAAAGTTCTGAA
CACGGAATTTGGCCGGGCCTCTTTTGCGATCCTTTTAATGCAGGACGTGGTGGCCATCCCGGCGTTGGCGGTGATTCCAA
GTCTGGGGCTGGTGACAGCCAGCACCCGCGAAGTGAACTGGGGCGGGGCTTTGGCGATCTTTATCGGACTGGCTTTGGGC
AGCCGTCTGCTGATGGGAAGATTTCTGCAGGTGGTGGCTGAGACCCGCAGCCGTGAGCTTTTCACGGGTGTCACTTTACT
GACCGTGATCGGGGTGGCTTTCCTGATGGAAAGTGTGGGCTTGTCTATGGCGCTTGGGGCGTTCCTGGCTGGGGTGCTGC
TTTCAGAATCAGAATACCGTCATGAGCTGGAAGCCGACCTTGAACCTTTCAAGGGTTTACTGATGGGTCTGTTCTTTGTC
TCCGTCGGTATGTCCGTCAAGCTGTCTTTACTGGTTGAAAATCCCGGCCTGATTCTGGGGATCACCGTGGGTTACATGGT
TCTGAAAGGGTTCCTGATTTACGGCGTCGGCCGTGTGATGAAGCTGCACCGTCCGGCCTCCAATAATCTGGCTGTGTATC
TGGTGCAGGGCGGGGAGTTCGCTTTCGTGATCTTTGGCGTGGGGCAAAGTGCGCAAGTGCTTTCACCGGAATGGACTCAA
AGATTCACTTTGGTGGTGACGCTTTCCATGATCGCAAGCCCCATCATCATCGTCCTAAATGAAAAGATTCAGGCCATGAT
CGCCTGCAAACGTCCTGGCGCAGGACCGCAGTATGATCAGATCGACGAAGCTGACAACGGGAACGCGGTGATCATTGCCG
GCTTCGGCCGGGTCGGTCAGATCTTTGGCCGTATTCTGCGCACCCAAGATGTAAAATTCACCGCGATTGAACATGACACT
GAACAGATCGACCTGCTTCGTCGTTTTGGCAATAAGGTCTATTATGGCGATGCCTCACGACCGGAAATTCTTGAGGCGGC
GGGCATCAAAAATGCCAAGTACTTTGTGCTGGCCGTGGATGATGTCGAGACCTCCAACAATATCGCCCGGATTCTGCACG
AAGATTATCCGCATGTGAAGGTCTTTGCCCGTTCCCGAAACCGTCAGCACACGTTTGACCTGATGGCGGCCGGGGTCACC
CAGGTCCGCCGTGAAACGATAGATTCCAGTATTGCCCTTTCCGAGCAGCTGCTGGTAGAGATGGGCACACCGGCCAAACG
CGCCCATGAGATCATTGAACGCTTCCGTCTGCATGATGAACTGATGCTGCAGGAGCAGTTCAAAGTCCGTCACGATCAAA
AGACCTTTATCGACGTTTCCCGCCAGGCCGCCCAGCAGCTGGCACAGGTCCTTAAAGAGGACGCCGAAAAGACTTATATT
GATCCCCAGCACCCGCCAGAGGCTTCTAAATAA

Upstream 100 bases:

>100_bases
TGAAATGAAATAGCCGAAGTATTCAGTGACCGAGGTTTCACTGGAAACAAAACGACGCATGATATCCGGAAGCGACGGGA
TCACCAAGCCCAGTCCGATC

Downstream 100 bases:

>100_bases
TAATTTAACCGACCGAAGCCCTGCTTGTTTCCTATAAATAGGAACAGGAGGGCACGGATGCGCTTCTTAATAATTTCACT
GATTTTAATGTCTGCTTCGT

Product: glutathione-regulated K+ efflux antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MSKVTVIKINQMPAVFFVIGLRLKDRSRLVTGFLPGSKPLGTFVSMILHEQLLQILAFLGFSVVLVSLFQKLGLGTILGY
LAAGILIGPLGWGLISDFHFVQTIAEFGVVFLLFIIGLELQPKKLWGLRKTLLGFGGLQILVCTVVFTLAGHQLGISWAS
AAVVGFALSLSSTAFALQSLSERKVLNTEFGRASFAILLMQDVVAIPALAVIPSLGLVTASTREVNWGGALAIFIGLALG
SRLLMGRFLQVVAETRSRELFTGVTLLTVIGVAFLMESVGLSMALGAFLAGVLLSESEYRHELEADLEPFKGLLMGLFFV
SVGMSVKLSLLVENPGLILGITVGYMVLKGFLIYGVGRVMKLHRPASNNLAVYLVQGGEFAFVIFGVGQSAQVLSPEWTQ
RFTLVVTLSMIASPIIIVLNEKIQAMIACKRPGAGPQYDQIDEADNGNAVIIAGFGRVGQIFGRILRTQDVKFTAIEHDT
EQIDLLRRFGNKVYYGDASRPEILEAAGIKNAKYFVLAVDDVETSNNIARILHEDYPHVKVFARSRNRQHTFDLMAAGVT
QVRRETIDSSIALSEQLLVEMGTPAKRAHEIIERFRLHDELMLQEQFKVRHDQKTFIDVSRQAAQQLAQVLKEDAEKTYI
DPQHPPEASK

Sequences:

>Translated_650_residues
MSKVTVIKINQMPAVFFVIGLRLKDRSRLVTGFLPGSKPLGTFVSMILHEQLLQILAFLGFSVVLVSLFQKLGLGTILGY
LAAGILIGPLGWGLISDFHFVQTIAEFGVVFLLFIIGLELQPKKLWGLRKTLLGFGGLQILVCTVVFTLAGHQLGISWAS
AAVVGFALSLSSTAFALQSLSERKVLNTEFGRASFAILLMQDVVAIPALAVIPSLGLVTASTREVNWGGALAIFIGLALG
SRLLMGRFLQVVAETRSRELFTGVTLLTVIGVAFLMESVGLSMALGAFLAGVLLSESEYRHELEADLEPFKGLLMGLFFV
SVGMSVKLSLLVENPGLILGITVGYMVLKGFLIYGVGRVMKLHRPASNNLAVYLVQGGEFAFVIFGVGQSAQVLSPEWTQ
RFTLVVTLSMIASPIIIVLNEKIQAMIACKRPGAGPQYDQIDEADNGNAVIIAGFGRVGQIFGRILRTQDVKFTAIEHDT
EQIDLLRRFGNKVYYGDASRPEILEAAGIKNAKYFVLAVDDVETSNNIARILHEDYPHVKVFARSRNRQHTFDLMAAGVT
QVRRETIDSSIALSEQLLVEMGTPAKRAHEIIERFRLHDELMLQEQFKVRHDQKTFIDVSRQAAQQLAQVLKEDAEKTYI
DPQHPPEASK
>Mature_649_residues
SKVTVIKINQMPAVFFVIGLRLKDRSRLVTGFLPGSKPLGTFVSMILHEQLLQILAFLGFSVVLVSLFQKLGLGTILGYL
AAGILIGPLGWGLISDFHFVQTIAEFGVVFLLFIIGLELQPKKLWGLRKTLLGFGGLQILVCTVVFTLAGHQLGISWASA
AVVGFALSLSSTAFALQSLSERKVLNTEFGRASFAILLMQDVVAIPALAVIPSLGLVTASTREVNWGGALAIFIGLALGS
RLLMGRFLQVVAETRSRELFTGVTLLTVIGVAFLMESVGLSMALGAFLAGVLLSESEYRHELEADLEPFKGLLMGLFFVS
VGMSVKLSLLVENPGLILGITVGYMVLKGFLIYGVGRVMKLHRPASNNLAVYLVQGGEFAFVIFGVGQSAQVLSPEWTQR
FTLVVTLSMIASPIIIVLNEKIQAMIACKRPGAGPQYDQIDEADNGNAVIIAGFGRVGQIFGRILRTQDVKFTAIEHDTE
QIDLLRRFGNKVYYGDASRPEILEAAGIKNAKYFVLAVDDVETSNNIARILHEDYPHVKVFARSRNRQHTFDLMAAGVTQ
VRRETIDSSIALSEQLLVEMGTPAKRAHEIIERFRLHDELMLQEQFKVRHDQKTFIDVSRQAAQQLAQVLKEDAEKTYID
PQHPPEASK

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=391, Percent_Identity=27.1099744245524, Blast_Score=100, Evalue=5e-21,
Organism=Escherichia coli, GI1786232, Length=602, Percent_Identity=42.0265780730897, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1789749, Length=587, Percent_Identity=38.160136286201, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1786685, Length=534, Percent_Identity=29.9625468164794, Blast_Score=188, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 71199; Mature: 71068

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVTVIKINQMPAVFFVIGLRLKDRSRLVTGFLPGSKPLGTFVSMILHEQLLQILAFLG
CCCEEEEEECCCCCEEHHEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
FSVVLVSLFQKLGLGTILGYLAAGILIGPLGWGLISDFHFVQTIAEFGVVFLLFIIGLEL
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QPKKLWGLRKTLLGFGGLQILVCTVVFTLAGHQLGISWASAAVVGFALSLSSTAFALQSL
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHH
SERKVLNTEFGRASFAILLMQDVVAIPALAVIPSLGLVTASTREVNWGGALAIFIGLALG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHH
SRLLMGRFLQVVAETRSRELFTGVTLLTVIGVAFLMESVGLSMALGAFLAGVLLSESEYR
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
HELEADLEPFKGLLMGLFFVSVGMSVKLSLLVENPGLILGITVGYMVLKGFLIYGVGRVM
HHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHH
KLHRPASNNLAVYLVQGGEFAFVIFGVGQSAQVLSPEWTQRFTLVVTLSMIASPIIIVLN
HHCCCCCCCEEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEC
EKIQAMIACKRPGAGPQYDQIDEADNGNAVIIAGFGRVGQIFGRILRTQDVKFTAIEHDT
CHHHEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCCH
EQIDLLRRFGNKVYYGDASRPEILEAAGIKNAKYFVLAVDDVETSNNIARILHEDYPHVK
HHHHHHHHHCCEEEECCCCCCHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCEE
VFARSRNRQHTFDLMAAGVTQVRRETIDSSIALSEQLLVEMGTPAKRAHEIIERFRLHDE
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LMLQEQFKVRHDQKTFIDVSRQAAQQLAQVLKEDAEKTYIDPQHPPEASK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SKVTVIKINQMPAVFFVIGLRLKDRSRLVTGFLPGSKPLGTFVSMILHEQLLQILAFLG
CCEEEEEECCCCCEEHHEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
FSVVLVSLFQKLGLGTILGYLAAGILIGPLGWGLISDFHFVQTIAEFGVVFLLFIIGLEL
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QPKKLWGLRKTLLGFGGLQILVCTVVFTLAGHQLGISWASAAVVGFALSLSSTAFALQSL
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHH
SERKVLNTEFGRASFAILLMQDVVAIPALAVIPSLGLVTASTREVNWGGALAIFIGLALG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHH
SRLLMGRFLQVVAETRSRELFTGVTLLTVIGVAFLMESVGLSMALGAFLAGVLLSESEYR
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
HELEADLEPFKGLLMGLFFVSVGMSVKLSLLVENPGLILGITVGYMVLKGFLIYGVGRVM
HHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHH
KLHRPASNNLAVYLVQGGEFAFVIFGVGQSAQVLSPEWTQRFTLVVTLSMIASPIIIVLN
HHCCCCCCCEEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEC
EKIQAMIACKRPGAGPQYDQIDEADNGNAVIIAGFGRVGQIFGRILRTQDVKFTAIEHDT
CHHHEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCCH
EQIDLLRRFGNKVYYGDASRPEILEAAGIKNAKYFVLAVDDVETSNNIARILHEDYPHVK
HHHHHHHHHCCEEEECCCCCCHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCEE
VFARSRNRQHTFDLMAAGVTQVRRETIDSSIALSEQLLVEMGTPAKRAHEIIERFRLHDE
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LMLQEQFKVRHDQKTFIDVSRQAAQQLAQVLKEDAEKTYIDPQHPPEASK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA