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The map label for this gene is tsr [H]

Identifier: 42521886

GI number: 42521886

Start: 249935

End: 251350

Strand: Direct

Name: tsr [H]

Synonym: Bd0262

Alternate gene names: 42521886

Gene position: 249935-251350 (Clockwise)

Preceding gene: 42521885

Following gene: 42521887

Centisome position: 6.61

GC content: 51.84

Gene sequence:

>1416_bases
ATGAGCTGGACTTTAAGAAAAAGACTGTTGTTCCTGTGTGGGGGATTCATCGTTGTTCTGGTGGGAGTGGCGGTTCTTTC
CTATGTGAATTCCACCACCTTGATGAATCAGTTTGATAATGTTGCTAAAGTTCAGCTGCCGGCGGTTCGTAACATGACTC
TGGCGGATATGATGCATGACGGTCTGCGATCCGTTGTGCTGGCATCCTTATTGGCGGCTGAAAGTAACGAAGCAGACAAT
CTCAAGGCGATTGCGCAAGAGACAGAGGAAAAAGCAGGTGACTTCCAACGGTATCTGCAGGCTTTGGAAGAATTGCCGTT
GAACGAAGGCACTCGTCGAGCCATTGCCGAAACCAAGCCCGAAATGGAAAGGTATATTGGGCAGACCCGAAAGATTGTGG
GTCTTGCCAGCACCCAGGGGTATCGGGCGGCCTTAAGCGAGCTTGAAGATTTCAACAAGAGCTTTAAGGTGCTTGAGGAA
AAAATGGAAGCGCTGGGGGGGCTGATAGAAAAGGATGCCGAAGCGGCCCATCAATCGGGAGCGGGTTTGAGAACCTTGAA
TGTGGTGGTGGCAGGTCTTGGTGTTTTGTTCTGTTTGGCGGGTGGAATGCTTGTGACCCAGAGTCTGGTAAGTCGAATGA
CCCGGTTTGCGGCCAATATCGAAAGTTCGGGAGATTCACTGGATGAAACCAGTGCTCATTTGAATCGTGCCAGTCAGGAT
TTGGCGCAAGGTGCGACCCAGTCCGCAGCCTCACTTGAAGAAACGGTGGCTTCTCTGGAGGAGCTTTCCGGCATGGTGAA
GTTGAACTCTGAAAGTGCAAAAACCGCATCAGCTTTGTCGGCCGAAAGTTTTGCCGCATCCAAGGCCGGGGCCGAGTCCG
TGCAGAAACTGATAGCCTCAATGGAGACATTAAAAGAATCCTCCGCGGCGATCCGGGATGTCAGCCAGGTGATCGATGAT
ATTGCCTTTCAGACAAACCTGCTGGCTTTAAATGCCTCAGTGGAAGCAGCCAGAGCCGGAGAGATGGGAAAAGGTTTTGC
GGTGGTTGCGGATGCTGTTCGGGGACTGGCGCAAAGAAGTGCCGATTCAGCCAAGGGCATATCCAAGATGATCGAAGAAA
GTGTTTCCCGCATTCACGACGGCAGCAAGGCGGCGGCCGAAAGCGGTGAGCAGCTTCAAAAGTTTTTGGACTCAGCAAAA
AAAGTGCTTGAGATCAATAACGAAATCGCCGGTGCCAGTCATGAACAGTCCCGCGGCATCACTTTGATCAGTGAAGCAAT
GAACAGGCTGGATCAGGCTTCACAAAAGAACGCCCAGGTCGCGCAGGAAGTGGCGCAGACCAGCGATCAAATGTCGCAGA
TGTCCCATGGGATGCAGGGGCTTGTGAGTGAATTAAAGTCCCTGGTCGGAAAGTAA

Upstream 100 bases:

>100_bases
CATTGGTGCACTGCTGGGGTTGGGTCCGTCAGCGGTAGAACATGAACGGGGTGTCTTCGTTTATCTCTCTATCGAATCCA
AGCTTTGGTAGAAGGCAGTC

Downstream 100 bases:

>100_bases
AGAAAGATCACGGACCTCGCCTCGAGGTCCGTAAACAAACAAGCCTTCTTGTTCTTTCATTCAGAATTTCTGCACTTGCA
GTCAATCTGGTGAAAAAAGT

Product: chemotaxis protein

Products: NA

Alternate protein names: Citrate chemoreceptor protein [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSWTLRKRLLFLCGGFIVVLVGVAVLSYVNSTTLMNQFDNVAKVQLPAVRNMTLADMMHDGLRSVVLASLLAAESNEADN
LKAIAQETEEKAGDFQRYLQALEELPLNEGTRRAIAETKPEMERYIGQTRKIVGLASTQGYRAALSELEDFNKSFKVLEE
KMEALGGLIEKDAEAAHQSGAGLRTLNVVVAGLGVLFCLAGGMLVTQSLVSRMTRFAANIESSGDSLDETSAHLNRASQD
LAQGATQSAASLEETVASLEELSGMVKLNSESAKTASALSAESFAASKAGAESVQKLIASMETLKESSAAIRDVSQVIDD
IAFQTNLLALNASVEAARAGEMGKGFAVVADAVRGLAQRSADSAKGISKMIEESVSRIHDGSKAAAESGEQLQKFLDSAK
KVLEINNEIAGASHEQSRGITLISEAMNRLDQASQKNAQVAQEVAQTSDQMSQMSHGMQGLVSELKSLVGK

Sequences:

>Translated_471_residues
MSWTLRKRLLFLCGGFIVVLVGVAVLSYVNSTTLMNQFDNVAKVQLPAVRNMTLADMMHDGLRSVVLASLLAAESNEADN
LKAIAQETEEKAGDFQRYLQALEELPLNEGTRRAIAETKPEMERYIGQTRKIVGLASTQGYRAALSELEDFNKSFKVLEE
KMEALGGLIEKDAEAAHQSGAGLRTLNVVVAGLGVLFCLAGGMLVTQSLVSRMTRFAANIESSGDSLDETSAHLNRASQD
LAQGATQSAASLEETVASLEELSGMVKLNSESAKTASALSAESFAASKAGAESVQKLIASMETLKESSAAIRDVSQVIDD
IAFQTNLLALNASVEAARAGEMGKGFAVVADAVRGLAQRSADSAKGISKMIEESVSRIHDGSKAAAESGEQLQKFLDSAK
KVLEINNEIAGASHEQSRGITLISEAMNRLDQASQKNAQVAQEVAQTSDQMSQMSHGMQGLVSELKSLVGK
>Mature_470_residues
SWTLRKRLLFLCGGFIVVLVGVAVLSYVNSTTLMNQFDNVAKVQLPAVRNMTLADMMHDGLRSVVLASLLAAESNEADNL
KAIAQETEEKAGDFQRYLQALEELPLNEGTRRAIAETKPEMERYIGQTRKIVGLASTQGYRAALSELEDFNKSFKVLEEK
MEALGGLIEKDAEAAHQSGAGLRTLNVVVAGLGVLFCLAGGMLVTQSLVSRMTRFAANIESSGDSLDETSAHLNRASQDL
AQGATQSAASLEETVASLEELSGMVKLNSESAKTASALSAESFAASKAGAESVQKLIASMETLKESSAAIRDVSQVIDDI
AFQTNLLALNASVEAARAGEMGKGFAVVADAVRGLAQRSADSAKGISKMIEESVSRIHDGSKAAAESGEQLQKFLDSAKK
VLEINNEIAGASHEQSRGITLISEAMNRLDQASQKNAQVAQEVAQTSDQMSQMSHGMQGLVSELKSLVGK

Specific function: Acts as a receptor for citrate and mediates taxis away from phenol. Also mediates an attractant response to metal-citrate complexes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=342, Percent_Identity=35.9649122807018, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1788195, Length=257, Percent_Identity=40.8560311284047, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1788194, Length=213, Percent_Identity=45.0704225352113, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1787690, Length=204, Percent_Identity=45.5882352941176, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1789453, Length=237, Percent_Identity=36.7088607594937, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR003122
- InterPro:   IPR004091
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 50078; Mature: 49947

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SWTLRKRLLFLCGGFIVVLVGVAVLSYVNSTTLMNQFDNVAKVQLPAVRNMTLADMMHD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCHHHHHHHHH
GLRSVVLASLLAAESNEADNLKAIAQETEEKAGDFQRYLQALEELPLNEGTRRAIAETKP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCH
EMERYIGQTRKIVGLASTQGYRAALSELEDFNKSFKVLEEKMEALGGLIEKDAEAAHQSG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGLRTLNVVVAGLGVLFCLAGGMLVTQSLVSRMTRFAANIESSGDSLDETSAHLNRASQD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LAQGATQSAASLEETVASLEELSGMVKLNSESAKTASALSAESFAASKAGAESVQKLIAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
METLKESSAAIRDVSQVIDDIAFQTNLLALNASVEAARAGEMGKGFAVVADAVRGLAQRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHC
ADSAKGISKMIEESVSRIHDGSKAAAESGEQLQKFLDSAKKVLEINNEIAGASHEQSRGI
CHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCH
TLISEAMNRLDQASQKNAQVAQEVAQTSDQMSQMSHGMQGLVSELKSLVGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8419927; 11677609 [H]