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The map label for this gene is trx [H]

Identifier: 42521808

GI number: 42521808

Start: 163152

End: 163502

Strand: Direct

Name: trx [H]

Synonym: Bd0175

Alternate gene names: 42521808

Gene position: 163152-163502 (Clockwise)

Preceding gene: 42521805

Following gene: 42521809

Centisome position: 4.31

GC content: 48.43

Gene sequence:

>351_bases
ATGGCTGTCGTAGAAATCACCAAGAACAACATTCAAGAGATCGTTGAAAGCAACAACATGATCATTCTGGATTTCTGGGC
CACATGGTGTGCACCTTGCCGTCGTTTTGCCCCGATCTTTGAGTCTGTGGCTGCAAAACACCCCGACGTGATTTTCGGAA
AGATCGACACCGAAGCGGAGGTGGAGTTGGCGGACAAGTTCCAGATCAAATCCATCCCGACTTTGATGATCATCAAAGAA
AGCGACATTATCTTCAGCCAGCCAGGCGCCTTGCCGGAAGAGATCTTTGAGCAGATCGTGGTGAAGGCCAAAGAAATCGA
CATGGAAGAGGTTCGTCGTGAAAACTCTTAA

Upstream 100 bases:

>100_bases
ACCGCGACGAGGCCGCAAACGGGCACTGGGGTGTCTAAATCTTGTGATTGTCTCATTCTGGGATTTGGGATAAGCCTAGC
GCCACAAAACAGGAGGCCCC

Downstream 100 bases:

>100_bases
GCCGTTGTTGCCACTTTTGGTGGTGCTGGCAGCATCCCAGTCCAAGGCGGTGTCCTGGAGAATCTTTGGCGCCTGCAAGA
ACTCTCCTGTGCATGAGGGA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 116; Mature: 115

Protein sequence:

>116_residues
MAVVEITKNNIQEIVESNNMIILDFWATWCAPCRRFAPIFESVAAKHPDVIFGKIDTEAEVELADKFQIKSIPTLMIIKE
SDIIFSQPGALPEEIFEQIVVKAKEIDMEEVRRENS

Sequences:

>Translated_116_residues
MAVVEITKNNIQEIVESNNMIILDFWATWCAPCRRFAPIFESVAAKHPDVIFGKIDTEAEVELADKFQIKSIPTLMIIKE
SDIIFSQPGALPEEIFEQIVVKAKEIDMEEVRRENS
>Mature_115_residues
AVVEITKNNIQEIVESNNMIILDFWATWCAPCRRFAPIFESVAAKHPDVIFGKIDTEAEVELADKFQIKSIPTLMIIKES
DIIFSQPGALPEEIFEQIVVKAKEIDMEEVRRENS

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=89, Percent_Identity=30.3370786516854, Blast_Score=63, Evalue=4e-11,
Organism=Homo sapiens, GI4758304, Length=79, Percent_Identity=34.1772151898734, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI1788936, Length=97, Percent_Identity=42.2680412371134, Blast_Score=89, Evalue=9e-20,
Organism=Escherichia coli, GI87082331, Length=100, Percent_Identity=26, Blast_Score=64, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=99, Percent_Identity=30.3030303030303, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71980565, Length=82, Percent_Identity=35.3658536585366, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=103, Percent_Identity=33.0097087378641, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=83, Percent_Identity=30.1204819277108, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=83, Percent_Identity=30.1204819277108, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=83, Percent_Identity=30.1204819277108, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507915, Length=82, Percent_Identity=34.1463414634146, Blast_Score=61, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6323072, Length=97, Percent_Identity=28.8659793814433, Blast_Score=66, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=32.5581395348837, Blast_Score=65, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319925, Length=84, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644807, Length=85, Percent_Identity=38.8235294117647, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 13252; Mature: 13121

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVVEITKNNIQEIVESNNMIILDFWATWCAPCRRFAPIFESVAAKHPDVIFGKIDTEAE
CEEEEECHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCE
VELADKFQIKSIPTLMIIKESDIIFSQPGALPEEIFEQIVVKAKEIDMEEVRRENS
EEHHCCEEECCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHCCCC
>Mature Secondary Structure 
AVVEITKNNIQEIVESNNMIILDFWATWCAPCRRFAPIFESVAAKHPDVIFGKIDTEAE
EEEEECHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCE
VELADKFQIKSIPTLMIIKESDIIFSQPGALPEEIFEQIVVKAKEIDMEEVRRENS
EEHHCCEEECCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]