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The map label for this gene is prsA [H]

Identifier: 42521883

GI number: 42521883

Start: 247520

End: 247792

Strand: Direct

Name: prsA [H]

Synonym: Bd0258

Alternate gene names: 42521883

Gene position: 247520-247792 (Clockwise)

Preceding gene: 42521881

Following gene: 42521884

Centisome position: 6.54

GC content: 50.92

Gene sequence:

>273_bases
ATGAAAATCAGAGCCAGCCATATTTTGGTAAAACATCAGTATGAGGCGGAAGACATTTTGCGTGCGCTGAAAAGTGGAAA
GACTTTTGAAGAACTGGCGCAAAGGTATTCCCAGTGCCCTTCGGCCCGTGTCGGCGGGGATTTGGGTGTTTTTGCCGAAG
GCCGTATGGACGAGGTTTTCGAGGAGGCCGCCTTTGCCCTGAAGGTGAATGAGACAACATTACACCCGGTGCGCACACGT
TTTGGCTATCACATCATCCGAAGAACGGAGTAG

Upstream 100 bases:

>100_bases
TTGCCCATGCGGAAAAGCTGAAAAGAAGCAGAAATAAAGTGAATTTCACATTTACGACCTTAAGGAAGCTTTAAGTGATC
GTCAAATTAAAAGGGACAGT

Downstream 100 bases:

>100_bases
GCATGAGACCCTTTCTTCCACTGCTGACTTTTATTGCGGTATTTTTGGGGAGTGGATTTTATTATTTGTGGCAGGGTGTG
GATTTCGCCTTCTATCAATT

Product: peptidyl-prolyl cis-trans isomerase C

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 90; Mature: 90

Protein sequence:

>90_residues
MKIRASHILVKHQYEAEDILRALKSGKTFEELAQRYSQCPSARVGGDLGVFAEGRMDEVFEEAAFALKVNETTLHPVRTR
FGYHIIRRTE

Sequences:

>Translated_90_residues
MKIRASHILVKHQYEAEDILRALKSGKTFEELAQRYSQCPSARVGGDLGVFAEGRMDEVFEEAAFALKVNETTLHPVRTR
FGYHIIRRTE
>Mature_90_residues
MKIRASHILVKHQYEAEDILRALKSGKTFEELAQRYSQCPSARVGGDLGVFAEGRMDEVFEEAAFALKVNETTLHPVRTR
FGYHIIRRTE

Specific function: Essential protein that plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Has PPIase activity but it is not essential for its function in vivo [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI5453898, Length=111, Percent_Identity=40.5405405405405, Blast_Score=73, Evalue=6e-14,
Organism=Homo sapiens, GI38679892, Length=89, Percent_Identity=43.8202247191011, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790211, Length=83, Percent_Identity=46.9879518072289, Blast_Score=79, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17537235, Length=89, Percent_Identity=42.6966292134831, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356303, Length=89, Percent_Identity=40.4494382022472, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF05698 Trigger_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 10322; Mature: 10322

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRASHILVKHQYEAEDILRALKSGKTFEELAQRYSQCPSARVGGDLGVFAEGRMDEVF
CCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
EEAAFALKVNETTLHPVRTRFGYHIIRRTE
HHHHHHEECCCCCCHHHHHHHHHHEEEECC
>Mature Secondary Structure
MKIRASHILVKHQYEAEDILRALKSGKTFEELAQRYSQCPSARVGGDLGVFAEGRMDEVF
CCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
EEAAFALKVNETTLHPVRTRFGYHIIRRTE
HHHHHHEECCCCCCHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1956302; 9579061; 9384377; 3145906 [H]