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The map label for this gene is xseA [H]

Identifier: 42521827

GI number: 42521827

Start: 183449

End: 184855

Strand: Direct

Name: xseA [H]

Synonym: Bd0197

Alternate gene names: 42521827

Gene position: 183449-184855 (Clockwise)

Preceding gene: 42521823

Following gene: 42521828

Centisome position: 4.85

GC content: 52.24

Gene sequence:

>1407_bases
ATGTCGGACTCTCCTAATCAGCCTCTTCGTAAAACAGATGTTTCAGCCCAAGCCAGTCTTGGAGCTGCGGACCTATTGAC
GAAGAACAACGAACCTTCCGTGCTTTCCGTCGAGCAGCTTAATATCTATGTGAAGCAGTTGCTGGAGGGTCAGATCGGGC
AGGTGTGGGTGAAGGGTGAAATTTCAAACTTCAAGGCTCACACCTCCGGTCACTTTTATTTCAGCCTGAAAGATTCCCGT
TCCCAGATCACGGCCGTGATGTTCCGTGGTAACAACGCCCGTTTGAAATTCAAACCTACCGATGGGATGGAAGTCATCGT
TCGCGGCCGCATCACGGTGTATGAGCCGCGTGGTAACTATCAGCTGATGTGCGAGATGATGGAACCCGTCGGTGCCGGAG
CTTTGCAAAAAGCTTTCGAGCAACTGAAAATGAAATTGAAAGCCGAGGGTTTGTTTGAATCAGCCCGCAAAAAGCCGATT
CCGACTTTCCCAAGACATATTGCGATCGTGACGTCTCCGACCGGAGCGGCGATTCGTGATATTTTGAACGTTCTTTCCCG
TCGCGCTAAAGCCATCCAGGTGACGGTGGTTCCAACCATCGTGCAGGGTGAGGCGGCAGCTCCACAAATTTGCGAGGCCT
TTAAAAAAGCCACCGCCCTTCCGGGTGTGGATGTGGTGATTGTCGGGCGCGGTGGTGGATCCATTGAAGACATGTGGTGT
TTCAATGATGAACGGCTTGCGCGTTTGATTGCGGCAAGCCCGGTCCCGGTGATTTCCGCCGTGGGGCACGAAATTGATTT
TACTATCGCTGACTTTGTGGCGGACTTGCGTGCGCCGACACCTTCGGCCGCGGCAGAACTTGTGGCGAAAAGCTCAGGCG
AACTGGCCAACAAGGTTGTGTCGCTGGAGCGCATGCTGCATCTGACTTTTGAAAAGAAGATGAAGTTCCTGCGTGAAAAG
ATGCTGGGTCTTTCCAAACGACTGGTGGATCCGAAGCGCCGTTTGCAGGATCTGGAGCTTCGCAACGATGATCTTTTGAA
CCGTCTGGAGTTCGCGATCAACCGCCGTCTGGCGGAGCGTCGCCACCGGGTGGAGCTGATGAGTCAGAAACTGGGAAGCC
CCCAGGATCTGATTGATGAAAAGAAAAAGGATCTGGAATATCTGAAGGCACGTTCTGAAAAGGCGCTACATTTTTCGATT
GAAAGAAAAAAGGCCCGCATGGGCAAGGTCATGGCTATGCTGGATAGTCTCAGTCCCCTGAAGGTGGTTGAGCGTGGCTA
TTCAATCGTGACCAAAAATTCTGAAGTTATTAAATCTGCGAGTCAGGTGAAAAAGGGAGACCTTTTGGATATCCGCCTGG
CTCAGGGCTCAGTGACCGCCATCGTGGATGGCGTGAAGGAGGAATAG

Upstream 100 bases:

>100_bases
GCGGATTGTGGTCCGTTCAGAACGTTTGGCACTCCAGTCTATAGGTCGTTGACTCTCAATGTATTGACTCCACCCCGAGG
GAGCATTAGCCTCTGCTCCC

Downstream 100 bases:

>100_bases
AATGGATTTTGAGAAGAAACTAGGCCGTCTTGAAGAGATCGTGCAAAAGATGGAAAAAGGCGATCTGGCTTTGGAAGAGT
CTTTGAAGCTGTTCGAGGAA

Product: exodeoxyribonuclease VII, large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSDSPNQPLRKTDVSAQASLGAADLLTKNNEPSVLSVEQLNIYVKQLLEGQIGQVWVKGEISNFKAHTSGHFYFSLKDSR
SQITAVMFRGNNARLKFKPTDGMEVIVRGRITVYEPRGNYQLMCEMMEPVGAGALQKAFEQLKMKLKAEGLFESARKKPI
PTFPRHIAIVTSPTGAAIRDILNVLSRRAKAIQVTVVPTIVQGEAAAPQICEAFKKATALPGVDVVIVGRGGGSIEDMWC
FNDERLARLIAASPVPVISAVGHEIDFTIADFVADLRAPTPSAAAELVAKSSGELANKVVSLERMLHLTFEKKMKFLREK
MLGLSKRLVDPKRRLQDLELRNDDLLNRLEFAINRRLAERRHRVELMSQKLGSPQDLIDEKKKDLEYLKARSEKALHFSI
ERKKARMGKVMAMLDSLSPLKVVERGYSIVTKNSEVIKSASQVKKGDLLDIRLAQGSVTAIVDGVKEE

Sequences:

>Translated_468_residues
MSDSPNQPLRKTDVSAQASLGAADLLTKNNEPSVLSVEQLNIYVKQLLEGQIGQVWVKGEISNFKAHTSGHFYFSLKDSR
SQITAVMFRGNNARLKFKPTDGMEVIVRGRITVYEPRGNYQLMCEMMEPVGAGALQKAFEQLKMKLKAEGLFESARKKPI
PTFPRHIAIVTSPTGAAIRDILNVLSRRAKAIQVTVVPTIVQGEAAAPQICEAFKKATALPGVDVVIVGRGGGSIEDMWC
FNDERLARLIAASPVPVISAVGHEIDFTIADFVADLRAPTPSAAAELVAKSSGELANKVVSLERMLHLTFEKKMKFLREK
MLGLSKRLVDPKRRLQDLELRNDDLLNRLEFAINRRLAERRHRVELMSQKLGSPQDLIDEKKKDLEYLKARSEKALHFSI
ERKKARMGKVMAMLDSLSPLKVVERGYSIVTKNSEVIKSASQVKKGDLLDIRLAQGSVTAIVDGVKEE
>Mature_467_residues
SDSPNQPLRKTDVSAQASLGAADLLTKNNEPSVLSVEQLNIYVKQLLEGQIGQVWVKGEISNFKAHTSGHFYFSLKDSRS
QITAVMFRGNNARLKFKPTDGMEVIVRGRITVYEPRGNYQLMCEMMEPVGAGALQKAFEQLKMKLKAEGLFESARKKPIP
TFPRHIAIVTSPTGAAIRDILNVLSRRAKAIQVTVVPTIVQGEAAAPQICEAFKKATALPGVDVVIVGRGGGSIEDMWCF
NDERLARLIAASPVPVISAVGHEIDFTIADFVADLRAPTPSAAAELVAKSSGELANKVVSLERMLHLTFEKKMKFLREKM
LGLSKRLVDPKRRLQDLELRNDDLLNRLEFAINRRLAERRHRVELMSQKLGSPQDLIDEKKKDLEYLKARSEKALHFSIE
RKKARMGKVMAMLDSLSPLKVVERGYSIVTKNSEVIKSASQVKKGDLLDIRLAQGSVTAIVDGVKEE

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=443, Percent_Identity=42.4379232505643, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 51895; Mature: 51764

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSPNQPLRKTDVSAQASLGAADLLTKNNEPSVLSVEQLNIYVKQLLEGQIGQVWVKGE
CCCCCCCCCHHCCCCHHHCCCHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEE
ISNFKAHTSGHFYFSLKDSRSQITAVMFRGNNARLKFKPTDGMEVIVRGRITVYEPRGNY
CCCCEEECCCEEEEEECCCCCCEEEEEEECCCCEEEEECCCCCEEEEECEEEEECCCCCH
QLMCEMMEPVGAGALQKAFEQLKMKLKAEGLFESARKKPIPTFPRHIAIVTSPTGAAIRD
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHH
ILNVLSRRAKAIQVTVVPTIVQGEAAAPQICEAFKKATALPGVDVVIVGRGGGSIEDMWC
HHHHHHCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEE
FNDERLARLIAASPVPVISAVGHEIDFTIADFVADLRAPTPSAAAELVAKSSGELANKVV
CCHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
SLERMLHLTFEKKMKFLREKMLGLSKRLVDPKRRLQDLELRNDDLLNRLEFAINRRLAER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
RHRVELMSQKLGSPQDLIDEKKKDLEYLKARSEKALHFSIERKKARMGKVMAMLDSLSPL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCHH
KVVERGYSIVTKNSEVIKSASQVKKGDLLDIRLAQGSVTAIVDGVKEE
HHHHCCCEEEECCHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCC
>Mature Secondary Structure 
SDSPNQPLRKTDVSAQASLGAADLLTKNNEPSVLSVEQLNIYVKQLLEGQIGQVWVKGE
CCCCCCCCHHCCCCHHHCCCHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEE
ISNFKAHTSGHFYFSLKDSRSQITAVMFRGNNARLKFKPTDGMEVIVRGRITVYEPRGNY
CCCCEEECCCEEEEEECCCCCCEEEEEEECCCCEEEEECCCCCEEEEECEEEEECCCCCH
QLMCEMMEPVGAGALQKAFEQLKMKLKAEGLFESARKKPIPTFPRHIAIVTSPTGAAIRD
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHH
ILNVLSRRAKAIQVTVVPTIVQGEAAAPQICEAFKKATALPGVDVVIVGRGGGSIEDMWC
HHHHHHCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEE
FNDERLARLIAASPVPVISAVGHEIDFTIADFVADLRAPTPSAAAELVAKSSGELANKVV
CCHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
SLERMLHLTFEKKMKFLREKMLGLSKRLVDPKRRLQDLELRNDDLLNRLEFAINRRLAER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
RHRVELMSQKLGSPQDLIDEKKKDLEYLKARSEKALHFSIERKKARMGKVMAMLDSLSPL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCHH
KVVERGYSIVTKNSEVIKSASQVKKGDLLDIRLAQGSVTAIVDGVKEE
HHHHCCCEEEECCHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA