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The map label for this gene is argD [H]

Identifier: 42521765

GI number: 42521765

Start: 111549

End: 112925

Strand: Direct

Name: argD [H]

Synonym: Bd0127

Alternate gene names: 42521765

Gene position: 111549-112925 (Clockwise)

Preceding gene: 42521747

Following gene: 42521766

Centisome position: 2.95

GC content: 50.11

Gene sequence:

>1377_bases
ATGAGTTCTCTTGTAGGTCATCAGATACAGCAATCCGATAAAATCAAATCCATGATTCAGGATCTTGTTGGCGAAGTTGG
AAAACTAAACGCACAGATCACTGGCATTCGCGCTCCGATGGATGAATTTAAAGATTCTGGAAAACAAAAGATTGATCTTG
CCGGTCAGTTCCGTGGTCGTCCTTTGCACTATCCGTACATGGGTACGGGCGCGGGCCGTGGTCCTTACGTGGAGCTTGAA
GATGGCAGCGTGAAACTGGATTTGATCAACGGTATCGGTATTCACCTGATGGGCCACTCTCACCCACGTGTGATCGCAGC
GGCAGTTCGTGGTTCTTTGGCGGACATCCTGACTCAAGGGAACTTGCAGCCGAACAACGAATACCGTCTGTTCACGGAAA
AGATCGTCAAACTTGCCAGCAAAAAAAGCCGTATGAAATACGCGTGGATCGCAACCTGCGGCACCATGGCCAATGAAAAC
GCGTTGAAACTTTCGCGCCAGAAAAATTCCCCGGCTCGTTTTGTGATGGGCTTTAAGGACGCCTTCGCGGGTCGTTCCAC
CATGATGGCCGAAGTGACCGACAACCCGGCATACAAACAGGGCCTGCCAGAATATAACGAAGTTTTGCGCGTTCCTTTCT
ATGACAAGCGTGATCCAAAATCCGGCGAAAAAGCTTTGAACGTGATGAAAGAGCACGTGGCAAAACACGAAGGCAATATC
TCTGTCTTTGGTTTTGAGCCGATGCTGGGTGAGGGCGGTTATCAGGCGGCTCCGCGTGAATTCTTCATCCCGCTTTTGGA
TTTCTGTAAATCCAAAAACATCGCAATCTGGGCGGACGAGGTTCAGACCTTCACACGCACAGGTGAATACTTTGCCTTTG
AAACTTTGGACATCGGCCAGTATATCGACATCTGCACGATCGCAAAAACAGCGCAGGTGGGTGCGACTCTTTACACCGAA
GAATACAATCCAAAACCAGGTTTGATTGCGGGCACATTCTCGGGCTCCACGCCGTCTTTGACAGCGGGTATGGAAATGCT
GGACATGCTGGGCGAAGGTTTCCTGGGTCCTCAGGGTCGTATCAATCAAATTCACAGACGCTTCATCGACGGCATCAACC
GTCTGAATGAAACATCCTGCAAAGGCATCGCTCAGGATGCGGGTGGTATGGGTCTGATGATTGCGTTCACTCCGCACGAT
GGCAAAAAAGAAAGCGTGAATGCCTTCCTGAATAAACTCTTCCAAAACGGCGTGATTGCTTTCCCTTGCGGTAAAGATCC
GGTTCGCGCCCGTTTCCTGGTGCCGGCGATCATTGAAGACGCTGACATCGACATCGCTTTGAAAGCGATCGAAAAAACTT
TGCTTGAAGGAGTCTAG

Upstream 100 bases:

>100_bases
TCTAGGGCGTGGCTTGTCTTAGTCCTGACCGAGGAGTAAACTAGACGGGCATTTCAAAAAACAATGGGTCCTGCTTAGAT
TAGGCCCCGCGAAAGGTATT

Downstream 100 bases:

>100_bases
TTGGACTTCATCGAGGCCTGCCGACAACTGATCGCTATCGACAGCTCACCCACTCACGGCAATAAAGAATTGTCCAAGTG
GGTGGCGGCCTTTTGCCGTC

Product: acetylornithine/succinyldiaminopimelate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSSLVGHQIQQSDKIKSMIQDLVGEVGKLNAQITGIRAPMDEFKDSGKQKIDLAGQFRGRPLHYPYMGTGAGRGPYVELE
DGSVKLDLINGIGIHLMGHSHPRVIAAAVRGSLADILTQGNLQPNNEYRLFTEKIVKLASKKSRMKYAWIATCGTMANEN
ALKLSRQKNSPARFVMGFKDAFAGRSTMMAEVTDNPAYKQGLPEYNEVLRVPFYDKRDPKSGEKALNVMKEHVAKHEGNI
SVFGFEPMLGEGGYQAAPREFFIPLLDFCKSKNIAIWADEVQTFTRTGEYFAFETLDIGQYIDICTIAKTAQVGATLYTE
EYNPKPGLIAGTFSGSTPSLTAGMEMLDMLGEGFLGPQGRINQIHRRFIDGINRLNETSCKGIAQDAGGMGLMIAFTPHD
GKKESVNAFLNKLFQNGVIAFPCGKDPVRARFLVPAIIEDADIDIALKAIEKTLLEGV

Sequences:

>Translated_458_residues
MSSLVGHQIQQSDKIKSMIQDLVGEVGKLNAQITGIRAPMDEFKDSGKQKIDLAGQFRGRPLHYPYMGTGAGRGPYVELE
DGSVKLDLINGIGIHLMGHSHPRVIAAAVRGSLADILTQGNLQPNNEYRLFTEKIVKLASKKSRMKYAWIATCGTMANEN
ALKLSRQKNSPARFVMGFKDAFAGRSTMMAEVTDNPAYKQGLPEYNEVLRVPFYDKRDPKSGEKALNVMKEHVAKHEGNI
SVFGFEPMLGEGGYQAAPREFFIPLLDFCKSKNIAIWADEVQTFTRTGEYFAFETLDIGQYIDICTIAKTAQVGATLYTE
EYNPKPGLIAGTFSGSTPSLTAGMEMLDMLGEGFLGPQGRINQIHRRFIDGINRLNETSCKGIAQDAGGMGLMIAFTPHD
GKKESVNAFLNKLFQNGVIAFPCGKDPVRARFLVPAIIEDADIDIALKAIEKTLLEGV
>Mature_457_residues
SSLVGHQIQQSDKIKSMIQDLVGEVGKLNAQITGIRAPMDEFKDSGKQKIDLAGQFRGRPLHYPYMGTGAGRGPYVELED
GSVKLDLINGIGIHLMGHSHPRVIAAAVRGSLADILTQGNLQPNNEYRLFTEKIVKLASKKSRMKYAWIATCGTMANENA
LKLSRQKNSPARFVMGFKDAFAGRSTMMAEVTDNPAYKQGLPEYNEVLRVPFYDKRDPKSGEKALNVMKEHVAKHEGNIS
VFGFEPMLGEGGYQAAPREFFIPLLDFCKSKNIAIWADEVQTFTRTGEYFAFETLDIGQYIDICTIAKTAQVGATLYTEE
YNPKPGLIAGTFSGSTPSLTAGMEMLDMLGEGFLGPQGRINQIHRRFIDGINRLNETSCKGIAQDAGGMGLMIAFTPHDG
KKESVNAFLNKLFQNGVIAFPCGKDPVRARFLVPAIIEDADIDIALKAIEKTLLEGV

Specific function: Unknown

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI188536080, Length=407, Percent_Identity=23.5872235872236, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI38679950, Length=407, Percent_Identity=23.5872235872236, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI38679946, Length=407, Percent_Identity=23.5872235872236, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1787560, Length=392, Percent_Identity=29.8469387755102, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789759, Length=391, Percent_Identity=28.3887468030691, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1789016, Length=396, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788044, Length=384, Percent_Identity=25.78125, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693181, Length=418, Percent_Identity=26.555023923445, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17541228, Length=485, Percent_Identity=24.1237113402062, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=25.9259259259259, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281366494, Length=427, Percent_Identity=24.5901639344262, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24667139, Length=427, Percent_Identity=24.5901639344262, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24667143, Length=427, Percent_Identity=24.5901639344262, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 50282; Mature: 50151

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLVGHQIQQSDKIKSMIQDLVGEVGKLNAQITGIRAPMDEFKDSGKQKIDLAGQFRGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHCCCCEEEEEECCCCCC
PLHYPYMGTGAGRGPYVELEDGSVKLDLINGIGIHLMGHSHPRVIAAAVRGSLADILTQG
EECCCCCCCCCCCCCEEEEECCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHCC
NLQPNNEYRLFTEKIVKLASKKSRMKYAWIATCGTMANENALKLSRQKNSPARFVMGFKD
CCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHEECCCCCCCCEEEEEHHH
AFAGRSTMMAEVTDNPAYKQGLPEYNEVLRVPFYDKRDPKSGEKALNVMKEHVAKHEGNI
HHCCCCEEEEEECCCCHHHHCCCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
SVFGFEPMLGEGGYQAAPREFFIPLLDFCKSKNIAIWADEVQTFTRTGEYFAFETLDIGQ
EEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCEEEEEEECCCC
YIDICTIAKTAQVGATLYTEEYNPKPGLIAGTFSGSTPSLTAGMEMLDMLGEGFLGPQGR
HHHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCH
INQIHRRFIDGINRLNETSCKGIAQDAGGMGLMIAFTPHDGKKESVNAFLNKLFQNGVIA
HHHHHHHHHHHHHHCCHHHHCCHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEE
FPCGKDPVRARFLVPAIIEDADIDIALKAIEKTLLEGV
ECCCCCCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSLVGHQIQQSDKIKSMIQDLVGEVGKLNAQITGIRAPMDEFKDSGKQKIDLAGQFRGR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHCCCCEEEEEECCCCCC
PLHYPYMGTGAGRGPYVELEDGSVKLDLINGIGIHLMGHSHPRVIAAAVRGSLADILTQG
EECCCCCCCCCCCCCEEEEECCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHCC
NLQPNNEYRLFTEKIVKLASKKSRMKYAWIATCGTMANENALKLSRQKNSPARFVMGFKD
CCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHEECCCCCCCCEEEEEHHH
AFAGRSTMMAEVTDNPAYKQGLPEYNEVLRVPFYDKRDPKSGEKALNVMKEHVAKHEGNI
HHCCCCEEEEEECCCCHHHHCCCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
SVFGFEPMLGEGGYQAAPREFFIPLLDFCKSKNIAIWADEVQTFTRTGEYFAFETLDIGQ
EEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCEEEEEEECCCC
YIDICTIAKTAQVGATLYTEEYNPKPGLIAGTFSGSTPSLTAGMEMLDMLGEGFLGPQGR
HHHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCH
INQIHRRFIDGINRLNETSCKGIAQDAGGMGLMIAFTPHDGKKESVNAFLNKLFQNGVIA
HHHHHHHHHHHHHHCCHHHHCCHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEE
FPCGKDPVRARFLVPAIIEDADIDIALKAIEKTLLEGV
ECCCCCCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]