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The map label for this gene is pbpC [H]

Identifier: 42521920

GI number: 42521920

Start: 285634

End: 287652

Strand: Direct

Name: pbpC [H]

Synonym: Bd0297

Alternate gene names: 42521920

Gene position: 285634-287652 (Clockwise)

Preceding gene: 42521919

Following gene: 42521925

Centisome position: 7.55

GC content: 53.64

Gene sequence:

>2019_bases
ATGAGAAAGAAACTGATCTGGGGACTTGCAGTGGCCGGGGTGCTGGGGGGAGTGGCTGGTGTGGCCATCATTGCCAGCAG
CGTGCCTTCCTTGCCAGCCTATGATTCGGTGAAAAAATCCTATGTCAGTTCCGATCTTTTCCTGGTGGACCGCAATGGCA
AACCTTTGCATCAGTGGCGCCAGGATCTGAAAGAGCGCACATTGTTGTGGGCGGATCACAAGGATATCGCTCCGGCCATG
ATCACGGCCTTGCTAAAATCCGAGGATAAGAACTTCTTCCATCACTGGGGTGTGGATCCCTTGGCGATGGCAGCTTCGGT
GTATCAGCGCAGTGTGAAGGATTCCCCGCGCGGGGCCAGCACCATCACCATGCAGTTGGTGAAGCTGCTTCATCCCAATA
AAAAAACCTGGCAGGGGCTGTCCGGAAAAATACGCCAGTCTTTCGCAGCCATGATGCTTGAAAGCCAATGGAGCAAAGAG
CAGATCCTGGAAAGCTATTTGAACCTGGTCAGCTTCCGCGGGGAACTGCGCGGGGTGAACGCGGCCTCGTGGATGATGTT
TGGTAAAAGTGCAGCGGATCTTTCCCGGGTGGATGCGACCCTCTTGTCGGTCCTGATTCGTTCACCAAATTCTGAAACAG
CCCAGTGGGAAAAGCGCGCCTGCTGGCAGGAACCAGATCTGTGTGCGACCTTCAAAGACAGCATCAGTCGTATTCAGCCG
CAGAAGATGATTTCTCAGAATCAGCAGGCCTTGCACTTGGCCCAGCGGTTTTCCAAAGAAGGCCGTCGTGGGCAGATCCA
AACAACCCTGGATCGCGATCTGCAAAGCTATATCCAGGAACAGATCACTTCCCAGATTCGCAGGCTGCAGGCACAGAACG
TGAATGATGCCGCGGTGATTGTGATTGAAAACCGCACCGGCGAGGTCTTTGCCTATGTTGGAGGATCCGGTGATCTTTCC
AGCGCGCCTTATGTCGACGGGGTGCAATCCCTAAGACAGGCAGGGTCCACATTAAAACCATTCTTGTATGCCACGGCATT
TGAAAAGAAATTGTTGAATCCGGAATCCTGGCTTGAGGATTCCGCTGTGGATATCGTCTTTGACCGGGGAGTTTACAAAC
CCCAAAATCACGACCGTCAGTTCTATGGCTGGGTGATGGTGAAGACGGCCCTGGGATCTTCACTGAATGTTCCGGCCGTG
AAGGCCTTTAAACTTTTGAATGATGAATCCTTCTGGGGAAAGTTAAAGGCTCTGAATTTTAGAAACCTGGAAGAACCCGA
ACACTATGGCCCGGCCTTGGCGCTGGGGGTGGCGGATGTGACCCTGGAAGATCTGGCGCAAGGTTATCGAACCTTGGCGC
AGGATGGATTCTTGTCGTCGCTAAAGTTTGAACCTCACCAGGAAACCGCCGAAGCCACGGAAGTGTTTGAGGCTGCCAGT
GCACGCGAAGTGAAAGAAATCCTGTCCGACAATCAGAACCGCGCCTTGGGGTTTGGTCTGGATTCAGCTTTGGCACTGCC
GGGGGCGGCGGTGAAAACCGGCACCAGCAAAGACATGCGCGACAACTGGTGTGTGGGCATGAATGACCGCTTCACTGTCG
GTGTGTGGGTTGGAAACTTCAGCGGAGAACCCATGTGGAATGTGATGGGCGTCAGTGGTGCGGCCCCGATCTGGAAGCGC
ACCATGATCTGGCTGCAGGATCACTATCCGTCGGAAGCCCGAATGGCTGAAGTCGTACCGGTCAAAGAGTCTCAGCCTGA
AGCTTATCCGGGGGCGCGGATTTTGTATCCGCAGGATGGCATGGTGCTGGCGCTGGATCCGGCGATCCCGGCGGGCAATC
AGAAGATGCCGCTGCTGGTGGAAAATTCTTTGAAGAAAGATCTGTACTGGAAAATCAACGAAGACAAAAAAATAAAGGCG
ACCGAGTCTTATCTATGGTCGCCTTCACTGGGTCGTCACCACTTTGTGCTTTATGAAGGAGACAGCAAAGTGGCCGAGGT
TTCTGTTCTGGTGAAATAA

Upstream 100 bases:

>100_bases
TCAATCAGTCAGGAACCTATGTGCTGCCAGCTCCACGGGTCGAAGCCATGTACAGCCCGGATCTGTTTGCTGAATTGCCA
GAATCGGTCTGGAGCGTGCA

Downstream 100 bases:

>100_bases
CTAGATGTCATAGTGGAACAAAACCGGAACCTGCATGTCCGGGTGAACGCTTTGTTTCACCGGGCAGGTCATGGCGATTT
GTTCCAGTTTCTTTCTGTAG

Product: bifunctional penicillin-binding protein

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 672; Mature: 672

Protein sequence:

>672_residues
MRKKLIWGLAVAGVLGGVAGVAIIASSVPSLPAYDSVKKSYVSSDLFLVDRNGKPLHQWRQDLKERTLLWADHKDIAPAM
ITALLKSEDKNFFHHWGVDPLAMAASVYQRSVKDSPRGASTITMQLVKLLHPNKKTWQGLSGKIRQSFAAMMLESQWSKE
QILESYLNLVSFRGELRGVNAASWMMFGKSAADLSRVDATLLSVLIRSPNSETAQWEKRACWQEPDLCATFKDSISRIQP
QKMISQNQQALHLAQRFSKEGRRGQIQTTLDRDLQSYIQEQITSQIRRLQAQNVNDAAVIVIENRTGEVFAYVGGSGDLS
SAPYVDGVQSLRQAGSTLKPFLYATAFEKKLLNPESWLEDSAVDIVFDRGVYKPQNHDRQFYGWVMVKTALGSSLNVPAV
KAFKLLNDESFWGKLKALNFRNLEEPEHYGPALALGVADVTLEDLAQGYRTLAQDGFLSSLKFEPHQETAEATEVFEAAS
AREVKEILSDNQNRALGFGLDSALALPGAAVKTGTSKDMRDNWCVGMNDRFTVGVWVGNFSGEPMWNVMGVSGAAPIWKR
TMIWLQDHYPSEARMAEVVPVKESQPEAYPGARILYPQDGMVLALDPAIPAGNQKMPLLVENSLKKDLYWKINEDKKIKA
TESYLWSPSLGRHHFVLYEGDSKVAEVSVLVK

Sequences:

>Translated_672_residues
MRKKLIWGLAVAGVLGGVAGVAIIASSVPSLPAYDSVKKSYVSSDLFLVDRNGKPLHQWRQDLKERTLLWADHKDIAPAM
ITALLKSEDKNFFHHWGVDPLAMAASVYQRSVKDSPRGASTITMQLVKLLHPNKKTWQGLSGKIRQSFAAMMLESQWSKE
QILESYLNLVSFRGELRGVNAASWMMFGKSAADLSRVDATLLSVLIRSPNSETAQWEKRACWQEPDLCATFKDSISRIQP
QKMISQNQQALHLAQRFSKEGRRGQIQTTLDRDLQSYIQEQITSQIRRLQAQNVNDAAVIVIENRTGEVFAYVGGSGDLS
SAPYVDGVQSLRQAGSTLKPFLYATAFEKKLLNPESWLEDSAVDIVFDRGVYKPQNHDRQFYGWVMVKTALGSSLNVPAV
KAFKLLNDESFWGKLKALNFRNLEEPEHYGPALALGVADVTLEDLAQGYRTLAQDGFLSSLKFEPHQETAEATEVFEAAS
AREVKEILSDNQNRALGFGLDSALALPGAAVKTGTSKDMRDNWCVGMNDRFTVGVWVGNFSGEPMWNVMGVSGAAPIWKR
TMIWLQDHYPSEARMAEVVPVKESQPEAYPGARILYPQDGMVLALDPAIPAGNQKMPLLVENSLKKDLYWKINEDKKIKA
TESYLWSPSLGRHHFVLYEGDSKVAEVSVLVK
>Mature_672_residues
MRKKLIWGLAVAGVLGGVAGVAIIASSVPSLPAYDSVKKSYVSSDLFLVDRNGKPLHQWRQDLKERTLLWADHKDIAPAM
ITALLKSEDKNFFHHWGVDPLAMAASVYQRSVKDSPRGASTITMQLVKLLHPNKKTWQGLSGKIRQSFAAMMLESQWSKE
QILESYLNLVSFRGELRGVNAASWMMFGKSAADLSRVDATLLSVLIRSPNSETAQWEKRACWQEPDLCATFKDSISRIQP
QKMISQNQQALHLAQRFSKEGRRGQIQTTLDRDLQSYIQEQITSQIRRLQAQNVNDAAVIVIENRTGEVFAYVGGSGDLS
SAPYVDGVQSLRQAGSTLKPFLYATAFEKKLLNPESWLEDSAVDIVFDRGVYKPQNHDRQFYGWVMVKTALGSSLNVPAV
KAFKLLNDESFWGKLKALNFRNLEEPEHYGPALALGVADVTLEDLAQGYRTLAQDGFLSSLKFEPHQETAEATEVFEAAS
AREVKEILSDNQNRALGFGLDSALALPGAAVKTGTSKDMRDNWCVGMNDRFTVGVWVGNFSGEPMWNVMGVSGAAPIWKR
TMIWLQDHYPSEARMAEVVPVKESQPEAYPGARILYPQDGMVLALDPAIPAGNQKMPLLVENSLKKDLYWKINEDKKIKA
TESYLWSPSLGRHHFVLYEGDSKVAEVSVLVK

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=508, Percent_Identity=32.8740157480315, Blast_Score=228, Evalue=1e-60,
Organism=Escherichia coli, GI1786343, Length=554, Percent_Identity=26.8953068592058, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI87082258, Length=208, Percent_Identity=31.25, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789601, Length=144, Percent_Identity=34.7222222222222, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 74885; Mature: 74885

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKLIWGLAVAGVLGGVAGVAIIASSVPSLPAYDSVKKSYVSSDLFLVDRNGKPLHQWR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHH
QDLKERTLLWADHKDIAPAMITALLKSEDKNFFHHWGVDPLAMAASVYQRSVKDSPRGAS
HHHHHHCEEEECCCCCHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCH
TITMQLVKLLHPNKKTWQGLSGKIRQSFAAMMLESQWSKEQILESYLNLVSFRGELRGVN
HHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
AASWMMFGKSAADLSRVDATLLSVLIRSPNSETAQWEKRACWQEPDLCATFKDSISRIQP
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCH
QKMISQNQQALHLAQRFSKEGRRGQIQTTLDRDLQSYIQEQITSQIRRLQAQNVNDAAVI
HHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VIENRTGEVFAYVGGSGDLSSAPYVDGVQSLRQAGSTLKPFLYATAFEKKLLNPESWLED
EEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHCC
SAVDIVFDRGVYKPQNHDRQFYGWVMVKTALGSSLNVPAVKAFKLLNDESFWGKLKALNF
CCEEEEEECCCCCCCCCCCEEHHHEEEEHHCCCCCCCCHHHHHHHHCCCCHHHHHEECCC
RNLEEPEHYGPALALGVADVTLEDLAQGYRTLAQDGFLSSLKFEPHQETAEATEVFEAAS
CCCCCCHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHH
AREVKEILSDNQNRALGFGLDSALALPGAAVKTGTSKDMRDNWCVGMNDRFTVGVWVGNF
HHHHHHHHCCCCCCEEECCCCHHHHCCCCCEECCCCCCCCCCCEECCCCCEEEEEEEECC
SGEPMWNVMGVSGAAPIWKRTMIWLQDHYPSEARMAEVVPVKESQPEAYPGARILYPQDG
CCCCCEEEECCCCCCCHHHHHEEEEECCCCCHHCCEEEECCCCCCCCCCCCCEEEECCCC
MVLALDPAIPAGNQKMPLLVENSLKKDLYWKINEDKKIKATESYLWSPSLGRHHFVLYEG
EEEEECCCCCCCCCCCCEEECCCCCCCEEEEECCCCEEEHHHHEECCCCCCCEEEEEEEC
DSKVAEVSVLVK
CCCEEEEEEEEC
>Mature Secondary Structure
MRKKLIWGLAVAGVLGGVAGVAIIASSVPSLPAYDSVKKSYVSSDLFLVDRNGKPLHQWR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHH
QDLKERTLLWADHKDIAPAMITALLKSEDKNFFHHWGVDPLAMAASVYQRSVKDSPRGAS
HHHHHHCEEEECCCCCHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCH
TITMQLVKLLHPNKKTWQGLSGKIRQSFAAMMLESQWSKEQILESYLNLVSFRGELRGVN
HHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
AASWMMFGKSAADLSRVDATLLSVLIRSPNSETAQWEKRACWQEPDLCATFKDSISRIQP
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCH
QKMISQNQQALHLAQRFSKEGRRGQIQTTLDRDLQSYIQEQITSQIRRLQAQNVNDAAVI
HHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VIENRTGEVFAYVGGSGDLSSAPYVDGVQSLRQAGSTLKPFLYATAFEKKLLNPESWLED
EEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHCC
SAVDIVFDRGVYKPQNHDRQFYGWVMVKTALGSSLNVPAVKAFKLLNDESFWGKLKALNF
CCEEEEEECCCCCCCCCCCEEHHHEEEEHHCCCCCCCCHHHHHHHHCCCCHHHHHEECCC
RNLEEPEHYGPALALGVADVTLEDLAQGYRTLAQDGFLSSLKFEPHQETAEATEVFEAAS
CCCCCCHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHH
AREVKEILSDNQNRALGFGLDSALALPGAAVKTGTSKDMRDNWCVGMNDRFTVGVWVGNF
HHHHHHHHCCCCCCEEECCCCHHHHCCCCCEECCCCCCCCCCCEECCCCCEEEEEEEECC
SGEPMWNVMGVSGAAPIWKRTMIWLQDHYPSEARMAEVVPVKESQPEAYPGARILYPQDG
CCCCCEEEECCCCCCCHHHHHEEEEECCCCCHHCCEEEECCCCCCCCCCCCCEEEECCCC
MVLALDPAIPAGNQKMPLLVENSLKKDLYWKINEDKKIKATESYLWSPSLGRHHFVLYEG
EEEEECCCCCCCCCCCCEEECCCCCCCEEEEECCCCEEEHHHHEECCCCCCCEEEEEEEC
DSKVAEVSVLVK
CCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]