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The map label for this gene is ctaB

Identifier: 42521913

GI number: 42521913

Start: 275180

End: 276058

Strand: Direct

Name: ctaB

Synonym: Bd0290

Alternate gene names: 42521913

Gene position: 275180-276058 (Clockwise)

Preceding gene: 42521912

Following gene: 42521915

Centisome position: 7.27

GC content: 50.74

Gene sequence:

>879_bases
GTGCTACGAATCTACGCAGATCTTACCAAGTTTGGCATAGTCGTTTTCTCAGTCCTAGCGGGACTGGCCGGCTATGCCAC
TGGTTTTCAGATCGAAAATCCCTTTGATTGGAAAATCTTTTTAGAAACCCTGCTGGGGATTTATTTCCTCAGCTCGGGCT
CTCTTGCGCTCAATCAGGTTCAAGACTGGAAGATCGACCAAAAAATGCCCCGTACAGCCAAGCGTCCGATCCCTTCCGGT
AAAATCAAGCCGGCAGCGGCGGGTATTTTGTCGGTAGGTCTTTTGCTGGTCGGTATGAACATGCTGTTCAAGCTGGAGCC
TGTGGCCGGCTGGGTGGGGTTGTTCTGCGTTTTCCTTTATAACGGTCCTTATACTTTGTGGTGGAAACGCCGTTGGGTCT
TTGCGGCCGTTCCGGGGGCGATCCCGGGGGCTTTGCCAGTGACTATCGGTTACGCGGTGGCAAATCCGGACATCTTCAAC
TCGGAGTCTTTGTATCTGTTCCTGATCATGTTCCTGTGGCAGATGCCGCACTTCTGGGTGCTGGCAATCCGTTACAAAGA
TGACTATGCAGCGGGCGGGATTCCGACTTTGCCGGTGGCTTTGGGCATGGAAAAAACCATGTTCCAGGTCGGCCTTTACA
CCTTAGTTTATGTGGGTGTGGCTTTGGCGGCGCCGATGTTTGTTCACGCCAGCTGGATGTTTGTTCTGCTGACGTTCCCG
TTTGTGTTCAAGGTTCTGCAAGAGTTCTATCGCTACTACAAGTCCAATGGGACTGAACGTTGGCTGGCCTTCTTTATGTG
GCTCAACGTTTCCATGTTAGTCTTCATCATCATCCCGGTGATTGATAAATGGAACTTCCTCTTCATTCATCATAACTAA

Upstream 100 bases:

>100_bases
GTCTTTGCATCTGGTTTCTTCTTCCTGGCGTTGCTGTTCGCGATCTGCGCGATCGACTTCGCGACTCGCGTTCACGAAGT
CAGCCCGCTGTAAGATTATC

Downstream 100 bases:

>100_bases
AAGAAAAGGCCCGTTTCCGGGCCTTTTTTATTTTTTGAATTCTTCGGGTGTATCCATCTGATTGAAGGGGTGGGCTTTCT
TGAAAGCTTCCAGCTTCAGG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MLRIYADLTKFGIVVFSVLAGLAGYATGFQIENPFDWKIFLETLLGIYFLSSGSLALNQVQDWKIDQKMPRTAKRPIPSG
KIKPAAAGILSVGLLLVGMNMLFKLEPVAGWVGLFCVFLYNGPYTLWWKRRWVFAAVPGAIPGALPVTIGYAVANPDIFN
SESLYLFLIMFLWQMPHFWVLAIRYKDDYAAGGIPTLPVALGMEKTMFQVGLYTLVYVGVALAAPMFVHASWMFVLLTFP
FVFKVLQEFYRYYKSNGTERWLAFFMWLNVSMLVFIIIPVIDKWNFLFIHHN

Sequences:

>Translated_292_residues
MLRIYADLTKFGIVVFSVLAGLAGYATGFQIENPFDWKIFLETLLGIYFLSSGSLALNQVQDWKIDQKMPRTAKRPIPSG
KIKPAAAGILSVGLLLVGMNMLFKLEPVAGWVGLFCVFLYNGPYTLWWKRRWVFAAVPGAIPGALPVTIGYAVANPDIFN
SESLYLFLIMFLWQMPHFWVLAIRYKDDYAAGGIPTLPVALGMEKTMFQVGLYTLVYVGVALAAPMFVHASWMFVLLTFP
FVFKVLQEFYRYYKSNGTERWLAFFMWLNVSMLVFIIIPVIDKWNFLFIHHN
>Mature_292_residues
MLRIYADLTKFGIVVFSVLAGLAGYATGFQIENPFDWKIFLETLLGIYFLSSGSLALNQVQDWKIDQKMPRTAKRPIPSG
KIKPAAAGILSVGLLLVGMNMLFKLEPVAGWVGLFCVFLYNGPYTLWWKRRWVFAAVPGAIPGALPVTIGYAVANPDIFN
SESLYLFLIMFLWQMPHFWVLAIRYKDDYAAGGIPTLPVALGMEKTMFQVGLYTLVYVGVALAAPMFVHASWMFVLLTFP
FVFKVLQEFYRYYKSNGTERWLAFFMWLNVSMLVFIIIPVIDKWNFLFIHHN

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=197, Percent_Identity=31.9796954314721, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786631, Length=239, Percent_Identity=30.1255230125523, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=237, Percent_Identity=26.1603375527426, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325085, Length=196, Percent_Identity=28.0612244897959, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921064, Length=290, Percent_Identity=25.8620689655172, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_BDEBA (Q6MR11)

Other databases:

- EMBL:   BX842646
- RefSeq:   NP_967293.1
- GeneID:   2734946
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd0290
- NMPDR:   fig|264462.1.peg.263
- OMA:   HADDYRR
- PhylomeDB:   Q6MR11
- BioCyc:   BBAC264462:BD0290-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33277; Mature: 33277

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xbd8a678)-; HASH(0x8b17a98)-; HASH(0xb0e19a4)-; HASH(0xcccc4b8)-; HASH(0xcdab3b8)-; HASH(0xabc9a04)-; HASH(0xc9da4d8)-; HASH(0x8b180a4)-; HASH(0xafdfe58)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIYADLTKFGIVVFSVLAGLAGYATGFQIENPFDWKIFLETLLGIYFLSSGSLALNQV
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHH
QDWKIDQKMPRTAKRPIPSGKIKPAAAGILSVGLLLVGMNMLFKLEPVAGWVGLFCVFLY
HCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHH
NGPYTLWWKRRWVFAAVPGAIPGALPVTIGYAVANPDIFNSESLYLFLIMFLWQMPHFWV
CCCEEEEEEEEEEEEECCCCCCCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEE
LAIRYKDDYAAGGIPTLPVALGMEKTMFQVGLYTLVYVGVALAAPMFVHASWMFVLLTFP
EEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVFKVLQEFYRYYKSNGTERWLAFFMWLNVSMLVFIIIPVIDKWNFLFIHHN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECH
>Mature Secondary Structure
MLRIYADLTKFGIVVFSVLAGLAGYATGFQIENPFDWKIFLETLLGIYFLSSGSLALNQV
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHH
QDWKIDQKMPRTAKRPIPSGKIKPAAAGILSVGLLLVGMNMLFKLEPVAGWVGLFCVFLY
HCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHH
NGPYTLWWKRRWVFAAVPGAIPGALPVTIGYAVANPDIFNSESLYLFLIMFLWQMPHFWV
CCCEEEEEEEEEEEEECCCCCCCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEE
LAIRYKDDYAAGGIPTLPVALGMEKTMFQVGLYTLVYVGVALAAPMFVHASWMFVLLTFP
EEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVFKVLQEFYRYYKSNGTERWLAFFMWLNVSMLVFIIIPVIDKWNFLFIHHN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA