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The map label for this gene is pepP [H]

Identifier: 42521832

GI number: 42521832

Start: 187711

End: 189033

Strand: Direct

Name: pepP [H]

Synonym: Bd0202

Alternate gene names: 42521832

Gene position: 187711-189033 (Clockwise)

Preceding gene: 42521831

Following gene: 42521834

Centisome position: 4.96

GC content: 50.72

Gene sequence:

>1323_bases
ATGAGCAGAAAACCCATCTATGACATGAACATCTTTTCCGAGAGAAGGAAAAAAGCCGGGGAGCAGATCCCAGGTGGTGC
TTTGGTTGTGGCTTCTCACCCGGAATACATCCGTAATCACGACTGCCATTTCCCTTACCGTCAGGATTCCAATCTGTTTT
ACCTGACGGGCTGGGAAGAGCCTGAGTCTGTTTTGATTCATCGCCCGGGTCTGACTCCGGAAACAGTGATGTTCGTGCGC
CGTCGTGACGTGGAAAGAGAAACCTGGGATGGTTTCCGCTATGGTCCGGAAGGCTGCGAGCGTGAATTTAAAATCGACAA
AGCGTATCCGTTTGATGAACTGACCAAGGTGGCGCCTCAGCTTTTGAAAGAAGTCGACCGCGTTTATTACAGCCAGTACA
AAAACCAGGAGATGGATCACAAGATGCAGGAGATTCTGCAAACGGTGAAAGCTCTTCAGGGGCGCATGGGGAATGGCCTG
TTGGCGATTCACGATGCGGATATTCTGCTGGGCGAGCTTCGTCTGGTGAAATCTGAATACGAACTGACTCAGCTGCGTGA
GGCGTGCGAGATTTCCGCTCAGGCCCACTTGGCAGCTATGCGTTTCACCCGTCCGGGTGTGACGGAACGCCAGGTTCAAG
GGGTGCTTGCGCACAACTTCTATATGAGAGGTTCTGCCCGTGAAGGTTACAACTATATCGTGGCTTCCGGAAATGCCGCG
ACGACCTTGCACTATAACTTCAATGACCAGGTCTGCAAAGACGGGGACCTGTTGCTGATTGATGCGGGTGCCGAGTTCAA
CTACTACACAGGTGATATCACCCGCACTTATCCGGTGAATGGCAAGTTCACGGACGAGCAGGCGCGTGTGTACGAAGGTG
TTTTGAAAGTTCAAAAGCAGATCTGTGACTATGTAAAGCCGGGGATTTTCTTTAAAGACCTGCACGACATGGGAACGTCT
TTATTGACGGATCTGATGTTGGATCTGGGTTTGTTGTCCGGTCGCAAGGATGATTTGATTCAGGCTTTGGCGCAGAAAAA
GTATTATCCACACGGTATCGGCCACTGGCTGGGTATGGATGTGCATGATGCGGGTCTGTACTTCAAAAAGAACGAACCGC
GTCCGATCGAAGCCAATATGTGCTTCACGATCGAACCGGGTCTTTACATCCCGGCTGACGATGCATCAGCTCCTCAGAAA
TACCGTGGTATCGGTATTCGTATCGAGGACAATCTGCGTGTGACGTCTTCAGGATCCGAGAACATGACTTCGTCTGTTCC
CAAAGAGATTGCTGACATTGAAAAGGTTGTCGGCAAAGCTTAA

Upstream 100 bases:

>100_bases
TGGATTTCGACAAGCGTCGTGAGATCATGAACAAGGGCGCAGACTCAGCTGCCCGTCAGTTGAAGGGTCTGACCCGCAAG
TGGGGACTTTAGGAGAATTT

Downstream 100 bases:

>100_bases
GCATTTGGAACCGAAAAAGGCTCACCGCAAGGTGGGCCTTTTTTATGTCAGCATGCTGTTGTCAACATGGCGAAGGTTCT
GCGAAATCACGGAAAGGTGA

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSRKPIYDMNIFSERRKKAGEQIPGGALVVASHPEYIRNHDCHFPYRQDSNLFYLTGWEEPESVLIHRPGLTPETVMFVR
RRDVERETWDGFRYGPEGCEREFKIDKAYPFDELTKVAPQLLKEVDRVYYSQYKNQEMDHKMQEILQTVKALQGRMGNGL
LAIHDADILLGELRLVKSEYELTQLREACEISAQAHLAAMRFTRPGVTERQVQGVLAHNFYMRGSAREGYNYIVASGNAA
TTLHYNFNDQVCKDGDLLLIDAGAEFNYYTGDITRTYPVNGKFTDEQARVYEGVLKVQKQICDYVKPGIFFKDLHDMGTS
LLTDLMLDLGLLSGRKDDLIQALAQKKYYPHGIGHWLGMDVHDAGLYFKKNEPRPIEANMCFTIEPGLYIPADDASAPQK
YRGIGIRIEDNLRVTSSGSENMTSSVPKEIADIEKVVGKA

Sequences:

>Translated_440_residues
MSRKPIYDMNIFSERRKKAGEQIPGGALVVASHPEYIRNHDCHFPYRQDSNLFYLTGWEEPESVLIHRPGLTPETVMFVR
RRDVERETWDGFRYGPEGCEREFKIDKAYPFDELTKVAPQLLKEVDRVYYSQYKNQEMDHKMQEILQTVKALQGRMGNGL
LAIHDADILLGELRLVKSEYELTQLREACEISAQAHLAAMRFTRPGVTERQVQGVLAHNFYMRGSAREGYNYIVASGNAA
TTLHYNFNDQVCKDGDLLLIDAGAEFNYYTGDITRTYPVNGKFTDEQARVYEGVLKVQKQICDYVKPGIFFKDLHDMGTS
LLTDLMLDLGLLSGRKDDLIQALAQKKYYPHGIGHWLGMDVHDAGLYFKKNEPRPIEANMCFTIEPGLYIPADDASAPQK
YRGIGIRIEDNLRVTSSGSENMTSSVPKEIADIEKVVGKA
>Mature_439_residues
SRKPIYDMNIFSERRKKAGEQIPGGALVVASHPEYIRNHDCHFPYRQDSNLFYLTGWEEPESVLIHRPGLTPETVMFVRR
RDVERETWDGFRYGPEGCEREFKIDKAYPFDELTKVAPQLLKEVDRVYYSQYKNQEMDHKMQEILQTVKALQGRMGNGLL
AIHDADILLGELRLVKSEYELTQLREACEISAQAHLAAMRFTRPGVTERQVQGVLAHNFYMRGSAREGYNYIVASGNAAT
TLHYNFNDQVCKDGDLLLIDAGAEFNYYTGDITRTYPVNGKFTDEQARVYEGVLKVQKQICDYVKPGIFFKDLHDMGTSL
LTDLMLDLGLLSGRKDDLIQALAQKKYYPHGIGHWLGMDVHDAGLYFKKNEPRPIEANMCFTIEPGLYIPADDASAPQKY
RGIGIRIEDNLRVTSSGSENMTSSVPKEIADIEKVVGKA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=434, Percent_Identity=34.5622119815668, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI149589008, Length=483, Percent_Identity=27.9503105590062, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI260593665, Length=299, Percent_Identity=34.7826086956522, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI260593663, Length=259, Percent_Identity=35.1351351351351, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1789275, Length=432, Percent_Identity=39.1203703703704, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1788728, Length=262, Percent_Identity=27.0992366412214, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1790282, Length=287, Percent_Identity=27.8745644599303, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17508215, Length=436, Percent_Identity=31.8807339449541, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71989583, Length=373, Percent_Identity=27.3458445040214, Blast_Score=154, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320922, Length=438, Percent_Identity=31.5068493150685, Blast_Score=223, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6321118, Length=429, Percent_Identity=31.7016317016317, Blast_Score=192, Evalue=9e-50,
Organism=Drosophila melanogaster, GI19920384, Length=378, Percent_Identity=32.8042328042328, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI21357079, Length=491, Percent_Identity=29.938900203666, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50116; Mature: 49984

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKPIYDMNIFSERRKKAGEQIPGGALVVASHPEYIRNHDCHFPYRQDSNLFYLTGWEE
CCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHCCCCCCCCCCCCCEEEEECCCC
PESVLIHRPGLTPETVMFVRRRDVERETWDGFRYGPEGCEREFKIDKAYPFDELTKVAPQ
CCEEEEECCCCCHHHHHHHHHHCCCCHHCCCCCCCCHHCCCCEEECCCCCHHHHHHHHHH
LLKEVDRVYYSQYKNQEMDHKMQEILQTVKALQGRMGNGLLAIHDADILLGELRLVKSEY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHH
ELTQLREACEISAQAHLAAMRFTRPGVTERQVQGVLAHNFYMRGSAREGYNYIVASGNAA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEECCCCCCCEEEEECCCEE
TTLHYNFNDQVCKDGDLLLIDAGAEFNYYTGDITRTYPVNGKFTDEQARVYEGVLKVQKQ
EEEEECCCCCCCCCCCEEEEECCCCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHH
ICDYVKPGIFFKDLHDMGTSLLTDLMLDLGLLSGRKDDLIQALAQKKYYPHGIGHWLGMD
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCCC
VHDAGLYFKKNEPRPIEANMCFTIEPGLYIPADDASAPQKYRGIGIRIEDNLRVTSSGSE
EECCCEEEECCCCCCEECCEEEEECCCEEECCCCCCCCHHHCCEEEEEECCEEEECCCCC
NMTSSVPKEIADIEKVVGKA
CHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRKPIYDMNIFSERRKKAGEQIPGGALVVASHPEYIRNHDCHFPYRQDSNLFYLTGWEE
CCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHCCCCCCCCCCCCCEEEEECCCC
PESVLIHRPGLTPETVMFVRRRDVERETWDGFRYGPEGCEREFKIDKAYPFDELTKVAPQ
CCEEEEECCCCCHHHHHHHHHHCCCCHHCCCCCCCCHHCCCCEEECCCCCHHHHHHHHHH
LLKEVDRVYYSQYKNQEMDHKMQEILQTVKALQGRMGNGLLAIHDADILLGELRLVKSEY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHH
ELTQLREACEISAQAHLAAMRFTRPGVTERQVQGVLAHNFYMRGSAREGYNYIVASGNAA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEECCCCCCCEEEEECCCEE
TTLHYNFNDQVCKDGDLLLIDAGAEFNYYTGDITRTYPVNGKFTDEQARVYEGVLKVQKQ
EEEEECCCCCCCCCCCEEEEECCCCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHH
ICDYVKPGIFFKDLHDMGTSLLTDLMLDLGLLSGRKDDLIQALAQKKYYPHGIGHWLGMD
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCCC
VHDAGLYFKKNEPRPIEANMCFTIEPGLYIPADDASAPQKYRGIGIRIEDNLRVTSSGSE
EECCCEEEECCCCCCEECCEEEEECCCEEECCCCCCCCHHHCCEEEEEECCEEEECCCCC
NMTSSVPKEIADIEKVVGKA
CHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]